{"id":"https://openalex.org/W2000631266","doi":"https://doi.org/10.1177/0748730403018003006","title":"In Search of the Pathways for Light-Induced Pacemaker Resetting in the Suprachiasmatic Nucleus","display_name":"In Search of the Pathways for Light-Induced Pacemaker Resetting in the Suprachiasmatic Nucleus","publication_year":2003,"publication_date":"2003-06-01","ids":{"openalex":"https://openalex.org/W2000631266","doi":"https://doi.org/10.1177/0748730403018003006","mag":"2000631266","pmid":"https://pubmed.ncbi.nlm.nih.gov/12828281"},"language":"en","primary_location":{"id":"doi:10.1177/0748730403018003006","doi":"https://doi.org/10.1177/0748730403018003006","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0748730403018003006","pdf_url":null,"source":{"id":"https://openalex.org/S192515372","display_name":"Journal of Biological Rhythms","issn_l":"0748-7304","issn":["0748-7304","1552-4531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Rhythms","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066128766","display_name":"Johanna H. Meijer","orcid":"https://orcid.org/0000-0001-6619-5312","observed_orcids":["https://orcid.org/0000-0001-6619-5312","https://orcid.org/0000-0001-9416-9496"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Johanna H. Meijer","raw_affiliation_strings":["Department of Physiology, Leiden University Medical Centre, 2300 RC Leiden, the Netherlands,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Leiden University Medical Centre, 2300 RC Leiden, the Netherlands,","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049687205","display_name":"William J. Schwartz","orcid":"https://orcid.org/0000-0002-7952-9729","observed_orcids":["https://orcid.org/0000-0002-7952-9729","https://orcid.org/0009-0003-5750-2167"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J. Schwartz","raw_affiliation_strings":["Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":1.4248,"has_fulltext":false,"cited_by_count":232,"citation_normalized_percentile":{"value":0.80081301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"18","issue":"3","first_page":"235","last_page":"249"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/suprachiasmatic-nucleus","display_name":"suprachiasmatic nucleus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/circadian-pacemaker","display_name":"circadian pacemaker","score":0.9309999942779541},{"id":"https://openalex.org/keywords/photic-entrainment","display_name":"light entrainment","score":0.8510000109672546},{"id":"https://openalex.org/keywords/light-induced-phase-shift","display_name":"light-induced phase shift","score":0.8529999852180481},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.550000011920929},{"id":"https://openalex.org/keywords/intracellular-signaling","display_name":"intracellular signaling","score":0.6449999809265137},{"id":"https://openalex.org/keywords/intercellular-coupling","display_name":"intercellular coupling","score":0.949999988079071},{"id":"https://openalex.org/keywords/protein-kinases","display_name":"protein kinases","score":0.6570000052452087},{"id":"https://openalex.org/keywords/locomotor-rhythm","display_name":"locomotor rhythm","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C2779317972","wikidata":"https://www.wikidata.org/wiki/Q1156516","display_name":"Suprachiasmatic nucleus","level":3,"score":0.8780041337013245},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7158406972885132},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.6303638815879822},{"id":"https://openalex.org/C139992725","wikidata":"https://www.wikidata.org/wiki/Q5380656","display_name":"Entrainment (biomusicology)","level":3,"score":0.612403392791748},{"id":"https://openalex.org/C201176492","wikidata":"https://www.wikidata.org/wiki/Q6546168","display_name":"Light effects on circadian rhythm","level":4,"score":0.5727388858795166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5611201524734497},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.41297468543052673},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3321976363658905},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.3152839243412018},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2324329912662506},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13648852705955505}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001683","descriptor_name":"Biological Clocks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001683","descriptor_name":"Biological Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010770","descriptor_name":"Phosphotransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010770","descriptor_name":"Phosphotransferases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013493","descriptor_name":"Suprachiasmatic