{"id":"https://openalex.org/W2000679795","doi":"https://doi.org/10.1677/joe.1.06713","title":"Transforming growth factor-\u03b21 and activin A generate antiproliferative signaling in thyroid cancer cells","display_name":"Transforming growth factor-\u03b21 and activin A generate antiproliferative signaling in thyroid cancer cells","publication_year":2006,"publication_date":"2006-07-01","ids":{"openalex":"https://openalex.org/W2000679795","doi":"https://doi.org/10.1677/joe.1.06713","mag":"2000679795","pmid":"https://pubmed.ncbi.nlm.nih.gov/16837618"},"language":"en","primary_location":{"id":"doi:10.1677/joe.1.06713","doi":"https://doi.org/10.1677/joe.1.06713","is_oa":true,"landing_page_url":"https://doi.org/10.1677/joe.1.06713","pdf_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/190/1/1900141.pdf","source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/190/1/1900141.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051948738","display_name":"S\u00edlvia E. Matsuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Si\u0301lvia Emiko Matsuo","raw_affiliation_strings":["Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Av. Prof. Lineu Prestes, 1524, 05508-000 S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Av. Prof. Lineu Prestes, 1524, 05508-000 S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033418445","display_name":"Suzana Garcia Leoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Suzana Garcia Leoni","raw_affiliation_strings":["Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Av. Prof. Lineu Prestes, 1524, 05508-000 S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Av. Prof. Lineu Prestes, 1524, 05508-000 S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042230902","display_name":"Alison Colquhoun","orcid":"https://orcid.org/0000-0002-0691-2364","observed_orcids":["https://orcid.org/0000-0002-0691-2364"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Alison Colquhoun","raw_affiliation_strings":["Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Av. Prof. Lineu Prestes, 1524, 05508-000 S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Av. Prof. Lineu Prestes, 1524, 05508-000 S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010577496","display_name":"Edna Teruko Kimura","orcid":"https://orcid.org/0000-0001-8403-4459","observed_orcids":["https://orcid.org/0000-0001-8403-4459"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Edna Teruko Kimura","raw_affiliation_strings":["Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Av. Prof. Lineu Prestes, 1524, 05508-000 S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Av. Prof. Lineu Prestes, 1524, 05508-000 S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":null,"apc_paid":null,"fwci":1.3474,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.76452359,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"190","issue":"1","first_page":"141","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9049999713897705},{"id":"https://openalex.org/keywords/activin-a","display_name":"activin A","score":1.0},{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.8600000143051147},{"id":"https://openalex.org/keywords/antiproliferative-signaling","display_name":"antiproliferative signaling","score":0.8690000176429749},{"id":"https://openalex.org/keywords/smad-proteins","display_name":"Smad proteins","score":0.9459999799728394},{"id":"https://openalex.org/keywords/smad7","display_name":"Smad7","score":0.9290000200271606},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/tpc-1-cells","display_name":"TPC-1 cells","score":0.9039999842643738},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.6919999718666077},{"id":"https://openalex.org/keywords/thyroid-tumorigenesis","display_name":"thyroid tumorigenesis","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.695610523223877},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6937390565872192},{"id":"https://openalex.org/C38643226","wikidata":"https://www.wikidata.org/wiki/Q4677604","display_name":"Activin type 2 receptors","level":4,"score":0.5092195272445679},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5007238388061523},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.49964332580566406},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.49239981174468994},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4872361719608307},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4415796399116516},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4360661506652832},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4162742495536804},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41423362493515015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3200591802597046},{"id":"https://openalex.org/C111001777","wikidata":"https://www.wikidata.org/wiki/Q3562192","display_name":"TGF beta signaling pathway","level":3,"score":0.3187371492385864},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15924295783042908},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0769830048084259}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028322","descriptor_name":"Inhibin-beta Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D028322","descriptor_name":"Inhibin-beta Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D028322","descriptor_name":"Inhibin-beta Subunits","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D028341","descriptor_name":"Activins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D028341","descriptor_name":"Activins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D028341","descriptor_name":"Activins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051899","descriptor_name":"Smad2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051900","descriptor_name":"Smad3 