{"id":"https://openalex.org/W2000618086","doi":"https://doi.org/10.5812/kowsar.1735143x.1004","title":"Frequency and Mutation Patterns of Resistance in Patients with Chronic Hepatitis B Infection Treated with Nucleos(t)ide Analogs in Add-On and Switch Strategies","display_name":"Frequency and Mutation Patterns of Resistance in Patients with Chronic Hepatitis B Infection Treated with Nucleos(t)ide Analogs in Add-On and Switch Strategies","publication_year":2011,"publication_date":"2011-09-30","ids":{"openalex":"https://openalex.org/W2000618086","doi":"https://doi.org/10.5812/kowsar.1735143x.1004","mag":"2000618086","pmid":"https://pubmed.ncbi.nlm.nih.gov/22224083","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3234585"},"language":"en","primary_location":{"id":"doi:10.5812/kowsar.1735143x.1004","doi":"https://doi.org/10.5812/kowsar.1735143x.1004","is_oa":true,"landing_page_url":"https://doi.org/10.5812/kowsar.1735143x.1004","pdf_url":"https://brieflands.com/articles/hepatmon-70190.pdf","source":{"id":"https://openalex.org/S151854748","display_name":"Hepatitis Monthly","issn_l":"1735-143X","issn":["1735-143X","1735-3408"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318596","host_organization_name":"Kowsar Publishing","host_organization_lineage":["https://openalex.org/P4310318596"],"host_organization_lineage_names":["Kowsar Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatitis Monthly","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2000618086"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://brieflands.com/articles/hepatmon-70190.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015427454","display_name":"Murat Sayan","orcid":"https://orcid.org/0000-0002-4374-7193","observed_orcids":["https://orcid.org/0000-0002-4374-7193"]},"institutions":[{"id":"https://openalex.org/I51826884","display_name":"Kocaeli \u00dcniversitesi","ror":"https://ror.org/0411seq30","country_code":"TR","type":"education","lineage":["https://openalex.org/I51826884"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Murat Sayan","raw_affiliation_strings":["University of Kocaeli, Faculty of Medicine, Clinical Laboratory, sayanmurat@hotmail.com, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kocaeli, Faculty of Medicine, Clinical Laboratory, sayanmurat@hotmail.com, Turkey","institution_ids":["https://openalex.org/I51826884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003156701","display_name":"S\u0131la Akhan","orcid":"https://orcid.org/0000-0002-2540-2060","observed_orcids":["https://orcid.org/0000-0002-2540-2060"]},"institutions":[{"id":"https://openalex.org/I51826884","display_name":"Kocaeli \u00dcniversitesi","ror":"https://ror.org/0411seq30","country_code":"TR","type":"education","lineage":["https://openalex.org/I51826884"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sila Cetin Akhan","raw_affiliation_strings":["University of Kocaeli, Faculty of Medicine, Department of Clinical Bacteriology and Infectious Diseases, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kocaeli, Faculty of Medicine, Department of Clinical Bacteriology and Infectious Diseases, Turkey","institution_ids":["https://openalex.org/I51826884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043609167","display_name":"\u00d6mer \u015eent\u00fcrk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51826884","display_name":"Kocaeli \u00dcniversitesi","ror":"https://ror.org/0411seq30","country_code":"TR","type":"education","lineage":["https://openalex.org/I51826884"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Omer Senturk","raw_affiliation_strings":["University of Kocaeli, Faculty of Medicine, Department of Clinical Bacteriology and Infectious Diseases, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kocaeli, Faculty of Medicine, Department of Clinical Bacteriology and Infectious