{"id":"https://openalex.org/W2000590593","doi":"https://doi.org/10.1089/jmf.2006.1089","title":"Cytotoxic Effect of Buckwheat ( Fagopyrum esculentum Moench) Hull Against Cancer Cells","display_name":"Cytotoxic Effect of Buckwheat ( Fagopyrum esculentum Moench) Hull Against Cancer Cells","publication_year":2007,"publication_date":"2007-06-01","ids":{"openalex":"https://openalex.org/W2000590593","doi":"https://doi.org/10.1089/jmf.2006.1089","mag":"2000590593","pmid":"https://pubmed.ncbi.nlm.nih.gov/17651057"},"language":"en","primary_location":{"id":"doi:10.1089/jmf.2006.1089","doi":"https://doi.org/10.1089/jmf.2006.1089","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jmf.2006.1089","pdf_url":null,"source":{"id":"https://openalex.org/S78718175","display_name":"Journal of Medicinal Food","issn_l":"1096-620X","issn":["1096-620X","1557-7600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Food","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100379505","display_name":"Soo-Hyun Kim","orcid":"https://orcid.org/0000-0002-8247-1062","observed_orcids":["https://orcid.org/0000-0002-8247-1062"]},"institutions":[{"id":"https://openalex.org/I146824383","display_name":"Hallym University","ror":"https://ror.org/03sbhge02","country_code":"KR","type":"education","lineage":["https://openalex.org/I146824383"]},{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soo-Hyun Kim","raw_affiliation_strings":["Department of Food Science and Nutrition, Hallym University, Chunchon, Republic of Korea","School of Food Bioscience and Biotechnology, Kangwon National University, Chunchon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Nutrition, Hallym University, Chunchon, Republic of Korea","institution_ids":["https://openalex.org/I146824383"]},{"raw_affiliation_string":"School of Food Bioscience and Biotechnology, Kangwon National University, Chunchon, Republic of Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049233008","display_name":"Chengbi Cui","orcid":"https://orcid.org/0000-0002-5207-3506","observed_orcids":["https://orcid.org/0000-0002-5207-3506"]},"institutions":[{"id":"https://openalex.org/I1793135","display_name":"Yanbian University","ror":"https://ror.org/039xnh269","country_code":"CN","type":"education","lineage":["https://openalex.org/I1793135"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng-Bi Cui","raw_affiliation_strings":["Department of Food Science and Engineering, Agricultural College of Yanbian University, Longjing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Engineering, Agricultural College of Yanbian University, Longjing, People's Republic of China","institution_ids":["https://openalex.org/I1793135"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016926065","display_name":"Il\u2010Jun Kang","orcid":"https://orcid.org/0000-0003-0314-5195","observed_orcids":["https://orcid.org/0000-0003-0314-5195"]},"institutions":[{"id":"https://openalex.org/I146824383","display_name":"Hallym University","ror":"https://ror.org/03sbhge02","country_code":"KR","type":"education","lineage":["https://openalex.org/I146824383"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Il-Jun Kang","raw_affiliation_strings":["Department of Food Science and Nutrition, Hallym University, Chunchon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Nutrition, Hallym University, Chunchon, Republic of Korea","institution_ids":["https://openalex.org/I146824383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100335632","display_name":"Sun Young Kim","orcid":"https://orcid.org/0000-0003-4115-4455","observed_orcids":["https://orcid.org/0000-0003-4115-4455","https://orcid.org/0009-0002-1737-2540"]},"institutions":[{"id":"https://openalex.org/I146824383","display_name":"Hallym University","ror":"https://ror.org/03sbhge02","country_code":"KR","type":"education","lineage":["https://openalex.org/I146824383"]},{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sun Young Kim","raw_affiliation_strings":["Department of Food Science and Nutrition, Hallym University, Chunchon, Republic of Korea","School of Food Bioscience and Biotechnology, Kangwon National University, Chunchon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Nutrition, Hallym University, Chunchon, Republic of Korea","institution_ids":["https://openalex.org/I146824383"]},{"raw_affiliation_string":"School of Food Bioscience and Biotechnology, Kangwon National University, Chunchon, Republic of Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113554335","display_name":"Seung\u2010Shi Ham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung-Shi Ham","raw_affiliation_strings":["School of Food Bioscience and Biotechnology, Kangwon National University, Chunchon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food Bioscience and Biotechnology, Kangwon National University, Chunchon, Republic of Korea","institution_ids":["https://openalex.org/I165507594"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2394,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.78847085,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"2","first_page":"232","last_page":"238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12403","display_name":"Seed and Plant Biochemistry","score":0.7275000214576721,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12403","display_name":"Seed and Plant Biochemistry","score":0.7275000214576721,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.15690000355243683,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.06430000066757202,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/buckwheat-hulls","display_name":"buckwheat hulls","score":0.9850000143051147},{"id":"https://openalex.org/keywords/buckwheat","display_name":"buckwheat","score":1.0},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8939999938011169},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9909999966621399},{"id":"https://openalex.org/keywords/ethanol-extract","display_name":"ethanol extract","score":0.7210000157356262},{"id":"https://openalex.org/keywords/ethyl-acetate-fraction","display_name":"ethyl acetate fraction","score":0.8569999933242798},{"id":"https://openalex.org/keywords/n-hexane-fraction","display_name":"n-hexane