{"id":"https://openalex.org/W2000561096","doi":"https://doi.org/10.1111/j.1601-183x.2009.00509.x","title":"Szt2, a novel gene for seizure threshold in mice","display_name":"Szt2, a novel gene for seizure threshold in mice","publication_year":2009,"publication_date":"2009-05-23","ids":{"openalex":"https://openalex.org/W2000561096","doi":"https://doi.org/10.1111/j.1601-183x.2009.00509.x","mag":"2000561096","pmid":"https://pubmed.ncbi.nlm.nih.gov/19624305","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2728062"},"language":"en","primary_location":{"id":"doi:10.1111/j.1601-183x.2009.00509.x","doi":"https://doi.org/10.1111/j.1601-183x.2009.00509.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1601-183x.2009.00509.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1601-183X.2009.00509.x","source":{"id":"https://openalex.org/S134433296","display_name":"Genes Brain & Behavior","issn_l":"1601-183X","issn":["1601-183X","1601-1848"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes, Brain and Behavior","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1601-183X.2009.00509.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109064072","display_name":"Wayne N. Frankel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W. N. Frankel","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine, USA. wayne.frankel@jax.org","The Jackson Laboratory, Bar Harbor, Maine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine, USA. wayne.frankel@jax.org","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101958337","display_name":"Yan Xiang Yang","orcid":"https://orcid.org/0000-0003-3510-702X","observed_orcids":["https://orcid.org/0000-0003-3510-702X"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Yang","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine, USA, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine, USA, and","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049849331","display_name":"Connie L. Mahaffey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. L. Mahaffey","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine, USA, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine, USA, and","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085082757","display_name":"Barbara J. Beyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. J. Beyer","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine, USA, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine, USA, and","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103879595","display_name":"T. P. O'Brien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. P. O'Brien","raw_affiliation_strings":["Department of Biomedical Sciences, Cornell University, Ithaca, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Cornell University, Ithaca, NY, USA","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109064072"],"corresponding_institution_ids":["https://openalex.org/I4210115256"],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":null,"fwci":0.8226,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.73452465,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"5","first_page":"568","last_page":"576"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/seizure-threshold","display_name":"seizure threshold","score":0.9879999756813049},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.5920000076293945},{"id":"https://openalex.org/keywords/epileptogenesis","display_name":"epileptogenesis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/genetic-mapping","display_name":"gene mapping","score":0.6309999823570251},{"id":"https://openalex.org/keywords/chromosome-4","display_name":"chromosome 4","score":0.75},{"id":"https://openalex.org/keywords/splice-donor-mutation","display_name":"splice donor mutation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/embryonic-lethality","display_name":"embryonic lethality","score":0.7620000243186951},{"id":"https://openalex.org/keywords/gene-expression-in-brain","display_name":"brain gene expression","score":0.5529999732971191},{"id":"https://openalex.org/keywords/med8","display_name":"MED8","score":0.609000027179718},{"id":"https://openalex.org/keywords/mediator-complex","display_name":"Mediator complex","score":0.9300000071525574},{"id":"https://openalex.org/keywords/conserved-genes","display_name":"conserved genes","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7889643907546997},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.7145048975944519},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6320102214813232},{"id":"https://openalex.org/C29906990","wikidata":"https://www.wikidata.org/wiki/Q1440688","display_name":"Frameshift mutation","level":4,"score":0.629758358001709},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6081171035766602},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4878733158111572},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4814035892486572},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.4540087878704071},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44809722900390625},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.43234214186668396}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016368","descriptor_name":"Frameshift Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1601-183x.2009.00509.x","doi":"https://doi.org/10.1111/j.1601-183x.2009.00509.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1601-183x.2009.00509.