{"id":"https://openalex.org/W2000684456","doi":"https://doi.org/10.1002/jbt.20282","title":"Oxidative damage and gene expression profile of antioxidant enzymes after T\u20102 toxin exposure in mice","display_name":"Oxidative damage and gene expression profile of antioxidant enzymes after T\u20102 toxin exposure in mice","publication_year":2009,"publication_date":"2009-05-01","ids":{"openalex":"https://openalex.org/W2000684456","doi":"https://doi.org/10.1002/jbt.20282","mag":"2000684456","pmid":"https://pubmed.ncbi.nlm.nih.gov/19526462"},"language":"en","primary_location":{"id":"doi:10.1002/jbt.20282","doi":"https://doi.org/10.1002/jbt.20282","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbt.20282","pdf_url":null,"source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical and Molecular Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088070313","display_name":"Manjari Chaudhari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800900741","display_name":"Defence Research and Development Establishment","ror":"https://ror.org/04sm60f26","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1340206300","https://openalex.org/I2799351866","https://openalex.org/I2800900741","https://openalex.org/I4210150591"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manjari Chaudhari","raw_affiliation_strings":["Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior 474002, Madhya Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior 474002, Madhya Pradesh, India","institution_ids":["https://openalex.org/I2800900741"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R. Jayaraj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800900741","display_name":"Defence Research and Development Establishment","ror":"https://ror.org/04sm60f26","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1340206300","https://openalex.org/I2799351866","https://openalex.org/I2800900741","https://openalex.org/I4210150591"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"R. Jayaraj","raw_affiliation_strings":["Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior 474 002, Madhya Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior 474 002, Madhya Pradesh, India","institution_ids":["https://openalex.org/I2800900741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109993473","display_name":"S.R. Santhosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800900741","display_name":"Defence Research and Development Establishment","ror":"https://ror.org/04sm60f26","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1340206300","https://openalex.org/I2799351866","https://openalex.org/I2800900741","https://openalex.org/I4210150591"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S. R. Santhosh","raw_affiliation_strings":["Division of Virology, Defence Research and Development Establishment, Gwalior 474 002, Madhya Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Virology, Defence Research and Development Establishment, Gwalior 474 002, Madhya Pradesh, India","institution_ids":["https://openalex.org/I2800900741"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103353648","display_name":"P.V. Lakshmana Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800900741","display_name":"Defence Research and Development Establishment","ror":"https://ror.org/04sm60f26","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1340206300","https://openalex.org/I2799351866","https://openalex.org/I2800900741","https://openalex.org/I4210150591"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"P. V. Lakshmana Rao","raw_affiliation_strings":["Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior 474 002, Madhya Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior 474 002, Madhya Pradesh, India","institution_ids":["https://openalex.org/I2800900741"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103353648"],"corresponding_institution_ids":["https://openalex.org/I2800900741"],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":null,"fwci":3.6339,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.91839205,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"23","issue":"3","first_page":"212","last_page":"221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-2-toxin","display_name":"T-2 toxin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/trichothecenes","display_name":"trichothecenes","score":0.949999988079071},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9449999928474426},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.9319999814033508},{"id":"https://openalex.org/keywords/gene-expression-profiles","display_name":"gene expression profiles","score":0.6449999809265137},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.7229999899864197},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.8619999885559082},{"id":"https://openalex.org/keywords/glutathione-reductase","display_name":"glutathione reductase","score":0.7720000147819519},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.8669999837875366},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.996999979019165},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":1.0},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.7379999756813049},{"id":"https://openalex.org/keywords/dose-dependent-toxicity","display_name":"dose-dependent toxicity","score":0.765999972820282},{"id":"https://openalex.org/keywords/mycotoxin-toxicity","display_name":"mycotoxin toxicity","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.7287665605545044},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.7224558591842651},{"id":"https://openalex.org/C165069038","wikidata":"https://www.wikidata.org/wiki/Q420930","display_name":"Glutathione