{"id":"https://openalex.org/W2000648375","doi":"https://doi.org/10.4161/auto.27955","title":"NOX4 regulates autophagy during energy deprivation","display_name":"NOX4 regulates autophagy during energy deprivation","publication_year":2014,"publication_date":"2014-01-31","ids":{"openalex":"https://openalex.org/W2000648375","doi":"https://doi.org/10.4161/auto.27955","mag":"2000648375","pmid":"https://pubmed.ncbi.nlm.nih.gov/24492492","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4091158"},"language":"en","primary_location":{"id":"doi:10.4161/auto.27955","doi":"https://doi.org/10.4161/auto.27955","is_oa":true,"landing_page_url":"https://doi.org/10.4161/auto.27955","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/auto.27955?needAccess=true&role=button","source":{"id":"https://openalex.org/S102544370","display_name":"Autophagy","issn_l":"1554-8627","issn":["1554-8627","1554-8635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/auto.27955?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031467506","display_name":"Sebastiano Sciarretta","orcid":"https://orcid.org/0000-0002-8633-6896","observed_orcids":["https://orcid.org/0000-0002-8633-6896"]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Sebastiano Sciarretta","raw_affiliation_strings":["Cardiovascular Research Institute; Department of Cell Biology and Molecular Medicine; Rutgers New Jersey Medical School; Newark, NJ USA; IRCCS Neuromed; Pozzilli (IS), Italy","Cardiovascular Research Institute","Department of Cell Biology and Molecular Medicine","IRCCS Neuromed","Newark, NJ USA","Pozzilli (IS), Italy","Rutgers New Jersey Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute; Department of Cell Biology and Molecular Medicine; Rutgers New Jersey Medical School; Newark, NJ USA; IRCCS Neuromed; Pozzilli (IS), Italy","institution_ids":["https://openalex.org/I3018288129","https://openalex.org/I4402554120"]},{"raw_affiliation_string":"Cardiovascular Research Institute","institution_ids":[]},{"raw_affiliation_string":"Department of Cell Biology and Molecular Medicine","institution_ids":[]},{"raw_affiliation_string":"IRCCS Neuromed","institution_ids":["https://openalex.org/I3018288129"]},{"raw_affiliation_string":"Newark, NJ USA","institution_ids":[]},{"raw_affiliation_string":"Pozzilli (IS), Italy","institution_ids":[]},{"raw_affiliation_string":"Rutgers New Jersey Medical School","institution_ids":["https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054282642","display_name":"Massimo Volpe","orcid":"https://orcid.org/0000-0002-9642-8380","observed_orcids":["https://orcid.org/0000-0002-9642-8380"]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Volpe","raw_affiliation_strings":["IRCCS Neuromed; Pozzilli (IS), Italy; Department of Clinical and Molecular Medicine; School of Medicine and Psicology; University \"Sapienza\"; Rome, Italy","Department of Clinical and Molecular Medicine","IRCCS Neuromed","Pozzilli (IS), Italy","Rome, Italy","School of Medicine and Psicology","University \"Sapienza\""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Neuromed; Pozzilli (IS), Italy; Department of Clinical and Molecular Medicine; School of Medicine and Psicology; University \"Sapienza\"; Rome, Italy","institution_ids":["https://openalex.org/I3018288129","https://openalex.org/I861853513"]},{"raw_affiliation_string":"Department of Clinical and Molecular Medicine","institution_ids":[]},{"raw_affiliation_string":"IRCCS Neuromed","institution_ids":["https://openalex.org/I3018288129"]},{"raw_affiliation_string":"Pozzilli (IS), Italy","institution_ids":[]},{"raw_affiliation_string":"Rome, Italy","institution_ids":[]},{"raw_affiliation_string":"School of Medicine and Psicology","institution_ids":[]},{"raw_affiliation_string":"University \"Sapienza\"","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091705107","display_name":"Junichi Sadoshima","orcid":"https://orcid.org/0000-0003-3724-4132","observed_orcids":["https://orcid.org/0000-0003-3724-4132"]},"institutions":[{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Junichi Sadoshima","raw_affiliation_strings":["Cardiovascular Research Institute; Department of Cell Biology and Molecular Medicine; Rutgers New Jersey Medical School; Newark, NJ USA","Cardiovascular Research Institute","Department of Cell Biology and Molecular Medicine","Newark, NJ USA","Rutgers New Jersey Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute; Department of Cell Biology and Molecular Medicine; Rutgers New Jersey Medical School; Newark, NJ USA","institution_ids":["https://openalex.org/I4402554120"]},{"raw_affiliation_string":"Cardiovascular Research Institute","institution_ids":[]},{"raw_affiliation_string":"Department of Cell Biology and Molecular Medicine","institution_ids":[]},{"raw_affiliation_string":"Newark, NJ USA","institution_ids":[]},{"raw_affiliation_string":"Rutgers New Jersey Medical School","institution_ids":["https://openalex.org/I4402554120"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5091705107"],"corresponding_institution_ids":["https://openalex.org/I4402554120"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"4","first_page":"699","last_page":"701"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nox4","display_name":"NOX4","score":1.0},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.8930000066757202},{"id":"https://openalex.org/keywords/energy-deprivation","display_name":"energy