{"id":"https://openalex.org/W2000578798","doi":"https://doi.org/10.1016/j.brainresbull.2006.01.011","title":"Effect of a serotonin depleting regimen of 3,4-methylenedioxymethamphetamine (MDMA) on the subsequent stimulation of acetylcholine release in the rat prefrontal cortex","display_name":"Effect of a serotonin depleting regimen of 3,4-methylenedioxymethamphetamine (MDMA) on the subsequent stimulation of acetylcholine release in the rat prefrontal cortex","publication_year":2006,"publication_date":"2006-02-15","ids":{"openalex":"https://openalex.org/W2000578798","doi":"https://doi.org/10.1016/j.brainresbull.2006.01.011","mag":"2000578798","pmid":"https://pubmed.ncbi.nlm.nih.gov/16624669"},"language":"en","primary_location":{"id":"doi:10.1016/j.brainresbull.2006.01.011","doi":"https://doi.org/10.1016/j.brainresbull.2006.01.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.brainresbull.2006.01.011","pdf_url":null,"source":{"id":"https://openalex.org/S8119441","display_name":"Brain Research Bulletin","issn_l":"0361-9230","issn":["0361-9230","1873-2747"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083943770","display_name":"Sunila G Nair","orcid":"https://orcid.org/0000-0003-0998-1629","observed_orcids":["https://orcid.org/0000-0003-0998-1629"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.G. Nair","raw_affiliation_strings":["College of Pharmacy, University of Cincinnati, 3223 Eden Av., Cincinnati, OH 45267, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, University of Cincinnati, 3223 Eden Av., Cincinnati, OH 45267, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112014625","display_name":"Gary A. Gudelsky","orcid":"https://orcid.org/0000-0003-2552-8592","observed_orcids":["https://orcid.org/0000-0003-2552-8592"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"G.A. Gudelsky","raw_affiliation_strings":["College of Pharmacy, University of Cincinnati, 3223 Eden Av., Cincinnati, OH 45267, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, University of Cincinnati, 3223 Eden Av., Cincinnati, OH 45267, USA","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112014625"],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":{"value":3280,"currency":"USD","value_usd":3280},"apc_paid":null,"fwci":1.3915,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.76733062,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"69","issue":"4","first_page":"382","last_page":"387"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.10289999842643738,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mdma","display_name":"MDMA","score":0.9710000157356262},{"id":"https://openalex.org/keywords/ecstasy","display_name":"ecstasy","score":0.699999988079071},{"id":"https://openalex.org/keywords/serotonin-depletion","display_name":"serotonin depletion","score":0.9589999914169312},{"id":"https://openalex.org/keywords/acetylcholine-release","display_name":"acetylcholine release","score":0.9290000200271606},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.9940000176429749},{"id":"https://openalex.org/keywords/serotonin-neurotoxicity","display_name":"serotonin neurotoxicity","score":0.6230000257492065},{"id":"https://openalex.org/keywords/5-ht1a-receptor-agonist","display_name":"5-HT1A receptor agonist","score":0.8629999756813049},{"id":"https://openalex.org/keywords/8-oh-dpat","display_name":"8-OH-DPAT","score":0.9599999785423279},{"id":"https://openalex.org/keywords/tail-pinch","display_name":"tail pinch","score":0.7630000114440918},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.6830000281333923},{"id":"https://openalex.org/keywords/microdialysis","display_name":"microdialysis","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C2780876324","wikidata":"https://www.wikidata.org/wiki/Q69488","display_name":"MDMA","level":2,"score":0.972856879234314},{"id":"https://openalex.org/C50156730","wikidata":"https://www.wikidata.org/wiki/Q3856966","display_name":"Microdialysis","level":3,"score":0.7217543125152588},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.686786413192749},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.620337963104248},{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.5656356811523438},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5532363653182983},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5520721077919006},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49919581413269043},{"id":"https://openalex.org/C2777193897","wikidata":"https://www.wikidata.org/wiki/Q179452","display_name":"Amphetamine","level":3,"score":0.4975426495075226},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.49298545718193054},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.4771009087562561},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.4495863914489746},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.4207155704498291},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.39826154708862305},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3957773447036743},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3468640446662903},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3349613547325134},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21998023986816406},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.12382832169532776},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08823859691619873}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017371","descriptor_name":"8-Hydroxy-2-(di-n-propylamino)tetralin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017551","descriptor_name":"Microdialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018490","descriptor_name":"Serotonin Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D018817","descriptor_name":"N-Methyl-3,4-methylenedioxyamphetamine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.brainresbull.2006.01.011","doi":"https://doi.org/10.1016/j.brainresbull.2006.01.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.brainresbull.2006.01.011","pdf_url":null,"source":{"id":"https://openalex.org/S8119441","display_name":"Brain Research Bulletin","issn_l":"0361-9230","issn":["0361-9230","1873-2747"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research Bulletin","raw_type":"journal-article"},{"id":"pmid:16624669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16624669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research bulletin","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2348430513","display_name":"Determinants and Consequences of MDMA Neurotoxicity","funder_award_id":"R01DA007427","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G349727063","display_name":null,"funder_award_id":"DA07427","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1597954511","https://openalex.org/W1600050350","https://openalex.org/W1899272159","https://openalex.org/W1913932761","https://openalex.org/W1978787522","https://openalex.org/W1983786855","https://openalex.org/W1983885383","https://openalex.org/W1987507203","https://openalex.org/W1990692265","https://openalex.org/W1991339455","https://openalex.org/W1994647182","https://openalex.org/W2014948578","https://openalex.org/W2021041549","https://openalex.org/W2029675439","https://openalex.org/W2049804872","https://openalex.org/W2050415436","https://openalex.org/W2059553248","https://openalex.org/W2061414707","https://openalex.org/W2061733755","https://openalex.org/W2066213523","https://openalex.org/W2067948112","https://openalex.org/W2068360712","https://openalex.org/W2073494415","https://openalex.org/W2078056234","https://openalex.org/W2083687710","https://openalex.org/W2094508033","https://openalex.org/W2095188030","https://openalex.org/W2117468337","https://openalex.org/W2122034964","https://openalex.org/W2132011757","https://openalex.org/W2134647442","https://openalex.org/W2143437320","https://openalex.org/W2146353697","https://openalex.org/W2146745496","https://openalex.org/W2153762687","https://openalex.org/W2155890773","https://openalex.org/W2168659851","https://openalex.org/W6876673915"],"related_works":["https://openalex.org/W2096888976","https://openalex.org/W2050415436","https://openalex.org/W2015485611","https://openalex.org/W1994647182","https://openalex.org/W2017646919","https://openalex.org/W2037485491","https://openalex.org/W2065619339","https://openalex.org/W1987507203","https://openalex.org/W7095260925","https://openalex.org/W4407024749"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}