{"id":"https://openalex.org/W2000655842","doi":"https://doi.org/10.1074/jbc.m110.148981","title":"Hsp90 Is Required for Transfer of the Cholera Toxin A1 Subunit from the Endoplasmic Reticulum to the Cytosol","display_name":"Hsp90 Is Required for Transfer of the Cholera Toxin A1 Subunit from the Endoplasmic Reticulum to the Cytosol","publication_year":2010,"publication_date":"2010-07-29","ids":{"openalex":"https://openalex.org/W2000655842","doi":"https://doi.org/10.1074/jbc.m110.148981","mag":"2000655842","pmid":"https://pubmed.ncbi.nlm.nih.gov/20667832","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2951200"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m110.148981","doi":"https://doi.org/10.1074/jbc.m110.148981","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.148981","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m110.148981","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010071461","display_name":"Michael Taylor","orcid":"https://orcid.org/0000-0003-1678-261X","observed_orcids":["https://orcid.org/0000-0003-1678-261X"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Taylor","raw_affiliation_strings":["Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32826, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32826, USA","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019886966","display_name":"Fernando Navarro\u2010Garc\u00eda","orcid":"https://orcid.org/0000-0002-9031-3232","observed_orcids":["https://orcid.org/0000-0002-9031-3232"]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Fernando Navarro-Garcia","raw_affiliation_strings":["Department of Cell Biology, Centro de Investigaci\u00f3n y de Estudios Avanzados del IPN (CINVESTAV-Zacatenco), 07000 M\u00e9xico DF, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Centro de Investigaci\u00f3n y de Estudios Avanzados del IPN (CINVESTAV-Zacatenco), 07000 M\u00e9xico DF, Mexico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036751897","display_name":"Jazm\u00edn Huerta-Cantillo","orcid":"https://orcid.org/0009-0006-7525-754X","observed_orcids":["https://orcid.org/0009-0006-7525-754X"]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jazmin Huerta","raw_affiliation_strings":["Department of Cell Biology, Centro de Investigaci\u00f3n y de Estudios Avanzados del IPN (CINVESTAV-Zacatenco), 07000 M\u00e9xico DF, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Centro de Investigaci\u00f3n y de Estudios Avanzados del IPN (CINVESTAV-Zacatenco), 07000 M\u00e9xico DF, Mexico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063439419","display_name":"Helen Burress","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen Burress","raw_affiliation_strings":["Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32826"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32826","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017768936","display_name":"Shane Massey","orcid":"https://orcid.org/0000-0003-0162-6710","observed_orcids":["https://orcid.org/0000-0003-0162-6710"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shane Massey","raw_affiliation_strings":["Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32826"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32826","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002962194","display_name":"Keith Ireton","orcid":"https://orcid.org/0000-0002-9188-1995","observed_orcids":["https://orcid.org/0000-0002-9188-1995"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith Ireton","raw_affiliation_strings":["Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32826"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32826","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054026012","display_name":"Ken Teter","orcid":"https://orcid.org/0000-0003-4176-9361","observed_orcids":["https://orcid.org/0000-0003-4176-9361"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ken Teter","raw_affiliation_strings":["Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32826"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32826","institution_ids":["https://openalex.org/I106165777"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054026012"],"corresponding_institution_ids":["https://openalex.org/I106165777"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.5148,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.93508999,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"285","issue":"41","first_page":"31261","last_page":"31267"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11684","display_name":"Vibrio bacteria research studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cholera-toxin","display_name":"cholera toxin","score":0.8889999985694885},{"id":"https://openalex.org/keywords/er-associated-degradation","display_name":"ER-associated degradation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cytosolic-chaperones","display_name":"cytosolic chaperones","score":0.7549999952316284},{"id":"https://openalex.org/keywords/geldanamycin","display_name":"geldanamycin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/grp94","display_name":"GRP94","score":0.9200000166893005},{"id":"https://openalex.org/keywords/atp-dependent-chaperone-activity","display_name":"ATP-dependent chaperone activity","score":0.6710000038146973},{"id":"https://openalex.org/keywords/toxin-secretion","display_name":"toxin secretion","score":0.37299999594688416},{"id":"https://openalex.org/keywords/ab5-toxins","display_name":"AB5 toxins","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C158619295","wikidata":"https://www.wikidata.org/wiki/Q21101062","display_name":"Endoplasmic-reticulum-associated protein degradation","level":4,"score":0.8475898504257202},{"id":"https://openalex.org/C2775932338","wikidata":"https://www.wikidata.org/wiki/Q24772687","display_name":"Hsp90","level":4,"score":0.8168983459472656},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.8152444362640381},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.804301917552948},{"id":"https://openalex.org/C2777006276","wikidata":"https://www.wikidata.org/wiki/Q83586","display_name":"Cholera