deprivation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.9760000109672546},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.9300000071525574},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9940000176429749},{"id":"https://openalex.org/keywords/perk","display_name":"PERK","score":0.8519999980926514},{"id":"https://openalex.org/keywords/atf4","display_name":"ATF4","score":0.8190000057220459},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.5099999904632568},{"id":"https://openalex.org/keywords/energy-stress","display_name":"energy stress","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C2779765511","wikidata":"https://www.wikidata.org/wiki/Q18039812","display_name":"NOX4","level":4,"score":0.9452677965164185},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.8481160402297974},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7714368104934692},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.7583205103874207},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7403360605239868},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.6727821826934814},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.5684012770652771},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.516486644744873},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4802025556564331},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.4539584219455719},{"id":"https://openalex.org/C2781331208","wikidata":"https://www.wikidata.org/wiki/Q18032378","display_name":"XBP1","level":5,"score":0.42643216252326965},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4176620543003082},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23337024450302124},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.21024754643440247},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015852","descriptor_name":"Eukaryotic Initiation Factor-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4161/auto.27955","doi":"https://doi.org/10.4161/auto.27955","is_oa":true,"landing_page_url":"https://doi.org/10.4161/auto.27955","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/auto.27955?needAccess=true&role=button","source":{"id":"https://openalex.org/S102544370","display_name":"Autophagy","issn_l":"1554-8627","issn":["1554-8627","1554-8635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4091158","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4091158","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"Text"},{"id":"pmid:24492492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24492492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/554283","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/554283","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.4161/auto.27955","doi":"https://doi.org/10.4161/auto.27955","is_oa":true,"landing_page_url":"https://doi.org/10.4161/auto.27955","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/auto.27955?needAccess=true&role=button","source":{"id":"https://openalex.org/S102544370","display_name":"Autophagy","issn_l":"1554-8627","issn":["1554-8627","1554-8635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2348369761","display_name":null,"funder_award_id":"HL102738","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G2733619014","display_name":null,"funder_award_id":"HL91469","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2829595218","display_name":null,"funder_award_id":"AG27211","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G289660099","display_name":"Regulation of myocardial growth and death by GSK-3","funder_award_id":"R01HL067724","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3077080134","display_name":null,"funder_award_id":"HL69020","funder_id":"https://openalex.org/F4320320890","funder_display_name":"Fondation Leducq"},{"id":"https://openalex.org/G3081755402","display_name":null,"funder_award_id":"AG23039","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G3405322071","display_name":null,"funder_award_id":"HL67724","funder_id":"https://openalex.org/F4320320890","funder_display_name":"Fondation Leducq"},{"id":"https://openalex.org/G3410819162","display_name":null,"funder_award_id":"HL69020","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3416025776","display_name":"Longevity and Stress Resistance","funder_award_id":"P01AG027211","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3738628576","display_name":null,"funder_award_id":"HL102738","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4015702995","display_name":null,"funder_award_id":"AG27211","funder_id":"https://openalex.org/F4320320890","funder_display_name":"Fondation Leducq"},{"id":"https://openalex.org/G4046088456","display_name":"Regulation of myocardial growth and death by autophagy","funder_award_id":"R01HL102738","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4101633970","display_name":null,"funder_award_id":"HL91469","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G429204276","display_name":null,"funder_award_id":"AG23039","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4466128033","display_name":"Redox regulation in myocardial disease","funder_award_id":"R01AG023039","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4557971983","display_name":null,"funder_award_id":"AG27211","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G4833141044","display_name":null,"funder_award_id":"AG27211","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4843078876","display_name":"REGULATION OF MYOCARDIAL GROWTH AND DEATH BY THE HIPPO