{"id":"https://openalex.org/W2000606729","doi":"https://doi.org/10.1530/jrf.0.0480367","title":"The effects of Nolvadex (tamoxifen citrate; ICI 46,474) on pregnancy in rabbits","display_name":"The effects of Nolvadex (tamoxifen citrate; ICI 46,474) on pregnancy in rabbits","publication_year":1976,"publication_date":"1976-11-01","ids":{"openalex":"https://openalex.org/W2000606729","doi":"https://doi.org/10.1530/jrf.0.0480367","mag":"2000606729","pmid":"https://pubmed.ncbi.nlm.nih.gov/994109"},"language":"en","primary_location":{"id":"doi:10.1530/jrf.0.0480367","doi":"https://doi.org/10.1530/jrf.0.0480367","is_oa":true,"landing_page_url":"https://doi.org/10.1530/jrf.0.0480367","pdf_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/48/2/jrf_48_2_025.pdf","source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/48/2/jrf_48_2_025.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113519941","display_name":"B.J.A. Furr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B. J. A. Furr","raw_affiliation_strings":["Imperial Chemical Industries Limited, Pharmaceuticals Division, Mereside, Alderley Park, Macclesfield, Cheshire, and","University of Oxford, Nuffield Institute for Medical Research, Headley Way, Headington, Oxford, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial Chemical Industries Limited, Pharmaceuticals Division, Mereside, Alderley Park, Macclesfield, Cheshire, and","institution_ids":[]},{"raw_affiliation_string":"University of Oxford, Nuffield Institute for Medical Research, Headley Way, Headington, Oxford, U.K","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038101661","display_name":"B. Valcaccia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B. Valcaccia","raw_affiliation_strings":["University of Oxford, Nuffield Institute for Medical Research, Headley Way, Headington, Oxford, U.K","Imperial Chemical Industries Limited, Pharmaceuticals Division, Mereside, Alderley Park, Macclesfield, Cheshire, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oxford, Nuffield Institute for Medical Research, Headley Way, Headington, Oxford, U.K","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Imperial Chemical Industries Limited, Pharmaceuticals Division, Mereside, Alderley Park, Macclesfield, Cheshire, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109262333","display_name":"John R. G. Challis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. R. G. Challis","raw_affiliation_strings":["Imperial Chemical Industries Limited , Pharmaceuticals Division , Mereside , Alderley Park , Macclesfield , Cheshire , and '","University of Oxford , Nuffield Institute for Medical Research , Headley Way , Headington , Oxford , U.K","School of Women's and Infants' Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial Chemical Industries Limited , Pharmaceuticals Division , Mereside , Alderley Park , Macclesfield , Cheshire , and '","institution_ids":[]},{"raw_affiliation_string":"University of Oxford , Nuffield Institute for Medical Research , Headley Way , Headington , Oxford , U.K","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"School of Women's and Infants' Health","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":null,"apc_paid":null,"fwci":0.1894,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.39071567,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"48","issue":"2","first_page":"367","last_page":"369"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.5015000104904175,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.5015000104904175,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.42649999260902405,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tamoxifen-citrate","display_name":"tamoxifen citrate","score":0.9390000104904175},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.6880000233650208},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.7839999794960022},{"id":"https://openalex.org/keywords/antiestrogens","display_name":"antiestrogens","score":0.7279999852180481},{"id":"https://openalex.org/keywords/corpus-luteum","display_name":"corpus luteum","score":0.875},{"id":"https://openalex.org/keywords/pseudopregnancy","display_name":"pseudopregnancy","score":0.8920000195503235},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8259999752044678},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.9190000295639038},{"id":"https://openalex.org/keywords/plasma-hormone-levels","display_name":"plasma hormone levels","score":0.6679999828338623},{"id":"https://openalex.org/keywords/ovarian-follicles","display_name":"ovarian