{"id":"https://openalex.org/W2000647917","doi":"https://doi.org/10.1080/15287397609529416","title":"Biliary excretion of cadmium by rats: Effects of zinc, cadmium, and selenium pretreatments","display_name":"Biliary excretion of cadmium by rats: Effects of zinc, cadmium, and selenium pretreatments","publication_year":1976,"publication_date":"1976-09-01","ids":{"openalex":"https://openalex.org/W2000647917","doi":"https://doi.org/10.1080/15287397609529416","mag":"2000647917","pmid":"https://pubmed.ncbi.nlm.nih.gov/994245"},"language":"en","primary_location":{"id":"doi:10.1080/15287397609529416","doi":"https://doi.org/10.1080/15287397609529416","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15287397609529416","pdf_url":null,"source":{"id":"https://openalex.org/S85071590","display_name":"Journal of Toxicology and Environmental Health","issn_l":"0098-4108","issn":["0098-4108","1087-2620"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology and Environmental Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035879699","display_name":"Howard D. Stowe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82497590","display_name":"Auburn University","ror":"https://ror.org/02v80fc35","country_code":"US","type":"education","lineage":["https://openalex.org/I82497590"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Howard D. Stowe","raw_affiliation_strings":["Department of Pathology and Parasitology, School of Veterinary Medicine, Auburn University, Auburn, Alabama, 36830"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Parasitology, School of Veterinary Medicine, Auburn University, Auburn, Alabama, 36830","institution_ids":["https://openalex.org/I82497590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035879699"],"corresponding_institution_ids":["https://openalex.org/I82497590"],"apc_list":null,"apc_paid":null,"fwci":2.138,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.83176661,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"2","issue":"1","first_page":"45","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.01889999955892563,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10139","display_name":"Heavy metals in environment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cadmium","display_name":"cadmium","score":0.9829999804496765},{"id":"https://openalex.org/keywords/biliary-excretion","display_name":"biliary excretion","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bile-flow","display_name":"bile flow","score":0.7279999852180481},{"id":"https://openalex.org/keywords/zinc-pretreatment","display_name":"zinc pretreatment","score":0.8790000081062317},{"id":"https://openalex.org/keywords/metal-binding-proteins","display_name":"metal-binding proteins","score":0.7620000243186951},{"id":"https://openalex.org/keywords/dietary-cadmium-exposure","display_name":"dietary cadmium exposure","score":0.734000027179718},{"id":"https://openalex.org/keywords/metallothionein","display_name":"metallothionein","score":0.5519999861717224},{"id":"https://openalex.org/keywords/metal-detoxification","display_name":"metal detoxification","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C544657597","wikidata":"https://www.wikidata.org/wiki/Q1091","display_name":"Cadmium","level":2,"score":0.758871853351593},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6706522703170776},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.6600292325019836},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6278313398361206},{"id":"https://openalex.org/C553756173","wikidata":"https://www.wikidata.org/wiki/Q876","display_name":"Selenium","level":2,"score":0.612648069858551},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5847934484481812},{"id":"https://openalex.org/C16527932","wikidata":"https://www.wikidata.org/wiki/Q1112860","display_name":"Excretory system","level":2,"score":0.5570122003555298},{"id":"https://openalex.org/C2779777945","wikidata":"https://www.wikidata.org/wiki/Q851111","display_name":"Bile duct","level":2,"score":0.47775426506996155},{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.47282397747039795},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28394079208374023},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001646","descriptor_name":"Bile","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001646","descriptor_name":"Bile","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012643","descriptor_name":"Selenium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/15287397609529416","doi":"https://doi.org/10.1080/15287397609529416","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15287397609529416","pdf_url":null,"source":{"id":"https://openalex.org/S85071590","display_name":"Journal