{"id":"https://openalex.org/W2000703296","doi":"https://doi.org/10.1002/dc.2840110203","title":"p53 immunolocalization in cytology specimens: A study in human esophageal carcinoma","display_name":"p53 immunolocalization in cytology specimens: A study in human esophageal carcinoma","publication_year":1994,"publication_date":"1994-08-01","ids":{"openalex":"https://openalex.org/W2000703296","doi":"https://doi.org/10.1002/dc.2840110203","mag":"2000703296","pmid":"https://pubmed.ncbi.nlm.nih.gov/7813357"},"language":"en","primary_location":{"id":"doi:10.1002/dc.2840110203","doi":"https://doi.org/10.1002/dc.2840110203","is_oa":false,"landing_page_url":"https://doi.org/10.1002/dc.2840110203","pdf_url":null,"source":{"id":"https://openalex.org/S23314063","display_name":"Diagnostic Cytopathology","issn_l":"1097-0339","issn":["1097-0339","8755-1039"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diagnostic Cytopathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010222435","display_name":"Yuji Goukon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yuji Goukon","raw_affiliation_strings":["Department of Pathology, Tohoku University School of Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Tohoku University School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111864416","display_name":"Hironobu Sasano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hironobu Sasano","raw_affiliation_strings":["Departments of Pathology and Surgery, Tohoku University School of Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Surgery, Tohoku University School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083243384","display_name":"Tetsuro Nishihira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuro Nishihira","raw_affiliation_strings":["Departments of Pathology and Surgery, Tohoku University School of Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Surgery, Tohoku University School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103649838","display_name":"Shozo Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shozo Mori","raw_affiliation_strings":["Departments of Pathology and Surgery, Tohoku University School of Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Surgery, Tohoku University School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100827233","display_name":"Hiroshi Nagura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Nagura","raw_affiliation_strings":["Departments of Pathology and Surgery, Tohoku University School of Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Surgery, Tohoku University School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010222435"],"corresponding_institution_ids":["https://openalex.org/I201537933"],"apc_list":{"value":3920,"currency":"USD","value_usd":3920},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"2","first_page":"113","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.17110000550746918,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9319999814033508},{"id":"https://openalex.org/keywords/esophageal-squamous-cell-carcinoma","display_name":"esophageal squamous cell carcinoma","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cytological-specimens","display_name":"cytology specimens","score":0.7509999871253967},{"id":"https://openalex.org/keywords/immunolocalization","display_name":"immunolocalization","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cytological-diagnosis","display_name":"cytological diagnosis","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C18823058","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cytology","level":2,"score":0.8315093517303467},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7865722179412842},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.7434732913970947},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7113386392593384},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5836442112922668},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5806971192359924}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003584","descriptor_name":"Cytological Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/dc.2840110203","doi":"https://doi.org/10.1002/dc.2840110203","is_oa":false,"landing_page_url":"https://doi.org/10.1002/dc.2840110203","pdf_url":null,"source":{"id":"https://openalex.org/S23314063","display_name":"Diagnostic Cytopathology","issn_l":"1097-0339","issn":["1097-0339","8755-1039"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diagnostic Cytopathology","raw_type":"journal-article"},{"id":"pmid:7813357","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7813357","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diagnostic cytopathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W35717447","https://openalex.org/W41972474","https://openalex.org/W1805678211","https://openalex.org/W1859397449","https://openalex.org/W1876331073","https://openalex.org/W2034639401","https://openalex.org/W2057397700","https://openalex.org/W2058183718","https://openalex.org/W2065505484","https://openalex.org/W2070051352","https://openalex.org/W2078604197","https://openalex.org/W2085172497","https://openalex.org/W2121328511","https://openalex.org/W2149287328","https://openalex.org/W2154381385","https://openalex.org/W2167257268","https://openalex.org/W2316096913","https://openalex.org/W2323033061","https://openalex.org/W2331385948","https://openalex.org/W2409492927","https://openalex.org/W2470267030","https://openalex.org/W4301156531"],"related_works":["https://openalex.org/W2070419431","https://openalex.org/W2467817070","https://openalex.org/W2099844251","https://openalex.org/W7220699326","https://openalex.org/W1981113304","https://openalex.org/W2346975511","https://openalex.org/W2153718516","https://openalex.org/W2007405905","https://openalex.org/W1990528135","https://openalex.org/W2120996376"],"abstract_inverted_index":{"Immunohistochemical":[0],"analysis":[1],"of":[2,9,14,23,36,52,88,105,115,133],"p53":[3,15,37,67,89,116,125],"has":[4,16],"become":[5],"an":[6],"established":[7],"method":[8,122],"detecting":[10,124],"mutated":[11],"p53.":[12],"Immunolocalization":[13],"been":[17],"extensively":[18],"studied":[19],"in":[20,29,38,49,72,77,80,94,99,117],"tissue":[21,42,82],"sections":[22],"many":[24],"human":[25,53],"neoplasms,":[26],"but":[27,75],"not":[28,76],"cytology":[30,40,84,95,118],"specimens.":[31],"Therefore,":[32],"we":[33],"performed":[34],"immunolocalization":[35],"both":[39,81,106],"and":[41,62,83,96,101,127,141],"preparations":[43],"obtained":[44],"from":[45],"the":[46,102,131],"same":[47],"specimens":[48],"19":[50],"cases":[51],"esophageal":[54],"squamous-cell":[55],"carcinoma.":[56],"Three":[57],"different":[58],"antibodies,":[59],"PAb1801,":[60],"DO-7,":[61],"CM-1,":[63],"were":[64],"employed.":[65],"Positive":[66],"nuclear":[68],"immunoreactivity":[69],"was":[70,91,108],"observed":[71],"carcinoma":[73],"cells,":[74,79],"noncarcinomatous":[78],"preparations.":[85],"The":[86],"incidence":[87],"positivity":[90],"53%":[92],"(10/19)":[93],"42%":[97],"(8/19)":[98],"tissue,":[100],"coincident":[103],"rate":[104],"results":[107],"89%":[109],"(17/19).":[110],"We":[111],"conclude":[112],"that":[113],"immunohistochemistry":[114],"is":[119,137],"a":[120,138],"useful":[121],"for":[123],"mutations,":[126],"may":[128],"contribute":[129],"to":[130],"diagnosis":[132],"malignancy,":[134],"because":[135],"it":[136],"simple,":[139],"easy,":[140],"rapid":[142],"technique.":[143]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}