toxin","level":2,"score":0.628993809223175},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.53560870885849},{"id":"https://openalex.org/C2780297055","wikidata":"https://www.wikidata.org/wiki/Q904475","display_name":"Geldanamycin","level":5,"score":0.522031307220459},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5018191337585449},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4889742136001587},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44532647728919983},{"id":"https://openalex.org/C199229279","wikidata":"https://www.wikidata.org/wiki/Q610647","display_name":"Translocon","level":4,"score":0.440717488527298},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37057703733444214},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.2953472137451172},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17369407415390015},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.14427784085273743},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.07397553324699402},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002772","descriptor_name":"Cholera Toxin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002772","descriptor_name":"Cholera Toxin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016227","descriptor_name":"Benzoquinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D047029","descriptor_name":"Lactams, Macrocyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1074/jbc.m110.148981","doi":"https://doi.org/10.1074/jbc.m110.148981","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.148981","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2192774","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2951200","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2951200","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2951200","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:20667832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20667832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:stars.library.ucf.edu:facultybib2010-1858","doi":null,"is_oa":true,"landing_page_url":"https://stars.library.ucf.edu/facultybib2010/859","pdf_url":null,"source":{"id":"https://openalex.org/S4210172555","display_name":"Journal of International Crisis and Risk Communication Research","issn_l":"2576-0017","issn":["2576-0017","2576-0025"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Bibliography 2010s","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m110.148981","doi":"https://doi.org/10.1074/jbc.m110.148981","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.148981","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4278889049","display_name":"Toxin Thermal Instability and Its Role in Host-Toxin Interactions","funder_award_id":"R01AI073783","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W65868975","https://openalex.org/W1494865255","https://openalex.org/W1520575681","https://openalex.org/W1549298104","https://openalex.org/W1558094240","https://openalex.org/W1964812214","https://openalex.org/W1968969013","https://openalex.org/W1976936483","https://openalex.org/W1978844022","https://openalex.org/W1980775568","https://openalex.org/W1982826698","https://openalex.org/W1989123847","https://openalex.org/W1989385635","https://openalex.org/W1994437994","https://openalex.org/W1995541840","https://openalex.org/W1997847272","https://openalex.org/W1998311599","https://openalex.org/W2008354149","https://openalex.org/W2009664225","https://openalex.org/W2014438788","https://openalex.org/W2017841977","https://openalex.org/W2023680254","https://openalex.org/W2032141646","https://openalex.org/W2034560886","https://openalex.org/W2037657846","https://openalex.org/W2042117395","https://openalex.org/W2047059517","https://openalex.org/W2047775296","https://openalex.org/W2052549964","https://openalex.org/W2076699025","https://openalex.org/W2084996959","https://openalex.org/W2085648931","https://openalex.org/W2098644179","https://openalex.org/W2100251862","https://openalex.org/W2103392159","https://openalex.org/W2109231616","https://openalex.org/W2110101671","https://openalex.org/W2118597394","https://openalex.org/W2124476511","https://openalex.org/W2127310249","https://openalex.org/W2132865043","https://openalex.org/W2137474289","https://openalex.org/W2137871980","https://openalex.org/W2138550883","https://openalex.org/W2141018705","https://openalex.org/W2145879362","https://openalex.org/W2152909574","https://openalex.org/W2156617634","https://openalex.org/W2159997339","https://openalex.org/W2162306218"],"related_works":["https://openalex.org/W2950862360","https://openalex.org/W2061263079","https://openalex.org/W2343082986","https://openalex.org/W3173860135","https://openalex.org/W2008595071","https://openalex.org/W2969993039","https://openalex.org/W2745597162","https://openalex.org/W2954793968","https://openalex.org/W3173567047","https://openalex.org/W2756063029"],"abstract_inverted_index":{"Cholera":[0],"toxin":[1,6,35],"(CT)":[2],"is":[3,59,69],"an":[4,82,91],"AB(5)":[5],"that":[7,64,85,123,132],"moves":[8],"from":[9,30,140],"the":[10,14,23,25,31,34,38,42,57,65,75,110,133,141,155],"cell":[11],"surface":[12],"to":[13,79],"endoplasmic":[15],"reticulum":[16],"(ER)":[17],"by":[18,40,88,106],"retrograde":[19],"vesicular":[20],"transport.":[21],"In":[22],"ER,":[24],"catalytic":[26],"A1":[27],"subunit":[28],"dissociates":[29],"rest":[32],"of":[33,46,113,136,143,158],"and":[36,100],"enters":[37],"cytosol":[39,58],"exploiting":[41],"quality":[43],"control":[44],"system":[45],"ER-associated":[47],"degradation":[48],"(ERAD).":[49],"The":[50],"driving":[51],"force":[52],"for":[53,71,152],"CTA1":[54,72,80],"dislocation":[55,157],"into":[56,74],"unknown.":[60],"Here,":[61],"we":[62],"demonstrate":[63],"cytosolic":[66,129],"chaperone":[67],"Hsp90":[68,77,93,144,153],"required":[70],"passage":[73],"cytosol.":[76],"bound":[78],"in":[81,154],"ATP-dependent":[83],"manner":[84],"was":[86,103,109],"blocked":[87,105],"geldanamycin":[89],"(GA),":[90],"established":[92],"inhibitor.":[94],"CT":[95],"activity":[96],"against":[97],"cultured":[98],"cells":[99],"ileal":[101],"loops":[102],"also":[104],"GA,":[107],"as":[108],"ER-to-cytosol":[111],"export":[112],"CTA1.":[114,159],"Experiments":[115],"using":[116],"RNA":[117],"interference":[118],"or":[119],"N-ethylcarboxamidoadenosine,":[120],"a":[121,149],"drug":[122],"inhibits":[124],"ER-localized":[125],"GRP94":[126],"but":[127],"not":[128],"Hsp90,":[130],"confirmed":[131],"inhibitory":[134],"effects":[135],"GA":[137],"resulted":[138],"specifically":[139],"loss":[142],"activity.":[145],"This":[146],"work":[147],"establishes":[148],"functional":[150],"role":[151],"ERAD-mediated":[156]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
