{"id":"https://openalex.org/W2000623239","doi":"https://doi.org/10.1074/jbc.273.17.10726","title":"Characterization of Insulin Receptor Substrate 4 in Human Embryonic Kidney 293 Cells","display_name":"Characterization of Insulin Receptor Substrate 4 in Human Embryonic Kidney 293 Cells","publication_year":1998,"publication_date":"1998-04-01","ids":{"openalex":"https://openalex.org/W2000623239","doi":"https://doi.org/10.1074/jbc.273.17.10726","mag":"2000623239","pmid":"https://pubmed.ncbi.nlm.nih.gov/9553137"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.273.17.10726","doi":"https://doi.org/10.1074/jbc.273.17.10726","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.17.10726","pdf_url":"http://www.jbc.org/article/S0021925818447928/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925818447928/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059897477","display_name":"Valeria R. Fantin","orcid":"https://orcid.org/0009-0005-8328-0152","observed_orcids":["https://orcid.org/0009-0005-8328-0152"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valeria R. Fantin","raw_affiliation_strings":["Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA","\u2020 Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"\u2020 Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000864671","display_name":"Joshua D Sparling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua D. Sparling","raw_affiliation_strings":["Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755","\u2020 Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"\u2020 Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020216583","display_name":"Jan Willem Slot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan W. Slot","raw_affiliation_strings":["Department of Cell Biology, Medical School, Utrecht University, 3584 CX Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Medical School, Utrecht University, 3584 CX Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076239980","display_name":"Susanna R. Keller","orcid":"https://orcid.org/0000-0002-3089-7766","observed_orcids":["https://orcid.org/0000-0002-3089-7766"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susanna R. Keller","raw_affiliation_strings":["Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755","\u2020 Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"\u2020 Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081710262","display_name":"Gustav E. Lienhard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gustav E. Lienhard","raw_affiliation_strings":["Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755","\u2020 Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"\u2020 Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091205151","display_name":"Brian E. Lavan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian E. Lavan","raw_affiliation_strings":["Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755","\u2020 Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"\u2020 Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755","institution_ids":["https://openalex.org/I107672454"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081710262"],"corresponding_institution_ids":["https://openalex.org/I107672454"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.5022,"has_fulltext":true,"cited_by_count":109,"citation_normalized_percentile":{"value":0.95569655,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"273","issue":"17","first_page":"10726","last_page":"10732"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.5365999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.5365999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.38960000872612,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.022700000554323196,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-receptor-substrate-4","display_name":"IRS4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.7879999876022339},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/plasma-membrane-localization","display_name":"plasma membrane localization","score":0.6830000281333923},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9380000233650208},{"id":"https://openalex.org/keywords/grb2","display_name":"Grb2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sh2-domain-proteins","display_name":"SH2 domain proteins","score":0.9139999747276306},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8560000061988831},{"id":"https://openalex.org/keywords/293-cells","display_name":"293 cells","score":0.6840000152587891},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.7252400517463684},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.607682466506958},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47415679693222046},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45913392305374146},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.4506129324436188},{"id":"https://openalex.org/C201624660","wikidata":"https://www.wikidata.org/wiki/Q15334084","display_name":"IRS1","level":5,"score":0.445026159286499},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.4428445100784302},{"id":"https://openalex.org/C185967709","wikidata":"https://www.wikidata.org/wiki/Q101433828","display_name":"Insulin receptor