{"id":"https://openalex.org/W2000654246","doi":"https://doi.org/10.1056/nejmoa041810","title":"Leflunomide or Methotrexate for Juvenile Rheumatoid Arthritis","display_name":"Leflunomide or Methotrexate for Juvenile Rheumatoid Arthritis","publication_year":2005,"publication_date":"2005-04-20","ids":{"openalex":"https://openalex.org/W2000654246","doi":"https://doi.org/10.1056/nejmoa041810","mag":"2000654246","pmid":"https://pubmed.ncbi.nlm.nih.gov/15843668"},"language":"en","primary_location":{"id":"doi:10.1056/nejmoa041810","doi":"https://doi.org/10.1056/nejmoa041810","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa041810","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa041810?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa041810?articleTools=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047679905","display_name":"Earl D. Silverman","orcid":"https://orcid.org/0000-0002-9841-3799","observed_orcids":["https://orcid.org/0000-0002-9841-3799"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Earl Silverman","raw_affiliation_strings":["Department of Pediatrics, University of Toronto, Toronto. esilverman@sickkids.ca","Departments of Pediatrics and Immunology, University of Toronto, Toronto","Division of Rheumatology, Hospital for Sick Children, Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Toronto, Toronto. esilverman@sickkids.ca","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Departments of Pediatrics and Immunology, University of Toronto, Toronto","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Division of Rheumatology, Hospital for Sick Children, Toronto","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036158155","display_name":"Richard Mouy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Richard Mouy","raw_affiliation_strings":["H\u00f4pital des Enfants Malades, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital des Enfants Malades, Paris","institution_ids":["https://openalex.org/I1288880153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043518902","display_name":"Lynn R. Spiegel","orcid":"https://orcid.org/0000-0003-1581-0789","observed_orcids":["https://orcid.org/0000-0003-1581-0789"]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lynn Spiegel","raw_affiliation_strings":["Division of Rheumatology, Hospital for Sick Children, Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Hospital for Sick Children, Toronto","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063009703","display_name":"Lawrence Kwok Leung Jung","orcid":"https://orcid.org/0000-0001-6366-1736","observed_orcids":["https://orcid.org/0000-0001-6366-1736"]},"institutions":[{"id":"https://openalex.org/I2800482329","display_name":"CHI Health Creighton University Medical Center - Bergan Mercy","ror":"https://ror.org/03z1w3b90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800482329","https://openalex.org/I2802665030","https://openalex.org/I2802797007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence K. Jung","raw_affiliation_strings":["Department of Pediatrics, Creighton University Medical Center, Omaha, Nebr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Creighton University Medical Center, Omaha, Nebr","institution_ids":["https://openalex.org/I2800482329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089810934","display_name":"Rotraud Katharina Saurenmann","orcid":"https://orcid.org/0000-0002-0726-7459","observed_orcids":["https://orcid.org/0000-0002-0726-7459"]},"institutions":[{"id":"https://openalex.org/I4210128593","display_name":"University Children's Hospital Zurich","ror":"https://ror.org/035vb3h42","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210128593"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Rotraud K. Saurenmann","raw_affiliation_strings":["University Children's Hospital, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children's Hospital, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I4210128593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071510702","display_name":"Pekka Lahdenne","orcid":"https://orcid.org/0000-0002-3983-2897","observed_orcids":["https://orcid.org/0000-0002-3983-2897"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Pekka Lahdenne","raw_affiliation_strings":["Hospital for Children and Adolescents, University of Helsinki, Helsinki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital for Children and Adolescents, University of Helsinki, Helsinki","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053719643","display_name":"Gerd Horneff","orcid":"https://orcid.org/0000-0001-5491-7832","observed_orcids":["https://orcid.org/0000-0001-5491-7832"]},"institutions":[{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerd Horneff","raw_affiliation_strings":["Martin Luther Uniklinik Halle, Halle, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Martin Luther Uniklinik Halle, Halle, Germany","institution_ids":["https://openalex.org/I68956291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109291121","display_name":"Inmaculada