{"id":"https://openalex.org/W2000660197","doi":"https://doi.org/10.3923/pjbs.2010.463.479","title":"Silymarin Ameliorates Cisplatin-Induced Hepatotoxicity in Rats: Histopathological and Ultrastructural Studies","display_name":"Silymarin Ameliorates Cisplatin-Induced Hepatotoxicity in Rats: Histopathological and Ultrastructural Studies","publication_year":2010,"publication_date":"2010-05-01","ids":{"openalex":"https://openalex.org/W2000660197","doi":"https://doi.org/10.3923/pjbs.2010.463.479","mag":"2000660197","pmid":"https://pubmed.ncbi.nlm.nih.gov/21848071"},"language":"en","primary_location":{"id":"doi:10.3923/pjbs.2010.463.479","doi":"https://doi.org/10.3923/pjbs.2010.463.479","is_oa":false,"landing_page_url":"https://doi.org/10.3923/pjbs.2010.463.479","pdf_url":null,"source":{"id":"https://openalex.org/S49288575","display_name":"Pakistan Journal of Biological Sciences","issn_l":"1028-8880","issn":["1028-8880","1812-5735"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322697005","host_organization_name":"Asian Network for Scientific Information","host_organization_lineage":["https://openalex.org/P4322697005"],"host_organization_lineage_names":["Asian Network for Scientific Information"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Biological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111611306","display_name":"N.E. Abdelmegui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"N.E. Abdelmegui","raw_affiliation_strings":["Department of Zoology, Faculty of Science, Alexandria University, Moharram Bey, Alexandria 2151, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Faculty of Science, Alexandria University, Moharram Bey, Alexandria 2151, Egypt","institution_ids":["https://openalex.org/I84524832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060556043","display_name":"Hania Nakkash Chmaisse","orcid":"https://orcid.org/0000-0001-5257-4231","observed_orcids":["https://orcid.org/0000-0001-5257-4231"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H.N. Chmaisse","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062737142","display_name":"Noura S. Abouzeinab","orcid":"https://orcid.org/0000-0001-7368-734X","observed_orcids":["https://orcid.org/0000-0001-7368-734X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N.S. Abou Zeinab","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8602,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.85022466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"10","first_page":"463","last_page":"479"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12689","display_name":"Silymarin and Mushroom Poisoning","score":0.7196999788284302,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12689","display_name":"Silymarin and Mushroom Poisoning","score":0.7196999788284302,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.27390000224113464,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/silymarin","display_name":"silymarin","score":1.0},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.906000018119812},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.5109999775886536},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.4020000100135803},{"id":"https://openalex.org/keywords/hepatocyte-ultrastructure","display_name":"hepatocyte ultrastructure","score":0.7559999823570251},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.8759999871253967},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.6970000267028809},{"id":"https://openalex.org/keywords/pretreatment-timing","display_name":"pretreatment timing","score":0.5379999876022339},{"id":"https://openalex.org/keywords/dietary-supplements","display_name":"dietary supplements","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.9591121673583984},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7650373578071594},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7015324234962463},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4741877019405365},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36865848302841187},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3609136939048767},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3212878108024597},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2527585029602051},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16026630997657776},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15408626198768616}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3923/pjbs.2010.463.479","doi":"https://doi.org/10.3923/pjbs.2010.463.479","is_oa":false,"landing_page_url":"https://doi.org/10.3923/pjbs.2010.463.479","pdf_url":null,"source":{"id":"https://openalex.org/S49288575","display_name":"Pakistan Journal of Biological Sciences","issn_l":"1028-8880","issn":["1028-8880","1812-5735"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322697005","host_organization_name":"Asian Network for Scientific Information","host_organization_lineage":["https://openalex.org/P4322697005"],"host_organization_lineage_names":["Asian Network for Scientific Information"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Biological Sciences","raw_type":"journal-article"},{"id":"pmid:21848071","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21848071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of