{"id":"https://openalex.org/W2000695783","doi":"https://doi.org/10.1038/gt.2008.170","title":"Tailoring the AAV vector capsid for gene therapy","display_name":"Tailoring the AAV vector capsid for gene therapy","publication_year":2008,"publication_date":"2008-12-04","ids":{"openalex":"https://openalex.org/W2000695783","doi":"https://doi.org/10.1038/gt.2008.170","mag":"2000695783","pmid":"https://pubmed.ncbi.nlm.nih.gov/19052631"},"language":"en","primary_location":{"id":"doi:10.1038/gt.2008.170","doi":"https://doi.org/10.1038/gt.2008.170","is_oa":false,"landing_page_url":"https://doi.org/10.1038/gt.2008.170","pdf_url":null,"source":{"id":"https://openalex.org/S65405509","display_name":"Gene Therapy","issn_l":"0969-7128","issn":["0969-7128","1476-5462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009839456","display_name":"Luk H. Vandenberghe","orcid":"https://orcid.org/0000-0002-3508-4924","observed_orcids":["https://orcid.org/0000-0002-3508-4924"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L H Vandenberghe","raw_affiliation_strings":["Gene Therapy Program, Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Therapy Program, Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051344823","display_name":"James M. Wilson","orcid":"https://orcid.org/0000-0002-9630-3131","observed_orcids":["https://orcid.org/0000-0002-9630-3131","https://orcid.org/0000-0002-7988-0201"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J M Wilson","raw_affiliation_strings":["Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, Gene Therapy Program, University of Pennsylvania, Philadelphia, PA, USA","Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, Gene Therapy Program, University of Pennsylvania, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, Gene Therapy Program, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, Gene Therapy Program, University of Pennsylvania, Philadelphia, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009470292","display_name":"Guangping Gao","orcid":"https://orcid.org/0000-0003-0097-9012","observed_orcids":["https://orcid.org/0000-0003-0097-9012"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"G Gao","raw_affiliation_strings":["Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, Gene Therapy Program, University of Pennsylvania, Philadelphia, PA, USA","Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA, USA","Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, Gene Therapy Program, University of Pennsylvania, Philadelphia, USA","Gene Therapy Center, University of Massachusetts Medical School, Worcester, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, Gene Therapy Program, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA, USA","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, Gene Therapy Program, University of Pennsylvania, Philadelphia, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Gene Therapy Center, University of Massachusetts Medical School, Worcester, USA","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009470292"],"corresponding_institution_ids":["https://openalex.org/I166722992","https://openalex.org/I79576946"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":0.9938,"has_fulltext":false,"cited_by_count":160,"citation_normalized_percentile":{"value":0.6965085,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"16","issue":"3","first_page":"311","last_page":"319"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adeno-associated-virus","display_name":"adeno-associated virus","score":0.9290000200271606},{"id":"https://openalex.org/keywords/aav-capsid","display_name":"AAV capsid","score":0.9380000233650208},{"id":"https://openalex.org/keywords/gene-therapy-vectors","display_name":"gene therapy vectors","score":0.8159999847412109},{"id":"https://openalex.org/keywords/capsid-engineering","display_name":"capsid engineering","score":0.652999997138977},{"id":"https://openalex.org/keywords/directed-evolution","display_name":"directed evolution","score":0.8109999895095825},{"id":"https://openalex.org/keywords/host-vector-interactions","display_name":"vector-host interactions","score":0.8309999704360962},{"id":"https://openalex.org/keywords/preclinical-to-clinical-translation","display_name":"preclinical to clinical translation","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.9681626558303833},{"id":"https://openalex.org/C2778107364","wikidata":"https://www.wikidata.org/wiki/Q355989","display_name":"Adeno-associated virus","level":5,"score":0.8313714265823364},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.7982133626937866},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.739633321762085},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.69114750623703},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6852214932441711},{"id":"https://openalex.org/C3018928802","wikidata":"https://www.wikidata.org/wiki/Q83185","display_name":"Gene transfer","level":3,"score":0.6160370707511902},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.6039062738418579},{"id":"https://openalex.org/C43953973","wikidata":"https://www.wikidata.org/wiki/Q7917858","display_name":"Vectors in gene