Calvo Penad\u00e9s","orcid":"https://orcid.org/0000-0001-5184-667X","observed_orcids":["https://orcid.org/0000-0001-5184-667X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Immaculada Calvo","raw_affiliation_strings":["Hospital Universitario Infantil, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario Infantil, Valencia, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111578230","display_name":"Ilona S. Szer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087384","display_name":"Rady Children's Hospital-San Diego","ror":"https://ror.org/00414dg76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilona S. Szer","raw_affiliation_strings":["Pediatric Rheumatology Division, Children's Hospital San Diego, San Diego, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Rheumatology Division, Children's Hospital San Diego, San Diego, Calif","institution_ids":["https://openalex.org/I4210087384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108627325","display_name":"Karen M. Simpson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111804","display_name":"Sanofi (United States)","ror":"https://ror.org/027vj4x92","country_code":"US","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210111804"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Simpson","raw_affiliation_strings":["Sanofi\u2013Aventis, Bridgewater, N.J"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi\u2013Aventis, Bridgewater, N.J","institution_ids":["https://openalex.org/I4210111804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081912758","display_name":"John A. Stewart","orcid":"https://orcid.org/0000-0002-9035-9812","observed_orcids":["https://orcid.org/0000-0002-9035-9812"]},"institutions":[{"id":"https://openalex.org/I4210104304","display_name":"Sanofi (Canada)","ror":"https://ror.org/01aptcd74","country_code":"CA","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210104304"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John A. Stewart","raw_affiliation_strings":["Sanofi\u2013Aventis Pharma Canada, Laval, Que"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi\u2013Aventis Pharma Canada, Laval, Que","institution_ids":["https://openalex.org/I4210104304"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012283576","display_name":"Vibeke Strand","orcid":"https://orcid.org/0000-0003-4978-4072","observed_orcids":["https://orcid.org/0000-0003-4978-4072"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vibeke Strand","raw_affiliation_strings":["Division of Immunology, Stanford University, Palo Alto, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Stanford University, Palo Alto, Calif","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.665,"has_fulltext":false,"cited_by_count":259,"citation_normalized_percentile":{"value":0.97654421,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"352","issue":"16","first_page":"1655","last_page":"1666"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.6952999830245972,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.6952999830245972,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.301800012588501,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leflunomide","display_name":"leflunomide","score":0.878000020980835},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":1.0},{"id":"https://openalex.org/keywords/juvenile-idiopathic-arthritis","display_name":"juvenile idiopathic arthritis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/polyarticular-juvenile-idiopathic-arthritis","display_name":"polyarticular juvenile idiopathic arthritis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/comparative-efficacy","display_name":"drug efficacy comparison","score":0.7649999856948853},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6430000066757202},{"id":"https://openalex.org/keywords/aminotransferase-elevation","display_name":"aminotransferase elevation","score":0.953000009059906}],"concepts":[{"id":"https://openalex.org/C2775905006","wikidata":"https://www.wikidata.org/wiki/Q248550","display_name":"Leflunomide","level":3,"score":0.9823145866394043},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9590575695037842},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.8931863307952881},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7746026515960693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6539440155029297},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6292172074317932},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.5310129523277283},{"id":"https://openalex.org/C2780574019","wikidata":"https://www.wikidata.org/wiki/Q861224","display_name":"Juvenile rheumatoid arthritis","level":3,"score":0.5117466449737549},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4894029200077057},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.46885499358177185},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4044833183288574},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3616623878479004}],"mesh":[{"descriptor_ui":"D000077339","descriptor_name":"Leflunomide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001171","descriptor_name":"Arthritis, Juvenile","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1056/nejmoa041810","doi":"https://doi.org/10.1056/nejmoa041810","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa041810","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa041810?