reductase","level":5,"score":0.7011836171150208},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6333088278770447},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5932989120483398},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.5844986438751221},{"id":"https://openalex.org/C158086472","wikidata":"https://www.wikidata.org/wiki/Q21103287","display_name":"GPX4","level":5,"score":0.5707883834838867},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5623377561569214},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5257328748703003},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.48103076219558716},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4623023569583893},{"id":"https://openalex.org/C2776907368","wikidata":"https://www.wikidata.org/wiki/Q307302","display_name":"Glutathione S-transferase","level":4,"score":0.42236340045928955},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35684865713119507},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3359490633010864},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.28898340463638306}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013605","descriptor_name":"T-2 Toxin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbt.20282","doi":"https://doi.org/10.1002/jbt.20282","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbt.20282","pdf_url":null,"source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical and Molecular Toxicology","raw_type":"journal-article"},{"id":"pmid:19526462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19526462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemical and molecular toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W88941266","https://openalex.org/W184607054","https://openalex.org/W191793640","https://openalex.org/W1491387523","https://openalex.org/W1545899030","https://openalex.org/W1546592314","https://openalex.org/W1581414347","https://openalex.org/W1775749144","https://openalex.org/W1964404503","https://openalex.org/W1966559024","https://openalex.org/W1968335636","https://openalex.org/W1981395921","https://openalex.org/W1983310681","https://openalex.org/W1997467451","https://openalex.org/W2004470754","https://openalex.org/W2011070432","https://openalex.org/W2015231939","https://openalex.org/W2026261400","https://openalex.org/W2028713528","https://openalex.org/W2051092517","https://openalex.org/W2069841527","https://openalex.org/W2079282623","https://openalex.org/W2083628739","https://openalex.org/W2086915839","https://openalex.org/W2091340154","https://openalex.org/W2093814939","https://openalex.org/W2107277218","https://openalex.org/W2135794349","https://openalex.org/W2141819645","https://openalex.org/W2151914840","https://openalex.org/W2315156311","https://openalex.org/W3023390318"],"related_works":["https://openalex.org/W2348431766","https://openalex.org/W1534968726","https://openalex.org/W7167614573","https://openalex.org/W2089558983","https://openalex.org/W2210050562","https://openalex.org/W2795326049","https://openalex.org/W2612454309","https://openalex.org/W2036706888","https://openalex.org/W2041258961","https://openalex.org/W7071349819"],"abstract_inverted_index":{"T-2":[0,26,65,206],"toxin":[1,27,66],"is":[2],"one":[3,201],"of":[4,25,36,64,88,93,105,133,202,205],"the":[5,20,103,110,203],"most":[6],"potent":[7],"trichothecenes,":[8],"and":[9,15,22,40,58,78,91,108,142,160,176],"on":[10,28],"exposure":[11],"causes":[12],"severe":[13],"human":[14],"animal":[16],"diseases.":[17],"We":[18,100],"investigated":[19],"dose-":[21],"time-dependent":[23],"effect":[24],"certain":[29],"biochemical":[30],"variables,":[31],"oxidative":[32,98,198],"damage":[33],"in":[34,44,70,83,131,155,172],"terms":[35],"antioxidant":[37,106],"enzyme":[38],"activity,":[39,156],"gene":[41,111,167],"expression":[42,92,112,168],"profile":[43,113,169],"mice.":[45],"Mice":[46],"treated":[47],"intraperitoneally":[48],"with":[49],"either":[50],"1":[51,145,179],"LD50":[52,55,146,150,180,184],"or":[53],"2":[54,149,183],"dose":[56,185],"(5.61":[57],"11.22":[59],"mg/kg":[60],"body":[61],"weight,":[62],"respectively)":[63],"showed":[67,153,162,170],"significant":[68,129,163],"alterations":[69],"hepatic":[71,84],"alanine":[72],"amino":[73,76],"transferase,":[74,77],"aspartate":[75],"lactate":[79],"dehydrogenase.":[80],"Significant":[81],"changes":[82],"lipid":[85],"peroxidation,":[86],"depletion":[87],"glutathione":[89,123,136],"(GSH),":[90],"heat":[94],"shock":[95],"protein-70":[96],"indicated":[97],"damage.":[99],"also":[101],"evaluated":[102],"activity":[104,132],"enzymes":[107],"compared":[109],"by":[114],"quantitative":[115],"real-time":[116],"reverse":[117],"transcriptase-polymerase":[118],"chain":[119],"reaction.":[120],"Except":[121],"for":[122],"reductase":[124],"(GR),":[125],"there":[126],"was":[127],"a":[128],"increase":[130],"glutathione-S-transferase":[134],"(GST),":[135],"peroxidase":[137],"(GPx),":[138],"superoxide":[139],"dismutase":[140],"(SOD),":[141],"catalase":[143,161,177],"at":[144,178],"dose.":[147,181],"At":[148,182],"dose,":[151],"SOD":[152],"decrease":[154],"whereas":[157],"GST,":[158,175],"GPx,":[159,174],"increase.":[164],"In":[165],"contrast,":[166],"downregulation":[171],"GR,":[173],"except":[186],"GSH":[187],"synthetase,":[188],"all":[189],"other":[190],"genes":[191],"were":[192],"downregulated.":[193],"The":[194],"results":[195],"clearly":[196],"show":[197],"stress":[199],"as":[200],"mechanisms":[204],"toxin-mediated":[207],"toxicity.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}