fraction","score":0.8119999766349792},{"id":"https://openalex.org/keywords/chloroform-fraction","display_name":"chloroform fraction","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8349999785423279},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.847000002861023},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/sarcoma-180","display_name":"sarcoma 180","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5659999847412109},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C2778229473","wikidata":"https://www.wikidata.org/wiki/Q7223832","display_name":"Fagopyrum","level":2,"score":0.8461238145828247},{"id":"https://openalex.org/C2779858419","wikidata":"https://www.wikidata.org/wiki/Q407153","display_name":"Ethyl acetate","level":2,"score":0.8223884105682373},{"id":"https://openalex.org/C2781144210","wikidata":"https://www.wikidata.org/wiki/Q172275","display_name":"Chloroform","level":2,"score":0.7134132981300354},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.7035864591598511},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.6998739242553711},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.636139452457428},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4878263771533966},{"id":"https://openalex.org/C2777077568","wikidata":"https://www.wikidata.org/wiki/Q150440","display_name":"Hexane","level":2,"score":0.44469594955444336},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.40982547402381897},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.35672104358673096},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31408506631851196},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2832813858985901},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.2389765977859497},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08492004871368408}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012510","descriptor_name":"Sarcoma 180","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012510","descriptor_name":"Sarcoma 180","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012639","descriptor_name":"Seeds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019612","descriptor_name":"Fagopyrum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/jmf.2006.1089","doi":"https://doi.org/10.1089/jmf.2006.1089","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jmf.2006.1089","pdf_url":null,"source":{"id":"https://openalex.org/S78718175","display_name":"Journal of Medicinal Food","issn_l":"1096-620X","issn":["1096-620X","1557-7600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Food","raw_type":"journal-article"},{"id":"pmid:17651057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17651057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal food","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W39582043","https://openalex.org/W189830354","https://openalex.org/W1629179716","https://openalex.org/W1969857753","https://openalex.org/W1987720877","https://openalex.org/W1988041967","https://openalex.org/W1989187255","https://openalex.org/W2001921930","https://openalex.org/W2007166015","https://openalex.org/W2012635889","https://openalex.org/W2017076019","https://openalex.org/W2028635876","https://openalex.org/W2031636608","https://openalex.org/W2035018038","https://openalex.org/W2056678264","https://openalex.org/W2071149346","https://openalex.org/W2073278265","https://openalex.org/W2073353638","https://openalex.org/W2077040585","https://openalex.org/W2077041474","https://openalex.org/W2082026141","https://openalex.org/W2097744068","https://openalex.org/W2098400443","https://openalex.org/W2128723116","https://openalex.org/W2143811153","https://openalex.org/W2157603347"],"related_works":["https://openalex.org/W2355485870","https://openalex.org/W1981257377","https://openalex.org/W3003946939","https://openalex.org/W2386626572","https://openalex.org/W2144654304","https://openalex.org/W2065825292","https://openalex.org/W795045956","https://openalex.org/W6892573270","https://openalex.org/W2167866711","https://openalex.org/W4391924186"],"abstract_inverted_index":{"Buckwheat":[0],"(Fagopyrum":[1],"esculentum":[2],"Moench)":[3],"hull":[4,207],"was":[5],"extracted":[6],"with":[7,14,82,143],"70%":[8],"ethanol":[9,167],"and":[10,19,30,50,64,98,108,135,140,175,184],"then":[11],"further":[12],"fractionated":[13],"n-hexane,":[15],"chloroform,":[16],"ethyl":[17,31,71],"acetate,":[18],"water":[20],"stepwise.":[21],"In":[22],"the":[23,45,75,83,96,138,166,196],"in":[24,187,190],"vitro":[25],"test":[26],"(SRB":[27],"assay),":[28],"hexane":[29,97],"acetate":[32,72],"fractions":[33,100],"showed":[34,90,113,178],"higher":[35,56,102,114],"inhibition":[36,57,77,93,115,128,152],"effects":[37,116],"against":[38,59,79,117,130,158,211],"MCF-7":[39],"cells":[40,61,81,132],"than":[41,95,122,156,182],"other":[42,124],"samples":[43,112,149],"at":[44,67,101,161,171],"1":[46,68],"mg/mL":[47],"level:":[48],"89%":[49],"93.2%,":[51],"respectively.":[52,146],"They":[53],"also":[54],"displayed":[55],"rates":[58,129],"Hep3B":[60],"of":[62,85,104,154,173,180,214],"83.6%":[63],"75.3%,":[65],"respectively,":[66,186],"mg/mL.":[69,110],"The":[70,127],"fraction":[73,142],"yielded":[74,150],"highest":[76],"rate":[78,94,153],"A549":[80],"level":[84],"0.25":[86],"mg/mL,":[87,145],"but":[88],"it":[89,202],"a":[91,212],"lower":[92],"chloroform":[99,139],"levels":[103],"sample,":[105],"i.e.,":[106],"0.75":[107],"1.0":[109],"All":[111,169],"AGS":[118],"human":[119],"gastric":[120],"carcinoma":[121],"any":[123],"cancer":[125,216],"cells.":[126],"HeLa":[131],"were":[133],"81.2%":[134],"82.0%":[136],"for":[137,195],"butanol":[141],"0.5":[144],"However,":[147],"all":[148,162],"an":[151],"less":[155],"35%":[157],"normal":[159],"cells,":[160],"treatment":[163],"levels,":[164],"except":[165,194],"extract.":[168],"extracts":[170],"doses":[172],"25":[174],"50":[176],"mg/kg":[177],"decreases":[179],"more":[181],"20%":[183],"42%,":[185],"tumor":[188],"formation":[189],"sarcoma-180":[191],"implanted":[192],"mice":[193],"aqueous":[197],"fraction.":[198],"From":[199],"these":[200],"results,":[201],"is":[203],"suggested":[204],"that":[205],"buckwheat":[206],"possesses":[208],"anticancer":[209],"properties":[210],"variety":[213],"different":[215],"cell":[217],"lines.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}