{"id":"https://openalex.org/W2000691052","doi":"https://doi.org/10.1097/ftd.0000000000000071","title":"Impact of Clinical Decision Support Guidelines on Therapeutic Drug Monitoring of Gentamicin in Newborns","display_name":"Impact of Clinical Decision Support Guidelines on Therapeutic Drug Monitoring of Gentamicin in Newborns","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W2000691052","doi":"https://doi.org/10.1097/ftd.0000000000000071","mag":"2000691052","pmid":"https://pubmed.ncbi.nlm.nih.gov/24690586"},"language":"en","primary_location":{"id":"doi:10.1097/ftd.0000000000000071","doi":"https://doi.org/10.1097/ftd.0000000000000071","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ftd.0000000000000071","pdf_url":null,"source":{"id":"https://openalex.org/S179268941","display_name":"Therapeutic Drug Monitoring","issn_l":"0163-4356","issn":["0163-4356","1536-3694"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Drug Monitoring","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://archive-ouverte.unige.ch/unige:38266","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016877483","display_name":"Caroline Fonzo\u2010Christe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Caroline Fonzo-Christe","raw_affiliation_strings":["*Service of Pharmacy; \u2020Pediatric Infectious Diseases Unit; \u2021Division of Pediatric Emergency; \u00a7Service of Clinical Pharmacology and Toxicology, Geneva University Hospitals; \u00b6School of Pharmaceutical Sciences, University of Geneva/University of Lausanne; \u2016Clinical Research Center and Division of Clinical Epidemiology; and **Neonatology and Pediatric Intensive Care Unit, Geneva University Hospitals, Switzerland","Service of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Service of Pharmacy; \u2020Pediatric Infectious Diseases Unit; \u2021Division of Pediatric Emergency; \u00a7Service of Clinical Pharmacology and Toxicology, Geneva University Hospitals; \u00b6School of Pharmaceutical Sciences, University of Geneva/University of Lausanne; \u2016Clinical Research Center and Division of Clinical Epidemiology; and **Neonatology and Pediatric Intensive Care Unit, Geneva University Hospitals, Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256","https://openalex.org/I97565354"]},{"raw_affiliation_string":"Service of Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091354728","display_name":"Bertrand Guignard","orcid":"https://orcid.org/0009-0002-4328-0375","observed_orcids":["https://orcid.org/0009-0002-4328-0375"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bertrand Guignard","raw_affiliation_strings":["Service of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077861770","display_name":"Claudia Zaugg","orcid":"https://orcid.org/0009-0001-9875-2125","observed_orcids":["https://orcid.org/0009-0001-9875-2125"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Claudia Zaugg","raw_affiliation_strings":["Service of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044311157","display_name":"Ana Coehlo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ana Coehlo","raw_affiliation_strings":["Service of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024739919","display_name":"Klara Maria Posfay-Barbe","orcid":"https://orcid.org/0000-0001-9464-5704","observed_orcids":["https://orcid.org/0000-0001-9464-5704"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Klara M. Posfay-Barbe","raw_affiliation_strings":["Pediatric Infectious Diseases Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Infectious Diseases Unit","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045584319","display_name":"Alain Gervaix","orcid":"https://orcid.org/0000-0002-8925-5936","observed_orcids":["https://orcid.org/0000-0002-8925-5936"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alain Gervaix","raw_affiliation_strings":["Division of Pediatric Emergency"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Emergency","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067282623","display_name":"Jules Alexandre Desmeules","orcid":"https://orcid.org/0000-0003-2702-1795","observed_orcids":["https://orcid.org/0000-0003-2702-1795"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jules Desmeules","raw_affiliation_strings":["School of Pharmaceutical Sciences, University of Geneva/University of Lausanne","Service of Clinical Pharmacology and Toxicology, Geneva University Hospitals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, University of Geneva/University of