{"id":"https://openalex.org/W2000559950","doi":"https://doi.org/10.1161/01.cir.90.2.928","title":"Sex-specific determinants of increased left ventricular mass in the Tecumseh Blood Pressure Study.","display_name":"Sex-specific determinants of increased left ventricular mass in the Tecumseh Blood Pressure Study.","publication_year":1994,"publication_date":"1994-08-01","ids":{"openalex":"https://openalex.org/W2000559950","doi":"https://doi.org/10.1161/01.cir.90.2.928","mag":"2000559950","pmid":"https://pubmed.ncbi.nlm.nih.gov/8044964"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.90.2.928","doi":"https://doi.org/10.1161/01.cir.90.2.928","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.90.2.928","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083867225","display_name":"Roy G. Marcus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Marcus","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109110265","display_name":"Lisa C. Krause","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Krause","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108598305","display_name":"A. B. Weder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A B Weder","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030562567","display_name":"A Dominguez-Meja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Dominguez-Meja","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077225971","display_name":"Nicholas J. Schork","orcid":"https://orcid.org/0000-0003-0920-5013","observed_orcids":["https://orcid.org/0000-0003-0920-5013"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N J Schork","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113782752","display_name":"Stevo Julius","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Julius","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":4.5262,"has_fulltext":false,"cited_by_count":172,"citation_normalized_percentile":{"value":0.95037765,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"90","issue":"2","first_page":"928","last_page":"936"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.9309999942779541},{"id":"https://openalex.org/keywords/left-ventricular-mass","display_name":"left ventricular mass","score":0.9169999957084656},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9490000009536743},{"id":"https://openalex.org/keywords/normotensive-young-adults","display_name":"normotensive young adults","score":0.7979999780654907},{"id":"https://openalex.org/keywords/sympathetic-nervous-system-reactivity","display_name":"sympathetic nervous system reactivity","score":0.9459999799728394},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9670000076293945},{"id":"https://openalex.org/keywords/fasting-insulin","display_name":"fasting insulin","score":0.7900000214576721},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9330000281333923},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8240000009536743},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9295741319656372},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6383908987045288},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6004016399383545},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.600257933139801}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001824","descriptor_name":"Body Constitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008824","descriptor_name":"Michigan","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/01.cir.90.2.928","doi":"https://doi.org/10.1161/01.cir.90.2.928","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.90.2.928","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:8044964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8044964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1005.6225","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1005.6225","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circ.ahajournals.org/content/circulationaha/90/2/928.full.pdf","raw_type":"text"},{"id":"mag:3142481605","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/circ.90.2.8044964?90/2/928=&cited-by=yes","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W59932970","https://openalex.org/W1963989474","https://openalex.org/W1974628497","https://openalex.org/W1975622210","https://openalex.org/W1975925766","https://openalex.org/W1978990205","https://openalex.org/W1979899573","https://openalex.org/W1983001941","https://openalex.org/W1984513597","https://openalex.org/W1995324568","https://openalex.org/W1995934832","https://openalex.org/W1996270196","https://openalex.org/W2000701450","https://openalex.org/W2004721298","https