{"id":"https://openalex.org/W2000587290","doi":"https://doi.org/10.1093/humrep/deu281","title":"Young women with polycystic ovary syndrome have raised levels of circulating annexin V-positive platelet microparticles","display_name":"Young women with polycystic ovary syndrome have raised levels of circulating annexin V-positive platelet microparticles","publication_year":2014,"publication_date":"2014-10-21","ids":{"openalex":"https://openalex.org/W2000587290","doi":"https://doi.org/10.1093/humrep/deu281","mag":"2000587290","pmid":"https://pubmed.ncbi.nlm.nih.gov/25336711"},"language":"en","primary_location":{"id":"doi:10.1093/humrep/deu281","doi":"https://doi.org/10.1093/humrep/deu281","is_oa":true,"landing_page_url":"https://doi.org/10.1093/humrep/deu281","pdf_url":"https://academic.oup.com/humrep/article-pdf/29/12/2756/17371726/deu281.pdf","source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/humrep/article-pdf/29/12/2756/17371726/deu281.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039732957","display_name":"Gareth R. Willis","orcid":"https://orcid.org/0000-0002-7302-8261","observed_orcids":["https://orcid.org/0000-0002-7302-8261"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G.R. Willis","raw_affiliation_strings":["Institute of Molecular and Experimental Medicine, Cardiff University, Cardiff CF14 4XN, UK","1Institute of Molecular and Experimental Medicine, Cardiff University, Cardiff CF14 4XN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Experimental Medicine, Cardiff University, Cardiff CF14 4XN, UK","institution_ids":["https://openalex.org/I79510175"]},{"raw_affiliation_string":"1Institute of Molecular and Experimental Medicine, Cardiff University, Cardiff CF14 4XN, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079556874","display_name":"Katherine D. Connolly","orcid":"https://orcid.org/0000-0003-1074-1710","observed_orcids":["https://orcid.org/0000-0003-1074-1710"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K. Connolly","raw_affiliation_strings":["Institute of Molecular and Experimental Medicine, Cardiff University, Cardiff CF14 4XN, UK","1Institute of Molecular and Experimental Medicine, Cardiff University, Cardiff CF14 4XN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Experimental Medicine, Cardiff University, Cardiff CF14 4XN, UK","institution_ids":["https://openalex.org/I79510175"]},{"raw_affiliation_string":"1Institute of Molecular and Experimental Medicine, Cardiff University, Cardiff CF14 4XN, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049518622","display_name":"Kristin Ladell","orcid":"https://orcid.org/0000-0002-9856-2938","observed_orcids":["https://orcid.org/0000-0002-9856-2938"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K. Ladell","raw_affiliation_strings":["Institute of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T.S. Davies","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T.S. Davies","raw_affiliation_strings":["School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080297176","display_name":"Irina A. Guschina","orcid":"https://orcid.org/0000-0002-2664-9145","observed_orcids":["https://orcid.org/0000-0002-2664-9145"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I.A. Guschina","raw_affiliation_strings":["School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046034466","display_name":"Dipak P. Ramji","orcid":"https://orcid.org/0000-0002-6419-5578","observed_orcids":["https://orcid.org/0000-0002-6419-5578"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. Ramji","raw_affiliation_strings":["School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068766881","display_name":"Kelly L. Miners","orcid":"https://orcid.org/0000-0002-7046-6493","observed_orcids":["https://orcid.org/0000-0002-7046-6493"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K. Miners","raw_affiliation_strings":["Institute of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100694592","display_name":"David A. Price","orcid":"https://orcid.org/0000-0001-9416-2737","observed_orcids":["https://orcid.org/0000-0001-9416-2737","https://orcid.org/0000-0002-0235-9450"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D.A. Price","raw_affiliation_strings":["Institute of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086641002","display_name":"Aled Clayton","orcid":"https://orcid.org/0000-0002-3087-9226","observed_orcids":["https://orcid.org/0000-0002-3087-9226"]},"institutions":[{"id":"https://openalex.org/I4210150388","display_name":"Velindre Cancer Centre","ror":"https://ror.org/049sr1d03","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799279586","https://openalex.org/I4210150388"]},{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Clayton","raw_affiliation_strings":["Institute