{"id":"https://openalex.org/W2000706451","doi":"https://doi.org/10.1083/jcb.200401138","title":"Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling","display_name":"Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling","publication_year":2004,"publication_date":"2004-06-28","ids":{"openalex":"https://openalex.org/W2000706451","doi":"https://doi.org/10.1083/jcb.200401138","mag":"2000706451","pmid":"https://pubmed.ncbi.nlm.nih.gov/15226309","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2172136"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.200401138","doi":"https://doi.org/10.1083/jcb.200401138","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.200401138","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2172136","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036953877","display_name":"Takashi Fujita","orcid":"https://orcid.org/0000-0001-9961-0535","observed_orcids":["https://orcid.org/0000-0001-9961-0535"]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Fujita","raw_affiliation_strings":["1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata 573-0101, Japan","Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, 573-0101, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata 573-0101, Japan","institution_ids":["https://openalex.org/I102826571"]},{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, 573-0101, Japan","institution_ids":["https://openalex.org/I102826571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084497296","display_name":"Yasu\u2010Taka Azuma","orcid":"https://orcid.org/0000-0002-3515-171X","observed_orcids":["https://orcid.org/0000-0002-3515-171X"]},"institutions":[{"id":"https://openalex.org/I92722194","display_name":"Osaka Dental University","ror":"https://ror.org/053kccs63","country_code":"JP","type":"education","lineage":["https://openalex.org/I92722194"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasutaka Azuma","raw_affiliation_strings":["2Department of Pharmacology, Osaka Dental University, Hirakata 573-1121, Japan","Department of Pharmacology, Osaka Dental University, Hirakata 573-1121, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pharmacology, Osaka Dental University, Hirakata 573-1121, Japan","institution_ids":["https://openalex.org/I92722194"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Dental University, Hirakata 573-1121, Japan","institution_ids":["https://openalex.org/I92722194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032088633","display_name":"Ryo Fukuyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131401","display_name":"Hiroshima International University","ror":"https://ror.org/03dk6an77","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210131401"]},{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryo Fukuyama","raw_affiliation_strings":["3Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Hiroshima International University, Kure 737-0112, Japan","4Division of Oral Cytology and Cell Biology, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Hiroshima International University, Kure 737-0112, Japan","institution_ids":["https://openalex.org/I4210131401"]},{"raw_affiliation_string":"4Division of Oral Cytology and Cell Biology, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuji Hattori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Hattori","raw_affiliation_strings":["1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata 573-0101, Japan","Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, 573-0101, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata 573-0101, Japan","institution_ids":["https://openalex.org/I102826571"]},{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, 573-0101, Japan","institution_ids":["https://openalex.org/I102826571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111698509","display_name":"Carolina Andrea Yoshida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Carolina Yoshida","raw_affiliation_strings":["4Division of Oral Cytology and Cell Biology, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan","5Department of Orthodontics and Dentofacial Orthopedics, Osaka University Faculty of Dentistry, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Division of Oral Cytology and Cell Biology, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan","institution_ids":["https://openalex.org/I43777268"]},{"raw_affiliation_string":"5Department of Orthodontics and Dentofacial Orthopedics, Osaka University Faculty of Dentistry, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086292182","display_name":"Masao Koida","orcid":"https://orcid.org/0000-0002-1201-7868","observed_orcids":["https://orcid.org/0000-0002-1201-7868"]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masao Koida","raw_affiliation_strings":["1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata 573-0101, Japan","Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, 573-0101, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata 573-0101, Japan","institution_ids":["https://openalex.org/I102826571"]},{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, 573-0101, Japan","institution_ids":["https://openalex.org/I102826571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083134882","display_name":"Kiyokazu Ogita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyokazu Ogita","raw_affiliation_strings":["1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata 573-0101, Japan","Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, 573-0101, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata 573-0101, Japan","institution_ids":["https://openalex.org/I102826571"]},{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, 573-0101, Japan","institution_ids":["https://openalex.org/I102826571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010742020","display_name":"Toshihisa Komori","orcid":"https://orcid.org/0000-0002-0284-5723","observed_orcids":["https://orcid.org/0000-0002-0284-5723"]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihisa Komori","raw_affiliation_strings":["4Division of Oral Cytology and Cell Biology, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Division of Oral Cytology and Cell Biology, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan","institution_ids":["https://openalex.org/I43777268"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.1967,"has_fulltext":false,"cited_by_count":473,"citation_normalized_percentile":{"value":0.95799449,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"166","issue":"1","first_page":"85","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.025599999353289604,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9789999723434448},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chondrogenic-differentiation","display_name":"chondrogenic