Diseases, Turkey","institution_ids":["https://openalex.org/I51826884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015427454"],"corresponding_institution_ids":["https://openalex.org/I51826884"],"apc_list":null,"apc_paid":null,"fwci":1.4927,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.78950714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"10","first_page":"835","last_page":"842"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.8619999885559082},{"id":"https://openalex.org/keywords/nucleoside-analogs","display_name":"nucleoside analogues","score":0.7110000252723694},{"id":"https://openalex.org/keywords/antiviral-resistance","display_name":"antiviral resistance","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hbv-polymerase-gene","display_name":"HBV polymerase gene","score":0.8930000066757202},{"id":"https://openalex.org/keywords/lamivudine-resistance","display_name":"lamivudine resistance","score":0.8349999785423279},{"id":"https://openalex.org/keywords/entecavir-resistance","display_name":"entecavir resistance","score":0.9210000038146973},{"id":"https://openalex.org/keywords/adefovir-resistance","display_name":"adefovir resistance","score":0.9940000176429749},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.8309999704360962},{"id":"https://openalex.org/keywords/treatment-switching","display_name":"treatment switching","score":0.9330000281333923},{"id":"https://openalex.org/keywords/salvage-therapy","display_name":"salvage therapy","score":0.722000002861023},{"id":"https://openalex.org/keywords/resistance-mutations","display_name":"resistance mutations","score":0.6489999890327454},{"id":"https://openalex.org/keywords/turkish-patients","display_name":"Turkish patients","score":0.7590000033378601},{"id":"https://openalex.org/keywords/rtl180m","display_name":"rtL180M","score":0.9419999718666077}],"concepts":[{"id":"https://openalex.org/C2779517838","wikidata":"https://www.wikidata.org/wiki/Q353551","display_name":"Adefovir","level":5,"score":0.955233097076416},{"id":"https://openalex.org/C2776175608","wikidata":"https://www.wikidata.org/wiki/Q418586","display_name":"Entecavir","level":5,"score":0.9212572574615479},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8479313850402832},{"id":"https://openalex.org/C2777869810","wikidata":"https://www.wikidata.org/wiki/Q422631","display_name":"Lamivudine","level":4,"score":0.7416305541992188},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.6237844824790955},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.6058250069618225},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5610353946685791},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5376516580581665},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4973144829273224},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.47458410263061523},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.44770553708076477},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4403848946094513},{"id":"https://openalex.org/C182707283","wikidata":"https://www.wikidata.org/wiki/Q7315622","display_name":"Resistance mutation","level":5,"score":0.4357197880744934},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3882070779800415},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3565455675125122},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.20310348272323608},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.18296808004379272},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1647580862045288},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09641966223716736},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07883399724960327},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.5812/kowsar.1735143x.1004","doi":"https://doi.org/10.5812/kowsar.1735143x.1004","is_oa":true,"landing_page_url":"https://doi.org/10.5812/kowsar.1735143x.1004","pdf_url":"https://brieflands.com/articles/hepatmon-70190.pdf","source":{"id":"https://openalex.org/S151854748","display_name":"Hepatitis Monthly","issn_l":"1735-143X","issn":["1735-143X","1735-3408"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318596","host_organization_name":"Kowsar Publishing","host_organization_lineage":["https://openalex.org/P4310318596"],"host_organization_lineage_names":["Kowsar Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatitis Monthly","raw_type":"journal-article"},{"id":"doi:10.5812/kowsar.1735143x.775","doi":"https://doi.org/10.5812/kowsar.1735143x.775","is_oa":true,"landing_page_url":"https://doi.org/10.5812/kowsar.1735143x.775","pdf_url":null,"source":{"id":"https://openalex.org/S151854748","display_name":"Hepatitis Monthly","issn_l":"1735-143X","issn":["1735-143X","1735-3408"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318596","host_organization_name":"Kowsar Publishing","host_organization_lineage":["https://openalex.org/P4310318596"],"host_organization_lineage_names":["Kowsar Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatitis Monthly","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2260355","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3234585","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22224083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22224083","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatitis monthly","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3234585","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3234585/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepat Mon","raw_type":"Text"},{"id":"pmh:e2d6f92a-9cd0-4d86-a924-2391a752b6b4","doi":null,"is_oa":true,"landing_page_url":"https://avesis.kocaeli.edu.tr/publication/details/e2d6f92a-9cd0-4d86-a924-2391a752b6b4/oai","pdf_url":"https://avesis.kocaeli.edu.tr/publication/details/e2d6f92a-9cd0-4d86-a924-2391a752b6b4/oai/document.pdf","source":{"id":"https://openalex.org/S7407055291","display_name":"Kocaeli \u00dcniversitesi - AVES\u0130S","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:9b073518-d621-4507-8f68-72ea60be97a0","doi":null,"is_oa":false,"landing_page_url":"https://avesis.kocaeli.edu.tr/publication/details/9b073518-d621-4507-8f68-72ea60be97a0/oai","pdf_url":null,"source":{"id":"https://openalex.org/S7407055291","display_name":"Kocaeli \u00dcniversitesi - AVES\u0130S","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":{"id":"doi:10.5812/kowsar.1735143x.1004","doi":"https://doi.org/10.5812/kowsar.1735143x.1004","is_oa":true,"landing_page_url":"https://doi.org/10.5812/kowsar.1735143x.1004","pdf_url":"https://brieflands.com/articles/hepatmon-70190.pdf","source":{"id":"https://openalex.org/S151854748","display_name":"Hepatitis Monthly","issn_l":"1735-143X","issn":["1735-143X","1735-3408"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318596","host_organization_name":"Kowsar Publishing","host_organization_lineage":["https://openalex.org/P4310318596"],"host_organization_lineage_names":["Kowsar Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatitis Monthly","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000618086.pdf","grobid_xml":"https://content.openalex.org/works/W2000618086.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W65089870","https://openalex.org/W124116101","https://openalex.org/W1493372259","https://openalex.org/W1526671947","https://openalex.org/W1541404344","https://openalex.org/W1820475767","https://openalex.org/W1976762454","https://openalex.org/W1983113514","https://openalex.org/W1984898374","https://openalex.org/W1996434058","https://openalex.org/W1996792477","https://openalex.org/W1996800338","https://openalex.org/W1997813753","https://openalex.org/W2006698257","https://openalex.org/W2011269097","https://openalex.org/W2012774039","https://openalex.org/W2023509812","https://openalex.org/W2046089461","https://openalex.org/W2046151142","https://openalex.org/W2047312769","https://openalex.org/W2051306094","https://openalex.org/W2051961789","https://openalex.org/W2051976356","https://openalex.org/W2059481170","https://openalex.org/W2061505027","https://openalex.org/W2064695462","https://openalex.org/W2069441352","https://openalex.org/W2073478615","https://openalex.org/W2075559061","https://openalex.org/W2088345510","https://openalex.org/W2104969243","https://openalex.org/W2110747022","https://openalex.org/W2110941134","https://openalex.org/W2115956200","https://openalex.org/W2116584773","https://openalex.org/W2118539769","https://openalex.org/W2122853284","https://openalex.org/W2126563189","https://openalex.org/W2132043