Nucleus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013493","descriptor_name":"Suprachiasmatic Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/0748730403018003006","doi":"https://doi.org/10.1177/0748730403018003006","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0748730403018003006","pdf_url":null,"source":{"id":"https://openalex.org/S192515372","display_name":"Journal of Biological Rhythms","issn_l":"0748-7304","issn":["0748-7304","1552-4531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Rhythms","raw_type":"journal-article"},{"id":"pmid:12828281","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12828281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological rhythms","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.914.1240","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.914.1240","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jbr.sagepub.com/content/18/3/235.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":177,"referenced_works":["https://openalex.org/W150521681","https://openalex.org/W1480583769","https://openalex.org/W1500623730","https://openalex.org/W1507909762","https://openalex.org/W1542888757","https://openalex.org/W1545480326","https://openalex.org/W1585819624","https://openalex.org/W1592749701","https://openalex.org/W1612126169","https://openalex.org/W1617798422","https://openalex.org/W1639478343","https://openalex.org/W1757207483","https://openalex.org/W1811606715","https://openalex.org/W1851766745","https://openalex.org/W1875621137","https://openalex.org/W1890508363","https://openalex.org/W1939208066","https://openalex.org/W1967340734","https://openalex.org/W1968099960","https://openalex.org/W1968161522","https://openalex.org/W1969564984","https://openalex.org/W1969741257","https://openalex.org/W1972391438","https://openalex.org/W1972437651","https://openalex.org/W1972646561","https://openalex.org/W1973103323","https://openalex.org/W1973369235","https://openalex.org/W1973728200","https://openalex.org/W1974310493","https://openalex.org/W1974726925","https://openalex.org/W1975768640","https://openalex.org/W1976197518","https://openalex.org/W1976397992","https://openalex.org/W1983583864","https://openalex.org/W1985170961","https://openalex.org/W1985280777","https://openalex.org/W1985474802","https://openalex.org/W1986479043","https://openalex.org/W1989018625","https://openalex.org/W1989378081","https://openalex.org/W1992182952","https://openalex.org/W1994008582","https://openalex.org/W1994922657","https://openalex.org/W1995230392","https://openalex.org/W1995233931","https://openalex.org/W1996569207","https://openalex.org/W1998448534","https://openalex.org/W1998515411","https://openalex.org/W2000054680","https://openalex.org/W2001829032","https://openalex.org/W2003751741","https://openalex.org/W2005882944","https://openalex.org/W2006824515","https://openalex.org/W2007157318","https://openalex.org/W2009633372","https://openalex.org/W2009850542","https://openalex.org/W2016021688","https://openalex.org/W2016027614","https://openalex.org/W2016772352","https://openalex.org/W2018885521","https://openalex.org/W2018905527","https://openalex.org/W2019322821","https://openalex.org/W2020340826","https://openalex.org/W2020364712","https://openalex.org/W2021229976","https://openalex.org/W2021654192","https://openalex.org/W2021731355","https://openalex.org/W2021985672","https://openalex.org/W2022107364","https://openalex.org/W2022123095","https://openalex.org/W2023383300","https://openalex.org/W2026318784","https://openalex.org/W2026884445","https://openalex.org/W2028606580","https://openalex.org/W2029227663","https://openalex.org/W2029351879","https://openalex.org/W2030205108","https://openalex.org/W2032656475","https://openalex.org/W2034998738","https://openalex.org/W2037010800","https://openalex.org/W2038065879","https://openalex.org/W2039991385","https://openalex.org/W2040964766","https://openalex.org/W2042542668","https://openalex.org/W2043403200","https://openalex.org/W2047175423","https://openalex.org/W2047678578","https://openalex.org/W2048466060","https://openalex.org/W2049677726","https://openalex.org/W2054433088","https://openalex.org/W2057456046","https://openalex.org/W2057522076","https://openalex.org/W2057625080","https://openalex.org/W2058594012","https://openalex.org/W2058861807","https://openalex.org/W2060006972","https://openalex.org/W2060242667","https://openalex.org/W2061630834","https://openalex.org/W2062228310","https://openalex.org/W2062798573","https://openalex.org/W2062999298","https://openalex.org/W2063313379","https://openalex.org/W2063976426","https://openalex.org/W2065437645","https://openalex.org/W2065565019","https://openalex.org/W2066528902","https://openalex.org