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051901","descriptor_name":"Smad4 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051906","descriptor_name":"Smad7 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1677/joe.1.06713","doi":"https://doi.org/10.1677/joe.1.06713","is_oa":true,"landing_page_url":"https://doi.org/10.1677/joe.1.06713","pdf_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/190/1/1900141.pdf","source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:16837618","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16837618","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of endocrinology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1677/joe.1.06713","doi":"https://doi.org/10.1677/joe.1.06713","is_oa":true,"landing_page_url":"https://doi.org/10.1677/joe.1.06713","pdf_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/190/1/1900141.pdf","source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000679795.pdf","grobid_xml":"https://content.openalex.org/works/W2000679795.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W68131063","https://openalex.org/W590561559","https://openalex.org/W1561326647","https://openalex.org/W1565561072","https://openalex.org/W1839178227","https://openalex.org/W1866375946","https://openalex.org/W1963532970","https://openalex.org/W1967403230","https://openalex.org/W1967960119","https://openalex.org/W1974036045","https://openalex.org/W1977963838","https://openalex.org/W1984445750","https://openalex.org/W1988897856","https://openalex.org/W1989052193","https://openalex.org/W1994142459","https://openalex.org/W2005436404","https://openalex.org/W2013303140","https://openalex.org/W2015129049","https://openalex.org/W2035659468","https://openalex.org/W2037038224","https://openalex.org/W2037518296","https://openalex.org/W2043867078","https://openalex.org/W2044954528","https://openalex.org/W2045208557","https://openalex.org/W2060889469","https://openalex.org/W2061758394","https://openalex.org/W2062175236","https://openalex.org/W2072075759","https://openalex.org/W2073473087","https://openalex.org/W2077243848","https://openalex.org/W2078771950","https://openalex.org/W2080409070","https://openalex.org/W2085131417","https://openalex.org/W2085747258","https://openalex.org/W2089249874","https://openalex.org/W2089612685","https://openalex.org/W2090659421","https://openalex.org/W2093974687","https://openalex.org/W2097774235","https://openalex.org/W2104976910","https://openalex.org/W2107277218","https://openalex.org/W2117258523","https://openalex.org/W2146900615","https://openalex.org/W2154601080","https://openalex.org/W2157364066","https://openalex.org/W2164940024","https://openalex.org/W2167836668","https://openalex.org/W2317977085","https://openalex.org/W4241398143","https://openalex.org/W6661751213"],"related_works":["https://openalex.org/W2110767133","https://openalex.org/W2063551564","https://openalex.org/W2157364066","https://openalex.org/W2072075759","https://openalex.org/W4255286426","https://openalex.org/W2090659421","https://openalex.org/W2154844439","https://openalex.org/W2410096384","https://openalex.org/W338351662","https://openalex.org/W2075924006"],"abstract_inverted_index":{"Transforming":[0],"growth":[1],"factor-beta":[2],"1":[3],"(TGF-beta1)":[4],"and":[5,59,68,101,107,111,120,126,160,175,179],"activin":[6],"A":[7],"(ActA)":[8],"induce":[9],"similar":[10],"intracellular":[11,102],"signaling":[12,164],"mediated":[13],"by":[14,55,84],"the":[15,33,43,47,63,75,94,129,168,195],"mothers":[16],"against":[17],"decapentaplegic":[18],"homolog":[19],"(SMAD)":[20],"proteins.":[21],"TGF-beta1":[22,67,79,119,125,159,178],"is":[23,37],"a":[24,141],"potent":[25],"antimitogenic":[26],"factor":[27],"for":[28],"thyroid":[29,49,71,186,198],"follicular":[30],"cells,":[31],"while":[32],"role":[34,193],"of":[35,45,66,77,97,131,170,197],"ActA":[36,58,69,81,121,127,161,180],"not":[38],"clear.":[39],"In":[40],"our":[41],"study,":[42],"proliferation":[44,100,106],"TPC-1,":[46],"papillary":[48,187],"carcinoma":[50,188],"cell":[51],"line,":[52],"was":[53,152],"reduced":[54,108,136],"both":[56,118,158],"recombinant":[57],"TGF-beta1.":[60],"Due":[61],"to":[62,92],"concomitant":[64],"expression":[65,114,130,145,169],"in":[70,87,90,99,117,143,146,194],"tumors,":[72],"we":[73,139],"investigated":[74],"effects":[76],"either":[78],"or":[80],"gene":[82],"silencing":[83],"RNA":[85],"interference":[86],"TPC-1":[88],"cells":[89,148],"order":[91],"distinguish":[93],"specific":[95],"participation":[96],"each":[98,166],"signaling.":[103],"An":[104],"increased":[105,128],"SMAD2,":[109],"SMAD3,":[110],"SMAD4":[112],"mRNA":[113],"were":[115],"observed":[116],"knockdown":[122,147],"cells.":[123],"Recombinant":[124],"inhibitory":[132],"SMAD7,":[133],"whereas":[134],"they":[135],"c-MYC.":[137,176],"Accordingly,":[138],"detected":[140],"reduction":[142],"SMAD7":[144,174],"while,":[149],"unexpectedly,":[150],"c-MYC":[151],"reduced.":[153],"Our":[154],"data":[155],"indicate":[156],"that":[157],"generate":[162],"SMADs":[163],"with":[165],"regulating":[167],"their":[171],"target":[172],"genes,":[173],"Furthermore,":[177],"have":[181],"an":[182,191],"antiproliferative":[183],"effect":[184],"on":[185],"cell,":[189],"exerting":[190],"important":[192],"control":[196],"tumorigenesis.":[199]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