follicles","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.7113412022590637},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5430476069450378},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.527310311794281},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5032472014427185},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4329095482826233},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4199824333190918},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3116706907749176},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.061908215284347534},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005327","descriptor_name":"Fetal Resorption","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011270","descriptor_name":"Pregnancy, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011555","descriptor_name":"Pseudopregnancy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1530/jrf.0.0480367","doi":"https://doi.org/10.1530/jrf.0.0480367","is_oa":true,"landing_page_url":"https://doi.org/10.1530/jrf.0.0480367","pdf_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/48/2/jrf_48_2_025.pdf","source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},{"id":"pmid:994109","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/994109","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of reproduction and fertility","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1012.9476","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1012.9476","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.reproduction-online.org/content/48/2/367.full.pdf","raw_type":"text"},{"id":"pmh:oai:pure.atira.dk:publications/025a1d3f-8643-4f2d-aa4e-7482433fbf80","doi":null,"is_oa":false,"landing_page_url":"https://research-repository.uwa.edu.au/en/publications/025a1d3f-8643-4f2d-aa4e-7482433fbf80","pdf_url":null,"source":{"id":"https://openalex.org/S4306402492","display_name":"UWA Profiles and Research Repository (UWA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Furr, BJA, Valcaccia, B & Challis, J 1976, 'EFFECTS OF NOLVADEX (TAMOXIFEN CITRATE - ICI 46,474) ON PREGNANCY IN RABBITS', Journal of Reproduction and Fertility, vol. 48, no. 2, pp. 367-369.","raw_type":"info:eu-repo/semantics/annotation"}],"best_oa_location":{"id":"doi:10.1530/jrf.0.0480367","doi":"https://doi.org/10.1530/jrf.0.0480367","is_oa":true,"landing_page_url":"https://doi.org/10.1530/jrf.0.0480367","pdf_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/48/2/jrf_48_2_025.pdf","source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000606729.pdf","grobid_xml":"https://content.openalex.org/works/W2000606729.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1976184465","https://openalex.org/W1990100521","https://openalex.org/W2002098044","https://openalex.org/W2044895981","https://openalex.org/W2081998748","https://openalex.org/W2116953349","https://openalex.org/W2122161572","https://openalex.org/W2315517563","https://openalex.org/W6600555654"],"related_works":["https://openalex.org/W2666614695","https://openalex.org/W2080448766","https://openalex.org/W2084062854","https://openalex.org/W2168971282","https://openalex.org/W2057020399","https://openalex.org/W2076933493","https://openalex.org/W2037442160","https://openalex.org/W7099508104","https://openalex.org/W2060900852","https://openalex.org/W4245604278"],"abstract_inverted_index":{"In":[0],"the":[1,10,16,23,39,61,70,74,87],"rabbit":[2],"there":[3,80],"is":[4,81],"evidence":[5],"that":[6,36,69],"oestrogen,":[7],"derived":[8],"from":[9],"ovarian":[11],"follicles,":[12],"forms":[13],"part":[14],"of":[15,22,27,38,54,65,77],"luteotrophic":[17,75],"complex":[18],"responsible":[19],"for":[20],"maintenance":[21],"corpora":[24],"lutea":[25],"(CL)":[26],"pregnancy":[28,47],"and":[29,52,63,67,100,104],"pseudopregnancy":[30,55],"(Hilliard,":[31],"1973).":[32],"Labhsetwar":[33],"(1971)":[34],"showed":[35],"administration":[37],"antioestrogen,":[40],"Nolvadex,":[41],"to":[42],"rabbits":[43,97],"either":[44],"early":[45],"in":[46,57,60],"or":[48],"between":[49],"Days":[50],"10":[51],"20":[53],"results":[56],"a":[58],"reduction":[59],"size":[62],"number":[64],"CL":[66],"concluded":[68],"drug":[71],"directly":[72],"counters":[73],"action":[76],"oestradiol.":[78],"However,":[79],"no":[82],"supporting":[83],"information":[84],"available":[85],"on":[86],"hormonal":[88],"changes":[89],"following":[90],"treatment":[91],"with":[92,98],"Nolvadex.":[93],"We":[94],"therefore":[95],"treated":[96],"Nolvadex":[99],"measured":[101],"plasma":[102],"progesterone":[103],"oestradiol":[105],"concentrations.":[106]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}