of Cancer and Genetics, Cardiff University, Velindre Cancer Centre, Whitchurch, Cardiff CF14 2TL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cancer and Genetics, Cardiff University, Velindre Cancer Centre, Whitchurch, Cardiff CF14 2TL, UK","institution_ids":["https://openalex.org/I4210150388","https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084107485","display_name":"Philip Eurig James","orcid":"https://orcid.org/0000-0001-5254-0250","observed_orcids":["https://orcid.org/0000-0001-5254-0250"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P.E. James","raw_affiliation_strings":["Institute of Molecular and Experimental Medicine, Cardiff University, Cardiff CF14 4XN, UK","1Institute of Molecular and Experimental Medicine, Cardiff University, Cardiff CF14 4XN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Experimental Medicine, Cardiff University, Cardiff CF14 4XN, UK","institution_ids":["https://openalex.org/I79510175"]},{"raw_affiliation_string":"1Institute of Molecular and Experimental Medicine, Cardiff University, Cardiff CF14 4XN, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088158896","display_name":"Aled Rees","orcid":"https://orcid.org/0000-0002-1165-9092","observed_orcids":["https://orcid.org/0000-0002-1165-9092"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"D.A. Rees","raw_affiliation_strings":["Institute of Molecular and Experimental Medicine, Cardiff University, Cardiff CF14 4XN, UK reesda@cf.ac.uk","1Institute of Molecular and Experimental Medicine, Cardiff University, Cardiff CF14 4XN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Experimental Medicine, Cardiff University, Cardiff CF14 4XN, UK reesda@cf.ac.uk","institution_ids":["https://openalex.org/I79510175"]},{"raw_affiliation_string":"1Institute of Molecular and Experimental Medicine, Cardiff University, Cardiff CF14 4XN, UK","institution_ids":["https://openalex.org/I79510175"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088158896"],"corresponding_institution_ids":["https://openalex.org/I79510175"],"apc_list":{"value":4097,"currency":"EUR","value_usd":4630},"apc_paid":null,"fwci":3.2283,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.8977209,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"29","issue":"12","first_page":"2756","last_page":"2763"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.34060001373291016,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":1.0},{"id":"https://openalex.org/keywords/circulating-microparticles","display_name":"circulating microparticles","score":0.875},{"id":"https://openalex.org/keywords/platelet-microparticles","display_name":"platelet microparticles","score":0.8799999952316284},{"id":"https://openalex.org/keywords/annexin-v","display_name":"annexin V","score":0.902999997138977},{"id":"https://openalex.org/keywords/phosphatidylserine-exposure","display_name":"phosphatidylserine exposure","score":0.9700000286102295},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6320000290870667},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.8650000095367432},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.7760000228881836},{"id":"https://openalex.org/keywords/young-women","display_name":"young women","score":0.6539999842643738},{"id":"https://openalex.org/keywords/microparticle-size-distribution","display_name":"microparticle size distribution","score":0.546999990940094},{"id":"https://openalex.org/keywords/monocyte-derived-microparticles","display_name":"monocyte-derived microparticles","score":0.6740000247955322},{"id":"https://openalex.org/keywords/endothelial-microparticles","display_name":"endothelial microparticles","score":0.9649999737739563},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7329999804496765},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.9482307434082031},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.5938112735748291},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5871922373771667},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5344941020011902},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5206276774406433},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5189732909202576},{"id":"https://openalex.org/C2780670749","wikidata":"https://www.wikidata.org/wiki/Q14908239","display_name":"Annexin A5","level":4,"score":0.4271470308303833},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.42604124546051025},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.414532870054245},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1314128041267395},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.1207684576511383},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.0910259485244751},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017304","descriptor_name":"Annexin