{"id":"https://openalex.org/W2000650397","doi":"https://doi.org/10.1097/mph.0b013e3181a1c104","title":"Effects of VEGF on Phenotypic Severity in Children With Hereditary Hemorrhagic Telangiectasia","display_name":"Effects of VEGF on Phenotypic Severity in Children With Hereditary Hemorrhagic Telangiectasia","publication_year":2009,"publication_date":"2009-07-27","ids":{"openalex":"https://openalex.org/W2000650397","doi":"https://doi.org/10.1097/mph.0b013e3181a1c104","mag":"2000650397","pmid":"https://pubmed.ncbi.nlm.nih.gov/19636272"},"language":"en","primary_location":{"id":"doi:10.1097/mph.0b013e3181a1c104","doi":"https://doi.org/10.1097/mph.0b013e3181a1c104","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mph.0b013e3181a1c104","pdf_url":null,"source":{"id":"https://openalex.org/S15952725","display_name":"Journal of Pediatric Hematology/Oncology","issn_l":"1077-4114","issn":["1077-4114","1536-3678"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Hematology/Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102737006","display_name":"Paola Giordano","orcid":"https://orcid.org/0000-0002-7762-3500","observed_orcids":["https://orcid.org/0000-0002-7762-3500"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Paola Giordano","raw_affiliation_strings":["Department of Biomedicine of Evolutionary Age daggerInternal Medicine and Public Health, HHT Inter-Departmental Centre, University of Bari, Bari, Italy","Biomedicine of Evolutionary Age"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine of Evolutionary Age daggerInternal Medicine and Public Health, HHT Inter-Departmental Centre, University of Bari, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]},{"raw_affiliation_string":"Biomedicine of Evolutionary Age","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102779588","display_name":"Gennaro Mariano Lenato","orcid":"https://orcid.org/0000-0002-4631-0173","observed_orcids":["https://orcid.org/0000-0002-4631-0173"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gennaro M. Lenato","raw_affiliation_strings":["Internal Medicine and Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine and Public Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052144030","display_name":"Paola Pierucci","orcid":"https://orcid.org/0000-0002-0201-0486","observed_orcids":["https://orcid.org/0000-0002-0201-0486"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paola Pierucci","raw_affiliation_strings":["Internal Medicine and Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine and Public Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084743208","display_name":"Patrizia Suppressa","orcid":"https://orcid.org/0000-0002-3146-9173","observed_orcids":["https://orcid.org/0000-0002-3146-9173"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrizia Suppressa","raw_affiliation_strings":["Internal Medicine and Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine and Public Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023011556","display_name":"Maria Altomare","orcid":"https://orcid.org/0000-0001-9409-261X","observed_orcids":["https://orcid.org/0000-0001-9409-261X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maria Altomare","raw_affiliation_strings":["Biomedicine of Evolutionary Age"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedicine of Evolutionary Age","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039839193","display_name":"Giancarlo Vecchio","orcid":"https://orcid.org/0000-0001-5462-0027","observed_orcids":["https://orcid.org/0000-0001-5462-0027"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Giancarlo Del Vecchio","raw_affiliation_strings":["Biomedicine of Evolutionary Age"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedicine of Evolutionary Age","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057873654","display_name":"Giovanna Di Bitonto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Giovanna Di Bitonto","raw_affiliation_strings":["Biomedicine of Evolutionary Age"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedicine of Evolutionary Age","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109202273","display_name":"Domenico De Mattia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Domenico De Mattia","raw_affiliation_strings":["Biomedicine of Evolutionary Age"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedicine of Evolutionary Age","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050466184","display_name":"Ginevra Guanti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ginevra Guanti","raw_affiliation_strings":["Unit of Medical Genetics, HHT Inter-departmental Centre, University of Bari, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Medical Genetics, HHT Inter-departmental Centre, University of Bari, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011825873","display_name":"Carlo Sabb\u00e0","orcid":"https://orcid.org/0000-0002-9874-8740","observed_orcids":["https://orcid.org/0000-0002-9874-8740"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlo Sabb\u00e0","raw_affiliation_strings":["Internal Medicine and Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine and Public Health","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023011556","https://openalex.org/A5039839193","https://openalex.org/A5057873654","https://openalex.org/A5102737006","https://openalex.org/A5109202273"],"corresponding_institution_ids":["https://openalex.org/I5561750"],"apc_list":null,"apc_paid":null,"fwci":0.9137,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.73672711,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"31","issue":"8","first_page":"577","last_page":"582"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hereditary-hemorrhagic-telangiectasia","display_name":"hereditary hemorrhagic telangiectasia","score":0.996999979019165},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9390000104904175},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.875},{"id":"https://openalex.org/keywords/arteriovenous-malformation","display_name":"arteriovenous