{"id":"https://openalex.org/W2000631265","doi":"https://doi.org/10.1002/jhet.5570260639","title":"3\u2010Aryl\u20105\u2010[(aryloxy)methyl]\u20103\u2010[(1H\u20101,2,4\u2010triazol\u20101\u2010yl)methyl]\u20102\u2010methylisoxazolidine derivatives. Synthesis and antifungal activity","display_name":"3\u2010Aryl\u20105\u2010[(aryloxy)methyl]\u20103\u2010[(1H\u20101,2,4\u2010triazol\u20101\u2010yl)methyl]\u20102\u2010methylisoxazolidine derivatives. Synthesis and antifungal activity","publication_year":1989,"publication_date":"1989-11-01","ids":{"openalex":"https://openalex.org/W2000631265","doi":"https://doi.org/10.1002/jhet.5570260639","mag":"2000631265"},"language":"en","primary_location":{"id":"doi:10.1002/jhet.5570260639","doi":"https://doi.org/10.1002/jhet.5570260639","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jhet.5570260639","pdf_url":null,"source":{"id":"https://openalex.org/S46134040","display_name":"Journal of Heterocyclic Chemistry","issn_l":"0022-152X","issn":["0022-152X","1943-5193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Heterocyclic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111755969","display_name":"GRACE A. BENNETT","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Grace A. Bennett","raw_affiliation_strings":["Department of Chemistry, Divisional Research and Development, Fisons Pharmaceuticals, Rochester, New York 14623"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Divisional Research and Development, Fisons Pharmaceuticals, Rochester, New York 14623","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028840225","display_name":"PATRICIA A. SWIFT","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia A. Swift","raw_affiliation_strings":["Department of Chemistry, Divisional Research and Development, Fisons Pharmaceuticals, Rochester, New York 14623"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Divisional Research and Development, Fisons Pharmaceuticals, Rochester, New York 14623","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108797008","display_name":"GEORGE B. MULLEN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George B. Mullen","raw_affiliation_strings":["Department of Chemistry, Divisional Research and Development, Fisons Pharmaceuticals, Rochester, New York 14623"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Divisional Research and Development, Fisons Pharmaceuticals, Rochester, New York 14623","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013120011","display_name":"Stanley D. Allen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stanley D. Allen","raw_affiliation_strings":["Department of Chemistry, Divisional Research and Development, Fisons Pharmaceuticals, Rochester, New York 14623"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Divisional Research and Development, Fisons Pharmaceuticals, Rochester, New York 14623","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jeffrey T. Mitchell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey T. Mitchell","raw_affiliation_strings":["Department of Chemistry, Divisional Research and Development, Fisons Pharmaceuticals, Rochester, New York 14623"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Divisional Research and Development, Fisons Pharmaceuticals, Rochester, New York 14623","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109993341","display_name":"Wendy E. Jones","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wendy E. Jones","raw_affiliation_strings":["Department of Chemistry, Divisional Research and Development, Fisons Pharmaceuticals, Rochester, New York 14623"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Divisional Research and Development, Fisons Pharmaceuticals, Rochester, New York 14623","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110010272","display_name":"Vassil St. Georgiev","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vassil St. Georgiev","raw_affiliation_strings":["Department of Chemistry, Divisional Research and Development, Fisons Pharmaceuticals, Rochester, New York 14623"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Divisional Research and Development, Fisons Pharmaceuticals, Rochester, New York 14623","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110010272"],"corresponding_institution_ids":[],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.4896,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.57453896,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"6","first_page":"1729","last_page":"1734"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.3991999924182892,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.3991999924182892,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.2485000044107437,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12410","display_name":"Structural