://openalex.org/W2005135255","https://openalex.org/W2005815716","https://openalex.org/W2012919732","https://openalex.org/W2022264052","https://openalex.org/W2028094557","https://openalex.org/W2030557186","https://openalex.org/W2031322169","https://openalex.org/W2033049176","https://openalex.org/W2034177003","https://openalex.org/W2036108134","https://openalex.org/W2047928947","https://openalex.org/W2052202426","https://openalex.org/W2055701323","https://openalex.org/W2067020618","https://openalex.org/W2068217843","https://openalex.org/W2072855368","https://openalex.org/W2076296398","https://openalex.org/W2081874034","https://openalex.org/W2085812290","https://openalex.org/W2090443364","https://openalex.org/W2093085685","https://openalex.org/W2099232807","https://openalex.org/W2106527155","https://openalex.org/W2109126662","https://openalex.org/W2110889457","https://openalex.org/W2120316040","https://openalex.org/W2121799265","https://openalex.org/W2137749789","https://openalex.org/W2148210349","https://openalex.org/W2151385266","https://openalex.org/W2153335704","https://openalex.org/W2165662047","https://openalex.org/W2166307462","https://openalex.org/W2170317646","https://openalex.org/W2214239405","https://openalex.org/W2224418909","https://openalex.org/W2244426299","https://openalex.org/W2246750959","https://openalex.org/W2320995185","https://openalex.org/W2334499091","https://openalex.org/W2396009686","https://openalex.org/W4244225558","https://openalex.org/W4298224327"],"related_works":["https://openalex.org/W2417816270","https://openalex.org/W2093818922","https://openalex.org/W6996223031","https://openalex.org/W1988933553","https://openalex.org/W4410604709","https://openalex.org/W2131802426","https://openalex.org/W2100763980","https://openalex.org/W2072225442","https://openalex.org/W2493783406","https://openalex.org/W2740690961"],"abstract_inverted_index":{"BACKGROUND:":[0],"Left":[1],"ventricular":[2],"hypertrophy":[3],"(LVH)":[4],"defined":[5],"by":[6,93,166],"either":[7],"ECG":[8],"or":[9],"echocardiographic":[10],"criteria":[11,127],"is":[12,98,144,205,231],"a":[13,51,206,212],"risk":[14],"factor":[15,246],"for":[16,73,128],"cardiovascular":[17],"morbidity":[18],"and":[19,38,59,77,154,159,178,195,225],"mortality.":[20],"A":[21],"number":[22],"of":[23,25,46,53,64,82,148,184,208],"determinants":[24,192],"LVH":[26,115,141,171,201],"have":[27,190],"been":[28],"described":[29],"in":[30,50,101,142,193,202,234,237],"previous":[31],"studies,":[32],"principally":[33],"male":[34],"sex,":[35],"hypertension,":[36,185,211],"obesity,":[37],"aortic":[39],"valvular":[40,65],"stenosis.":[41],"We":[42,138,197],"examined":[43],"the":[44,80,121,182,244],"distribution":[45],"LV":[47],"mass":[48],"(LVM)":[49],"population":[52],"18-":[54],"to":[55,68,78,189,216,242],"42-year-old":[56],"normotensive":[57],"men":[58,102,143,194,204],"women":[60,108],"who":[61],"were":[62],"free":[63],"heart":[66],"disease":[67],"establish":[69],"sex-specific":[70,126],"normal":[71],"values":[72],"LVM":[74,87],"index":[75],"(LVMI)":[76],"determine":[79],"correlates":[81],"LVMI.":[83],"METHODS":[84],"AND":[85],"RESULTS:":[86],"was":[88,172],"derived":[89],"from":[90],"measurements":[91],"obtained":[92],"M-mode":[94],"echocardiography.":[95],"Average":[96],"LVMI":[97,118,187],"significantly":[99],"greater":[100,119],"(102.9":[103],"+/-":[104,110],"0.7":[105,111],"g/m2)":[106],"than":[107,120],"(88.2":[109],"g/m2).":[112],"By":[113],"defining":[114],"as":[116],"an":[117],"90th":[122],"percentile,":[123],"we":[124],"developed":[125],"LVH:":[129],"men,":[130],">":[131,135],"125.4":[132],"g/m2;":[133],"women,":[134,170,236],"110":[136],"g/m2.":[137],"found":[139],"that":[140,199],"associated":[145,173,218,247],"with":[146,155,174,219,248],"indices":[147],"enhanced":[149],"sympathetic":[150,221],"nervous":[151,222],"system":[152,223],"reactivity":[153],"elevated":[156],"fasting":[157],"insulin":[158,167,226],"triglyceride":[160],"levels,":[161],"which":[162],"may":[163],"be":[164,217,243],"caused":[165],"resistance.":[168,227],"In":[169],"higher":[175],"body":[176],"weight":[177],"obesity.":[179],"CONCLUSIONS:":[180],"Before":[181],"onset":[183],"increased":[186,220,239],"appears":[188],"different":[191],"women.":[196],"suggest":[198],"early":[200],"young":[203,235],"manifestation":[207],"hyperkinetic":[209,229],"borderline":[210],"state":[213,230],"previously":[214],"shown":[215],"activity":[224],"The":[228],"less":[232],"prevalent":[233],"whom":[238],"adiposity":[240],"seems":[241],"predominant":[245],"LVH.":[249]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}