{"id":"https://openalex.org/W2000685893","doi":"https://doi.org/10.2217/imt.14.6","title":"Benefits of a Continuous Therapy for Cancer Patients with a Novel Adoptive Cell Therapy by Cascade Priming (CAPRI)","display_name":"Benefits of a Continuous Therapy for Cancer Patients with a Novel Adoptive Cell Therapy by Cascade Priming (CAPRI)","publication_year":2014,"publication_date":"2014-03-01","ids":{"openalex":"https://openalex.org/W2000685893","doi":"https://doi.org/10.2217/imt.14.6","mag":"2000685893","pmid":"https://pubmed.ncbi.nlm.nih.gov/24762072"},"language":"en","primary_location":{"id":"doi:10.2217/imt.14.6","doi":"https://doi.org/10.2217/imt.14.6","is_oa":false,"landing_page_url":"https://doi.org/10.2217/imt.14.6","pdf_url":null,"source":{"id":"https://openalex.org/S71887004","display_name":"Immunotherapy","issn_l":"1750-743X","issn":["1750-743X","1750-7448"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunotherapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047867988","display_name":"Rudolf Wank","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rudolf Wank","raw_affiliation_strings":["Immunotherapy Research Center Munich,\rPettenkoferstr. 8,\rMunich\r80336\rGermany","Immunotherapy Research Center Munich, Pettenkoferstr. 8, 80336 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunotherapy Research Center Munich,\rPettenkoferstr. 8,\rMunich\r80336\rGermany","institution_ids":[]},{"raw_affiliation_string":"Immunotherapy Research Center Munich, Pettenkoferstr. 8, 80336 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101458652","display_name":"Xin Song","orcid":"https://orcid.org/0000-0002-1509-6223","observed_orcids":["https://orcid.org/0000-0002-1509-6223"]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Song","raw_affiliation_strings":["Third Affiliated Hospital,Kunming Medical University,\rNo 519 Kunzhou Road, Kunming,\rYunnan\r650118\rChina","Third Affiliated Hospital, Kunming Medical University, No 519 Kunzhou Road, Kunming, 650118 Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Affiliated Hospital,Kunming Medical University,\rNo 519 Kunzhou Road, Kunming,\rYunnan\r650118\rChina","institution_ids":["https://openalex.org/I26080491"]},{"raw_affiliation_string":"Third Affiliated Hospital, Kunming Medical University, No 519 Kunzhou Road, Kunming, 650118 Yunnan, China","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111748449","display_name":"Songhai Gu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Songhai Gu","raw_affiliation_strings":["Immunotherapy Research Center Munich,\rPettenkoferstr. 8,\rMunich\r80336\rGermany","Immunotherapy Research Center Munich, Pettenkoferstr. 8, 80336 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunotherapy Research Center Munich,\rPettenkoferstr. 8,\rMunich\r80336\rGermany","institution_ids":[]},{"raw_affiliation_string":"Immunotherapy Research Center Munich, Pettenkoferstr. 8, 80336 Munich, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005105756","display_name":"Barbara Laumbacher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Laumbacher","raw_affiliation_strings":["Immunotherapy Research Center Munich,\rPettenkoferstr. 8,\rMunich\r80336\rGermany","Immunotherapy Research Center Munich, Pettenkoferstr. 8, 80336 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunotherapy Research Center Munich,\rPettenkoferstr. 8,\rMunich\r80336\rGermany","institution_ids":[]},{"raw_affiliation_string":"Immunotherapy Research Center Munich, Pettenkoferstr. 8, 80336 Munich, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.093,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.05960549,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"6","issue":"3","first_page":"269","last_page":"282"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.921999990940094},{"id":"https://openalex.org/keywords/continuous-treatment","display_name":"continuous treatment","score":0.5889999866485596},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8220000267028809},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.8700000047683716},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.8370000123977661},{"id":"https://openalex.org/keywords/lymphokine-activated-killer-cells","display_name":"lymphokine-activated killer cells","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cytokine-induced-killer-cells","display_name":"cytokine-induced killer cells","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tumor-antigen-presentation","display_name":"tumor antigen presentation","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.5883044004440308},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.541704535484314},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.5291298627853394},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.5162277221679688},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3925342261791229},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3515377938747406},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24874231219291687},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23464617133140564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22792065143585205},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0793541967868805},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005805","descriptor_name":"Genes, MHC