{"id":"https://openalex.org/W2000588507","doi":"https://doi.org/10.1021/bi0257033","title":"Participation of Rac GTPase Activating Proteins in the Deactivation of the Phagocytic NADPH Oxidase","display_name":"Participation of Rac GTPase Activating Proteins in the Deactivation of the Phagocytic NADPH Oxidase","publication_year":2002,"publication_date":"2002-08-01","ids":{"openalex":"https://openalex.org/W2000588507","doi":"https://doi.org/10.1021/bi0257033","mag":"2000588507","pmid":"https://pubmed.ncbi.nlm.nih.gov/12186557"},"language":"en","primary_location":{"id":"doi:10.1021/bi0257033","doi":"https://doi.org/10.1021/bi0257033","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi0257033","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024717565","display_name":"Patryk Moskwa","orcid":"https://orcid.org/0000-0002-0374-3761","observed_orcids":["https://orcid.org/0000-0002-0374-3761"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}],"countries":["FR","HU"],"is_corresponding":false,"raw_author_name":"Patryk Moskwa","raw_affiliation_strings":["Department of Physiology, Semmelweis University, P.O. Box 259, H-1444 Budapest, Hungary, Laboratoire DBMS/BBSI, CEA Grenoble, 17 Rue des Martyrs, 38054 Grenoble Cedex 9, France, and GREPI, Laboratoire d'Enzymologie, CHU Albert Michallon BP 217, 38043 Grenoble Cedex 9, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Semmelweis University, P.O. Box 259, H-1444 Budapest, Hungary, Laboratoire DBMS/BBSI, CEA Grenoble, 17 Rue des Martyrs, 38054 Grenoble Cedex 9, France, and GREPI, Laboratoire d'Enzymologie, CHU Albert Michallon BP 217, 38043 Grenoble Cedex 9, France","institution_ids":["https://openalex.org/I101202996","https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039401361","display_name":"Marie\u2010Claire Dagher","orcid":"https://orcid.org/0000-0001-6878-3169","observed_orcids":["https://orcid.org/0000-0001-6878-3169"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}],"countries":["FR","HU"],"is_corresponding":false,"raw_author_name":"Marie-Claire Dagher","raw_affiliation_strings":["Department of Physiology, Semmelweis University, P.O. Box 259, H-1444 Budapest, Hungary, Laboratoire DBMS/BBSI, CEA Grenoble, 17 Rue des Martyrs, 38054 Grenoble Cedex 9, France, and GREPI, Laboratoire d'Enzymologie, CHU Albert Michallon BP 217, 38043 Grenoble Cedex 9, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Semmelweis University, P.O. Box 259, H-1444 Budapest, Hungary, Laboratoire DBMS/BBSI, CEA Grenoble, 17 Rue des Martyrs, 38054 Grenoble Cedex 9, France, and GREPI, Laboratoire d'Enzymologie, CHU Albert Michallon BP 217, 38043 Grenoble Cedex 9, France","institution_ids":["https://openalex.org/I101202996","https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111896136","display_name":"Marie\u2010H\u00e9l\u00e8ne Paclet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}],"countries":["FR","HU"],"is_corresponding":false,"raw_author_name":"Marie-H\u00e9l\u00e8ne Paclet","raw_affiliation_strings":["Department of Physiology, Semmelweis University, P.O. Box 259, H-1444 Budapest, Hungary, Laboratoire DBMS/BBSI, CEA Grenoble, 17 Rue des Martyrs, 38054 Grenoble Cedex 9, France, and GREPI, Laboratoire d'Enzymologie, CHU Albert Michallon BP 217, 38043 Grenoble Cedex 9, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Semmelweis University, P.O. Box 259, H-1444 Budapest, Hungary, Laboratoire DBMS/BBSI, CEA Grenoble, 17 Rue des Martyrs, 38054 Grenoble Cedex 9, France, and GREPI, Laboratoire d'Enzymologie, CHU Albert Michallon BP 217, 38043 Grenoble Cedex 9, France","institution_ids":["https://openalex.org/I101202996","https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032651599","display_name":"Fran\u00e7oise Morel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}],"countries":["FR","HU"],"is_corresponding":false,"raw_author_name":"Francoise Morel","raw_affiliation_strings":["Department of Physiology, Semmelweis University, P.O. Box 259, H-1444 Budapest, Hungary, Laboratoire DBMS/BBSI, CEA Grenoble, 17 Rue des Martyrs, 38054 Grenoble Cedex 9, France, and GREPI, Laboratoire d'Enzymologie, CHU Albert Michallon BP 217, 38043 Grenoble Cedex 9, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Semmelweis University, P.O. Box 259, H-1444 Budapest, Hungary, Laboratoire DBMS/BBSI, CEA Grenoble, 17 Rue des Martyrs, 38054 Grenoble Cedex 9, France, and