therapy","level":5,"score":0.5155346393585205},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.4882350265979767},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47703808546066284},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4762023687362671},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.44931501150131226},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.378240168094635},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.29738807678222656},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28428176045417786},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.13181275129318237}],"mesh":[{"descriptor_ui":"D000229","descriptor_name":"Dependovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/gt.2008.170","doi":"https://doi.org/10.1038/gt.2008.170","is_oa":false,"landing_page_url":"https://doi.org/10.1038/gt.2008.170","pdf_url":null,"source":{"id":"https://openalex.org/S65405509","display_name":"Gene Therapy","issn_l":"0969-7128","issn":["0969-7128","1476-5462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Therapy","raw_type":"journal-article"},{"id":"pmid:19052631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19052631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W15418036","https://openalex.org/W23651898","https://openalex.org/W1220172926","https://openalex.org/W1487084354","https://openalex.org/W1504723104","https://openalex.org/W1505196125","https://openalex.org/W1598111769","https://openalex.org/W1963623233","https://openalex.org/W1965786463","https://openalex.org/W1966493859","https://openalex.org/W1968382713","https://openalex.org/W1970138286","https://openalex.org/W1971410862","https://openalex.org/W1973658117","https://openalex.org/W1975528602","https://openalex.org/W1976329054","https://openalex.org/W1977108718","https://openalex.org/W1978519692","https://openalex.org/W1982869964","https://openalex.org/W1984764475","https://openalex.org/W1987013465","https://openalex.org/W1988197108","https://openalex.org/W2000185853","https://openalex.org/W2003523739","https://openalex.org/W2007261697","https://openalex.org/W2008254103","https://openalex.org/W2008289270","https://openalex.org/W2008389564","https://openalex.org/W2008895870","https://openalex.org/W2012104351","https://openalex.org/W2014537162","https://openalex.org/W2017608179","https://openalex.org/W2019656743","https://openalex.org/W2021202438","https://openalex.org/W2022161423","https://openalex.org/W2024617071","https://openalex.org/W2025763389","https://openalex.org/W2029612951","https://openalex.org/W2031675363","https://openalex.org/W2033689077","https://openalex.org/W2036877355","https://openalex.org/W2041157989","https://openalex.org/W2042598793","https://openalex.org/W2042811786","https://openalex.org/W2045292147","https://openalex.org/W2046488302","https://openalex.org/W2046740401","https://openalex.org/W2047608515","https://openalex.org/W2047667011","https://openalex.org/W2048008983","https://openalex.org/W2053706844","https://openalex.org/W2054153962","https://openalex.org/W2054677438","https://openalex.org/W2057548071","https://openalex.org/W2058010019","https://openalex.org/W2062249345","https://openalex.org/W2064199560","https://openalex.org/W2065380345","https://openalex.org/W2066015597","https://openalex.org/W2068359087","https://openalex.org/W2072311045","https://openalex.org/W2077265814","https://openalex.org/W2077387683","https://openalex.org/W2079248564","https://openalex.org/W2080951809","https://openalex.org/W2088555526","https://openalex.org/W2090256568","https://openalex.org/W2091134968","https://openalex.org/W2091177028","https://openalex.org/W2095401453","https://openalex.org/W2097092564","https://openalex.org/W2097281779","https://openalex.org/W2098603564","https://openalex.org/W2102111681","https://openalex.org/W2103918419","https://openalex.org/W2107753368","https://openalex.org/W2109751467","https://openalex.org/W2110746342","https://openalex.org/W2111837903","https://openalex.org/W2113082692","https://openalex.org/W2113444875","https://openalex.org/W2113637218","https://openalex.org/W2120777256","https://openalex.org/W2120913633","https://openalex.org/W2125160350","https://openalex.org/W2125375279","https://openalex.org/W2128033750","https://openalex.org/W2136085939","https://openalex.org/W2136742761","https://openalex.org/W2137222303","https://openalex.org/W2137702198","https://openalex.org/W2138104392","https://openalex.org/W2141236766","https://openalex.org/W2141354154","https://openalex.org/W2145365087","https://openalex.org/W2147193337","https://openalex.org/W2147844196","https://openalex.org/W2148389596","https://openalex.org/W2148601484","https://openalex.org/W2151809142","https://openalex.org/W2153140538","https://openalex.org/W2153867928","https://openalex.org/W2154329712","https://openalex.org/W2155710930","https://openalex.org/W2158522626","https://openalex.org/W2158647587","https://openalex.org/W2158777932","https://openalex.org/W2158855588","https://openalex.org/W2161655523","https://openalex.org/W2162857177","https://openalex.org/W2164453107","https://openalex.org/W2169257419","https://openalex.org/W2170205772","https://openalex.org/W2170490863","https://openalex.org/W2172107348","https://openalex.org/W2177438840","https://openalex.org/W2316922932","https://openalex.org/W2410236485","https://openalex.org/W3075888328","https://openalex.org/W4206826545","https://openalex.org/W4244155923"],"related_works":["https://openalex.org/W7009194791","https://openalex.org/W4409066985","https://openalex.org/W4210695959","https://openalex.org/W7067917932","https://openalex.org/W4292805590","https://openalex.org/W7213667993","https://openalex.org/W1153412892","https://openalex.org/W2745542146","https://openalex.org/W7223080143","https://openalex.org/W4414300664"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
