{"id":"https://openalex.org/W2000604849","doi":"https://doi.org/10.1038/bcj.2011.39","title":"Analysis of genomic aberrations and gene expression profiling identifies novel lesions and pathways in myeloproliferative neoplasms","display_name":"Analysis of genomic aberrations and gene expression profiling identifies novel lesions and pathways in myeloproliferative neoplasms","publication_year":2011,"publication_date":"2011-11-11","ids":{"openalex":"https://openalex.org/W2000604849","doi":"https://doi.org/10.1038/bcj.2011.39","mag":"2000604849","pmid":"https://pubmed.ncbi.nlm.nih.gov/22829077"},"language":"en","primary_location":{"id":"doi:10.1038/bcj.2011.39","doi":"https://doi.org/10.1038/bcj.2011.39","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bcj.2011.39","pdf_url":"https://www.nature.com/articles/bcj201139.pdf","source":{"id":"https://openalex.org/S2496263508","display_name":"Blood Cancer Journal","issn_l":"2044-5385","issn":["2044-5385"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/bcj201139.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020761649","display_name":"Kim L. Rice","orcid":"https://orcid.org/0009-0006-4499-0773","observed_orcids":["https://orcid.org/0009-0006-4499-0773"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K L Rice","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","Division of Hematology-Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Division of Hematology-Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":null,"display_name":"X Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X Lin","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","Division of Hematology-Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Division of Hematology-Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070753351","display_name":"Kristy Lucile Wolniak","orcid":"https://orcid.org/0000-0001-6307-5489","observed_orcids":["https://orcid.org/0000-0001-6307-5489"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Wolniak","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","Division of Hematology-Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Division of Hematology-Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070668676","display_name":"Benjamin L. Ebert","orcid":"https://orcid.org/0000-0003-0197-5451","observed_orcids":["https://orcid.org/0000-0003-0197-5451"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B L Ebert","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA","Division of Hematology, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032412371","display_name":"Windy Berkofsky\u2010Fessler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Berkofsky-Fessler","raw_affiliation_strings":["Translational Research Sciences, Hoffmann-La Roche, Inc., Nutley, NJ, USA","Translational Research Sciences, Hoffmann-La Roche, Inc., Nutley, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Research Sciences, Hoffmann-La Roche, Inc., Nutley, NJ, USA","institution_ids":[]},{"raw_affiliation_string":"Translational Research Sciences, Hoffmann-La Roche, Inc., Nutley, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037899722","display_name":"Monica Buzzai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139938","display_name":"Novartis (Italy)","ror":"https://ror.org/04rcxhq50","country_code":"IT","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210139938"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Buzzai","raw_affiliation_strings":["Oncology, Novartis, Origgio, VA, Italy","Oncology, Novartis, Origgio, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology, Novartis, Origgio, VA, Italy","institution_ids":["https://openalex.org/I4210139938"]},{"raw_affiliation_string":"Oncology, Novartis, Origgio, Italy","institution_ids":["https://openalex.org/I4210139938"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324220072","display_name":"Mount Sinai Hospital","ror":"https://ror.org/01zkyz108","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I1324220072"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Sun","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Center of Biomedical Informatics, Mount Sinai School of Medicine, New York, NY, USA","Division of Hematology/Oncology, Department of Medicine, Center of Biomedical Informatics, Mount Sinai School of Medicine, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Center of Biomedical Informatics, Mount Sinai School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I1324220072","https://openalex.org/I98704320"]},{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Center of Biomedical Informatics, Mount Sinai School of Medicine, New York, USA","institution_ids":["https://openalex.org/I1324220072","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C Xi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324220072","display_name":"Mount Sinai Hospital","ror":"https://ror.org/01zkyz108","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I1324220072"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Xi","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Center of Biomedical Informatics, Mount Sinai