{"id":"https://openalex.org/W2000649903","doi":"https://doi.org/10.3109/03009748709102922","title":"Hepatotoxicity Associated with Low-dose, Long-term Methotrexate Treatment of Rheumatoid Arthritis","display_name":"Hepatotoxicity Associated with Low-dose, Long-term Methotrexate Treatment of Rheumatoid Arthritis","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2000649903","doi":"https://doi.org/10.3109/03009748709102922","mag":"2000649903","pmid":"https://pubmed.ncbi.nlm.nih.gov/3629206"},"language":"en","primary_location":{"id":"doi:10.3109/03009748709102922","doi":"https://doi.org/10.3109/03009748709102922","is_oa":false,"landing_page_url":"https://doi.org/10.3109/03009748709102922","pdf_url":null,"source":{"id":"https://openalex.org/S42124886","display_name":"Scandinavian Journal of Rheumatology","issn_l":"0300-9742","issn":["0300-9742","1502-7732"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035002160","display_name":"E. Szanto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Szanto","raw_affiliation_strings":["Department of Medicine, Division of Rheumatology, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Rheumatology, Stockholm, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014814396","display_name":"Bengt Sandstedt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802208705","display_name":"Danderyds sjukhus","ror":"https://ror.org/00hm9kt34","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2802208705","https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"B. Sandstedt","raw_affiliation_strings":["Department of Pathology at Dunderyd Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology at Dunderyd Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I2802208705"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070719060","display_name":"Bo Kollberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Kollberg","raw_affiliation_strings":["Division of Gastro-Enterology, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastro-Enterology, Stockholm, Sweden","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9916,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.70160398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"16","issue":"4","first_page":"229","last_page":"234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.03999999910593033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.984000027179718},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/liver-biopsy","display_name":"liver biopsy","score":0.5809999704360962},{"id":"https://openalex.org/keywords/portal-fibrosis","display_name":"portal fibrosis","score":0.6159999966621399},{"id":"https://openalex.org/keywords/fatty-liver-infiltration","display_name":"liver fatty infiltration","score":0.6140000224113464},{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.7300000190734863},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9713689088821411},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.89396071434021},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.8203026056289673},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4638547897338867},{"id":"https://openalex.org/C2909063479","wikidata":"https://www.wikidata.org/wiki/Q810254","display_name":"Antirheumatic Agents","level":3,"score":0.46166282892227173},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4303198754787445},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.41976919770240784},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3315771818161011},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3109/03009748709102922","doi":"https://doi.org/10.3109/03009748709102922","is_oa":false,"landing_page_url":"https://doi.org/10.3109/03009748709102922","pdf_url":null,"source":{"id":"https://openalex.org/S42124886","display_name":"Scandinavian Journal of Rheumatology","issn_l":"0300-9742","issn":["0300-9742","1502-7732"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Rheumatology","raw_type":"journal-article"},{"id":"pmid:3629206","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3629206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of rheumatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W43249627","https://openalex.org/W1979360787","https://openalex.org/W1979363802","https://openalex.org/W1986827858","https://openalex.org/W1988957647","https://openalex.org/W1995161962","https://openalex.org/W1999497055","https://openalex.org/W2008516875","https://openalex.org/W2009614949","https://openalex.org/W2011322797","https://openalex.org/W2034962567","https://openalex.org/W2039551697","https://openalex.org/W2043544048","https://openalex.org/W2057542535","https://openalex.org/W2065696821","https://openalex.org/W2068273197","https://openalex.org/W2080270092","https://openalex.org/W2082064509","https://openalex.org/W2089931465","https://openalex.org/W2096458389","https://openalex.org/W2127426526","https://openalex.org/W2406035041","https://openalex.org/W2415800613","https://openalex.org/W3172850718"],"related_works":["https://openalex.org/W2065696821","https://openalex.org/W1979295423","https://openalex.org/W32775975","https://openalex.org/W65084144","https://openalex.org/W2086477757","https://openalex.org/W2154209905","https://openalex.org/W1974528604","https://openalex.org/W1974065253","https://openalex.org/W2068273197","https://openalex.org/W2414942112"],"abstract_inverted_index":{"Liver":[0],"biopsies":[1,51],"were":[2,12],"performed":[3],"in":[4,64,86,92],"17":[5],"patients":[6],"with":[7,15,68,73],"therapy-refractory":[8],"rheumatoid":[9],"arthritis":[10],"who":[11,89],"treated":[13],"successfully":[14],"5-15":[16],"mg/week":[17],"methotrexate":[18],"(mtx).":[19],"The":[20,50],"average":[21],"duration":[22],"of":[23,55,58],"exposure":[24],"to":[25,94],"mtx":[26,39],"therapy":[27],"for":[28],"each":[29],"patient":[30,88],"was":[31,84],"2.8":[32],"years":[33],"(range":[34],"1.5-5":[35],"years).":[36],"Total":[37],"cumulative":[38],"doses":[40],"ranged":[41],"between":[42],"633":[43],"and":[44,77],"1,655":[45],"mg":[46],"(mean":[47],"1,060":[48],"mg).":[49],"revealed":[52],"16":[53],"cases":[54],"normal":[56],"histology,":[57],"which":[59],"3":[60],"showed":[61],"nuclear":[62],"variability":[63],"the":[65],"hepatocytes;":[66],"4":[67],"mild":[69,74],"fatty":[70,75],"infiltration,":[71],"2":[72],"infiltration":[76],"portal":[78],"round":[79],"cell":[80],"infiltration.":[81],"Portal":[82],"fibrosis":[83],"found":[85],"one":[87],"had":[90],"psoriasis":[91],"addition":[93],"clinical":[95],"RA.":[96]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}