Lausanne","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I97565354"]},{"raw_affiliation_string":"Service of Clinical Pharmacology and Toxicology, Geneva University Hospitals","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000011411","display_name":"Victoria Rollason","orcid":"https://orcid.org/0000-0002-8073-6610","observed_orcids":["https://orcid.org/0000-0002-8073-6610"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Victoria Rollason","raw_affiliation_strings":["School of Pharmaceutical Sciences, University of Geneva/University of Lausanne","Service of Clinical Pharmacology and Toxicology, Geneva University Hospitals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, University of Geneva/University of Lausanne","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I97565354"]},{"raw_affiliation_string":"Service of Clinical Pharmacology and Toxicology, Geneva University Hospitals","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013896104","display_name":"Christophe Combescure","orcid":"https://orcid.org/0000-0003-2631-4780","observed_orcids":["https://orcid.org/0000-0003-2631-4780"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christophe Combescure","raw_affiliation_strings":["Clinical Research Center and Division of Clinical Epidemiology; and","Clinical Research Center and Division of Clinical Epidemiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center and Division of Clinical Epidemiology; and","institution_ids":[]},{"raw_affiliation_string":"Clinical Research Center and Division of Clinical Epidemiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049043453","display_name":"Regula Corbelli","orcid":"https://orcid.org/0000-0002-7530-1049","observed_orcids":["https://orcid.org/0000-0002-7530-1049"]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Regula Corbelli","raw_affiliation_strings":["Service of Pharmacy","Neonatology and Pediatric Intensive Care Unit, Geneva University Hospitals, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"Neonatology and Pediatric Intensive Care Unit, Geneva University Hospitals, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007971944","display_name":"Peter C. Rimensberger","orcid":"https://orcid.org/0000-0002-9760-9220","observed_orcids":["https://orcid.org/0000-0002-9760-9220"]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Peter Rimensberger","raw_affiliation_strings":["Service of Pharmacy","Neonatology and Pediatric Intensive Care Unit, Geneva University Hospitals, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"Neonatology and Pediatric Intensive Care Unit, Geneva University Hospitals, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038235289","display_name":"Riccardo Erennio Pfister","orcid":"https://orcid.org/0000-0002-7395-0512","observed_orcids":["https://orcid.org/0000-0002-7395-0512"]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Riccardo Pfister","raw_affiliation_strings":["Service of Pharmacy","Neonatology and Pediatric Intensive Care Unit, Geneva University Hospitals, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"Neonatology and Pediatric Intensive Care Unit, Geneva University Hospitals, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001683266","display_name":"Pascal Bonnabry","orcid":"https://orcid.org/0000-0002-8690-649X","observed_orcids":["https://orcid.org/0000-0002-8690-649X"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Pascal Bonnabry","raw_affiliation_strings":["School of Pharmaceutical Sciences, University of Geneva/University of Lausanne","Service of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, University of Geneva/University of Lausanne","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I97565354"]},{"raw_affiliation_string":"Service of Pharmacy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5001683266","https://openalex.org/A5007971944","https://openalex.org/A5016877483","https://openalex.org/A5038235289","https://openalex.org/A5044311157","https://openalex.org/A5049043453","https://openalex.org/A5077861770","https://openalex.org/A5091354728"],"corresponding_institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256","https://openalex.org/I97565354"],"apc_list":null,"apc_paid":null,"fwci":0.6603,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.65912704,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"36","issue":"5","first_page":"656","last_page":"662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.03280000016093254,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10350","display_name":"Electronic Health Records