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:15843668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15843668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Clinical Trial"},{"id":"pmh:oai:iris.unil.ch:iris/117111","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/117111","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:serval.unil.ch:BIB_37162","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_37162","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"New England Journal of Medicine, vol. 352, no. 16, pp. 1655-1666","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1056/nejmoa041810","doi":"https://doi.org/10.1056/nejmoa041810","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa041810","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa041810?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000654246.pdf"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W204500871","https://openalex.org/W1974734161","https://openalex.org/W1991605430","https://openalex.org/W1993198453","https://openalex.org/W1996075673","https://openalex.org/W2030541223","https://openalex.org/W2035457339","https://openalex.org/W2048860421","https://openalex.org/W2066546529","https://openalex.org/W2073700972","https://openalex.org/W2082741765","https://openalex.org/W2097564087","https://openalex.org/W2108075643","https://openalex.org/W2111540856","https://openalex.org/W2114490834","https://openalex.org/W2119781059","https://openalex.org/W2131747734","https://openalex.org/W2155694144","https://openalex.org/W2168958406","https://openalex.org/W2228301361","https://openalex.org/W2312982528","https://openalex.org/W2342174771"],"related_works":["https://openalex.org/W2357647844","https://openalex.org/W2035457339","https://openalex.org/W2077360327","https://openalex.org/W153555947","https://openalex.org/W4323544556","https://openalex.org/W1987733166","https://openalex.org/W2333093468","https://openalex.org/W2319960807","https://openalex.org/W2342174771","https://openalex.org/W7216827397"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1],"compared":[2],"the":[3,14,68,88,107,116,121,137,140,157,194,198,221,229],"safety":[4],"and":[5,67,76,83,180,197,210],"efficacy":[6],"of":[7,11,16,33,55,58,101,104,217],"leflunomide":[8,36,122,192,211],"with":[9,188,191,204],"that":[10],"methotrexate":[12,38,117,189,209,235],"in":[13,21,42,115,120,173,214,232],"treatment":[15],"polyarticular":[17,205],"juvenile":[18,206],"rheumatoid":[19,207],"arthritis":[20],"a":[22,43,49],"multinational,":[23],"randomized,":[24,96],"controlled":[25],"trial.":[26],"METHODS:":[27],"Patients":[28],"3":[29],"to":[30],"17":[31],"years":[32],"age":[34],"received":[35],"or":[37],"for":[39,80,139,226],"16":[40,81,99,162],"weeks":[41,79,82,86,100],"double-dummy,":[44],"blinded":[45,51],"fashion,":[46],"followed":[47],"by":[48],"32-week":[50,89],"extension.":[52],"The":[53,168],"rates":[54,216],"American":[56],"College":[57],"Rheumatology":[59],"Pediatric":[60],"30":[61,128],"percent":[62,131,149],"responses":[63],"(ACR":[64],"Pedi":[65,127],"30)":[66],"Percent":[69,141],"Improvement":[70,142],"Index":[71,143],"were":[72,163,185],"assessed":[73],"at":[74,160,165],"baseline":[75],"every":[77,84],"4":[78],"8":[85],"during":[87,193],"extension":[90,108,199],"study.":[91,109,200],"RESULTS:":[92],"Of":[93],"94":[94],"patients":[95,114,203],"86":[97],"completed":[98],"treatment,":[102],"70":[103],"whom":[105],"entered":[106],"At":[110,228],"week":[111,161,166],"16,":[112],"more":[113,186,237],"group":[118,123],"than":[119,190,239],"had":[124],"an":[125],"ACR":[126],"response":[129],"(89":[130],"vs.":[132,150],"68":[133],"percent,":[134,152],"P=0.02),":[135],"whereas":[136],"values":[138],"did":[144],"not":[145],"differ":[146],"significantly":[147],"(-52.87":[148],"-44.41":[151],"P=0.18).":[153],"In":[154,202],"both":[155,174,212],"groups,":[156],"improvements":[158],"achieved":[159],"maintained":[164],"48.":[167],"most":[169],"common":[170],"adverse":[171],"events":[172],"groups":[175],"included":[176],"gastrointestinal":[177],"symptoms,":[178],"headache,":[179],"nasopharyngeal":[181],"symptoms.":[182],"Aminotransferase":[183],"elevations":[184],"frequent":[187],"initial":[195],"study":[196],"CONCLUSIONS:":[201],"arthritis,":[208],"resulted":[213],"high":[215],"clinical":[218],"improvement,":[219],"but":[220],"rate":[222],"was":[223,236],"slightly":[224],"greater":[225],"methotrexate.":[227],"doses":[230],"used":[231],"this":[233],"study,":[234],"effective":[238],"leflunomide.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