malformation","score":0.902999997138977},{"id":"https://openalex.org/keywords/pulmonary-arteriovenous-malformation","display_name":"pulmonary arteriovenous malformation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.8700000047683716},{"id":"https://openalex.org/keywords/intestinal-bleeding","display_name":"intestinal bleeding","score":0.8119999766349792},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C2776330896","wikidata":"https://www.wikidata.org/wiki/Q1634800","display_name":"Telangiectasia","level":2,"score":0.9565463066101074},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9443076848983765},{"id":"https://openalex.org/C175554068","wikidata":"https://www.wikidata.org/wiki/Q14914463","display_name":"ACVRL1","level":5,"score":0.7363967299461365},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.6311523914337158},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.5360046029090881},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5352697372436523},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5298839807510376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.489053338766098},{"id":"https://openalex.org/C6061869","wikidata":"https://www.wikidata.org/wiki/Q18250377","display_name":"Endoglin","level":4,"score":0.45216548442840576},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35577794909477234},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013683","descriptor_name":"Telangiectasia, Hereditary Hemorrhagic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013683","descriptor_name":"Telangiectasia, Hereditary Hemorrhagic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/mph.0b013e3181a1c104","doi":"https://doi.org/10.1097/mph.0b013e3181a1c104","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mph.0b013e3181a1c104","pdf_url":null,"source":{"id":"https://openalex.org/S15952725","display_name":"Journal of Pediatric Hematology/Oncology","issn_l":"1077-4114","issn":["1077-4114","1536-3678"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Hematology/Oncology","raw_type":"journal-article"},{"id":"pmid:19636272","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19636272","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric hematology/oncology","raw_type":"Comparative Study"},{"id":"pmh:oai:ricerca.uniba.it:11586/122243","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11586/122243","pdf_url":null,"source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W2000210566","https://openalex.org/W2000686607","https://openalex.org/W2001775383","https://openalex.org/W2005259727","https://openalex.org/W2009465979","https://openalex.org/W2021605609","https://openalex.org/W2031284906","https://openalex.org/W2032686344","https://openalex.org/W2036541038","https://openalex.org/W2040008417","https://openalex.org/W2044931994","https://openalex.org/W2060372234","https://openalex.org/W2070796521","https://openalex.org/W2073386061","https://openalex.org/W2075249851","https://openalex.org/W2075998623","https://openalex.org/W2080299984","https://openalex.org/W2083332894","https://openalex.org/W2086425449","https://openalex.org/W2093316809","https://openalex.org/W2102275580","https://openalex.org/W2158847377","https://openalex.org/W2163504684","https://openalex.org/W2410408420","https://openalex.org/W2413205791","https://openalex.org/W2770216137","https://openalex.org/W4234343739","https://openalex.org/W6715345612"],"related_works":["https://openalex.org/W2040008417","https://openalex.org/W2160176331","https://openalex.org/W2073263978","https://openalex.org/W4405282698","https://openalex.org/W2050576444","https://openalex.org/W2069277048","https://openalex.org/W2106609267","https://openalex.org/W2896737176","https://openalex.org/W2236800958","https://openalex.org/W2914981442"],"abstract_inverted_index":{"The":[0,180],"purpose":[1],"of":[2,39,68,93,96,119,157,182,194],"this":[3],"study":[4],"was":[5,102,140],"to":[6,33,36,65,190],"estimate":[7],"vascular":[8],"endothelial":[9],"growth":[10,15],"factor":[11,16,153],"(VEGF)":[12],"and":[13,29,32,59,70,82,106,132],"transforming":[14],"(TGF)-beta1":[17],"serum":[18,117],"levels":[19,45,108,118,139,148],"in":[20,49,77,109,121,142,160,178,197],"children":[21,79],"with":[22,56,80,130,200],"hereditary":[23],"hemorrhagic":[24],"telangiectasia":[25],"(HHT)":[26],"type":[27,30],"1":[28],"2":[31,88],"correlate":[34],"them":[35],"the":[37,66,91,94,155,192,195,198],"presence":[38,193],"arteriovenous":[40],"malformations":[41],"(AVMs).":[42],"High":[43],"VEGF":[44,69,105,120,147,165],"were":[46,85,125],"initially":[47],"found":[48,103,141],"an":[50,175],"infant":[51,199],"who":[52],"had":[53],"been":[54],"hospitalized":[55],"intestinal":[57,201],"bleeding":[58],"suspected":[60],"HHT.":[61,179],"This":[62],"case":[63],"led":[64],"evaluation":[67],"TGF-beta1":[71,107,138,167],"by":[72],"standard":[73],"enzyme-linked":[74],"immunosorbent":[75],"assay":[76],"13":[78],"HHT":[81,110,115,161,183],"familiarity.":[83],"Patients":[84],"divided":[86],"into":[87],"groups":[89],"on":[90],"basis":[92],"presence/absence":[95],"pulmonary":[97,158],"AVMs.":[98],"No":[99,135],"significant":[100],"difference":[101,136],"for":[104,137,174],"patients":[111],"versus":[112],"controls.":[113,134],"Among":[114],"patients,":[116],"those":[122,129],"without":[123],"AVM":[124,131],"significantly":[126],"lower":[127],"than":[128],"normal":[133],"these":[143],"patient":[144],"subgroups.":[145],"Low":[146],"may":[149],"represent":[150],"a":[151],"protection":[152],"against":[154],"onset":[156],"AVMs":[159],"children.":[162],"However,":[163],"neither":[164],"nor":[166],"can":[168],"be":[169],"used":[170],"as":[171],"biochemical":[172],"markers":[173],"early":[176],"diagnosis":[177,181],"still":[184],"requires":[185],"clinical":[186],"criteria,":[187],"which":[188],"permitted":[189],"confirm":[191],"disease":[196],"bleeding.":[202]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
