{"id":"https://openalex.org/W2000618586","doi":"https://doi.org/10.1007/s10989-010-9208-x","title":"The Peptides Mimicking the Third Intracellular Loop of 5-Hydroxytryptamine Receptors of the Types 1B and 6 Selectively Activate G Proteins and Receptor-Specifically Inhibit Serotonin Signaling via the Adenylyl Cyclase System","display_name":"The Peptides Mimicking the Third Intracellular Loop of 5-Hydroxytryptamine Receptors of the Types 1B and 6 Selectively Activate G Proteins and Receptor-Specifically Inhibit Serotonin Signaling via the Adenylyl Cyclase System","publication_year":2010,"publication_date":"2010-03-29","ids":{"openalex":"https://openalex.org/W2000618586","doi":"https://doi.org/10.1007/s10989-010-9208-x","mag":"2000618586"},"language":"en","primary_location":{"id":"doi:10.1007/s10989-010-9208-x","doi":"https://doi.org/10.1007/s10989-010-9208-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10989-010-9208-x","pdf_url":null,"source":{"id":"https://openalex.org/S197593595","display_name":"International Journal of Peptide Research and Therapeutics","issn_l":"1573-3149","issn":["1573-3149","1573-3904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Peptide Research and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029237066","display_name":"Alexander Olegovich Shpakov","orcid":"https://orcid.org/0000-0002-4293-3162","observed_orcids":["https://orcid.org/0000-0002-4293-3162"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I163234304","display_name":"Institute of Evolutionary Physiology and Biochemistry","ror":"https://ror.org/02vf4sk45","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I163234304","https://openalex.org/I4210115279"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Alexander O. Shpakov","raw_affiliation_strings":["Department of Biochemistry, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Science, Thorez av. 44, 194223, St. Petersburg, Russia","Russian Academy of Science#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Science, Thorez av. 44, 194223, St. Petersburg, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I163234304"]},{"raw_affiliation_string":"Russian Academy of Science#TAB#","institution_ids":["https://openalex.org/I1313323035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019098289","display_name":"Elena A. Shpakova","orcid":"https://orcid.org/0000-0002-5645-455X","observed_orcids":["https://orcid.org/0000-0002-5645-455X"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210091702","display_name":"Institute of Macromolecular Compounds","ror":"https://ror.org/00hgmwb30","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091702","https://openalex.org/I4210145551"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Elena A. Shpakova","raw_affiliation_strings":["Institute of Macromolecular Compounds, Russian Academy of Science, St. Petersburg, Russia","Russian Academy of Science#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Macromolecular Compounds, Russian Academy of Science, St. Petersburg, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210091702"]},{"raw_affiliation_string":"Russian Academy of Science#TAB#","institution_ids":["https://openalex.org/I1313323035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090137741","display_name":"Irina I. Tarasenko","orcid":"https://orcid.org/0000-0002-8896-4028","observed_orcids":["https://orcid.org/0000-0002-8896-4028"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210091702","display_name":"Institute of Macromolecular Compounds","ror":"https://ror.org/00hgmwb30","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091702","https://openalex.org/I4210145551"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Irina I. Tarasenko","raw_affiliation_strings":["Institute of Macromolecular Compounds, Russian Academy of Science, St. Petersburg, Russia","Russian Academy of Science#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Macromolecular Compounds, Russian Academy of Science, St. Petersburg, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210091702"]},{"raw_affiliation_string":"Russian Academy of Science#TAB#","institution_ids":["https://openalex.org/I1313323035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067687796","display_name":"Kira Viktorovna Derkach","orcid":"https://orcid.org/0000-0001-6555-9540","observed_orcids":["https://orcid.org/0000-0001-6555-9540"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I163234304","display_name":"Institute of Evolutionary Physiology and Biochemistry","ror":"https://ror.org/02vf4sk45","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I163234304","https://openalex.org/I4210115279"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Kira V. Derkach","raw_affiliation_strings":["Department of Biochemistry, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Science, Thorez av. 44, 194223, St. Petersburg, Russia","Russian Academy of Science#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Science, Thorez av. 44, 194223, St. Petersburg, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I163234304"]},{"raw_affiliation_string":"Russian Academy of Science#TAB#","institution_ids":["https://openalex.org/I1313323035"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111617800","display_name":"Gennady P. Vlasov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210091702","display_name":"Institute of Macromolecular Compounds","ror":"https://ror.org/00hgmwb30","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091702","https://openalex.org/I4210145551"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Gennady P. Vlasov","raw_affiliation_strings":["Institute of Macromolecular Compounds, Russian Academy of Science, St. Petersburg, Russia","Russian Academy of Science#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Macromolecular Compounds, Russian Academy of Science, St. Petersburg, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210091702"]},{"raw_affiliation_string":"Russian Academy of