{"id":"https://openalex.org/W2000630426","doi":"https://doi.org/10.1089/hum.1998.9.12-1769","title":"\u03b2 -Galactosidase Gene Transfer to Human Malignant Glioma In Vivo Using Replication-Deficient Retroviruses and Adenoviruses","display_name":"\u03b2 -Galactosidase Gene Transfer to Human Malignant Glioma In Vivo Using Replication-Deficient Retroviruses and Adenoviruses","publication_year":1998,"publication_date":"1998-08-10","ids":{"openalex":"https://openalex.org/W2000630426","doi":"https://doi.org/10.1089/hum.1998.9.12-1769","mag":"2000630426","pmid":"https://pubmed.ncbi.nlm.nih.gov/9721087"},"language":"en","primary_location":{"id":"doi:10.1089/hum.1998.9.12-1769","doi":"https://doi.org/10.1089/hum.1998.9.12-1769","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.1998.9.12-1769","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032701890","display_name":"Anu-Maaria Puumalainen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Anu-Maaria Puumalainen","raw_affiliation_strings":["A.I. Virtanen Institute, Department of Neurosurgery, University of Kuopio, Kuopio University Hospital, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.I. Virtanen Institute, Department of Neurosurgery, University of Kuopio, Kuopio University Hospital, Finland","institution_ids":["https://openalex.org/I175532246","https://openalex.org/I4210092991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113684425","display_name":"Matti P. Vapalahti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matti Vapalahti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087928722","display_name":"Reitu S. Agrawal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reitu S. Agrawal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062130968","display_name":"Maija Kossila","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maija Kossila","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108666905","display_name":"Johanna M Laukkanen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johanna Laukkanen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108472405","display_name":"Pauliina Lehtolainen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pauliina Lehtolainen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014661853","display_name":"Helena Viita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helena Viita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028187108","display_name":"Leo Palj\u00e4rvi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leo Palj\u00e4rvi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103462587","display_name":"Ritva Vanninen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ritva Vanninen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5014220812","display_name":"Seppo Yl\u00e4\u2010Herttuala","orcid":"https://orcid.org/0000-0001-7593-2708","observed_orcids":["https://orcid.org/0000-0001-7593-2708"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Seppo Yl\u00e4-Herttuala","raw_affiliation_strings":["Address reprint requests to: Dr. Seppo Yl\u00e4-Herttuala, A.I. Virtanen Institute, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address reprint requests to: Dr. Seppo Yl\u00e4-Herttuala, A.I. Virtanen Institute, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014220812"],"corresponding_institution_ids":["https://openalex.org/I175532246"],"apc_list":null,"apc_paid":null,"fwci":4.5392,"has_fulltext":false,"cited_by_count":197,"citation_normalized_percentile":{"value":0.95460441,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"12","first_page":"1769","last_page":"1774"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.9330000281333923},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.7009999752044678},{"id":"https://openalex.org/keywords/beta-galactosidase","display_name":"beta-galactosidase","score":0.925000011920929},{"id":"https://openalex.org/keywords/retroviral-vectors","display_name":"retroviral vectors","score":0.7329999804496765},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.9909999966621399},{"id":"https://openalex.org/keywords/in-vivo-gene-transfer","display_name":"in vivo gene delivery","score":0.7459999918937683},{"id":"https://openalex.org/keywords/gene-transfer-efficiency","display_name":"gene transfer efficiency","score":0.7839999794960022},{"id":"https://openalex.org/keywords/vector-safety","display_name":"vector safety","score":0.6050000190734863},{"id":"https://openalex.org/keywords/x-gal-staining","display_name":"X-gal staining","score":0.5519999861717224},{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.8098737597465515},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.7100119590759277},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5455621480941772},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.532526969909668},{"id":"https://openalex.org/C2778431562","wikidata":"https://www.wikidata.org/wiki/Q189308","display_name":"Retrovirus","level":3,"score":0.5273845195770264},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.506658136844635},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4728829264640808},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.46941858530044556},{"id":"https://openalex.org/C2776954459","wikidata":"https://www.wikidata.org/wiki/Q193447","display_name":"Adenoviridae","level":4,"score":0.46631062030792236},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4561215937137604},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.44642823934555054},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.44386547803878784},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3507377505302429},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.320068895816803},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.28709083795547485},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20160987973213196},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.10293889045715332},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/hum.1998.9.12-1769","doi":"https://doi.org/10.1089/hum.1998.9.12-1769","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.1998.9.12-1769","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},{"id":"pmid:9721087","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9721087","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human