/W2068283481","https://openalex.org/W2068412840","https://openalex.org/W2071997711","https://openalex.org/W2072361295","https://openalex.org/W2074251693","https://openalex.org/W2075459548","https://openalex.org/W2075930909","https://openalex.org/W2076875536","https://openalex.org/W2077748814","https://openalex.org/W2079249488","https://openalex.org/W2080467139","https://openalex.org/W2080591707","https://openalex.org/W2082351155","https://openalex.org/W2084059630","https://openalex.org/W2085904808","https://openalex.org/W2086679987","https://openalex.org/W2090816060","https://openalex.org/W2091044869","https://openalex.org/W2092147371","https://openalex.org/W2092961177","https://openalex.org/W2093148563","https://openalex.org/W2093986158","https://openalex.org/W2095535075","https://openalex.org/W2096819583","https://openalex.org/W2096882849","https://openalex.org/W2097162146","https://openalex.org/W2100696979","https://openalex.org/W2102048968","https://openalex.org/W2103758039","https://openalex.org/W2107083462","https://openalex.org/W2107246324","https://openalex.org/W2108914538","https://openalex.org/W2111700367","https://openalex.org/W2115785913","https://openalex.org/W2117091732","https://openalex.org/W2118397674","https://openalex.org/W2118646967","https://openalex.org/W2120187370","https://openalex.org/W2123702853","https://openalex.org/W2127447141","https://openalex.org/W2130179391","https://openalex.org/W2130807836","https://openalex.org/W2131110243","https://openalex.org/W2131462335","https://openalex.org/W2136983368","https://openalex.org/W2137947730","https://openalex.org/W2146576859","https://openalex.org/W2148316290","https://openalex.org/W2149814646","https://openalex.org/W2151468131","https://openalex.org/W2151984162","https://openalex.org/W2153042537","https://openalex.org/W2157617217","https://openalex.org/W2159094371","https://openalex.org/W2159503014","https://openalex.org/W2166020726","https://openalex.org/W2167026771","https://openalex.org/W2168431489","https://openalex.org/W2170283405","https://openalex.org/W2170783613","https://openalex.org/W2173055176","https://openalex.org/W2181566532","https://openalex.org/W2220187261","https://openalex.org/W2242548875","https://openalex.org/W2416348645","https://openalex.org/W3112761749","https://openalex.org/W3217417991","https://openalex.org/W4245011475","https://openalex.org/W4246795590","https://openalex.org/W4253635097","https://openalex.org/W4298289227"],"related_works":["https://openalex.org/W7100552384","https://openalex.org/W137282001","https://openalex.org/W2093010728","https://openalex.org/W2418852840","https://openalex.org/W153497009","https://openalex.org/W1639672833","https://openalex.org/W26637213","https://openalex.org/W38120270","https://openalex.org/W7221126315","https://openalex.org/W2285865041"],"abstract_inverted_index":{"Within":[0],"the":[1,6,24,36,56,69,74,82,89],"suprachiasmatic":[2],"nucleus":[3],"(SCN)":[4],"of":[5,44,101],"mammalian":[7],"hypothalamus":[8],"is":[9,21],"a":[10,16,41],"circadian":[11,106],"pacemaker":[12,149],"that":[13,34,54,72,93],"functions":[14],"as":[15,86,88,109],"clock.":[17],"Its":[18],"endogenous":[19],"period":[20],"adjusted":[22],"to":[23,97,124],"external":[25],"24-h":[26],"light-dark":[27],"cycle,":[28],"primarily":[29],"by":[30],"light-induced":[31],"phase":[32,99,146],"shifts":[33,100,147],"reset":[35,73],"pacemaker's":[37],"oscillation.":[38],"Evidence":[39],"using":[40],"wide":[42],"variety":[43],"neurobiological":[45],"and":[46,104,111,120,127,136,144],"molecular":[47,76],"genetic":[48],"tools":[49],"has":[50],"elucidated":[51],"key":[52],"elements":[53],"comprise":[55],"visual":[57],"input":[58],"pathway":[59],"for":[60,148],"SCN":[61,95,112],"photoentrainment":[62],"in":[63,81],"rodents.":[64],"Important":[65],"questions":[66],"remain":[67],"regarding":[68],"intracellular":[70],"signals":[71],"autoregulatory":[75],"loop":[77],"within":[78],"photoresponsive":[79],"cells":[80],"SCN's":[83],"retino-recipient":[84],"subdivision,":[85],"well":[87],"intercellular":[90],"coupling":[91],"mechanisms":[92],"enable":[94],"tissue":[96],"generate":[98],"overt":[102],"behavioral":[103],"physiological":[105],"rhythms":[107],"such":[108],"locomotion":[110],"neuronal":[113],"firing":[114],"rate.":[115],"Multiple":[116],"neurotransmitters,":[117],"protein":[118],"kinases,":[119],"photoinducible":[121],"genes":[122],"add":[123],"system":[125],"complexity,":[126],"we":[128],"still":[129],"do":[130],"not":[131],"fully":[132],"understand":[133],"how":[134],"dawn":[135],"dusk":[137],"light":[138],"pulses":[139],"ultimately":[140],"produce":[141],"bidirectional,":[142],"advancing":[143],"delaying":[145],"entrainment.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}