Science#TAB#","institution_ids":["https://openalex.org/I1313323035"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029237066"],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I163234304"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":null,"fwci":2.8358,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.90955398,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"16","issue":"2","first_page":"95","last_page":"105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin-receptors","display_name":"serotonin receptors","score":0.824999988079071},{"id":"https://openalex.org/keywords/5-ht1b-receptor","display_name":"5-HT1B receptor","score":0.902999997138977},{"id":"https://openalex.org/keywords/5-ht6-receptor","display_name":"5-HT6 receptor","score":1.0},{"id":"https://openalex.org/keywords/third-intracellular-loop","display_name":"third intracellular loop","score":0.9729999899864197},{"id":"https://openalex.org/keywords/g-protein-coupling","display_name":"G protein coupling","score":0.722000002861023},{"id":"https://openalex.org/keywords/adenylyl-cyclase-signaling","display_name":"adenylyl cyclase signaling","score":0.871999979019165},{"id":"https://openalex.org/keywords/gs-protein","display_name":"Gs protein","score":0.6510000228881836},{"id":"https://openalex.org/keywords/gi-protein","display_name":"Gi protein","score":0.996999979019165},{"id":"https://openalex.org/keywords/synaptosomal-membranes","display_name":"synaptosomal membranes","score":0.6769999861717224},{"id":"https://openalex.org/keywords/gtp-binding","display_name":"GTP binding","score":0.5690000057220459},{"id":"https://openalex.org/keywords/receptor-agonists","display_name":"receptor agonists","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C2779178603","wikidata":"https://www.wikidata.org/wiki/Q356257","display_name":"Adenylyl cyclase","level":3,"score":0.9010703563690186},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.6247202157974243},{"id":"https://openalex.org/C176303035","wikidata":"https://www.wikidata.org/wiki/Q5513929","display_name":"Gs alpha subunit","level":4,"score":0.5957059264183044},{"id":"https://openalex.org/C139407321","wikidata":"https://www.wikidata.org/wiki/Q408561","display_name":"Heterotrimeric G protein","level":4,"score":0.5936571359634399},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.5769370198249817},{"id":"https://openalex.org/C2779276759","wikidata":"https://www.wikidata.org/wiki/Q412747","display_name":"Forskolin","level":3,"score":0.5748178362846375},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5212831497192383},{"id":"https://openalex.org/C115466790","wikidata":"https://www.wikidata.org/wiki/Q5008667","display_name":"cAMP-dependent pathway","level":4,"score":0.5114125609397888},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5014505386352539},{"id":"https://openalex.org/C161473406","wikidata":"https://www.wikidata.org/wiki/Q24719569","display_name":"Gi alpha subunit","level":4,"score":0.495328813791275},{"id":"https://openalex.org/C49773422","wikidata":"https://www.wikidata.org/wiki/Q4859345","display_name":"Pertussis toxin","level":4,"score":0.4953116476535797},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.47293972969055176},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.46730542182922363},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43457329273223877},{"id":"https://openalex.org/C69101867","wikidata":"https://www.wikidata.org/wiki/Q17709777","display_name":"ADCY9","level":4,"score":0.4322471022605896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4018844962120056},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3868297338485718},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.36247652769088745}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s10989-010-9208-x","doi":"https://doi.org/10.1007/s10989-010-9208-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10989-010-9208-x","pdf_url":null,"source":{"id":"https://openalex.org/S197593595","display_name":"International Journal of Peptide Research and Therapeutics","issn_l":"1573-3149","issn":["1573-3149","1573-3904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Peptide Research and Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321079","display_name":"Russian Foundation for Basic Research","ror":"https://ror.org/02mh1ke95"},{"id":"https://openalex.org/F4320334801","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1517746500","https://openalex.org/W1541290863","https://openalex.org/W1542041788","https://openalex.org/W1574889225","https://openalex.org/W1763096406","https://openalex.org/W1775749144","https://openalex.org/W1795151741","https://openalex.org/W1966363217","https://openalex.org/W1968713339","https://openalex.org/W1973458872","https://openalex.org/W1982713624","https://openalex.org/W1997013778","https://openalex.org/W1997438917","https://openalex.org/W2001328807","https://openalex.org/W2006491709","https://openalex.org/W2007095368","https://openalex.org/W2010739774","https://openalex.org/W2019712079","https://openalex.org/W2021177219","https://openalex.org/W2021398035","https://openalex.org/W2026327534","https://openalex.org/W2030822641","https://openalex.org/W2036888975","https://openalex.org/W2038490441","https://openalex.org/W2043395175","https://openalex.org/W2044098020","https://openalex.org/W2045395275","https://openalex.org/W2049391660","https://openalex.org/W2052243336","https://openalex.org/W2056023204","https://openalex.org/W2062144110","https://openalex.org/W2063504313","https://openalex.org/W2064476297","https://openalex.org/W2069302934","https://openalex.org/W2073230423","https://openalex.org/W2080709350","https://openalex.org/W2085236297","https://openalex.org/W2094168002","https://openalex.org/W2109849823","https://openalex.org/W2172659222","https://openalex.org/W2397079880","https://openalex.org/W2397480746","https://openalex.org/W2407826331","https://openalex.org/W2416635877","https://openalex.org/W2416969764","https://openalex.org/W2471212791"],"related_works":["https://openalex.org/W2169658404","https://openalex.org/W4243372088","https://openalex.org/W2059147358","https://openalex.org/W3015329054","https://openalex.org/W616660348","https://openalex.org/W1604214492","https://openalex.org/W1996177010","https://openalex.org/W2064679203","https://openalex.org/W1520595787","https://openalex.org/W1964349120"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}