{"id":"https://openalex.org/W2000696784","doi":"https://doi.org/10.1111/j.1600-065x.1978.tb00264.x","title":"Thymus and Lymphohemopoietic Cells: Their Role in T Cell Maturation in Selection of T Cells' H\u20102\u2010Restriction\u2010Specificity and in H\u20102 Linked Ir Gene Control","display_name":"Thymus and Lymphohemopoietic Cells: Their Role in T Cell Maturation in Selection of T Cells' H\u20102\u2010Restriction\u2010Specificity and in H\u20102 Linked Ir Gene Control","publication_year":1978,"publication_date":"1978-12-01","ids":{"openalex":"https://openalex.org/W2000696784","doi":"https://doi.org/10.1111/j.1600-065x.1978.tb00264.x","mag":"2000696784","pmid":"https://pubmed.ncbi.nlm.nih.gov/83701"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-065x.1978.tb00264.x","doi":"https://doi.org/10.1111/j.1600-065x.1978.tb00264.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-065x.1978.tb00264.x","pdf_url":null,"source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2000696784"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113991567","display_name":"Rolf M. Zinkernagel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R. M. ZINKERNAGEL","raw_affiliation_strings":["Immunology Dept., Scripps Clinic and Research Foundation, La Jolla, Calif. 92037, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Dept., Scripps Clinic and Research Foundation, La Jolla, Calif. 92037, U.S.A","institution_ids":["https://openalex.org/I4210146328"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113991567"],"corresponding_institution_ids":["https://openalex.org/I4210146328"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":4.0884,"has_fulltext":false,"cited_by_count":293,"citation_normalized_percentile":{"value":0.94444444,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"42","issue":"1","first_page":"224","last_page":"270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymus","display_name":"thymus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.9940000176429749},{"id":"https://openalex.org/keywords/t-cell-selection","display_name":"T cell selection","score":0.7599999904632568},{"id":"https://openalex.org/keywords/h-2-restriction","display_name":"H-2 restriction","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.6518523693084717},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5546398162841797},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.4576801657676697},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41869762539863586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3593977689743042},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3324735760688782},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.3310762643814087},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.20326176285743713},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.19485297799110413},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.15593424439430237}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005802","descriptor_name":"Genes, MHC Class II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006183","descriptor_name":"H-2 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011828","descriptor_name":"Radiation Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1600-065x.1978.tb00264.x","doi":"https://doi.org/10.1111/j.1600-065x.1978.tb00264.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-065x.1978.tb00264.x","pdf_url":null,"source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},{"id":"pmid:83701","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/83701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological reviews","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:ssbb1978-3569","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1978/2570","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1978","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":123,"referenced_works":["https://openalex.org/W60987328","https://openalex.org/W67799235","https://openalex.org/W269894721","https://openalex.org/W379981514","https://openalex.org/W1503737096","https://openalex.org/W1535493568","https://openalex.org/W1541406880","https://openalex.org/W1547978013","https://openalex.org/W1549257194","https://openalex.org/W1572952371","https://openalex.org/W1596182019","https://openalex.org/W1597280377","https://openalex.org/W1602167378","https://openalex.org/W1646154561","https://openalex.org/W1964597036","https://openalex.org/W1967179992","https://openalex.org/W1967552760","https://openalex.org/W1967702267","https://openalex.org/W1968039269","https://openalex.org/W1974388054","https://openalex.org/W1974828072","https://openalex.org/W1974906068","https://openalex.org/W1976046966","https://openalex.org/W1976161875","https://openalex.org/W1976184790","https://openalex.org/W1977774984","https://openalex.org/W1977904979","https://openalex.org/W1978824428","https://openalex.org/W1982817758","https://openalex.org/W1984712515","https://openalex.org/W1987514925","https://openalex.org/W1988109949","https://openalex.org/W1990261578","https://openalex.org/W1998240361","https://openalex.org/W2000351210","https://openalex.org/W2003080472","https://openalex.org/W2005096752","https://openalex.org/W2007777360","https://openalex.org/W2009427931","https://openalex.org/W2010133207","https://openalex.org/W2011044270","https://openalex.org/W2013861745","https://openalex.org/W2015192887","https://openalex.org/W2015442219","https://openalex.org/W2016657861","https://openalex.org/W2018855162","https://openalex.org/W2021169541","https://openalex.org/W2024251508","https://openalex.org/W2027577736","https://openalex.org/W2028670006","https://openalex.org/W2028726208","https://openalex.org/W2031567486","https://openalex.org/W2031811466","https://openalex.org/W2035195082","https://openalex.org/W2035387224","https://openalex.org/W2043407462","https://openalex.org/W2044050266","https://openalex.org/W2044306335","https://openalex.org/W2045294108","https://openalex.org/W2045496674","https://openalex.org/W2046061999","https://openalex.org/W2046618270","https://openalex.org/W2048198586","https://openalex.org/W2068398001","https://openalex.org/W2069142618","https://openalex.org/W2071021373","https://openalex.org/W2072478036","https://openalex.org/W2075756811","https://openalex.org/W2075778307","https://openalex.org/W2076211567","https://openalex.org/W2077775925","https://openalex.org/W2078951917","https://openalex.org/W2085619452","https://openalex.org/W2085915950","https://openalex.org/W2086198523","https://openalex.org/W2089463704","https://openalex.org/W2089751182","https://openalex.org/W2092632215","https://openalex.org/W2093658487","https://openalex.org/W2094118670","https://openalex.org/W2095207573","https://openalex.org/W2095549345","https://openalex.org/W2098777022","https://openalex.org/W2099112157","https://openalex.org/W2100375684","https://openalex.org/W2108794662","https://openalex.org/W2115769887","https://openalex.org/W2118396154","https://openalex.org/W2119026807","https://openalex.org/W2120370266","https://openalex.org/W2120897839","https://openalex.org/W2120912287","https://openalex.org/W2121285814","https://openalex.org/W2122833369","https://openalex.org/W2124120453","https://openalex.org/W2125407224","https://openalex.org/W2129203922","https://openalex.org/W2129996008","https://openalex.org/W2131467024","https://openalex.org/W2133072517","https://openalex.org/W2136301217","https://openalex.org/W2139195098","https://openalex.org/W2143480041","https://openalex.org/W2148756418","https://openalex.org/W2152214043","https://openalex.org/W2154131040","https://openalex.org/W2158055057","https://openalex.org/W2159580995","https://openalex.org/W2166673558","https://openalex.org/W2167167519","https://openalex.org/W2169522414","https://openalex.org/W2235675419","https://openalex.org/W2286796591","https://openalex.org/W2287324627","https://openalex.org/W2409124640","https://openalex.org/W2416583180","https://openalex.org/W2530023051","https://openalex.org/W3027998753","https://openalex.org/W4231870994","https://openalex.org/W4238071526","https://openalex.org/W4247887240","https://openalex.org/W6986744278","https://openalex.org/W7097144768"],"related_works":["https://openalex.org/W2014698792","https://openalex.org/W2049645481","https://openalex.org/W7015870529","https://openalex.org/W7095421877","https://openalex.org/W2167102170","https://openalex.org/W2062304565","https://openalex.org/W2061058424","https://openalex.org/W2152831418","https://openalex.org/W2068401310"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
