{"id":"https://openalex.org/W2000654975","doi":"https://doi.org/10.1074/jbc.m112.350124","title":"Expression in Drosophila of Tandem Amyloid \u03b2 Peptides Provides Insights into Links between Aggregation and Neurotoxicity","display_name":"Expression in Drosophila of Tandem Amyloid \u03b2 Peptides Provides Insights into Links between Aggregation and Neurotoxicity","publication_year":2012,"publication_date":"2012-03-30","ids":{"openalex":"https://openalex.org/W2000654975","doi":"https://doi.org/10.1074/jbc.m112.350124","mag":"2000654975","pmid":"https://pubmed.ncbi.nlm.nih.gov/22461632","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3370257"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m112.350124","doi":"https://doi.org/10.1074/jbc.m112.350124","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.350124","pdf_url":"http://www.jbc.org/article/S0021925820499442/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820499442/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000788984","display_name":"Elena Speretta","orcid":"https://orcid.org/0000-0003-1506-7438","observed_orcids":["https://orcid.org/0000-0003-1506-7438"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elena Speretta","raw_affiliation_strings":["Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom","Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014795732","display_name":"Thomas Robert Jahn","orcid":"https://orcid.org/0000-0002-9266-6736","observed_orcids":["https://orcid.org/0000-0002-9266-6736"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas R. Jahn","raw_affiliation_strings":["Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom","Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052209378","display_name":"Gian Gaetano Tartaglia","orcid":"https://orcid.org/0000-0001-7524-6310","observed_orcids":["https://orcid.org/0000-0001-7524-6310"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gian Gaetano Tartaglia","raw_affiliation_strings":["Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041839086","display_name":"Giorgio Favrin","orcid":"https://orcid.org/0000-0002-1884-7352","observed_orcids":["https://orcid.org/0000-0002-1884-7352"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Giorgio Favrin","raw_affiliation_strings":["Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059017804","display_name":"Teresa Pereira de Barros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Teresa P. Barros","raw_affiliation_strings":["Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom","Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038054585","display_name":"Sara Imarisio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sara Imarisio","raw_affiliation_strings":["Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110895214","display_name":"David A. Lomas","orcid":"https://orcid.org/0000-0003-2339-6979","observed_orcids":["https://orcid.org/0000-0003-2339-6979"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David A. Lomas","raw_affiliation_strings":["Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 0XY, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 0XY, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007132814","display_name":"Leila M. Luheshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Leila M. Luheshi","raw_affiliation_strings":["Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045465592","display_name":"Damian C. Crowther","orcid":"https://orcid.org/0000-0001-7791-1396","observed_orcids":["https://orcid.org/0000-0001-7791-1396"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Damian C. Crowther","raw_affiliation_strings":["Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom","Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 0XY, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 0XY, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091898546","display_name":"Christopher Martin Dobson","orcid":"https://orcid.org/0000-0002-5445-680X","observed_orcids":["https://orcid.org/0000-0002-5445-680X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Christopher M. Dobson","raw_affiliation_strings":["Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007132814","https://openalex.org/A5045465592","https://openalex.org/A5091898546"],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.6187,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.80475152,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"287","issue":"24","first_page":"20748","last_page":"20754"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7639999985694885},{"id":"https://openalex.org/keywords/amyloid-beta-40","display_name":"A\u03b240","score":0.699999988079071},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.9990000128746033},{"id":"https://openalex.org/keywords/peptide-aggregation","display_name":"peptide aggregation","score":0.6399999856948853},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8289999961853027},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8190000057220459},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.8479999899864197},{"id":"https://openalex.org/keywords/oligomeric-intermediates","display_name":"oligomeric intermediates","score":0.8519999980926514},{"id":"https://openalex.org/keywords/soluble-oligomers","display_name":"soluble oligomers","score":0.746999979019165},{"id":"https://openalex.org/keywords/aggregation-kinetics","display_name":"aggregation kinetics","score":0.671999990940094},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7073506116867065},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6713744401931763},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.6519553661346436},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.6079761981964111},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5733782052993774},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5646054148674011},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5260986089706421},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5213742852210999},{"id":"https://openalex.org/C27149982","wikidata":"https://www.wikidata.org/wiki/Q3456514","display_name":"Tandem