PATHWAY","funder_award_id":"R01HL112330","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5103921932","display_name":null,"funder_award_id":"HL67724","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G538767246","display_name":null,"funder_award_id":"HL-67724","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5538412199","display_name":null,"funder_award_id":"HL67724","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G5804956950","display_name":null,"funder_award_id":"HL91469","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G5806494660","display_name":null,"funder_award_id":"HL91469","funder_id":"https://openalex.org/F4320320890","funder_display_name":"Fondation Leducq"},{"id":"https://openalex.org/G5925465205","display_name":null,"funder_award_id":"AG23039","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G6118534991","display_name":null,"funder_award_id":"AG27211","funder_id":"https://openalex.org/F4320331529","funder_display_name":"Societ\u00e0 Italiana di Cardiologia"},{"id":"https://openalex.org/G6368583586","display_name":null,"funder_award_id":"HL102738","funder_id":"https://openalex.org/F4320331529","funder_display_name":"Societ\u00e0 Italiana di Cardiologia"},{"id":"https://openalex.org/G7130972895","display_name":null,"funder_award_id":"HL69020","funder_id":"https://openalex.org/F4320331529","funder_display_name":"Societ\u00e0 Italiana di Cardiologia"},{"id":"https://openalex.org/G7295199721","display_name":null,"funder_award_id":"HL69020","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G7351897116","display_name":null,"funder_award_id":"HL69020","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G7384925648","display_name":null,"funder_award_id":"HL102738","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G7497252558","display_name":"Mechanisms of myocardial ischemia and reperfusion","funder_award_id":"P01HL069020","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7549431907","display_name":null,"funder_award_id":"HL91469","funder_id":"https://openalex.org/F4320331529","funder_display_name":"Societ\u00e0 Italiana di Cardiologia"},{"id":"https://openalex.org/G759537036","display_name":null,"funder_award_id":"AG23039","funder_id":"https://openalex.org/F4320331529","funder_display_name":"Societ\u00e0 Italiana di Cardiologia"},{"id":"https://openalex.org/G76062032","display_name":null,"funder_award_id":"AG23039","funder_id":"https://openalex.org/F4320320890","funder_display_name":"Fondation Leducq"},{"id":"https://openalex.org/G8570913175","display_name":null,"funder_award_id":"HL67724","funder_id":"https://openalex.org/F4320331529","funder_display_name":"Societ\u00e0 Italiana di Cardiologia"},{"id":"https://openalex.org/G8842179039","display_name":null,"funder_award_id":"HL102738","funder_id":"https://openalex.org/F4320320890","funder_display_name":"Fondation Leducq"},{"id":"https://openalex.org/G9000871788","display_name":"Cysteine oxidation in the heart","funder_award_id":"R01HL091469","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320318516","display_name":"Societ\u00e0 Italiana dell'Ipertensione Arteriosa","ror":"https://ror.org/05wma2347"},{"id":"https://openalex.org/F4320320890","display_name":"Fondation Leducq","ror":"https://ror.org/01czwga19"},{"id":"https://openalex.org/F4320331529","display_name":"Societ\u00e0 Italiana di Cardiologia","ror":"https://ror.org/00pbv8f56"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000648375.pdf","grobid_xml":"https://content.openalex.org/works/W2000648375.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2159156984","https://openalex.org/W1988702747","https://openalex.org/W306966558","https://openalex.org/W2618964129","https://openalex.org/W2940679947","https://openalex.org/W1977551186","https://openalex.org/W4220984077","https://openalex.org/W4388869391","https://openalex.org/W1983045014","https://openalex.org/W2516416731"],"abstract_inverted_index":{"NADPH":[0,23],"oxidase":[1,24],"is":[2,40,84,99],"a":[3,41,85,117,130],"cellular":[4,105,124],"enzyme":[5],"devoted":[6],"to":[7,49,103],"the":[8,19,26,45,60,71,82,94],"production":[9,78],"of":[10,22,44,68,74,79,93,121],"reactive":[11],"oxygen":[12],"species":[13],"(ROS).":[14],"NOX4":[15,52,122],"and":[16,54,107],"NOX2":[17],"are":[18,57],"main":[20],"isoforms":[21],"in":[25,59,66,81,111],"cardiovascular":[27],"system.":[28],"In":[29],"our":[30,127],"recent":[31],"study,":[32],"we":[33],"demonstrated":[34],"that":[35,88,134],"NOX4,":[36],"but":[37,64],"not":[38,65],"NOX2,":[39],"critical":[42,86],"mediator":[43],"cardiomyocyte":[46],"adaptive":[47],"response":[48],"energy":[50,75,106,125],"stress.":[51],"activity":[53],"protein":[55],"levels":[56],"increased":[58],"endoplasmic":[61],"reticulum":[62],"(ER)":[63],"mitochondria":[67],"cardiomyocytes":[69],"during":[70,123],"early":[72],"phase":[73],"deprivation.":[76],"NOX4-derived":[77],"ROS":[80],"ER":[83],"event":[87],"activates":[89],"autophagy":[90,98,136],"through":[91],"stimulation":[92],"EIF2AK3/PERK-EIF2S1/eIF-2\u03b1-ATF4":[95],"pathway.":[96],"NOX4-dependent":[97],"an":[100],"important":[101],"mechanism":[102,133],"preserve":[104],"limit":[108],"cell":[109],"death":[110],"energy-deprived":[112],"cardiomyocytes.":[113],"Aside":[114],"from":[115],"elucidating":[116],"crucial":[118],"physiological":[119],"function":[120],"stress,":[126],"study":[128],"dissects":[129],"novel":[131],"signaling":[132],"regulates":[135],"under":[137],"this":[138],"condition.":[139]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}