Systems","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":0.9390000104904175},{"id":"https://openalex.org/keywords/newborns","display_name":"neonates","score":0.9700000286102295},{"id":"https://openalex.org/keywords/clinical-decision-support","display_name":"clinical decision support","score":0.9049999713897705},{"id":"https://openalex.org/keywords/dosing-recommendations","display_name":"dosing recommendations","score":0.7239999771118164},{"id":"https://openalex.org/keywords/once-daily-dosing","display_name":"once-daily dosing","score":0.8629999756813049},{"id":"https://openalex.org/keywords/extended-dosing-interval","display_name":"extended dosing interval","score":0.9990000128746033},{"id":"https://openalex.org/keywords/trough-concentration","display_name":"trough concentration","score":0.8690000176429749},{"id":"https://openalex.org/keywords/peak-concentration","display_name":"peak concentration","score":0.7979999780654907},{"id":"https://openalex.org/keywords/blood-sampling","display_name":"blood sampling","score":0.890999972820282},{"id":"https://openalex.org/keywords/computerized-physician-order-entry","display_name":"computerized physician order entry","score":0.9179999828338623},{"id":"https://openalex.org/keywords/guideline-implementation","display_name":"guideline implementation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/aminoglycoside-dosing","display_name":"aminoglycoside dosing","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.7409999966621399},{"id":"https://openalex.org/keywords/gestational-age","display_name":"gestational age","score":0.5740000009536743},{"id":"https://openalex.org/keywords/neonatal-pharmacokinetics","display_name":"neonatal pharmacokinetics","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.8408899307250977},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8367255926132202},{"id":"https://openalex.org/C2780272996","wikidata":"https://www.wikidata.org/wiki/Q1261151","display_name":"Therapeutic drug monitoring","level":3,"score":0.8206952214241028},{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.6854874491691589},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.6497985124588013},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.573045015335083},{"id":"https://openalex.org/C2910800852","wikidata":"https://www.wikidata.org/wiki/Q7846541","display_name":"Trough Concentration","level":3,"score":0.5441617965698242},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5248056650161743},{"id":"https://openalex.org/C31785415","wikidata":"https://www.wikidata.org/wiki/Q7846541","display_name":"Trough level","level":4,"score":0.4845794439315796},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.4192761480808258},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4116829037666321},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.38008955121040344},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.2919257879257202},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2539800703525543},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07098263502120972},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.0677264928817749},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007363","descriptor_name":"Intensive Care Units, Neonatal","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1097/ftd.0000000000000071","doi":"https://doi.org/10.1097/ftd.0000000000000071","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ftd.0000000000000071","pdf_url":null,"source":{"id":"https://openalex.org/S179268941","display_name":"Therapeutic Drug Monitoring","issn_l":"0163-4356","issn":["0163-4356","1536-3694"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Drug Monitoring","raw_type":"journal-article"},{"id":"pmid:24690586","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24690586","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic drug monitoring","raw_type":"Journal Article"},{"id":"pmh:oai:unige.ch:unige:38266","doi":null,"is_oa":false,"landing_page_url":"https://archive-ouverte.unige.ch/unige:38266","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISSN: 