A5","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D055252","descriptor_name":"Cell-Derived Microparticles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/humrep/deu281","doi":"https://doi.org/10.1093/humrep/deu281","is_oa":true,"landing_page_url":"https://doi.org/10.1093/humrep/deu281","pdf_url":"https://academic.oup.com/humrep/article-pdf/29/12/2756/17371726/deu281.pdf","source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},{"id":"pmid:25336711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25336711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human reproduction (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:oai:figshare.com:article/19802827","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Young_women_with_polycystic_ovary_syndrome_have_raised_levels_of_circulating_annexin_V-positive_platelet_microparticles/19802827","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:69574","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/69574/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:repository.cardiffmet.ac.uk:10369/7731","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10369/7731","pdf_url":null,"source":{"id":"https://openalex.org/S4306401326","display_name":"Cardiff Metropolitan Research Repository (Cardiff Metropolitan University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8408910","host_organization_name":"Cardiff Metropolitan University","host_organization_lineage":["https://openalex.org/I8408910"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/humrep/deu281","doi":"https://doi.org/10.1093/humrep/deu281","is_oa":true,"landing_page_url":"https://doi.org/10.1093/humrep/deu281","pdf_url":"https://academic.oup.com/humrep/article-pdf/29/12/2756/17371726/deu281.pdf","source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4225670654","display_name":"The immunopathogenesis of Epstein-Barr virus-associated malignancies.","funder_award_id":"100326","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5080491770","display_name":"The immunopathogenesis of Epstein-Barr virus-associated malignancies.","funder_award_id":"100326/Z/12/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000587290.pdf","grobid_xml":"https://content.openalex.org/works/W2000587290.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W157203447","https://openalex.org/W1709272109","https://openalex.org/W1969327353","https://openalex.org/W1973894250","https://openalex.org/W1985578715","https://openalex.org/W1986309137","https://openalex.org/W1989475947","https://openalex.org/W2017906741","https://openalex.org/W2019823845","https://openalex.org/W2030643176","https://openalex.org/W2041663853","https://openalex.org/W2048353910","https://openalex.org/W2060384563","https://openalex.org/W2061650392","https://openalex.org/W2076637458","https://openalex.org/W2080013284","https://openalex.org/W2100224373","https://openalex.org/W2105139020","https://openalex.org/W2108375854","https://openalex.org/W2110778029","https://openalex.org/W2111213998","https://openalex.org/W2114577467","https://openalex.org/W2116612435","https://openalex.org/W2123409535","https://openalex.org/W2124000087","https://openalex.org/W2124339684","https://openalex.org/W2124480950","https://openalex.org/W2135971398","https://openalex.org/W2137742067","https://openalex.org/W2140713125","https://openalex.org/W2150577386","https://openalex.org/W2168183582","https://openalex.org/W2330822612"],"related_works":["https://openalex.org/W2057980021","https://openalex.org/W7100225688","https://openalex.org/W2105139020","https://openalex.org/W2573938994","https://openalex.org/W4283072341","https://openalex.org/W1989475947","https://openalex.org/W3008790005","https://openalex.org/W2315046152","https://openalex.org/W4225838765","https://openalex.org/W7095777265"],"abstract_inverted_index":{"STUDY":[0,89,458],"QUESTION:":[1],"Are":[2],"circulating":[3,24,455],"microparticles":[4],"(MPs)":[5],"altered":[6,34,422],"in":[7,55,73,83,134,239,244,251,364,378,400],"young":[8,56],"women":[9,57,97,417],"with":[10,18,39,58,75,85,98,198,221,266,325,356,418],"polycystic":[11],"ovary":[12],"syndrome":[13],"(PCOS)?":[14],"SUMMARY":[15],"ANSWER:":[16],"Women":[17],"PCOS":[19,59,86,99,191,255,326,419],"have":[20,48,420,480],"elevated":[21,72],"concentrations":[22,196],"of":[23,81,225,261,284,343,368,375,483],"platelet-derived":[25,289],"MPs,":[26,285],"which":[27,64,219,286,333,438],"exhibit":[28],"increased":[29,54,194],"annexin":[30,161,262],"V":[31,162],"binding":[32],"and":[33,113,142,160,175,305,394,442,473],"microRNA":[35],"(miR)":[36],"profiles":[37,179],"compared":[38,181,197,265],"healthy":[40,115,199,267],"volunteers.":[41],"WHAT":[42],"IS":[43],"KNOWN":[44],"ALREADY:":[45],"Some":[46],"studies":[47,427],"shown":[49],"that":[50,416,447],"cardiovascular":[51,76],"risk":[52],"is":[53,382,396],"but":[60,78,280,311,425],"the":[61,79,222,245,281,330,344,369,390,401,435,468],"mechanisms":[62,436],"by":[63,172,182,329,437,465],"this":[65],"occurs":[66],"are":[67,71,87,428,451],"uncertain.":[68],"Circulating":[69],"MPs":[70,82,240,264],"patients":[74,84,256,355],"disease":[77],"characteristics":[80],"unclear.":[88],"DESIGN,":[90],"SIZE,":[91],"DURATION:":[92],"Case-control":[93],"study":[94,131,371,414,462],"comprising":[95],"17":[96],"(mean":[100,201],"\u00b1":[101,105,110,119,124,202,205,211,270,274,292,296],"SD;":[102,203],"age":[103],"31":[104,118],"7":[106],"years,":[107,121],"BMI":[108,122],"29":[109],"6":[111,120,125],"kg/m(2))":[112],"18":[114,271],"volunteers":[116,200,268],"(age":[117],"30":[123],"kg/m(2)).":[126],"PARTICIPANTS/MATERIALS,":[127],"SETTING,":[128],"METHODS:":[129],"The":[130,461,478],"was":[132,170,236,243,307,361,463],"conducted":[133],"a":[135,258,335,379],"University":[136],"hospital.":[137],"Nanoparticle":[138],"tracking":[139],"analysis":[140,169,360],"(NTA)":[141],"flow":[143],"cytometry":[144],"(CD41":[145],"platelet,":[146],"CD11b":[147],"monocyte,":[148],"CD144":[149],"endothelial)":[150],"were":[151,180,287,314,327,387],"used":[152],"to":[153,353,430,433,443,453,485],"determine":[154],"MP":[155,176,195,301,423,456],"size,":[156],"concentration,":[157],"cellular":[158,282],"origin":[159,283],"positivity":[163],"(reflecting":[164],"phosphatidylserine":[165],"exposure).":[166],"Fatty":[167],"acid":[168,303],"performed":[171],"gas":[173],"chromatography":[174],"miR":[177,385],"expression":[178,359],"microarray.":[183],"MAIN":[184],"RESULTS":[185],"AND":[186],"THE":[187,411],"ROLE":[188],"OF":[189,410],"CHANCE:":[190],"subjects":[192],"showed":[193,257],"11.5":[204],"5":[206],"\u00d7":[207,213],"10(12)/ml":[208],"versus":[209,272],"10.0":[210],"4":[212],"10(12)/ml,":[214],"respectively;":[215],"P":[216,231,277],"=":[217,229,232,278],"0.03),":[218],"correlated":[220],"homeostasis":[223],"model":[224],"insulin":[226,449],"resistance":[227],"(r":[228],"0.53,":[230],"0.03).":[233],"This":[234,413],"difference":[235],"predominantly":[237,288],"seen":[238],"whose":[241],"size":[242],"small":[246],"exosomal":[247],"range":[248],"(<150":[249],"nm":[250],"diameter,":[252],"P<":[253],"0.05).":[254,319],"greater":[259],"percentage":[260],"V(+)":[263],"(84":[269],"74":[273],"24%,":[275],"respectively,":[276],"0.05)":[279],"(PCOS:":[290],"99":[291,295],"0.9%;":[293],"controls:":[294],"2.5%),":[297],"did":[298],"not":[299,350],"differ.":[300],"fatty":[302],"concentration":[304],"composition":[306],"similar":[308],"between":[309],"groups":[310],"16":[312],"miRs":[313,393,404],"differentially":[315],"expressed":[316,392,403],"(P":[317],"<":[318],"LIMITATIONS,":[320],"REASON":[321],"FOR":[322],"CAUTION:":[323],"Patients":[324],"classified":[328],"Rotterdam":[331],"criteria,":[332],"describes":[334],"less":[336],"severe":[337],"metabolic":[338],"phenotype":[339],"than":[340],"other":[341],"definitions":[342],"syndrome.":[345],"Our":[346],"findings":[347,377],"may":[348],"thus":[349],"be":[351],"generalizable":[352],"all":[354],"PCOS.":[357],"MicroRNA":[358],"only":[362],"undertaken":[363],"an":[365,421],"exploratory":[366],"subset":[367],"overall":[370],"population":[372],"hence,":[373],"validation":[374],"our":[376],"larger":[380],"cohort":[381],"mandatory.":[383],"Furthermore,":[384],"levels":[386],"unaltered":[388],"for":[389],"highly":[391],"it":[395],"unclear":[397],"whether":[398,445],"differences":[399],"lowly":[402],"carries":[405],"pathological":[406],"relevance.":[407],"WIDER":[408],"IMPLICATIONS":[409],"FINDINGS:":[412],"suggests":[415],"profile":[424],"further":[426],"needed":[429],"confirm":[431],"this,":[432],"explore":[434],"these":[439],"alterations":[440],"develop":[441],"establish":[444],"therapies":[446],"improve":[448],"sensitivity":[450],"able":[452],"reduce":[454],"concentrations.":[457],"FUNDING/COMPETING":[459],"INTERESTS:":[460],"funded":[464],"grants":[466],"from":[467],"Wales":[469],"Heart":[470],"Research":[471],"Institute":[472],"Mrs":[474],"John":[475],"Nixon":[476],"Scholarship.":[477],"authors":[479],"no":[481],"conflicts":[482],"interest":[484],"declare.":[486]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}