School of Medicine, New York, NY, USA","Division of Hematology/Oncology, Department of Medicine, Center of Biomedical Informatics, Mount Sinai School of Medicine, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Center of Biomedical Informatics, Mount Sinai School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I1324220072","https://openalex.org/I98704320"]},{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Center of Biomedical Informatics, Mount Sinai School of Medicine, New York, USA","institution_ids":["https://openalex.org/I1324220072","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070359287","display_name":"Peter L. Elkin","orcid":"https://orcid.org/0000-0001-9616-6811","observed_orcids":["https://orcid.org/0000-0001-9616-6811"]},"institutions":[{"id":"https://openalex.org/I1324220072","display_name":"Mount Sinai Hospital","ror":"https://ror.org/01zkyz108","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I1324220072"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Elkin","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Center of Biomedical Informatics, Mount Sinai School of Medicine, New York, NY, USA","Division of Hematology/Oncology, Department of Medicine, Center of Biomedical Informatics, Mount Sinai School of Medicine, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Center of Biomedical Informatics, Mount Sinai School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I1324220072","https://openalex.org/I98704320"]},{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Center of Biomedical Informatics, Mount Sinai School of Medicine, New York, USA","institution_ids":["https://openalex.org/I1324220072","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025660159","display_name":"Ross L. Levine","orcid":"https://orcid.org/0000-0002-7884-1905","observed_orcids":["https://orcid.org/0000-0002-7884-1905"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Levine","raw_affiliation_strings":["Department of Medicine, Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA","Department of Medicine, Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Medicine, Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001449157","display_name":"Todd R. Golub","orcid":"https://orcid.org/0000-0003-0113-2403","observed_orcids":["https://orcid.org/0000-0003-0113-2403"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Golub","raw_affiliation_strings":["The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA","The Eli and Edythe L Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I63966007"]},{"raw_affiliation_string":"The Eli and Edythe L Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, USA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113728001","display_name":"D. Gary Gilliland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D G Gilliland","raw_affiliation_strings":["Oncology, Merck Research Laboratories, North Wales, PA, USA","Oncology, Merck Research Laboratories, North Wales, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology, Merck Research Laboratories, North Wales, PA, USA","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Oncology, Merck Research Laboratories, North Wales, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079900802","display_name":"John D. Crispino","orcid":"https://orcid.org/0000-0002-8182-8306","observed_orcids":["https://orcid.org/0000-0002-8182-8306"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J D Crispino","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","Division of Hematology-Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Division of Hematology-Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034992183","display_name":"Jonathan D. Licht","orcid":"https://orcid.org/0000-0002-3942-1369","observed_orcids":["https://orcid.org/0000-0002-3942-1369"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J D Licht","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","Division of Hematology-Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Division of Hematology-Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100457936","display_name":"Weijia Zhang","orcid":"https://orcid.org/0000-0001-6928-0416","observed_orcids":["https://orcid.org/0000-0001-6928-0416"]},"institutions":[{"id":"https://openalex.org/I1324220072","display_name":"Mount Sinai Hospital","ror":"https://ror.org/01zkyz108","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I1324220072"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W Zhang","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Center of Biomedical Informatics, Mount Sinai School of Medicine, New York, NY, USA","Division of Hematology/Oncology, Department of Medicine, Center of Biomedical Informatics, Mount Sinai School of Medicine, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Center of Biomedical Informatics, Mount Sinai School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I1324220072","https://openalex.org/I98704320"]},{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Center of Biomedical Informatics, Mount Sinai School of Medicine, New