{"id":"https://openalex.org/W2000677694","doi":"https://doi.org/10.1097/00007890-199105000-00034","title":"APPLICATION OF HLA-DR OLIGOTYPING TO 110 KIDNEY TRANSPLANT PATIENTS WITH DOUBTFUL SEROLOGICAL TYPING","display_name":"APPLICATION OF HLA-DR OLIGOTYPING TO 110 KIDNEY TRANSPLANT PATIENTS WITH DOUBTFUL SEROLOGICAL TYPING","publication_year":1991,"publication_date":"1991-05-01","ids":{"openalex":"https://openalex.org/W2000677694","doi":"https://doi.org/10.1097/00007890-199105000-00034","mag":"2000677694","pmid":"https://pubmed.ncbi.nlm.nih.gov/1674388"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-199105000-00034","doi":"https://doi.org/10.1097/00007890-199105000-00034","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199105000-00034","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113572281","display_name":"Jean\u2010Marie Tiercy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"JEAN-MARIE TIERCY","raw_affiliation_strings":["Transplantation Immunology Unit, H\u00f4pital Cantonal Universitaire, Geneva, Switzerland","University of Geneva Medical School, Centre Medical Universitaire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Immunology Unit, H\u00f4pital Cantonal Universitaire, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]},{"raw_affiliation_string":"University of Geneva Medical School, Centre Medical Universitaire","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086350920","display_name":"C Goumaz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CLAUDINE GOUMAZ","raw_affiliation_strings":["Hopital Cantonal Universitaire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopital Cantonal Universitaire","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111567010","display_name":"Bernard Mach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"BERNARD MACH","raw_affiliation_strings":["University of Geneva Medical School, Centre Medical Universitaire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Geneva Medical School, Centre Medical Universitaire","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110167786","display_name":"Michel Jeannet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MICHEL JEANNET","raw_affiliation_strings":["Hopital Cantonal Universitaire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopital Cantonal Universitaire","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.4693,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.98895434,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"51","issue":"5","first_page":"1110","last_page":"1114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/hla-dr-matching","display_name":"HLA-DR matching","score":0.8119999766349792},{"id":"https://openalex.org/keywords/serological-hla-typing","display_name":"serological HLA typing","score":0.6460000276565552},{"id":"https://openalex.org/keywords/hla-class-ii-polymorphism","display_name":"HLA class II polymorphism","score":0.7129999995231628},{"id":"https://openalex.org/keywords/oligonucleotide-probes","display_name":"oligonucleotide probes","score":0.8040000200271606},{"id":"https://openalex.org/keywords/hla-mismatch","display_name":"HLA mismatch","score":0.44999998807907104},{"id":"https://openalex.org/keywords/graft-rejection","display_name":"graft rejection","score":0.628000020980835},{"id":"https://openalex.org/keywords/rflp-typing","display_name":"RFLP typing","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.7566235065460205},{"id":"https://openalex.org/C2781209916","wikidata":"https://www.wikidata.org/wiki/Q3215756","display_name":"Typing","level":2,"score":0.6868771314620972},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.5974354147911072},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5541971325874329},{"id":"https://openalex.org/C2909478873","wikidata":"https://www.wikidata.org/wiki/Q3991680","display_name":"Histocompatibility Testing","level":4,"score":0.548012375831604},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4932798743247986},{"id":"https://openalex.org/C2779067128","wikidata":"https://www.wikidata.org/wiki/Q5630163","display_name":"HLA-DR","level":3,"score":0.4859567880630493},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4676468074321747},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3133586049079895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24517697095870972},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2248857021331787},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.21131491661071777},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17659714818000793},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.15702763199806213},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.058941930532455444}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006650","descriptor_name":"Histocompatibility Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012150","descriptor_name":"Polymorphism, Restriction