repeat","level":4,"score":0.5151740312576294},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.4966149926185608},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4432273805141449},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.432498961687088},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.42460396885871887},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27704986929893494},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13081330060958862},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08304840326309204},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1074/jbc.m112.350124","doi":"https://doi.org/10.1074/jbc.m112.350124","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.350124","pdf_url":"http://www.jbc.org/article/S0021925820499442/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2381638","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3370257","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22461632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22461632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3370257","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3370257/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmh:oai:iris.uniroma1.it:11573/1451755","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11573/1451755","pdf_url":"https://iris.uniroma1.it/bitstream/11573/1451755/1/Speretta_Expression_2012.pdf","source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1382031","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1382031/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JOURNAL OF BIOLOGICAL CHEMISTRY , 287 (24) pp. 20748-20754. (2012)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m112.350124","doi":"https://doi.org/10.1074/jbc.m112.350124","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.350124","pdf_url":"http://www.jbc.org/article/S0021925820499442/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5130116780","display_name":"Mechanisms of neurotoxicity of amyloid aggregates.","funder_award_id":"089703/Z/09/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8639491176","display_name":"Mechanisms of neurotoxicity of amyloid aggregates","funder_award_id":"MC_G1000734","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000654975.pdf","grobid_xml":"https://content.openalex.org/works/W2000654975.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1618236677","https://openalex.org/W1677883125","https://openalex.org/W1956744515","https://openalex.org/W1969333011","https://openalex.org/W1970016175","https://openalex.org/W1976201852","https://openalex.org/W1980947093","https://openalex.org/W1989948422","https://openalex.org/W1991435932","https://openalex.org/W2014875724","https://openalex.org/W2015640782","https://openalex.org/W2032920422","https://openalex.org/W2040863516","https://openalex.org/W2052112605","https://openalex.org/W2071953900","https://openalex.org/W2075481535","https://openalex.org/W2076162696","https://openalex.org/W2076834744","https://openalex.org/W2082429191","https://openalex.org/W2094881767","https://openalex.org/W2096410114","https://openalex.org/W2108587019","https://openalex.org/W2109727228","https://openalex.org/W2112232744","https://openalex.org/W2124097456","https://openalex.org/W2137587206","https://openalex.org/W2159290882","https://openalex.org/W2160770834","https://openalex.org/W2165186407","https://openalex.org/W2166427101"],"related_works":["https://openalex.org/W2624769333","https://openalex.org/W2467834109","https://openalex.org/W7017641219","https://openalex.org/W4404607488","https://openalex.org/W1665432046","https://openalex.org/W7063932268","https://openalex.org/W7064314992","https://openalex.org/W2536027605","https://openalex.org/W2147231139","https://openalex.org/W3021453777"],"abstract_inverted_index":{"The":[0,22,97,171],"generation":[1],"and":[2,46,89,117,131,161],"subsequent":[3],"aggregation":[4,82,134],"of":[5,18,26,51,65,69,84,99,114,136,146,154,157,174,189,200,209],"amyloid":[6],"\u03b2":[7],"(A\u03b2)":[8],"peptides":[9,28,72,138],"play":[10],"a":[11,39,63,92,162],"crucial":[12],"initiating":[13],"role":[14],"in":[15,44,55,57,77,80,91,108,139,166,168,178],"the":[16,36,48,52,75,81,111,121,127,137,140,147,152,175,185,190],"pathogenesis":[17],"Alzheimer":[19],"disease":[20],"(AD).":[21],"two":[23],"main":[24,49],"isoforms":[25],"these":[27,70],"have":[29,61],"40":[30],"(A\u03b2(40))":[31],"or":[32],"42":[33],"residues":[34],"(A\u03b2(42)),":[35],"latter":[37],"having":[38],"higher":[40,128,186,207],"propensity":[41],"to":[42,73,104,184,198,205],"aggregate":[43],"vitro":[45],"being":[47],"component":[50],"plaques":[53],"observed":[54],"vivo":[56,169,179],"AD":[58],"patients.":[59],"We":[60],"designed":[62],"series":[64],"tandem":[66,112,141],"dimeric":[67],"constructs":[68,113],"A\u03b2":[71,85],"probe":[74],"manner":[76],"which":[78],"changes":[79],"kinetics":[83],"affect":[86],"its":[87,206],"deposition":[88],"toxicity":[90],"Drosophila":[93],"melanogaster":[94],"model":[95],"system.":[96],"levels":[98,156],"insoluble":[100],"aggregates":[101,160],"were":[102],"found":[103],"be":[105,182],"substantially":[106],"elevated":[107],"flies":[109],"expressing":[110],"both":[115],"A\u03b2(40)":[116,201],"A\u03b2(42)":[118,148,176],"compared":[119],"with":[120,126],"equivalent":[122],"monomeric":[123],"peptides,":[124],"consistent":[125],"effective":[129],"concentration,":[130],"hence":[132],"increased":[133],"rate,":[135],"repeat.":[142],"A":[143],"unique":[144],"feature":[145],"constructs,":[149],"however,":[150],"is":[151],"appearance":[153],"high":[155],"soluble":[158],"oligomeric":[159,191],"corresponding":[163],"dramatic":[164],"increase":[165],"their":[167],"toxicity.":[170],"toxic":[172],"nature":[173],"peptide":[177],"can":[180],"therefore":[181],"attributed":[183],"kinetic":[187],"stability":[188],"intermediate":[192],"states":[193],"that":[194],"it":[195],"populates":[196],"relative":[197],"those":[199],"rather":[202],"than":[203],"simply":[204],"rate":[208],"aggregation.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}