{"id":"https://openalex.org/W2000655392","doi":"https://doi.org/10.1523/jneurosci.1125-05.2005","title":"The Generation of a 17 kDa Neurotoxic Fragment: An Alternative Mechanism by which Tau Mediates \u03b2-Amyloid-Induced Neurodegeneration","display_name":"The Generation of a 17 kDa Neurotoxic Fragment: An Alternative Mechanism by which Tau Mediates \u03b2-Amyloid-Induced Neurodegeneration","publication_year":2005,"publication_date":"2005-06-01","ids":{"openalex":"https://openalex.org/W2000655392","doi":"https://doi.org/10.1523/jneurosci.1125-05.2005","mag":"2000655392","pmid":"https://pubmed.ncbi.nlm.nih.gov/15930385","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1352316"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.1125-05.2005","doi":"https://doi.org/10.1523/jneurosci.1125-05.2005","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1125-05.2005","pdf_url":"https://www.jneurosci.org/content/jneuro/25/22/5365.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/25/22/5365.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100417985","display_name":"So\u2010Young Park","orcid":"https://orcid.org/0000-0002-6018-0440","observed_orcids":["https://orcid.org/0000-0002-6018-0440"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"So-Young Park","raw_affiliation_strings":["Department of Cell and Molecular Biology, Feinberg School of Medicine, and Institute for Neuroscience, Northwestern University, Chicago, Illinois 60611, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, Feinberg School of Medicine, and Institute for Neuroscience, Northwestern University, Chicago, Illinois 60611, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081561753","display_name":"Adriana Ferreira","orcid":"https://orcid.org/0000-0003-3705-3918","observed_orcids":["https://orcid.org/0000-0003-3705-3918"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adriana Ferreira","raw_affiliation_strings":["Department of Cell and Molecular Biology , Feinberg School of Medicine , and Institute for Neuroscience , Northwestern University , Chicago , Illinois 60611","Institute for Neuroscience , Northwestern Univer- sity , Searle Building Room 5-474 , 320 East Superior Street , Chicago , IL 60611 ","Cell & Developmental Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology , Feinberg School of Medicine , and Institute for Neuroscience , Northwestern University , Chicago , Illinois 60611","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Institute for Neuroscience , Northwestern Univer- sity , Searle Building Room 5-474 , 320 East Superior Street , Chicago , IL 60611 ","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Cell & Developmental Biology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":3.9357,"has_fulltext":true,"cited_by_count":269,"citation_normalized_percentile":{"value":0.94765231,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"25","issue":"22","first_page":"5365","last_page":"5375"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13637","display_name":"Calpain Protease Function and Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.8539999723434448},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9459999799728394},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.7829999923706055},{"id":"https://openalex.org/keywords/calpain-1","display_name":"calpain-1","score":0.859000027179718},{"id":"https://openalex.org/keywords/tau-cleavage","display_name":"tau cleavage","score":0.8230000138282776},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.7870000004768372},{"id":"https://openalex.org/keywords/neurite-degeneration","display_name":"neurite degeneration","score":0.9739999771118164},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.6110000014305115},{"id":"https://openalex.org/keywords/caspases","display_name":"caspases","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.8796054720878601},{"id":"https://openalex.org/C56928146","wikidata":"https://www.wikidata.org/wiki/Q2934402","display_name":"Calpain","level":3,"score":0.852676510810852},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7762906551361084},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.7245635986328125},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.6156284809112549},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5133020281791687},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.505713701248169},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4886973202228546},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47522905468940735},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.4683605432510376},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.460989773273468},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.42880910634994507},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3797938823699951},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3484671711921692},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25937947630882263},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2398841679096222},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.1833610236644745},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1101619303226471},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10981309413909912},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08800095319747925},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06687679886817932},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.059654057025909424},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002154","descriptor_name":"Calpain","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002154","descriptor_name":"Calpain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061945","descriptor_name":"Caspase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.1125-05.2005","doi":"https://doi.org/10.1523/jneurosci.1125-05.2005","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1125-05.2005","pdf_url":"https://www.jneurosci.org/content/jneuro/25/22/5365.