{"id":"https://openalex.org/W2000623630","doi":"https://doi.org/10.1038/psp.2013.46","title":"Opinion: The Pharmacometrics of Infectious Disease","display_name":"Opinion: The Pharmacometrics of Infectious Disease","publication_year":2013,"publication_date":"2013-08-01","ids":{"openalex":"https://openalex.org/W2000623630","doi":"https://doi.org/10.1038/psp.2013.46","mag":"2000623630","pmid":"https://pubmed.ncbi.nlm.nih.gov/23985968","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3828010"},"language":"en","primary_location":{"id":"doi:10.1038/psp.2013.46","doi":"https://doi.org/10.1038/psp.2013.46","is_oa":true,"landing_page_url":"https://doi.org/10.1038/psp.2013.46","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/psp.2013.46","source":{"id":"https://openalex.org/S4210231731","display_name":"CPT Pharmacometrics & Systems Pharmacology","issn_l":"2163-8306","issn":["2163-8306"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CPT: Pharmacometrics & Systems Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/psp.2013.46","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085271816","display_name":"Geraint Davies","orcid":"https://orcid.org/0000-0002-3819-490X","observed_orcids":["https://orcid.org/0000-0002-3819-490X"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"GR Davies","raw_affiliation_strings":["Department of Clinical Infection, Microbiology and Immunology, Institutes of Infection and Global Health and Translational Medicine, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Infection, Microbiology and Immunology, Institutes of Infection and Global Health and Translational Medicine, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057302419","display_name":"William W. Hope","orcid":"https://orcid.org/0000-0001-6187-878X","observed_orcids":["https://orcid.org/0000-0001-6187-878X"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"W Hope","raw_affiliation_strings":["Department of Molecular and Clinical Pharmacology; Institute of Translational Medicine; University of Liverpool; Liverpool UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Clinical Pharmacology; Institute of Translational Medicine; University of Liverpool; Liverpool UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110185300","display_name":"SH Khoo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S Khoo","raw_affiliation_strings":["Department of Molecular and Clinical Pharmacology; Institute of Translational Medicine; University of Liverpool; Liverpool UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Clinical Pharmacology; Institute of Translational Medicine; University of Liverpool; Liverpool UK","institution_ids":["https://openalex.org/I146655781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085271816"],"corresponding_institution_ids":["https://openalex.org/I146655781"],"apc_list":{"value":4140,"currency":"USD","value_usd":4140},"apc_paid":{"value":4140,"currency":"USD","value_usd":4140},"fwci":0.7342,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.70258402,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2","issue":"8","first_page":"1","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.5741999745368958,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.5741999745368958,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.30570000410079956,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.06319999694824219,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacometrics","display_name":"pharmacometrics","score":0.9670000076293945},{"id":"https://openalex.org/keywords/infectious-diseases","display_name":"infectious diseases","score":0.8899999856948853},{"id":"https://openalex.org/keywords/infection-treatment","display_name":"infection treatment","score":0.7059999704360962},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.5929999947547913},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.7720000147819519},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.8259999752044678},{"id":"https://openalex.org/keywords/mechanistic-modeling","display_name":"mechanistic modeling","score":0.7210000157356262},{"id":"https://openalex.org/keywords/preclinical-pharmacology","display_name":"preclinical pharmacology","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.534058690071106},{"id":"https://openalex.org/C63433958","wikidata":"https://www.wikidata.org/wiki/Q1774688","display_name":"Clinical pharmacology","level":2,"score":0.5101966857910156},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4551844298839569},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.4475227892398834},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.4405668079853058},{"id":"https://openalex.org/C3020580240","wikidata":"https://www.wikidata.org/wiki/Q663272","display_name":"Expert opinion","level":2,"score":0.4344315528869629},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4041840434074402},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.32829785346984863},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3227085769176483},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3113481402397156},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2791348397731781},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2517715096473694},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.24260863661766052},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19159695506095886},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/psp.2013.46","doi":"https://doi.org/10.1038/psp.2013.46","is_oa":true,"landing_page_url":"https://doi.org/10.1038/psp.2013.46","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/psp.2013.46","source":{"id":"https://openalex.org/S4210231731","display_name":"CPT Pharmacometrics & Systems Pharmacology","issn_l":"2163-8306","issn":["2163-8306"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CPT: Pharmacometrics & Systems Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2815529","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3828010","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3828010","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3828010","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CPT Pharmacometrics Syst Pharmacol","raw_type":"Text"},{"id":"pmid:23985968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23985968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CPT: pharmacometrics & systems pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/psp.2013.46","doi":"https://doi.org/10.1038/psp.2013.46","is_oa":true,"landing_page_url":"https://doi.org/10.1038/psp.2013.46","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/psp.2013.46","source":{"id":"https://openalex.org/S4210231731","display_name":"CPT Pharmacometrics & Systems Pharmacology","issn_l":"2163-8306","issn":["2163-8306"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CPT: Pharmacometrics & Systems Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6499999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1435053517","display_name":"Goal-oriented and model-based pharmokinetic dosing of voriconazole in immunocompromised patients","funder_award_id":"CS/08/08/10","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000623630.pdf","grobid_xml":"https://content.openalex.org/works/W2000623630.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1978430573","https://openalex.org/W2076183255","https://openalex.org/W2083842366","https://openalex.org/W2093162201","https://openalex.org/W2099365065","https://openalex.org/W2099481682","https://openalex.org/W2122967261","https://openalex.org/W2132748184","https://openalex.org/W2142344105","https://openalex.org/W2150702714","https://openalex.org/W2150863693","https://openalex.org/W2162465279"],"related_works":["https://openalex.org/W2021287690","https://openalex.org/W2603042022","https://openalex.org/W3216781814","https://openalex.org/W2462100214","https://openalex.org/W2900960174","https://openalex.org/W1846418067","https://openalex.org/W7165728226","https://openalex.org/W7095525465","https://openalex.org/W4391490963","https://openalex.org/W2356064013"],"abstract_inverted_index":{"The":[0,46],"application":[1],"of":[2,8,19,24,49],"pharmacometric":[3,25],"principles":[4],"to":[5],"the":[6,17],"treatment":[7],"infectious":[9],"diseases":[10],"must":[11],"address":[12],"important":[13,33],"biological":[14],"issues":[15],"across":[16],"diversity":[18],"pathogenic":[20],"organisms.":[21],"Recent":[22],"applications":[23],"tools":[26],"in":[27,38],"this":[28],"therapeutic":[29],"area":[30],"have":[31],"had":[32],"translational":[34],"impact":[35],"not":[36],"only":[37],"drug":[39],"development":[40],"but":[41],"on":[42],"real-world":[43],"clinical":[44],"practice.":[45],"fruitful":[47],"fusion":[48],"preclinical":[50],"and":[51,57],"population":[52],"methodologies":[53],"promises":[54],"increasingly":[55],"personalized":[56],"mechanistic":[58],"approaches.CPT:":[59],"Pharmacometrics":[60],"&":[61],"Systems":[62],"Pharmacology":[63],"(2013)":[64],"2,":[65],"e70;":[66],"doi:10.1038/psp.2013.46;":[67],"published":[68],"online":[69],"28":[70],"August":[71],"2013.":[72]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}