York, USA","institution_ids":["https://openalex.org/I1324220072","https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5034992183","https://openalex.org/A5100457936"],"corresponding_institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1324220072","https://openalex.org/I98704320"],"apc_list":{"value":5290,"currency":"USD","value_usd":5290},"apc_paid":{"value":5290,"currency":"USD","value_usd":5290},"fwci":1.0123,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.75157536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"1","issue":"11","first_page":"e40","last_page":"e40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":1.0},{"id":"https://openalex.org/keywords/polycythemia-vera","display_name":"polycythemia vera","score":0.9990000128746033},{"id":"https://openalex.org/keywords/essential-thrombocythemia","display_name":"essential thrombocythemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/primary-myelofibrosis","display_name":"primary myelofibrosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/jak2-v617f-mutation","display_name":"JAK2 V617F mutation","score":0.925000011920929},{"id":"https://openalex.org/keywords/trisomy-9","display_name":"trisomy 9","score":0.8899999856948853},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.8629999756813049},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5270000100135803},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-2","display_name":"polycomb repressive complex 2","score":0.7789999842643738},{"id":"https://openalex.org/keywords/nfib","display_name":"NFIB","score":0.6909999847412109},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.32499998807907104},{"id":"https://openalex.org/keywords/cytokine-withdrawal","display_name":"cytokine withdrawal","score":0.6779999732971191},{"id":"https://openalex.org/keywords/stat5b","display_name":"STAT5B","score":0.6499999761581421},{"id":"https://openalex.org/keywords/mapk14","display_name":"MAPK14","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.6972464323043823},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6525143384933472},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6353247165679932},{"id":"https://openalex.org/C2781057849","wikidata":"https://www.wikidata.org/wiki/Q1368780","display_name":"Essential thrombocythemia","level":3,"score":0.6230928897857666},{"id":"https://openalex.org/C2778837598","wikidata":"https://www.wikidata.org/wiki/Q948318","display_name":"Polycythemia vera","level":2,"score":0.5582888722419739},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5029940009117126},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5023181438446045},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4683719575405121},{"id":"https://openalex.org/C2780365373","wikidata":"https://www.wikidata.org/wiki/Q2454191","display_name":"Trisomy 8","level":5,"score":0.4646536707878113},{"id":"https://openalex.org/C2776229224","wikidata":"https://www.wikidata.org/wiki/Q844903","display_name":"Trisomy","level":2,"score":0.45511937141418457},{"id":"https://openalex.org/C2781107747","wikidata":"https://www.wikidata.org/wiki/Q1898104","display_name":"Myeloproliferative neoplasm","level":4,"score":0.45445773005485535},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4482738971710205},{"id":"https://openalex.org/C68838962","wikidata":"https://www.wikidata.org/wiki/Q852654","display_name":"Haploinsufficiency","level":4,"score":0.4479137659072876},{"id":"https://openalex.org/C122060243","wikidata":"https://www.wikidata.org/wiki/Q7391885","display_name":"SNP array","level":5,"score":0.43273115158081055},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.42519333958625793},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.41436368227005005},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3115469217300415},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.2990338206291199},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22573566436767578},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.20937541127204895},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.14876443147659302},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.12848666310310364},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.11352953314781189}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/bcj.2011.39","doi":"https://doi.org/10.1038/bcj.2011.39","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bcj.2011.39","pdf_url":"https://www.nature.com/articles/bcj201139.pdf","source":{"id":"https://openalex.org/S2496263508","display_name":"Blood Cancer Journal","issn_l":"2044-5385","issn":["2044-5385"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Journal","raw_type":"journal-article"},{"id":"pmid:22829077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22829077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood cancer journal","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2263650","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3256752","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3256752","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3256752","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood Cancer J","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/bcj.2011.39","doi":"https://doi.org/10.1038/bcj.2011.39","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bcj.2011.39","pdf_url":"https://www.nature.com/articles/bcj201139.pdf","source":{"id":"https://openalex.org/S2496263508","display_name":"Blood Cancer Journal","issn_l":"2044-5385","issn":["2044-5385"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7300000190734863,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G5217826310","display_name":null,"funder_award_id":"R01 HL082950","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000604849.pdf","grobid_xml":"https://content.openalex.org/works/W2000604849.