differentiation","score":0.968999981880188},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9800000190734863},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8180000185966492},{"id":"https://openalex.org/keywords/pi3k-p85","display_name":"PI3K p85","score":0.7639999985694885},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.6060000061988831},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/growth-plate","display_name":"growth plate","score":0.8579999804496765},{"id":"https://openalex.org/keywords/c3h10t1-2-cells","display_name":"C3H10T1/2 cells","score":0.8569999933242798},{"id":"https://openalex.org/keywords/mc3t3-e1-cells","display_name":"MC3T3-E1 cells","score":0.9490000009536743},{"id":"https://openalex.org/keywords/atdc5-cells","display_name":"ATDC5 cells","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C2776363554","wikidata":"https://www.wikidata.org/wiki/Q14907085","display_name":"RUNX2","level":4,"score":0.9661344289779663},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7744331359863281},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7490103244781494},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.6722012162208557},{"id":"https://openalex.org/C2776912716","wikidata":"https://www.wikidata.org/wiki/Q4042503","display_name":"LY294002","level":4,"score":0.6537653207778931},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.6352612972259521},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5798872113227844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5734803676605225},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4151628017425537},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.11745256185531616},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10047072172164917},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.07172253727912903},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005799","descriptor_name":"Genes, Dominant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050659","descriptor_name":"Core Binding Factor Alpha 1 Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1083/jcb.200401138","doi":"https://doi.org/10.1083/jcb.200401138","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.200401138","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2172136","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2172136","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:15226309","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15226309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.273.4589","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.273.4589","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/6d/4a/J_Cell_Biol_2004_Jul_5_166(1)_85-95.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2172136","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2172136","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W26433322","https://openalex.org/W1552563052","https://openalex.org/W1574722884","https://openalex.org/W1963714463","https://openalex.org/W1967025304","https://openalex.org/W1971551127","https://openalex.org/W1984706102","https://openalex.org/W1989533590","https://openalex.org/W1992184028","https://openalex.org/W1993672117","https://openalex.org/W1994596418","https://openalex.org/W1997812904","https://openalex.org/W2003865274","https://openalex.org/W2010254035","https://openalex.org/W2020811802","https://openalex.org/W2025046506","https://openalex.org/W2036597924","https://openalex.org/W2041840159","https://openalex.org/W2063220206","https://openalex.org/W2065063645","https://openalex.org/W2065547075","https://openalex.org/W2066504997","https://openalex.org/W2070591061","https://openalex.org/W2075529268","https://openalex.org/W2079475603","https://openalex.org/W2083319499","https://openalex.org/W2083882414","https://openalex.org/W2095220412","https://openalex.org/W2102059629","https://openalex.org/W2104601536","https://openalex.org/W2117517020","https://openalex.org/W2122367477","https://openalex.org/W2122433264","https://openalex.org/W2130671879","https://openalex.org/W2137563421","https://openalex.org/W2150684620","https://openalex.org/W2157102677","https://openalex.org/W2163995267","https://openalex.org/W2401164797"],"related_works":["https://openalex.org/W7099462877","https://openalex.org/W1919536350","https://openalex.org/W2789054899","https://openalex.org/W2081264270","https://openalex.org/W898760283","https://openalex.org/W1980106834","https://openalex.org/W2392553863","https://openalex.org/W3028374389","https://openalex.org/W3022578129","https://openalex.org/W932475686"],"abstract_inverted_index":{"Runx2":[0,19,26,63,76,88,106,122,137],"and":[1,11,20,32,35,93,95,97,123,138,152,155],"phosphatidylinositol":[2],"3-kinase":[3],"(PI3K)-Akt":[4],"signaling":[5,140],"play":[6],"important":[7],"roles":[8],"in":[9,107,147],"osteoblast":[10,151],"chondrocyte":[12,153],"differentiation.":[13],"We":[14],"investigated":[15],"the":[16,73,148],"relationship":[17],"between":[18],"PI3K-Akt":[21,139],"signaling.":[22],"Forced":[23,60],"expression":[24,61,99,128],"of":[25,30,39,57,62,86,105,115,121,129,150],"enhanced":[27,36,66,131],"osteoblastic":[28],"differentiation":[29,38,154],"C3H10T1/2":[31],"MC3T3-E1":[33],"cells":[34],"chondrogenic":[37],"ATDC5":[40],"cells,":[41],"whereas":[42,72,126],"these":[43],"effects":[44],"were":[45,101],"blocked":[46],"by":[47,75,79],"treatment":[48,80],"with":[49,81,111],"IGF-I":[50],"antibody":[51],"or":[52,54,64,67,83,113],"LY294002":[53,82,112],"adenoviral":[55,84],"introduction":[56,85,114],"dominant-negative":[58],"(dn)-Akt.":[59],"dn-Runx2":[65],"inhibited":[68],"cell":[69],"migration,":[70],"respectively,":[71],"enhancement":[74],"was":[77],"abolished":[78],"dn-Akt.":[87],"up-regulated":[89],"PI3K":[90],"subunits":[91],"(p85":[92],"p110beta)":[94],"Akt,":[96],"their":[98,156],"patterns":[100],"similar":[102],"to":[103],"that":[104,136],"growth":[108],"plates.":[109],"Treatment":[110],"dn-Akt":[116],"severely":[117],"diminished":[118],"DNA":[119],"binding":[120],"Runx2-dependent":[124],"transcription,":[125],"forced":[127],"myrAkt":[130],"them.":[132],"These":[133],"findings":[134],"demonstrate":[135],"are":[141],"mutually":[142],"dependent":[143],"on":[144],"each":[145],"other":[146],"regulation":[149],"migration.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":25},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":26},{"year":2018,"cited_by_count":22},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":29},{"year":2014,"cited_by_count":31},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":24}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}