Class I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015979","descriptor_name":"Killer Cells, Lymphokine-Activated","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017260","descriptor_name":"Receptor-CD3 Complex, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037182","descriptor_name":"T-Cell Antigen Receptor Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055612","descriptor_name":"Cytokine-Induced Killer Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2217/imt.14.6","doi":"https://doi.org/10.2217/imt.14.6","is_oa":false,"landing_page_url":"https://doi.org/10.2217/imt.14.6","pdf_url":null,"source":{"id":"https://openalex.org/S71887004","display_name":"Immunotherapy","issn_l":"1750-743X","issn":["1750-743X","1750-7448"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunotherapy","raw_type":"journal-article"},{"id":"pmid:24762072","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24762072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W647332421","https://openalex.org/W1587494635","https://openalex.org/W1964046801","https://openalex.org/W1965304265","https://openalex.org/W1966023886","https://openalex.org/W1969174874","https://openalex.org/W1970503784","https://openalex.org/W1974559272","https://openalex.org/W1975186329","https://openalex.org/W1979936799","https://openalex.org/W1985770829","https://openalex.org/W1985981664","https://openalex.org/W1987250705","https://openalex.org/W1989360502","https://openalex.org/W1991593737","https://openalex.org/W1997247261","https://openalex.org/W1999047172","https://openalex.org/W2005316115","https://openalex.org/W2015438948","https://openalex.org/W2018279786","https://openalex.org/W2021438212","https://openalex.org/W2028824724","https://openalex.org/W2033637872","https://openalex.org/W2033779312","https://openalex.org/W2036322538","https://openalex.org/W2041142042","https://openalex.org/W2042411369","https://openalex.org/W2042784923","https://openalex.org/W2050973237","https://openalex.org/W2052912081","https://openalex.org/W2058295413","https://openalex.org/W2060813234","https://openalex.org/W2067700533","https://openalex.org/W2067963142","https://openalex.org/W2076734829","https://openalex.org/W2083500661","https://openalex.org/W2084323507","https://openalex.org/W2088164932","https://openalex.org/W2118271123","https://openalex.org/W2120869188","https://openalex.org/W2121556079","https://openalex.org/W2122507780","https://openalex.org/W2122835511","https://openalex.org/W2124937026","https://openalex.org/W2128983326","https://openalex.org/W2130374917","https://openalex.org/W2130386024","https://openalex.org/W2141269240","https://openalex.org/W2160855841","https://openalex.org/W2166852908","https://openalex.org/W2170024262","https://openalex.org/W2442152210","https://openalex.org/W2463877885","https://openalex.org/W3145402682","https://openalex.org/W4235642752","https://openalex.org/W4240866515","https://openalex.org/W4243858897"],"related_works":["https://openalex.org/W3024706376","https://openalex.org/W1990602451","https://openalex.org/W2607033742","https://openalex.org/W3011157443","https://openalex.org/W4382893761","https://openalex.org/W7017180210","https://openalex.org/W3028957928","https://openalex.org/W1587494635","https://openalex.org/W2357840158","https://openalex.org/W2255379229"],"abstract_inverted_index":{"A":[0],"growing":[1],"body":[2],"of":[3,30,66,116,132],"evidence":[4],"shows":[5],"that":[6],"immune":[7,22,31,80,119],"cells":[8,32,105],"are":[9],"pivotal":[10],"in":[11,33,52,72,122],"the":[12,28,34,44,77,88,107,113,117,129],"fight":[13],"against":[14,25,106],"cancer.":[15,26,109],"First,":[16],"association":[17],"studies":[18],"have":[19],"identified":[20],"immune-protective":[21],"response":[23],"genes":[24],"Second,":[27],"presence":[29],"respective":[35],"malignant":[36,62],"tumor":[37,96],"correlated":[38],"with":[39,128],"a":[40,70],"better":[41,98],"prognosis":[42],"for":[43,61],"patients.":[45],"Third,":[46],"adoptive":[47],"cell":[48,120],"therapy":[49],"(ACT)":[50],"showed,":[51],"recent":[53],"reports,":[54],"an":[55],"efficient":[56],"reduction":[57],"or":[58],"even":[59],"cure":[60],"tumors.":[63],"The":[64,82,110],"focus":[65],"this":[67],"review":[68],"is":[69,126],"novel":[71],"vitro":[73],"ACT":[74,130],"technique,":[75],"using":[76],"patient's":[78,108],"cascade-primed":[79,118],"cells.":[81],"cascade-priming":[83],"procedure":[84],"stimulates":[85],"APCs":[86,92],"from":[87],"peripheral":[89],"blood.":[90],"Stimulated":[91],"digest":[93],"and":[94,99,112,142],"present":[95],"material":[97],"differentiate":[100],"naive":[101],"cytotoxic":[102],"T-lymphocyte":[103],"effector":[104],"principle":[111],"impressive":[114],"results":[115],"treatment":[121],"patient":[123],"case":[124],"series":[125],"compared":[127],"concepts":[131],"lymphokine-activated":[133],"killer,":[134,136],"macrophage-activated":[135,137],"killer-dendritic":[138],"cell,":[139],"cytokine-induced":[140],"killer":[141],"tumor-infiltrating":[143],"lymphocyte":[144],"methods.":[145]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