GREPI, Laboratoire d'Enzymologie, CHU Albert Michallon BP 217, 38043 Grenoble Cedex 9, France","institution_ids":["https://openalex.org/I101202996","https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023653704","display_name":"Erzs\u00e9bet Ligeti","orcid":"https://orcid.org/0000-0001-6374-729X","observed_orcids":["https://orcid.org/0000-0001-6374-729X"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}],"countries":["FR","HU"],"is_corresponding":true,"raw_author_name":"Erzs\u00e9bet Ligeti","raw_affiliation_strings":["Department of Physiology, Semmelweis University, P.O. Box 259, H-1444 Budapest, Hungary, Laboratoire DBMS/BBSI, CEA Grenoble, 17 Rue des Martyrs, 38054 Grenoble Cedex 9, France, and GREPI, Laboratoire d'Enzymologie, CHU Albert Michallon BP 217, 38043 Grenoble Cedex 9, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Semmelweis University, P.O. Box 259, H-1444 Budapest, Hungary, Laboratoire DBMS/BBSI, CEA Grenoble, 17 Rue des Martyrs, 38054 Grenoble Cedex 9, France, and GREPI, Laboratoire d'Enzymologie, CHU Albert Michallon BP 217, 38043 Grenoble Cedex 9, France","institution_ids":["https://openalex.org/I101202996","https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5023653704"],"corresponding_institution_ids":["https://openalex.org/I101202996","https://openalex.org/I2738703131","https://openalex.org/I3020098449"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.9486,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.72321054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"41","issue":"34","first_page":"10710","last_page":"10716"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.07599999755620956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0494999997317791,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.9440000057220459},{"id":"https://openalex.org/keywords/rac-gtpase","display_name":"Rac GTPase","score":0.9580000042915344},{"id":"https://openalex.org/keywords/gtpase-activating-protein","display_name":"GTPase-activating protein","score":0.9350000023841858},{"id":"https://openalex.org/keywords/superoxide-production","display_name":"superoxide production","score":0.6629999876022339},{"id":"https://openalex.org/keywords/phagocytes","display_name":"phagocytes","score":0.5989999771118164},{"id":"https://openalex.org/keywords/p67phox","display_name":"p67phox","score":0.9169999957084656},{"id":"https://openalex.org/keywords/p47phox","display_name":"p47phox","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gdp-binding","display_name":"GDP binding","score":0.4909999966621399},{"id":"https://openalex.org/keywords/gtp-hydrolysis","display_name":"GTP hydrolysis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/guanine-nucleotide-dissociation-inhibitor","display_name":"guanine nucleotide dissociation inhibitor","score":0.906000018119812},{"id":"https://openalex.org/keywords/p21-activated-kinase","display_name":"p21-activated kinase","score":0.9610000252723694},{"id":"https://openalex.org/keywords/enzyme-inactivation","display_name":"enzyme inactivation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/electron-transfer","display_name":"electron transfer","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.7840678691864014},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.7762913703918457},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6529663801193237},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.5794208645820618},{"id":"https://openalex.org/C2780298669","wikidata":"https://www.wikidata.org/wiki/Q415071","display_name":"Small GTPase","level":3,"score":0.5745497941970825},{"id":"https://openalex.org/C2909331102","wikidata":"https://www.wikidata.org/wiki/Q7278834","display_name":"Rac GTP-Binding Proteins","level":4,"score":0.5671452283859253},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5501474142074585},{"id":"https://openalex.org/C38485361","wikidata":"https://www.wikidata.org/wiki/Q576379","display_name":"Oxidase test","level":3,"score":0.538141131401062},{"id":"https://openalex.org/C125209161","wikidata":"https://www.wikidata.org/wiki/Q422816","display_name":"Enzyme activator","level":3,"score":0.531703770160675},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5177621245384216},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5073084235191345},{"id":"https://openalex.org/C163181125","wikidata":"https://www.wikidata.org/wiki/Q408592","display_name":"GTPase-activating