substrate","level":5,"score":0.4256257712841034},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4236682951450348},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4163154661655426},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4142373502254486},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38668927550315857},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36055105924606323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2549363970756531},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2180025279521942},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.21385955810546875},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06771916151046753},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016253","descriptor_name":"Microscopy, Immunoelectron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016253","descriptor_name":"Microscopy, Immunoelectron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016253","descriptor_name":"Microscopy, Immunoelectron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018909","descriptor_name":"src Homology Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018909","descriptor_name":"src Homology Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018909","descriptor_name":"src Homology Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055504","descriptor_name":"Insulin Receptor Substrate Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055504","descriptor_name":"Insulin Receptor Substrate Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055504","descriptor_name":"Insulin Receptor Substrate Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.273.17.10726","doi":"https://doi.org/10.1074/jbc.273.17.10726","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.17.10726","pdf_url":"http://www.jbc.org/article/S0021925818447928/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9553137","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9553137","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.273.17.10726","doi":"https://doi.org/10.1074/jbc.273.17.10726","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.17.10726","pdf_url":"http://www.jbc.org/article/S0021925818447928/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G482854693","display_name":null,"funder_award_id":"DK42816","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000623239.pdf","grobid_xml":"https://content.openalex.org/works/W2000623239.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1508994506","https://openalex.org/W1565831796","https://openalex.org/W1572009433","https://openalex.org/W1726025741","https://openalex.org/W1818471554","https://openalex.org/W1891791960","https://openalex.org/W1979676829","https://openalex.org/W1985113364","https://openalex.org/W1994584656","https://openalex.org/W2002564733","https://openalex.org/W2007308578","https://openalex.org/W2008954530","https://openalex.org/W2011421558","https://openalex.org/W2031504013","https://openalex.org/W2041636434","https://openalex.org/W2044296969","https://openalex.org/W2046013699","https://openalex.org/W2047531477","https://openalex.org/W2049609626","https://openalex.org/W2052759550","https://openalex.org/W2055920490","https://openalex.org/W2057364591","https://openalex.org/W2071049538","https://openalex.org/W2072948376","https://openalex.org/W2080415718","https://openalex.org/W2084354461","https://openalex.org/W2091545748","https://openalex.org/W2096965078","https://openalex.org/W2098601481","https://openalex.org/W2105606183","https://openalex.org/W2107905355","https://openalex.org/W2122393978","https://openalex.org/W2132382863","https://openalex.org/W2136400536","https://openalex.org/W2154713680","https://openalex.org/W2333879119"],"related_works":["https://openalex.org/W4206613984","https://openalex.org/W2011333153","https://openalex.org/W1969744026","https://openalex.org/W2058280890","https://openalex.org/W2116713371","https://openalex.org/W2188233681","https://openalex.org/W4243247781","https://openalex.org/W233490114","https://openalex.org/W2105412616","https://openalex.org/W1991603687"],"abstract_inverted_index":{"We":[0],"recently":[1],"cloned":[2],"IRS-4,":[3,164],"a":[4,71],"new":[5],"member":[6],"of":[7,48,74,83,163],"the":[8,34,63,75,80,84,89,112,115,123,137],"insulin":[9,158],"receptor":[10,153],"substrate":[11],"(IRS)":[12],"family.":[13],"In":[14],"this":[15],"study":[16],"we":[17],"have":[18],"characterized":[19],"IRS-4":[20,32,49,59,76,94],"in":[21,39,52,87,159],"human":[22],"embryonic":[23],"kidney":[24],"293":[25],"cells,":[26],"where":[27],"it":[28],"was":[29,33,50,60,77,95,129,154],"originally":[30],"discovered.":[31],"predominant":[35],"insulin-elicited":[36],"phosphotyrosine":[37],"protein":[38,139],"these":[40],"cells.":[41],"Subcellular":[42],"fractionation":[43],"revealed":[44],"that":[45,58,70],"about":[46],"50%":[47],"located":[51,78],"cellular":[53],"membranes,":[54],"and":[55,91,110,143,168],"immunofluorescence":[56],"indicated":[57],"concentrated":[61],"at":[62,79],"plasma":[64,85],"membrane.":[65],"Immunoelectron":[66],"microscopy":[67],"conclusively":[68],"established":[69],"large":[72],"portion":[73],"cytoplasmic":[81],"surface":[82],"membrane":[86],"both":[88],"unstimulated":[90],"insulin-treated":[92],"states.":[93],"found":[96],"to":[97,114],"be":[98],"associated":[99],"with":[100,131],"two":[101,132],"src":[102],"homology":[103],"2":[104,142],"(SH2)":[105],"domain-containing":[106],"proteins,":[107,136],"phosphatidylinositol":[108],"3-kinase":[109],"Grb2,":[111],"adaptor":[113],"guanine":[116],"nucleotide":[117],"exchange":[118],"factor":[119,148,171],"for":[120],"Ras.":[121],"On":[122],"other":[124,133],"hand,":[125],"no":[126],"significant":[127],"association":[128],"detected":[130],"SH2":[134],"domain":[135],"SH2-containing":[138],"tyrosine":[140,161],"phosphatase":[141],"phospholipase":[144],"Cgamma.":[145],"Insulin-like":[146],"growth":[147,170],"I":[149],"acting":[150],"through":[151],"its":[152],"as":[155,157],"effective":[156],"eliciting":[160],"phosphorylation":[162],"but":[165],"interleukin":[166],"4":[167],"epidermal":[169],"were":[172],"ineffective.":[173]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