Fragment Length","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015345","descriptor_name":"Oligonucleotide Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007890-199105000-00034","doi":"https://doi.org/10.1097/00007890-199105000-00034","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199105000-00034","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:1674388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1674388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/16","display_name":"Peace, justice, and strong institutions","score":0.6800000071525574}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2405262111","https://openalex.org/W2415665377","https://openalex.org/W2012886444","https://openalex.org/W1979771506","https://openalex.org/W1987829792","https://openalex.org/W1965142480","https://openalex.org/W2186918598","https://openalex.org/W2387733798","https://openalex.org/W2396882024","https://openalex.org/W2419212128"],"abstract_inverted_index":{"In":[0,49,88,127,185],"renal":[1],"transplantation":[2,61],"a":[3,10,20,66],"good":[4],"HLA-DR":[5,39,68,86,194,266],"match":[6],"is":[7],"associated":[8],"with":[9,76,145,152,247,275],"higher":[11],"success":[12],"rate":[13],"of":[14,22,38,51,55,100,108,133,165,187,201,210,228,238,256],"graft":[15,278],"outcome.":[16],"However,":[17],"due":[18,214],"to":[19,82,123,129,215,264],"number":[21,37],"technical":[23],"problems,":[24],"reliable":[25],"serological":[26,149],"DR":[27,45,153],"typing":[28,251],"cannot":[29],"always":[30],"be":[31,262],"obtained,":[32],"and":[33,159,198,242],"the":[34,52,90,97,101,131,166,188,202,211,221,226,234,239,248,257],"very":[35,118],"large":[36],"alleles":[40,110],"now":[41],"discovered":[42],"renders":[43],"such":[44,111],"matching":[46,267],"more":[47],"difficult.":[48],"view":[50],"medical":[53],"importance":[54],"HLA":[56],"class":[57],"II":[58],"polymorphism":[59],"in":[60,93,163,199,217,225,268,272],"immunology,":[62],"we":[63,136,168],"have":[64,137],"developed":[65],"simple":[67],"oligotyping":[69,140,160,204,240,258],"procedure":[70],"on":[71],"PCR-amplified":[72],"DNA,":[73],"by":[74,125,139,182],"hybridization":[75],"14":[77],"synthetic":[78],"oligonucleotide":[79],"probes":[80,91],"able":[81],"recognize":[83],"all":[84,209],"major":[85],"specificities.":[87],"particular,":[89],"used":[92],"this":[94,134],"study":[95,232],"allow":[96],"unambiguous":[98],"discrimination":[99],"DRw11,":[102],"w12,":[103],"w13,":[104],"w14-Dw9":[105],"specificities":[106],"or":[107,114,121,147,151],"rare":[109],"as":[112,179,245],"DR-Br":[113],"DRw13-DwHAG,":[115],"which":[116],"are":[117,177],"often":[119],"difficult":[120],"impossible":[122],"identify":[124],"serology.":[126,207],"order":[128],"explore":[130],"potential":[132],"methodology,":[135],"analyzed":[138],"110":[141],"kidney":[142,277],"transplant":[143],"patients":[144,167,176,189],"doubtful":[146],"unreliable":[148],"assignment,":[150],"blank":[154],"alleles.":[155,230],"Comparison":[156],"between":[157],"serology":[158],"shows":[161],"that":[162],"66.3%":[164],"observed":[169],"an":[170],"excellent":[171],"correlation.":[172],"About":[173],"half":[174],"these":[175],"homozygotes,":[178],"ultimately":[180],"verified":[181],"RFLP":[183,249],"typing.":[184],"26.4%":[186],"however,":[190],"at":[191],"least":[192],"one":[193],"antigen":[195],"was":[196],"discrepant,":[197],"7.3%":[200],"cases":[203],"resolved":[205],"uninterpretable":[206],"Almost":[208],"discrepancies":[212],"were":[213],"errors":[216],"allele":[218],"assignment":[219],"within":[220],"DRw52":[222],"group,":[223],"mostly":[224],"case":[227],"DRw13":[229],"This":[231],"confirms":[233],"expected":[235],"qualitative":[236],"advantage":[237],"technique":[241],"its":[243],"simplicity":[244],"compared":[246],"DNA":[250],"procedure.":[252],"Large":[253],"scale":[254],"application":[255],"methodology":[259],"will":[260],"therefore":[261],"beneficial":[263],"optimize":[265],"organ":[269],"transplantation,":[270],"particularly":[271],"high":[273],"responders":[274],"first":[276],"rejection.":[279]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}