protein","level":4,"score":0.4923204183578491},{"id":"https://openalex.org/C126619667","wikidata":"https://www.wikidata.org/wiki/Q901088","display_name":"Guanine nucleotide exchange factor","level":3,"score":0.48497605323791504},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.3711611032485962},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.27901971340179443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20341718196868896},{"id":"https://openalex.org/C2779717556","wikidata":"https://www.wikidata.org/wiki/Q15325735","display_name":"RAC1","level":3,"score":0.12258368730545044}],"mesh":[{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006153","descriptor_name":"Guanosine Diphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006153","descriptor_name":"Guanosine Diphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020744","descriptor_name":"rac GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/bi0257033","doi":"https://doi.org/10.1021/bi0257033","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi0257033","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:12186557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12186557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00820765v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00820765","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochemistry, 2002, 41 (34), pp.10710-6","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1505601192","https://openalex.org/W1513607523","https://openalex.org/W1598822958","https://openalex.org/W1606357879","https://openalex.org/W1883982053","https://openalex.org/W1964980219","https://openalex.org/W1970543829","https://openalex.org/W1973287769","https://openalex.org/W1978071486","https://openalex.org/W2006236607","https://openalex.org/W2011756230","https://openalex.org/W2026335497","https://openalex.org/W2030118718","https://openalex.org/W2035644849","https://openalex.org/W2083108636","https://openalex.org/W2155774039","https://openalex.org/W2370426177","https://openalex.org/W4206624550"],"related_works":["https://openalex.org/W1971530975","https://openalex.org/W2041916161","https://openalex.org/W2074423228","https://openalex.org/W2093736156","https://openalex.org/W2088006040","https://openalex.org/W2006236607","https://openalex.org/W2906819101","https://openalex.org/W2052272939","https://openalex.org/W2065586676","https://openalex.org/W2084572807"],"abstract_inverted_index":{"The":[0],"aim":[1],"of":[2,18,25,33,44,99,107,147,165],"the":[3,16,19,40,47,58,96,100,108,119,133,143,163],"present":[4],"study":[5],"was":[6],"to":[7,31,46,52,132],"investigate":[8],"possible":[9],"mechanisms":[10],"that":[11,142,156],"could":[12],"be":[13],"involved":[14],"in":[15,57,62,162],"deactivation":[17,164],"assembled,":[20,134],"catalytically":[21,135],"active":[22,48,136,145],"NADPH":[23,109,166],"oxidase":[24,49,110],"phagocytic":[26],"cells":[27],"and":[28,61,95,155],"thereby":[29],"lead":[30],"termination":[32],"O(2)(.-)":[34,54],"production.":[35],"Our":[36],"major":[37],"findings":[38],"are":[39],"following:":[41],"(1)":[42],"Addition":[43],"GDP":[45],"is":[50,149],"able":[51],"reduce":[53],"production":[55],"both":[56],"fully":[59],"purified":[60],"a":[63,160],"semi-recombinant":[64],"cell-free":[65],"activation":[66,106],"system.":[67],"(2)":[68],"p67(phox)":[69],"inhibits":[70],"GTP":[71],"hydrolysis":[72],"on":[73,80,115],"Rac":[74,81,148],"whereas":[75],"p47(phox)":[76],"has":[77],"no":[78,113],"effect":[79,114],"GTPase":[82,125],"activity.":[83],"(3)":[84],"Soluble":[85],"regulatory":[86],"proteins":[87,127],"(GTPase":[88],"activating":[89,126],"protein,":[90],"guanine":[91],"nucleotide":[92],"dissociation":[93],"inhibitor,":[94],"Rac-binding":[97],"domain":[98],"target":[101],"protein":[102],"p21-activated":[103],"kinase)":[104],"inhibit":[105],"but":[111],"have":[112,129,159],"electron":[116],"transfer":[117],"via":[118],"assembled":[120],"enzyme":[121,153],"complex.":[122],"(4)":[123],"Membrane-associated":[124],"(GAPs)":[128],"access":[130],"also":[131],"oxidase.":[137,167],"Taken":[138],"together,":[139],"we":[140],"propose":[141],"GTP-bound":[144],"form":[146],"required":[150],"for":[151],"sustained":[152],"activity":[154],"membrane-localized":[157],"GAPs":[158],"role":[161]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}