997","https://openalex.org/W2138306213","https://openalex.org/W2140116049","https://openalex.org/W2145899386","https://openalex.org/W2166274558","https://openalex.org/W2181762296","https://openalex.org/W2392082701","https://openalex.org/W2739535516","https://openalex.org/W3030265267","https://openalex.org/W4246097226","https://openalex.org/W4247967755"],"related_works":["https://openalex.org/W7098415233","https://openalex.org/W2524823030","https://openalex.org/W2620688277","https://openalex.org/W2348599093","https://openalex.org/W2073478615","https://openalex.org/W2313890354","https://openalex.org/W1492134529","https://openalex.org/W2139154545","https://openalex.org/W2893918185"],"abstract_inverted_index":{":":[0],"Background:":[1],"Treatment":[2],"for":[3,226,256],"chronic":[4,247,269],"hepatitis":[5,46,248,270],"B":[6,47,249,293],"(CHB)":[7],"has":[8],"improved":[9],"over":[10],"the":[11,18,31,37,45,91,173,217,260],"last":[12],"10":[13,122],"years":[14],"mainly":[15],"due":[16],"to":[17,35,44],"development":[19],"of":[20,30,42,54,73,199,219,231,246,262,286],"effective":[21],"oral":[22],"antiviral":[23],"agents":[24],"[nucleoside/nucleotide":[25],"analogs":[26],"(NUCs)].Objectives:":[27],"The":[28,68,153,194],"aim":[29],"present":[32],"study":[33],"is":[34,253],"identify":[36],"frequency":[38,195],"and":[39,62,66,82,97,114,129,137,145,157,164,169,196,208,236,241,283,301],"major":[40,232],"patterns":[41,235],"resistance":[43,159,178,186,200,234],"virus":[48],"(HBV)":[49],"in":[50,106,111,116,126,131,142,147,203,216,222,239,244,259,265,268,288,299],"a":[51,71],"Turkish":[52],"population":[53],"CHB":[55,182],"patients":[56,75,108,123,139,204,267],"treated":[57,78,85,205],"with":[58,181,206,290,296],"NUCs":[59],"using":[60,79,86,189],"add-on":[61,80,112,127,143,207,240],"switch":[63,87,117,132,148,209,242],"therapy":[64],"strategies.Patients":[65],"Methods:":[67],"investigation":[69],"involved":[70,258],"total":[72],"194":[74],"(88":[76],"were":[77,84,104,161,172,187,201],"therapy,":[81,113,128,144],"106":[83],"therapy).":[88],"We":[89],"analyzed":[90],"HBV":[92],"polymerase":[93],"gene":[94],"by":[95],"amplification":[96],"direct":[98],"sequencing":[99],"procedures.Results:":[100],"Primary":[101],"drug-resistance":[102],"mutations":[103,160],"detected":[105],"84":[107],"(43%;":[109],"42":[110,115],"therapy)":[118,133,149],"taking":[119,134,150],"lamivudine":[120],"(LAM),":[121],"(5%;":[124],"6":[125],"4":[130],"entecavir":[135],"(ETV),":[136],"16":[138],"(8%;":[140],"8":[141,146],"adefovir":[151],"(ADV).":[152],"most":[154,174],"common":[155],"LAM":[156],"ETV":[158],"rtM204I/V,":[162],"rtL180M":[163],"rtT184A/I/S,":[165],"respectively,":[166],"while":[167],"rtA181T/V":[168],"rtN236T":[170],"substitutions":[171],"frequently":[175],"observed":[176],"ADV":[177],"mutations.Conclusions:":[179],"Patients":[180,289],"who":[183],"developed":[184],"NUC":[185],"managed":[188],"2":[190],"different":[191],"rescue":[192,220,263],"strategies.":[193,210],"mutation":[197],"pattern":[198],"similar":[202],"These":[211],"findings":[212],"may":[213],"be":[214],"helpful":[215,255],"management":[218,261],"strategies":[221,243,264],"LAM-resistant":[223],"patients.":[224],"Implication":[225],"health":[227],"policy/practice/research/medical":[228],"education:Authors":[229],"revealed":[230],"drug":[233],"their":[237],"frequencies":[238],"treatment":[245],"virus.":[250],"This":[251],"article":[252],"an":[254],"clinicians":[257],"lamivudine-resistant":[266],"B.":[271],"Please":[272],"cite":[273],"this":[274],"paper":[275],"as:Sayan":[276],"M,":[277],"Akhan":[278],"SC,":[279],"Senturk":[280],"O.":[281],"Frequency":[282],"Mutation":[284],"Patterns":[285],"Resistance":[287],"Chronic":[291],"Hepatitis":[292],"Infection":[294],"Treated":[295],"Nucleos(t)ide":[297],"Analogs":[298],"Add-On":[300],"Switch":[302],"Strategies.":[303],"Hepat":[304],"Mon.2011;11(10):835-42.":[305],"DOI:":[306],"10.5812/kowsar.1735143X.775":[307],"\u00a9":[308],"2011":[309],"Kowsar":[310],"M.P.Co.":[311],"All":[312],"rights":[313],"reserved.":[314]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