0163-4356","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:unige.ch:aou:unige:38266","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:38266","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0163-4356","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:unige.ch:aou:unige:38266","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:38266","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0163-4356","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1867125196","https://openalex.org/W1977590359","https://openalex.org/W1979551928","https://openalex.org/W1982262091","https://openalex.org/W1985689967","https://openalex.org/W1996084875","https://openalex.org/W2009737896","https://openalex.org/W2013955219","https://openalex.org/W2019905097","https://openalex.org/W2057939341","https://openalex.org/W2067847321","https://openalex.org/W2083732042","https://openalex.org/W2085503521","https://openalex.org/W2112939945","https://openalex.org/W2119750371","https://openalex.org/W2122527560","https://openalex.org/W2122821906","https://openalex.org/W2128672370","https://openalex.org/W2137049143","https://openalex.org/W2139684243","https://openalex.org/W2143342896","https://openalex.org/W2170073083","https://openalex.org/W2171697855","https://openalex.org/W2182245133","https://openalex.org/W2335517442","https://openalex.org/W2559248122","https://openalex.org/W2927183570"],"related_works":["https://openalex.org/W1972673983","https://openalex.org/W2151569239","https://openalex.org/W2514399433","https://openalex.org/W1975620953","https://openalex.org/W2102532692","https://openalex.org/W2785150917","https://openalex.org/W3138211928","https://openalex.org/W1952853861","https://openalex.org/W1539359337","https://openalex.org/W2128672370"],"abstract_inverted_index":{"BACKGROUND:":[0],"Our":[1],"institution's":[2],"gentamicin":[3,123,269],"dosing":[4,20,24,270],"and":[5,26,38,56,72,111,179,240,271,277],"therapeutic":[6],"drug":[7],"monitoring":[8],"(TDM)":[9],"practices":[10,273],"for":[11,81],"newborns":[12,82],"were":[13,30,36,59,115,125,138,208,274],"suspected":[14],"to":[15],"be":[16,285],"very":[17],"heterogeneous.":[18],"Once-daily":[19],"(ODD)":[21],"or":[22,101,190],"extended-interval":[23],"(EID)":[25],"trough":[27,107,206,221],"concentration":[28,103,124,192,222],"measurement":[29],"recommended.":[31],"Clinical":[32,265],"decision":[33,42],"support":[34,43],"guidelines":[35,77],"developed":[37],"implemented":[39],"as":[40],"clinical":[41,278],"in":[44,241,262],"the":[45,74,153,168,180,242],"computerized":[46],"prescriber":[47],"order":[48],"entry":[49],"system.":[50],"Impact":[51],"on":[52],"dosing,":[53],"TDM":[54,272],"practices,":[55],"blood":[57,183,263,282],"sampling":[58,283],"evaluated.":[60,286],"METHODS:":[61],"A":[62,201],"1-year":[63],"retrospective":[64],"historically":[65],"controlled":[66],"study":[67],"before":[68],"(April":[69],"2008-March":[70],"2009)":[71],"after":[73],"implementation":[75,151,257],"of":[76,85,92,97,106,152,170,182,205,219,267,280],"(January":[78],"2010-December":[79],"2010)":[80],"(<30":[83],"days":[84],"life)":[86],"receiving":[87],"gentamicin.":[88],"Blood":[89],"concentrations":[90,94,108,172,207],"(%":[91],"peak":[93,171],"sampled,":[95,104],"%":[96,105],"patients":[98,137],"with":[99,122,226],"zero":[100],"one":[102],"\u22641":[109,209,223],"mg/L)":[110],"dose":[112],"regimen":[113,157,229],"(ODD/EID)":[114],"compared":[116],"between":[117],"groups.":[118],"Factors":[119],"potentially":[120],"associated":[121],"analyzed":[126],"(multivariate":[127],"analysis).":[128],"RESULTS:":[129],"One":[130],"hundred":[131],"thirty-two":[132],"(postguidelines)":[133],"versus":[134,144,163,174,194,212],"102":[135],"(preguidelines)":[136],"included":[139],"(median":[140],"gestational":[141],"age:":[142],"34.3":[143],"35.8":[145],"weeks,":[146],"P":[147,165,176,196,214,237,252],">":[148],"0.05).":[149],"After":[150],"guidelines,":[154],"an":[155,227],"ODD/EID":[156,228],"was":[158],"almost":[159],"exclusively":[160],"used":[161],"(97.7%":[162],"61.6%,":[164],"<":[166,177,197,215,238],"0.001),":[167],"percentage":[169,204],"(0.9%":[173],"17.2%,":[175],"0.001)":[178,198,239],"number":[181],"samples":[184],"per":[185],"patient":[186],"(87.1%":[187],"having":[188],"0":[189],"1":[191],"measured":[193],"48.0,":[195],"sharply":[199],"reduced.":[200],"significantly":[202],"higher":[203],"mg/L":[210,224],"(68.5%":[211],"33.0%,":[213],"0.001).":[216],"The":[217],"probability":[218],"a":[220,259],"increased":[225],"(odds":[230,245],"ratio,":[231,246],"7.23;":[232],"95%":[233,248],"confidence":[234,249],"interval:":[235,250],"3.48-15.0,":[236],"postguidelines":[243],"group":[244],"2.02;":[247],"1.01-4.02,":[251],"=":[253],"0.045).":[254],"CONCLUSIONS:":[255],"Guideline":[256],"generated":[258],"sharp":[260],"reduction":[261],"sampling.":[264],"benefits":[266],"better":[268],"evident.":[275],"Cost-effectiveness":[276],"benefit":[279],"reduced":[281],"should":[284]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}