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W108809021","https://openalex.org/W1835174359","https://openalex.org/W1866691507","https://openalex.org/W1963679004","https://openalex.org/W1963891525","https://openalex.org/W1970390241","https://openalex.org/W1972420606","https://openalex.org/W1984065010","https://openalex.org/W1984567268","https://openalex.org/W1998393353","https://openalex.org/W1998548151","https://openalex.org/W2001006614","https://openalex.org/W2002302430","https://openalex.org/W2005293659","https://openalex.org/W2007567598","https://openalex.org/W2011476899","https://openalex.org/W2018983791","https://openalex.org/W2022930434","https://openalex.org/W2025391163","https://openalex.org/W2028803880","https://openalex.org/W2038195476","https://openalex.org/W2039736695","https://openalex.org/W2040551905","https://openalex.org/W2041062474","https://openalex.org/W2047079894","https://openalex.org/W2049145190","https://openalex.org/W2049545543","https://openalex.org/W2049819186","https://openalex.org/W2051181798","https://openalex.org/W2057360098","https://openalex.org/W2061289307","https://openalex.org/W2073653195","https://openalex.org/W2073783443","https://openalex.org/W2074452757","https://openalex.org/W2079421855","https://openalex.org/W2085404468","https://openalex.org/W2096717046","https://openalex.org/W2097743943","https://openalex.org/W2098528717","https://openalex.org/W2098731025","https://openalex.org/W2105949419","https://openalex.org/W2116318886","https://openalex.org/W2122410503","https://openalex.org/W2133174470","https://openalex.org/W2150823341","https://openalex.org/W2156694334","https://openalex.org/W2169172058"],"related_works":["https://openalex.org/W2611711560","https://openalex.org/W2768900384","https://openalex.org/W4225657301","https://openalex.org/W3122862987","https://openalex.org/W970891229","https://openalex.org/W2950070322","https://openalex.org/W2109520421","https://openalex.org/W2513623177","https://openalex.org/W4256407125","https://openalex.org/W4320478167"],"abstract_inverted_index":{"Polycythemia":[0],"vera":[1],"(PV),":[2],"essential":[3],"thrombocythemia":[4],"and":[5,16,54,61,68,102,118,130,133,140,155,157,165,178],"primary":[6],"myelofibrosis,":[7],"are":[8,17],"myeloproliferative":[9],"neoplasms":[10],"(MPNs)":[11],"with":[12,19,72,77,101],"distinct":[13],"clinical":[14],"features":[15],"associated":[18,76],"the":[20,29,50],"JAK2V617F":[21,79,94],"mutation.":[22],"To":[23],"identify":[24],"genomic":[25],"anomalies":[26],"involved":[27,111],"in":[28,112,174,180],"pathogenesis":[30,114],"of":[31,63,86,99,125,148],"these":[32],"disorders,":[33],"we":[34],"profiled":[35],"87":[36],"MPN":[37,176],"patients":[38,100,177],"using":[39],"Affymetrix":[40],"250K":[41],"single-nucleotide":[42],"polymorphism":[43],"(SNP)":[44],"arrays.":[45],"Aberrations":[46],"affecting":[47,135,146],"chr9":[48,87,104],"were":[49,75],"most":[51],"frequently":[52],"observed":[53,122],"included":[55],"9pLOH":[56],"(n=16),":[57],"trisomy":[58,73],"9":[59,74],"(n=6)":[60],"amplifications":[62],"9p13.3-23.3":[64],"(n=1),":[65],"9q33.1-34.13":[66],"(n=1)":[67],"9q34.13":[69],"(n=6).":[70],"Patients":[71],"elevated":[78],"mutant":[80],"allele":[81],"burden,":[82],"suggesting":[83],"that":[84,169],"gain":[85],"represents":[88],"an":[89],"alternative":[90],"mechanism":[91],"for":[92],"increasing":[93],"dosage.":[95],"Gene":[96],"expression":[97,142],"profiling":[98],"without":[103],"abnormalities":[105],"(+9,":[106],"9pLOH),":[107],"identified":[108,144],"genes":[109,158],"potentially":[110],"disease":[113],"including":[115],"JAK2,":[116],"STAT5B":[117],"MAPK14.":[119],"We":[120,167],"also":[121],"recurrent":[123],"gains":[124],"1p36.31-36.33":[126],"(n=6),":[127],"17q21.2-q21.31":[128],"(n=5)":[129,132],"17q25.1-25.3":[131],"deletions":[134],"18p11.31-11.32":[136],"(n=8).":[137],"Combined":[138],"SNP":[139],"gene":[141],"analysis":[143],"aberrations":[145],"components":[147],"a":[149,160],"non-canonical":[150],"PRC2":[151],"complex":[152],"(EZH1,":[153],"SUZ12":[154],"JARID2)":[156],"comprising":[159],"'HSC":[161],"signature'":[162],"(MLLT3,":[163],"SMARCA2":[164],"PBX1).":[166],"show":[168],"NFIB,":[170],"which":[171],"is":[172],"amplified":[173],"7/87":[175],"upregulated":[179],"PV":[181],"CD34+":[182],"cells,":[183],"protects":[184],"cells":[185],"from":[186],"apoptosis":[187],"induced":[188],"by":[189],"cytokine":[190],"withdrawal.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}