{"id":"https://openalex.org/W2000626804","doi":"https://doi.org/10.1016/s0301-472x(00)00514-2","title":"Quantitation of minimal residual disease in multiple myeloma using an allele-specific real-time PCR assay","display_name":"Quantitation of minimal residual disease in multiple myeloma using an allele-specific real-time PCR assay","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W2000626804","doi":"https://doi.org/10.1016/s0301-472x(00)00514-2","mag":"2000626804","pmid":"https://pubmed.ncbi.nlm.nih.gov/11008016"},"language":"en","primary_location":{"id":"doi:10.1016/s0301-472x(00)00514-2","doi":"https://doi.org/10.1016/s0301-472x(00)00514-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0301-472x(00)00514-2","pdf_url":"http://www.exphem.org/article/S0301472X00005142/pdf","source":{"id":"https://openalex.org/S72188638","display_name":"Experimental Hematology","issn_l":"0301-472X","issn":["0301-472X","1873-2399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Hematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.exphem.org/article/S0301472X00005142/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114007728","display_name":"Thomas Rasmussen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Thomas Rasmussen","raw_affiliation_strings":["Department of Hematology L, Herlev Hospital, University of Copenhagen, Herlev, Denmark. thra@herlevhosp.kbhamt.dk","Department of Hematology L, Herlev Hospital, University of Copenhagen, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology L, Herlev Hospital, University of Copenhagen, Herlev, Denmark. thra@herlevhosp.kbhamt.dk","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801827564"]},{"raw_affiliation_string":"Department of Hematology L, Herlev Hospital, University of Copenhagen, Herlev, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801827564"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087286512","display_name":"Tim Svenstrup Poulsen","orcid":"https://orcid.org/0000-0001-9781-0541","observed_orcids":["https://orcid.org/0000-0001-9781-0541"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Tim Svenstrup Poulsen","raw_affiliation_strings":["Department of Hematology L, Herlev Hospital, University of Copenhagen, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology L, Herlev Hospital, University of Copenhagen, Herlev, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801827564"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085330932","display_name":"Lone Honor\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lone Honor\u00e9","raw_affiliation_strings":["Department of Hematology L, Herlev Hospital, University of Copenhagen, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology L, Herlev Hospital, University of Copenhagen, Herlev, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801827564"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066949744","display_name":"Hans Erik Johnsen","orcid":"https://orcid.org/0000-0001-8253-2913","observed_orcids":["https://orcid.org/0000-0001-8253-2913"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Hans Erik Johnsen","raw_affiliation_strings":["Department of Hematology L, Herlev Hospital, University of Copenhagen, Herlev, Denmark","Department of Hematology L 54P4, Herlev Hospital, University of Copenhagen, Herlev, Denmark. thra@herlevhosp.kbhamt.dk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology L, Herlev Hospital, University of Copenhagen, Herlev, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801827564"]},{"raw_affiliation_string":"Department of Hematology L 54P4, Herlev Hospital, University of Copenhagen, Herlev, Denmark. thra@herlevhosp.kbhamt.dk","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801827564"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5114007728"],"corresponding_institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801827564"],"apc_list":{"value":3250,"currency":"USD","value_usd":3250},"apc_paid":null,"fwci":4.417,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.9502465,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"28","issue":"9","first_page":"1039","last_page":"1045"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9089999794960022},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.968999981880188},{"id":"https://openalex.org/keywords/allele-specific-oligonucleotides","display_name":"allele-specific oligonucleotides","score":0.718999981880188},{"id":"https://openalex.org/keywords/real-time-quantitative-pcr","display_name":"real-time quantitative PCR","score":0.7089999914169312},{"id":"https://openalex.org/keywords/taqman-probes","display_name":"TaqMan probes","score":0.8970000147819519},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.8309999704360962},{"id":"https://openalex.org/keywords/peripheral-blood-stem-cell-transplantation","display_name":"peripheral blood stem cell transplantation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.8857845067977905},{"id":"https://openalex.org/C143660080","wikidata":"https://www.wikidata.org/wiki/Q7684883","display_name":"TaqMan","level":4,"score":0.8533997535705566},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.6612107753753662},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6259210109710693},{"id":"https://openalex.org/C2909638373","wikidata":"https://www.wikidata.org/wiki/Q1706485","display_name":"Plasma cell neoplasm","level":4,"score":0.5878992080688477},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.5830809473991394},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5304540991783142},{"id":"https://openalex.org/C2777563447","wikidata":"https://www.wikidata.org/wiki/Q7243397","display_name":"Primer (cosmetics)","level":2,"score":0.48047345876693726},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.4471662938594818},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.42202118039131165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36193278431892395},{"id":"https://openalex.org/C2778964538","wikidata":"https://www.wikidata.org/wiki/Q2090167","display_name":"Plasmacytoma","level":3,"score":0.3074447512626648},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30183732509613037},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23624512553215027},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1816311776638031},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17291924357414246},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.059162676334381104},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011933","descriptor_name":"Reagent Kits, Diagnostic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018365","descriptor_name":"Neoplasm, Residual","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018365","descriptor_name":"Neoplasm, Residual","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018365","descriptor_name":"Neoplasm, Residual","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0301-472x(00)00514-2","doi":"https://doi.org/10.1016/s0301-472x(00)00514-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0301-472x(00)00514-2","pdf_url":"http://www.exphem.org/article/S0301472X00005142/pdf","source":{"id":"https://openalex.org/S72188638","display_name":"Experimental Hematology","issn_l":"0301-472X","issn":["0301-472X","1873-2399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Hematology","raw_type":"journal-article"},{"id":"pmid:11008016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11008016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1016/s0301-472x(00)00514-2","doi":"https://doi.org/10.1016/s0301-472x(00)00514-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0301-472x(00)00514-2","pdf_url":"http://www.exphem.org/article/S0301472X00005142/pdf","source":{"id":"https://openalex.org/S72188638","display_name":"Experimental Hematology","issn_l":"0301-472X","issn":["0301-472X","1873-2399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310455","display_name":"Kr\u00e6ftens Bek\u00e6mpelse","ror":"https://ror.org/03ytt7k16"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000626804.pdf","grobid_xml":"https://content.openalex.org/works/W2000626804.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W38065407","https://openalex.org/W47299474","https://openalex.org/W1497974883","https://openalex.org/W1499460075","https://openalex.org/W1561328814","https://openalex.org/W1576668137","https://openalex.org/W1591369027","https://openalex.org/W1965069159","https://openalex.org/W1976963122","https://openalex.org/W1979942491","https://openalex.org/W2001101301","https://openalex.org/W2032322877","https://openalex.org/W2045011755","https://openalex.org/W2088397058","https://openalex.org/W2128133990","https://openalex.org/W2145684092","https://openalex.org/W2159325547","https://openalex.org/W2164578725","https://openalex.org/W2262776735","https://openalex.org/W2295603781","https://openalex.org/W2301504565","https://openalex.org/W2334542393","https://openalex.org/W2461838534"],"related_works":["https://openalex.org/W1499460075","https://openalex.org/W2019612632","https://openalex.org/W7095772515","https://openalex.org/W2403257166","https://openalex.org/W2132155854","https://openalex.org/W2012271436","https://openalex.org/W2963362868","https://openalex.org/W2530305952","https://openalex.org/W1990835696","https://openalex.org/W2003172563"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}