of Toxicology and Environmental Health","issn_l":"0098-4108","issn":["0098-4108","1087-2620"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology and Environmental Health","raw_type":"journal-article"},{"id":"pmid:994245","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/994245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of toxicology and environmental health","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W59881090","https://openalex.org/W1513835984","https://openalex.org/W1543160729","https://openalex.org/W1580085046","https://openalex.org/W1664826582","https://openalex.org/W1698449099","https://openalex.org/W1983891235","https://openalex.org/W1989446088","https://openalex.org/W1992165172","https://openalex.org/W1995548974","https://openalex.org/W2010411836","https://openalex.org/W2013334689","https://openalex.org/W2016102510","https://openalex.org/W2018591605","https://openalex.org/W2027194233","https://openalex.org/W2053208311","https://openalex.org/W2053930325","https://openalex.org/W2078641429","https://openalex.org/W2082662940","https://openalex.org/W2084044795","https://openalex.org/W2126393573","https://openalex.org/W2255157304","https://openalex.org/W2326702300","https://openalex.org/W2327447535","https://openalex.org/W2344656008","https://openalex.org/W2402833398","https://openalex.org/W2410056921","https://openalex.org/W2412958386","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2312981827","https://openalex.org/W2041341731","https://openalex.org/W2024591925","https://openalex.org/W2318928466","https://openalex.org/W2085815866","https://openalex.org/W2016297030","https://openalex.org/W2086036209","https://openalex.org/W2061061251","https://openalex.org/W2312843654","https://openalex.org/W2017172110"],"abstract_inverted_index":{"The":[0,61,205],"significance":[1],"of":[2,32,45,57,101,133,153,166,185,198,217],"bile":[3,27,35,62,120,170,202],"as":[4],"an":[5],"excretory":[6],"route":[7],"for":[8,77,92,118,208],"cadmium":[9],"(Cd)":[10],"was":[11],"studied":[12],"in":[13,34,119,162,194],"anesthetized,":[14],"bile-duct-cannulated":[15],"Sprague-Dawley":[16],"rats":[17,79,93],"during":[18,122,168,200],"a":[19,159,191],"6-hr":[20],"collection":[21,171,203],"period.":[22,172,204],"Observations":[23],"were":[24],"made":[25],"on":[26,143],"flow":[28,63],"rates,":[29],"the":[30,43,54,102,123,127,150,163,169,182,195,201,215,222],"concentrations":[31],"Cd":[33,40,51,103,129,167,199],"following":[36,126],"dietary":[37],"and":[38,42,50,68,80,83,146],"parenteral":[39,128],"exposure,":[41],"influences":[44],"zinc":[46],"(Zn),":[47],"selenium":[48],"(Se),":[49],"pretreatments":[52],"upon":[53],"biliary":[55,164,196],"excretion":[56,165,197],"subsequently":[58],"administered":[59,104],"Cd.":[60,97],"rates":[64,107],"ranged":[65],"between":[66,81],"1.96":[67],"2.89":[69],"mg/g":[70,85],"rat-hr":[71,86],"(22":[72],"+/-":[73,88],"3":[74,178],"ppb":[75,90],"Cd)":[76,91],"normal":[78],"2.68":[82],"4.09":[84],"(58":[87],"6":[89],"fed":[94],"100":[95],"ppm":[96],"Less":[98],"than":[99],"0.1%":[100],"subcutaneously":[105],"at":[106],"ranging":[108],"from":[109],"0.25":[110],"to":[111,181],"40":[112],"mg/kg":[113],"rat":[114,137,142,157,177,189],"could":[115],"be":[116],"accounted":[117],"collected":[121],"5-hr":[124],"period":[125],"injections.":[130],"Subcutaneous":[131],"administration":[132,152,184],"8":[134],"mg":[135,140,155,175,187],"Zn/kg":[136],"or":[138],"0.5":[139],"Cd/kg":[141,156,188],"days":[144,179],"1":[145,154,186],"6,":[147],"respectively,":[148],"before":[149],"postcannulation":[151,183],"caused":[158,190],"significant":[160,192],"reduction":[161],"Administering":[173],"2":[174],"Se/kg":[176],"prior":[180],"increase":[193],"biochemical":[206],"bases":[207],"these":[209],"observations":[210],"are":[211],"believed":[212],"associated":[213],"with":[214],"type":[216],"metal-binding":[218],"protein":[219],"induced":[220],"by":[221],"respective":[223],"pretreatments.":[224]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}