{"id":"https://openalex.org/W2000610781","doi":"https://doi.org/10.1016/j.lfs.2003.06.013","title":"Mechanism for generation of hydrogen peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis","display_name":"Mechanism for generation of hydrogen peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis","publication_year":2003,"publication_date":"2003-10-15","ids":{"openalex":"https://openalex.org/W2000610781","doi":"https://doi.org/10.1016/j.lfs.2003.06.013","mag":"2000610781","pmid":"https://pubmed.ncbi.nlm.nih.gov/14561532"},"language":"en","primary_location":{"id":"doi:10.1016/j.lfs.2003.06.013","doi":"https://doi.org/10.1016/j.lfs.2003.06.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lfs.2003.06.013","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047991150","display_name":"Saeko Tada\u2010Oikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Saeko Tada-Oikawa","raw_affiliation_strings":["Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2-174 Edobashi, -Tsu-shi, Mie, 514-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2-174 Edobashi, -Tsu-shi, Mie, 514-8507, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062182998","display_name":"Yusuke Hiraku","orcid":"https://orcid.org/0000-0002-4351-1498","observed_orcids":["https://orcid.org/0000-0002-4351-1498"]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Hiraku","raw_affiliation_strings":["Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2\u2013174 Edobashi, Tsu-shi, Mie, 514-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2\u2013174 Edobashi, Tsu-shi, Mie, 514-8507, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110768524","display_name":"Michiko Kawanishi","orcid":"https://orcid.org/0009-0004-8973-2140","observed_orcids":["https://orcid.org/0009-0004-8973-2140"]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Michiko Kawanishi","raw_affiliation_strings":["Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2\u2013174 Edobashi, Tsu-shi, Mie, 514-8507, Japan","Department of Microbiology, Graduate School of Medicine, Kyoto University, Kyoto 606-8315, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2\u2013174 Edobashi, Tsu-shi, Mie, 514-8507, Japan","institution_ids":["https://openalex.org/I178574317"]},{"raw_affiliation_string":"Department of Microbiology, Graduate School of Medicine, Kyoto University, Kyoto 606-8315, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077773100","display_name":"Shosuke Kawanishi","orcid":"https://orcid.org/0000-0002-7525-7658","observed_orcids":["https://orcid.org/0000-0002-7525-7658"]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shosuke Kawanishi","raw_affiliation_strings":["Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2\u2013174 Edobashi, Tsu-shi, Mie, 514-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2\u2013174 Edobashi, Tsu-shi, Mie, 514-8507, Japan","institution_ids":["https://openalex.org/I178574317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077773100","https://openalex.org/A5110768524"],"corresponding_institution_ids":["https://openalex.org/I178574317","https://openalex.org/I22299242"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":2.0742,"has_fulltext":false,"cited_by_count":118,"citation_normalized_percentile":{"value":0.86608336,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"73","issue":"25","first_page":"3277","last_page":"3288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.02250000089406967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rotenone","display_name":"rotenone","score":0.996999979019165},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/hydrogen-peroxide-production","display_name":"hydrogen peroxide production","score":0.8999999761581421},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.996999979019165},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.968999981880188},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.640999972820282},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8880000114440918},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.953000009059906},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.8949999809265137},{"id":"https://openalex.org/keywords/bjab-cells","display_name":"BJAB cells","score":0.847000002861023},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.7730000019073486},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C2778389096","wikidata":"https://www.wikidata.org/wiki/Q412388","display_name":"Rotenone","level":3,"score":0.9360341429710388},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.747016429901123},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.7425347566604614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6632115244865417},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5377382040023804},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5266649127006531},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4876236021518707},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.47770407795906067},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.4617370069026947},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4612919092178345},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.4535267949104309},{"id":"https://openalex.org/C123249941","wikidata":"https://www.wikidata.org/wiki/Q306116","display_name":"Cytochrome c oxidase","level":3,"score":0.4326298236846924},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.41759154200553894},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.4149896204471588},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28654754161834717},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16376256942749023},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007306","descriptor_name":"Insecticides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009245","descriptor_name":"NADH Dehydrogenase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009245","descriptor_name":"NADH Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012402","descriptor_name":"Rotenone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.lfs.2003.06.013","doi":"https://doi.org/10.1016/j.lfs.2003.06.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lfs.2003.06.013","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},{"id":"pmid:14561532","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14561532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W121254590","https://openalex.org/W171873722","https://openalex.org/W1504584187","https://openalex.org/W1542061701","https://openalex.org/W1550247880","https://openalex.org/W1609959357","https://openalex.org/W1644794975","https://openalex.org/W1651860280","https://openalex.org/W1655481075","https://openalex.org/W1980969730","https://openalex.org/W1988054144","https://openalex.org/W1993929800","https://openalex.org/W2000834350","https://openalex.org/W2003394221","https://openalex.org/W2004758859","https://openalex.org/W2006059185","https://openalex.org/W2022089184","https://openalex.org/W2043819590","https://openalex.org/W2059718548","https://openalex.org/W2060620829","https://openalex.org/W2061362388","https://openalex.org/W2062251719","https://openalex.org/W2063747608","https://openalex.org/W2069664359","https://openalex.org/W2075820089","https://openalex.org/W2083018249","https://openalex.org/W2096298540","https://openalex.org/W2126243900","https://openalex.org/W2144254441","https://openalex.org/W2154346380","https://openalex.org/W2163349780","https://openalex.org/W2171030272","https://openalex.org/W2257018843","https://openalex.org/W2271272206","https://openalex.org/W6637019226"],"related_works":["https://openalex.org/W7100542936","https://openalex.org/W2150215749","https://openalex.org/W2156241187","https://openalex.org/W1967853821","https://openalex.org/W2163349780","https://openalex.org/W2275240514","https://openalex.org/W2405154954","https://openalex.org/W2016953129","https://openalex.org/W3129196677","https://openalex.org/W2042226288"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}