and Chemical Analysis of Organic and Inorganic Compounds","score":0.2070000022649765,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-2-4-triazole-derivatives","display_name":"1,2,4-triazole derivatives","score":0.9079999923706055},{"id":"https://openalex.org/keywords/antifungal-agents","display_name":"antifungal agents","score":0.8830000162124634},{"id":"https://openalex.org/keywords/dermatophytes","display_name":"dermatophytes","score":0.9620000123977661},{"id":"https://openalex.org/keywords/yeast-fungi","display_name":"yeast fungi","score":0.7360000014305115},{"id":"https://openalex.org/keywords/systemic-candidiasis","display_name":"systemic candidiasis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7720000147819519},{"id":"https://openalex.org/keywords/ketoconazole-comparison","display_name":"ketoconazole comparison","score":0.8199999928474426},{"id":"https://openalex.org/keywords/in-vitro-antifungal-activity","display_name":"in vitro antifungal activity","score":0.777999997138977},{"id":"https://openalex.org/keywords/in-vivo-antifungal-activity","display_name":"in vivo antifungal activity","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9133144617080688},{"id":"https://openalex.org/C2781064554","wikidata":"https://www.wikidata.org/wiki/Q407883","display_name":"Ketoconazole","level":3,"score":0.8679096698760986},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.742479681968689},{"id":"https://openalex.org/C2781076698","wikidata":"https://www.wikidata.org/wiki/Q718074","display_name":"Aryl","level":3,"score":0.6850498914718628},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.6735154986381531},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.5771846771240234},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5733641982078552},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.538136899471283},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.5067525506019592},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.5005087852478027},{"id":"https://openalex.org/C111771559","wikidata":"https://www.wikidata.org/wiki/Q66295","display_name":"Derivative (finance)","level":2,"score":0.42201143503189087},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1802496314048767},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17174237966537476},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.12486106157302856},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.056903451681137085},{"id":"https://openalex.org/C106159729","wikidata":"https://www.wikidata.org/wiki/Q2294553","display_name":"Financial economics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/jhet.5570260639","doi":"https://doi.org/10.1002/jhet.5570260639","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jhet.5570260639","pdf_url":null,"source":{"id":"https://openalex.org/S46134040","display_name":"Journal of Heterocyclic Chemistry","issn_l":"0022-152X","issn":["0022-152X","1943-5193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Heterocyclic Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1995471077","https://openalex.org/W2001703643","https://openalex.org/W2008950143","https://openalex.org/W2033912788","https://openalex.org/W2088030225"],"related_works":["https://openalex.org/W2008950143","https://openalex.org/W2001703643","https://openalex.org/W2950026613","https://openalex.org/W2952136431","https://openalex.org/W2048826956","https://openalex.org/W1995471077","https://openalex.org/W2085271870","https://openalex.org/W269247334","https://openalex.org/W2437790924","https://openalex.org/W2129051771"],"abstract_inverted_index":{"Abstract":[0],"The":[1,14,46],"synthesis":[2],"and":[3,29,58],"antifungal":[4],"activity":[5,17,35,47],"of":[6,10,27,43,48,56],"a":[7,25,69],"novel":[8],"series":[9,51],"3\u2010aryl\u20105\u2010[(aryloxy)methyl]\u20103\u2010[(1H\u20101,2,4\u2010triazol\u20101\u2010yl)\u2010methyl]\u20102\u2010methylisoxazolidines":[11],"are":[12,80],"described.":[13],"in":[15,20,33,38,72,74],"vitro":[16],"was":[18,36,52,65],"evaluated":[19],"solid":[21],"agar":[22],"cultures":[23],"against":[24],"variety":[26],"dermatophytes":[28],"yeast":[30],"fungi,":[31],"while":[32],"vivo":[34,75],"measured":[37],"an":[39],"immune\u2010compromised":[40],"mouse":[41],"model":[42],"systemic":[44],"candidiasis.":[45],"the":[49,61,73],"title":[50],"compared":[53],"to":[54,67],"that":[55],"ketoconazole":[57],"one":[59],"derivative,":[60],"cis\u20103\u2010(4\u2010chlorophenyl)\u20105\u2010(4\u2010chlorophenyloxy)methyl":[62],"analogue":[63],"5f":[64],"found":[66],"possess":[68],"similar":[70],"potency":[71],"assay.":[76],"Structure\u2010activity":[77],"relationship":[78],"correlations":[79],"also":[81],"discussed.":[82]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