gene therapy","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309652","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291"},{"id":"https://openalex.org/F4320322356","display_name":"Kuopion Yliopistollinen Sairaala","ror":"https://ror.org/00fqdfs68"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1968683066","https://openalex.org/W1973504318","https://openalex.org/W1991780275","https://openalex.org/W1995975136","https://openalex.org/W2005010475","https://openalex.org/W2011486273","https://openalex.org/W2016138321","https://openalex.org/W2022168012","https://openalex.org/W2022439153","https://openalex.org/W2029969090","https://openalex.org/W2048303863","https://openalex.org/W2055825871","https://openalex.org/W2062901218","https://openalex.org/W2063975188","https://openalex.org/W2066993893","https://openalex.org/W2080179979","https://openalex.org/W2091987058","https://openalex.org/W2121421904","https://openalex.org/W2319534054","https://openalex.org/W2367235064","https://openalex.org/W2403719174","https://openalex.org/W2414495570"],"related_works":["https://openalex.org/W2091622538","https://openalex.org/W2072394129","https://openalex.org/W2225805177","https://openalex.org/W2012315955","https://openalex.org/W2250109435","https://openalex.org/W2029969090","https://openalex.org/W1964863866","https://openalex.org/W1990699098","https://openalex.org/W2019267938","https://openalex.org/W1995192046"],"abstract_inverted_index":{"Both":[0,243],"retro-":[1,256,278],"and":[2,40,44,95,167,221,225,228,246,257,264,279,307],"adenovirus-mediated":[3,45],"gene":[4,27,47,54,82,85,164,174,269,292,316],"therapy":[5,317],"have":[6,299],"been":[7],"suggested":[8],"as":[9],"a":[10,64,116,134],"novel":[11],"approach":[12],"to":[13,57,102,162,271],"the":[14,26,38,68,77,110,113,137,144,152,170,206,233,241,249,262,303],"treatment":[15,305,310],"of":[16,42,151,169,205,266,295,309],"malignant":[17,32,51,61,273,320],"brain":[18],"tumors.":[19,154,242],"However,":[20,232],"little":[21],"information":[22],"is":[23],"available":[24],"about":[25],"transfer":[28,48,83,86,165,175,209,216,270],"efficiency":[29,166,217],"in":[30,34,49,74,132,141,189,203,212,240,248,267,288,290],"human":[31,50,272],"glioma":[33,62,244,274],"vivo.":[35],"We":[36],"compared":[37],"feasibility":[39,265],"safety":[41,263],"retrovirus-":[43],"beta-galactosidase":[46,158],"glioma.":[52,321],"Beta-galactosidase":[53,173],"was":[55,72,130,139,160,176,210,236,275],"transferred":[56],"10":[58],"patients":[59,185],"with":[60,179,186,223,230,255,277],"via":[63,112],"catheter":[65,71,114,138],"inserted":[66],"into":[67,109],"tumor.":[69],"The":[70,312],"left":[73],"place":[75,142],"until":[76],"tumor":[78,111,124,250],"resection.":[79],"To":[80],"maximize":[81],"efficiency,":[84],"vectors":[87],"(BAG":[88],"retroviruses,":[89],"titer,":[90],"6":[91],"x":[92,100,104],"10(5)":[93],"CFU;":[94],"adenoviruses,":[96],"titer":[97],"from":[98],"3":[99,103],"10(8)":[101],"10(10)":[105],"PFU)":[106],"were":[107,201,253,283],"injected":[108],"once":[115],"day":[117],"for":[118,157,183,302,319],"three":[119],"consecutive":[120],"days,":[121],"followed":[122],"by":[123],"resection":[125],"1-2":[126],"days":[127],"later.":[128],"Tumor":[129],"resected":[131],"such":[133],"way":[135],"that":[136],"still":[140],"inside":[143],"tumor,":[145],"which":[146],"permitted":[147],"accurate":[148],"histological":[149],"analysis":[150],"transduced":[153,254],"X-Gal":[155],"staining":[156],"activity":[159,235],"used":[161],"study":[163],"distribution":[168],"marker":[171],"gene.":[172],"well":[177],"tolerated":[178],"both":[180],"vectors.":[181,259,281],"Except":[182],"two":[184],"clear":[187],"increases":[188],"serum":[190],"adenovirus":[191,258,280],"antibody":[192],"titers,":[193],"no":[194],"adverse":[195],"tissue":[196],"responses":[197],"or":[198],"systemic":[199],"complications":[200],"noticed":[202],"any":[204],"patients.":[207,214],"Gene":[208,215],"successful":[211],"all":[213],"varied":[218],"between":[219,226],"<0.01":[220,227],"4%":[222],"retroviruses":[224,287],"11%":[229],"adenoviruses.":[231],"transgene":[234],"not":[237],"evenly":[238],"distributed":[239],"cells":[245,297],"endothelium":[247],"blood":[251],"vessels":[252],"In":[260],"conclusion,":[261],"vivo":[268,291],"established":[276],"Adenoviruses":[282],"more":[284],"efficient":[285],"than":[286],"achieving":[289],"transfer.":[293],"Transduction":[294],"endothelial":[296],"may":[298],"important":[300],"consequences":[301],"proposed":[304],"strategies":[306],"selection":[308],"genes.":[311],"results":[313],"justify":[314],"clinical":[315],"trials":[318]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}