biological sciences : PJBS","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W62069695","https://openalex.org/W94897181","https://openalex.org/W188953848","https://openalex.org/W1493780140","https://openalex.org/W1540306958","https://openalex.org/W1558395737","https://openalex.org/W1578668611","https://openalex.org/W1751092985","https://openalex.org/W1966794054","https://openalex.org/W1971304191","https://openalex.org/W1977776248","https://openalex.org/W1977812939","https://openalex.org/W1978777859","https://openalex.org/W1985978023","https://openalex.org/W1989061890","https://openalex.org/W1991366313","https://openalex.org/W1994716500","https://openalex.org/W2014738532","https://openalex.org/W2016176618","https://openalex.org/W2020168919","https://openalex.org/W2024498485","https://openalex.org/W2026085986","https://openalex.org/W2026181664","https://openalex.org/W2035302590","https://openalex.org/W2043373896","https://openalex.org/W2044295544","https://openalex.org/W2047627994","https://openalex.org/W2060899580","https://openalex.org/W2080735998","https://openalex.org/W2092954078","https://openalex.org/W2094964582","https://openalex.org/W2096110839","https://openalex.org/W2097582131","https://openalex.org/W2100728179","https://openalex.org/W2102836067","https://openalex.org/W2104709039","https://openalex.org/W2109392900","https://openalex.org/W2110045337","https://openalex.org/W2117319789","https://openalex.org/W2123291552","https://openalex.org/W2128161758","https://openalex.org/W2131890408","https://openalex.org/W2135469933","https://openalex.org/W2137709880","https://openalex.org/W2138269815","https://openalex.org/W2145867958","https://openalex.org/W2148224662","https://openalex.org/W2158734702","https://openalex.org/W2169175581","https://openalex.org/W2234862753","https://openalex.org/W2285053403","https://openalex.org/W6602524109"],"related_works":["https://openalex.org/W4402975092","https://openalex.org/W2716127265","https://openalex.org/W2020168919","https://openalex.org/W3188085548","https://openalex.org/W2318579851","https://openalex.org/W2181924556","https://openalex.org/W2333138376","https://openalex.org/W2587437844","https://openalex.org/W1998299784","https://openalex.org/W4285599488"],"abstract_inverted_index":{"The":[0],"benefit":[1],"of":[2,26,58,85,142,208],"silymarin,":[3],"a":[4,38,222,234,243],"plant":[5,216],"extract":[6,217],"with":[7,119,171,238],"strong":[8],"antioxidant":[9],"activity":[10],"against":[11,163,197],"hepatotoxicity":[12],"induced":[13,182],"by":[14,168,183,225],"cisplatin":[15,70,77,98,131,176,184,198,239],"in":[16,20,112,137,160,201,212,246],"rats":[17,56,62],"was":[18],"investigated":[19],"this":[21,215],"study.":[22],"Cisplatin":[23],"is":[24,210],"one":[25],"the":[27,150,164,179],"most":[28,115],"effective":[29],"chemotherapeutic":[30],"drugs,":[31],"yet":[32,157],"it":[33,46,154,158,241],"alone":[34],"does":[35],"not":[36],"achieve":[37],"satisfactory":[39],"therapeutic":[40],"outcome":[41],"and":[42,72,82,92,124,135,185,230],"at":[43],"high":[44],"doses":[45],"can":[47,218],"produce":[48],"undesirable":[49],"side":[50],"effects.":[51],"Five":[52],"equal-sized":[53],"groups":[54],"(18":[55],"each)":[57],"male":[59],"Sprague":[60],"Dawley":[61],"[control,":[63],"vehicle;":[64],"cisplatin;":[65],"silymarin":[66,73,143,172,193,209],"2":[67,74,144,173],"h":[68,75,145,174],"after":[69,146],"injection;":[71],"before":[76,175],"injection]":[78],"were":[79,87],"used.":[80],"Histopathological":[81],"ultrastructural":[83],"observation":[84],"livers":[86],"carried":[88],"out":[89],"using":[90],"light":[91],"electron":[93],"microscopy.":[94],"Results":[95],"documented":[96],"that":[97,130,192],"produced":[99],"behavioral,":[100],"external":[101],"features":[102],"animal":[103,202],"changes,":[104],"as":[105,107,221,233],"well":[106],"hazard":[108],"pathological":[109,165,180],"picture":[110],"changes":[111,181],"liver":[113,139],"where":[114],"hepatocytes":[116],"appeared":[117,186],"diminutive":[118],"vacuolated":[120],"cytoplasm,":[121],"sinusoids":[122],"dilated":[123],"organelle":[125],"disorganized.":[126],"These":[127,189],"results":[128,190],"revealed":[129],"may":[132],"be":[133,219],"toxic":[134],"terminates":[136],"complex":[138],"damage.":[140],"Administrations":[141],"cisplatin,":[147],"significantly":[148,177],"increase":[149],"body":[151],"weight":[152],"returning":[153],"to":[155],"normal,":[156],"failed":[159],"complete":[161],"protection":[162],"alteration":[166],"caused":[167],"cisplatin.":[169],"Pretreatment":[170],"decreased":[178],"highly":[187],"protective.":[188],"suggested":[191],"possess":[194],"protective":[195],"effects":[196],"hepatotoxic":[199],"action":[200],"models.":[203],"Since,":[204],"no":[205],"significant":[206,244],"toxicity":[207],"reported":[211],"human":[213],"studies,":[214],"used":[220],"dietary":[223],"supplement":[224],"patients":[226],"taking":[227],"anticancerous":[228],"medications":[229],"might":[231],"serve":[232],"novel":[235],"combination":[236],"agent":[237],"since":[240],"plays":[242],"role":[245],"reducing":[247],"its":[248],"toxicity.":[249]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