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1352316","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1352316","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:15930385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15930385","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.1125-05.2005","doi":"https://doi.org/10.1523/jneurosci.1125-05.2005","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1125-05.2005","pdf_url":"https://www.jneurosci.org/content/jneuro/25/22/5365.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2224586393","display_name":"Novel Tau-mediated Neurodegeneration Mechanisms","funder_award_id":"R01NS039080","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000655392.pdf","grobid_xml":"https://content.openalex.org/works/W2000655392.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W171278538","https://openalex.org/W625946172","https://openalex.org/W1500549861","https://openalex.org/W1501007031","https://openalex.org/W1577397450","https://openalex.org/W1775749144","https://openalex.org/W1818767073","https://openalex.org/W1939090720","https://openalex.org/W1966002653","https://openalex.org/W1967237003","https://openalex.org/W1970374401","https://openalex.org/W1973231428","https://openalex.org/W1979364057","https://openalex.org/W1985446830","https://openalex.org/W1991483073","https://openalex.org/W1994945404","https://openalex.org/W1996397393","https://openalex.org/W1996917933","https://openalex.org/W1998225973","https://openalex.org/W2003424773","https://openalex.org/W2008219426","https://openalex.org/W2008354106","https://openalex.org/W2011246846","https://openalex.org/W2012008959","https://openalex.org/W2012420226","https://openalex.org/W2017008097","https://openalex.org/W2018289835","https://openalex.org/W2019834014","https://openalex.org/W2021017365","https://openalex.org/W2021271933","https://openalex.org/W2031102482","https://openalex.org/W2032920422","https://openalex.org/W2036745486","https://openalex.org/W2037801678","https://openalex.org/W2040197139","https://openalex.org/W2041740325","https://openalex.org/W2041767244","https://openalex.org/W2046299498","https://openalex.org/W2053695273","https://openalex.org/W2060458492","https://openalex.org/W2060565058","https://openalex.org/W2066869951","https://openalex.org/W2078989453","https://openalex.org/W2081768153","https://openalex.org/W2082429191","https://openalex.org/W2082963940","https://openalex.org/W2083663079","https://openalex.org/W2084461848","https://openalex.org/W2086539466","https://openalex.org/W2089331767","https://openalex.org/W2090784961","https://openalex.org/W2092607846","https://openalex.org/W2093076184","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2103626309","https://openalex.org/W2111066733","https://openalex.org/W2122437043","https://openalex.org/W2125172225","https://openalex.org/W2138523588","https://openalex.org/W2155429403","https://openalex.org/W2158118162","https://openalex.org/W2164296549","https://openalex.org/W2327752912"],"related_works":["https://openalex.org/W2131831022","https://openalex.org/W104689190","https://openalex.org/W2169388089","https://openalex.org/W2081768153","https://openalex.org/W2000608506","https://openalex.org/W2061864873","https://openalex.org/W1970334418","https://openalex.org/W2087016326","https://openalex.org/W1981243966","https://openalex.org/W2024291740"],"abstract_inverted_index":{"Recently,":[0],"we":[1,35],"have":[2],"shown":[3],"that":[4,49,138],"the":[5,19,32,53,73,92,95,106,116,126,149],"microtubule-associated":[6],"protein":[7],"tau":[8,23,38,59,88,157,170],"is":[9],"essential":[10],"for":[11],"beta-amyloid":[12],"(Abeta)-induced":[13],"neurotoxicity":[14,140],"in":[15,43,61,111,146],"hippocampal":[16,63,113],"neurons.":[17,64],"However,":[18],"mechanisms":[20],"by":[21,72,168],"which":[22,169],"mediates":[24],"Abeta-induced":[25,102,139,173],"neurite":[26,133],"degeneration":[27,128],"remain":[28],"poorly":[29],"understood.":[30],"In":[31],"present":[33],"study,":[34],"analyzed":[36],"whether":[37],"cleavage":[39],"played":[40],"a":[41,56,153,165],"role":[42],"these":[44,160],"events.":[45],"Our":[46],"results":[47,136,161],"showed":[48],"pre-aggregated":[50],"Abeta":[51],"induced":[52,115],"generation":[54,66,93,151],"of":[55,67,75,79,84,94,108,118,129,131,152],"17":[57,96,155],"kDa":[58,97,156],"fragment":[60,69,98,110],"cultured":[62,112],"The":[65],"this":[68,80,109],"was":[70],"preceded":[71],"activation":[74],"calpain-1.":[76],"Conversely,":[77],"inhibitors":[78],"protease,":[81],"but":[82],"not":[83],"caspases,":[85],"completely":[86],"prevented":[87],"proteolysis":[89],"leading":[90],"to":[91],"and":[99],"significantly":[100],"reduced":[101],"neuronal":[103],"death.":[104],"Furthermore,":[105],"expression":[107],"neurons":[114],"formation":[117],"numerous":[119],"varicosity-bearing":[120],"tortuous":[121],"processes,":[122],"as":[123,125],"well":[124],"complete":[127],"some":[130],"those":[132],"processes.":[134],"These":[135],"suggest":[137],"may":[141],"be":[142],"mediated,":[143],"at":[144],"least":[145],"part,":[147],"through":[148],"calpain-mediated":[150],"toxic":[154],"fragment.":[158],"Collectively,":[159],"provide":[162],"insight":[163],"into":[164],"novel":[166],"mechanism":[167],"could":[171],"mediate":[172],"neurotoxicity.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":23}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}