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1601-183X.2009.00509.x","source":{"id":"https://openalex.org/S134433296","display_name":"Genes Brain & Behavior","issn_l":"1601-183X","issn":["1601-183X","1601-1848"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes, Brain and Behavior","raw_type":"journal-article"},{"id":"pmid:19624305","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19624305","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes, brain, and behavior","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2728062","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2728062","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Genes Brain Behav","raw_type":"Text"},{"id":"pmh:oai:mouseion.jax.org:stfb2000_2009-3022","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/stfb2000_2009/2023","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 2000 - 2009","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1111/j.1601-183x.2009.00509.x","doi":"https://doi.org/10.1111/j.1601-183x.2009.00509.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1601-183x.2009.00509.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1601-183X.2009.00509.x","source":{"id":"https://openalex.org/S134433296","display_name":"Genes Brain & Behavior","issn_l":"1601-183X","issn":["1601-183X","1601-1848"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes, Brain and Behavior","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.766700029373169}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1778963489","display_name":null,"funder_award_id":"#CA34196","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6063896096","display_name":"Genetic Determinants of Epilepsy in Murine Systems","funder_award_id":"R37NS031348","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6271047126","display_name":null,"funder_award_id":"NS31348","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8239243766","display_name":"Region Based Functional Annotation of the Mouse Genome","funder_award_id":"R01HD041066","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G8886052464","display_name":null,"funder_award_id":"HD41066","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000880787","display_name":"Genetic Determinants of Epilepsy in Murine Systems","funder_award_id":"R01NS031348","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000917281","display_name":"Cancer Center Support (CORE) Grant","funder_award_id":"P30CA034196","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2000561096.pdf"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1978252391","https://openalex.org/W1989469368","https://openalex.org/W2030455873","https://openalex.org/W2039641169","https://openalex.org/W2067658528","https://openalex.org/W2070032514","https://openalex.org/W2102037126","https://openalex.org/W2103946141","https://openalex.org/W2120772351","https://openalex.org/W2144432126","https://openalex.org/W2166793463"],"related_works":["https://openalex.org/W2945610513","https://openalex.org/W2618166841","https://openalex.org/W2896246841","https://openalex.org/W2144432126","https://openalex.org/W1984991894","https://openalex.org/W2793983755","https://openalex.org/W2968734480","https://openalex.org/W4386219967","https://openalex.org/W3024435987","https://openalex.org/W2799652389"],"abstract_inverted_index":{"In":[0],"a":[1,12,38,79,99,119,127,172,193,202],"chemical":[2],"mutagenesis":[3],"screen":[4],"we":[5],"identified":[6],"Szt2":[7,69,97,116,145,165,189,216],"(seizure":[8],"threshold":[9,18,130,228],"2)":[10],"as":[11],"gene":[13,77,190],"that":[14,230],"confers":[15],"low":[16,128],"seizure":[17,129,227],"to":[19,31,37,58,89],"mice":[20],"and":[21,34,111,131,157,181,224],"may":[22],"also":[23,125,160],"enhance":[24],"epileptogenesis.":[25],"The":[26,73,93],"semidominant":[27],"phenotype":[28],"was":[29,56],"mapped":[30],"Chromosome":[32],"4":[33],"narrowed":[35],"further":[36],"critical":[39,54],"interval":[40,55],"of":[41,96,215],"approximately":[42],"650":[43],"kb.":[44],"A":[45,114],"novel":[46],"large":[47],"(>":[48],"10":[49],"kb)":[50],"transcript":[51],"in":[52,68,122,148,155,169,177,182,186,192,236],"the":[53,65,137,152,188,212,237],"found":[57,176],"have":[59],"fourfold":[60],"increased":[61,132],"steady-state":[62],"expression":[63,154],"at":[64],"RNA":[66,133],"level":[67],"homozygous":[70],"mutant":[71,94],"brain.":[72],"corresponding":[74],"72":[75],"exon":[76,104,123],"encodes":[78,201],"378-kD":[80],"protein":[81],"with":[82,151,171,198],"no":[83],"significant":[84],"or":[85],"suggestive":[86],"sequence":[87],"similarities":[88],"any":[90],"other":[91],"protein.":[92],"allele":[95],"contains":[98],"splice":[100],"donor":[101],"mutation":[102,121],"after":[103],"32,":[105],"predicting":[106],"transcriptional":[107],"read-through,":[108],"translational":[109],"frameshift":[110],"premature":[112],"stop.":[113],"second":[115],"allele,":[117,139],"containing":[118],"gene-trap":[120,141],"21,":[124],"conferred":[126],"expression,":[134],"but":[135],"unlike":[136],"original":[138],"some":[140],"homozygotes":[142],"died":[143],"embryonically.":[144],"is":[146,159,166],"transcribed":[147],"many":[149,183],"tissues,":[150],"highest":[153],"brain,":[156],"it":[158,231],"expressed":[161],"during":[162],"embryonic":[163],"development.":[164],"highly":[167,194],"conserved":[168,195],"evolution,":[170],"clear,":[173],"single":[174],"orthologue":[175],"all":[178],"land":[179],"vertebrates":[180],"invertebrates.":[184],"Interestingly,":[185],"mammals":[187],"resides":[191],"head-to-head":[196],"configuration":[197],"Med8":[199],"(which":[200],"Mediator":[203],"complex":[204],"subunit),":[205],"separated":[206],"by":[207],"only":[208],"91":[209],"nt.":[210],"While":[211],"biological":[213],"function":[214],"remains":[217],"unknown,":[218],"its":[219],"high":[220],"conservation,":[221],"unique":[222],"structure":[223],"effect":[225],"on":[226],"suggest":[229],"serves":[232],"an":[233],"important":[234],"role":[235],"central":[238],"nervous":[239],"system.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}