{"id":"https://openalex.org/W2000558013","doi":"https://doi.org/10.1038/sj.bjp.0706954","title":"Niflumic acid inhibits chloride conductance of rat skeletal muscle by directly inhibiting the CLC\u20101 channel and by increasing intracellular calcium","display_name":"Niflumic acid inhibits chloride conductance of rat skeletal muscle by directly inhibiting the CLC\u20101 channel and by increasing intracellular calcium","publication_year":2006,"publication_date":"2006-11-27","ids":{"openalex":"https://openalex.org/W2000558013","doi":"https://doi.org/10.1038/sj.bjp.0706954","mag":"2000558013","pmid":"https://pubmed.ncbi.nlm.nih.gov/17128287"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjp.0706954","doi":"https://doi.org/10.1038/sj.bjp.0706954","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0706954","pdf_url":null,"source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2042903","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043399255","display_name":"Antonella Liantonio","orcid":"https://orcid.org/0000-0002-4103-7577","observed_orcids":["https://orcid.org/0000-0002-4103-7577"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Liantonio","raw_affiliation_strings":["Unit\u00e0 di Farmacologia, Dipartimento Farmacobiologico, Facolt\u00e0 di Farmacia, Universit\u00e0 di Bari, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e0 di Farmacologia, Dipartimento Farmacobiologico, Facolt\u00e0 di Farmacia, Universit\u00e0 di Bari, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051256686","display_name":"Viviana Giannuzzi","orcid":"https://orcid.org/0000-0002-2534-6783","observed_orcids":["https://orcid.org/0000-0002-2534-6783"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"V Giannuzzi","raw_affiliation_strings":["Unita\u0300 di Farmacologia, Dipartimento Farmacobiologico, Facolta\u0300 di Farmacia, Universita\u0300 di Bari, Bari, Italy","Unit\u00e0 di Farmacologia, Dipartimento Farmacobiologico, Facolt\u00e0 di Farmacia, Universit\u00e0 di Bari, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unita\u0300 di Farmacologia, Dipartimento Farmacobiologico, Facolta\u0300 di Farmacia, Universita\u0300 di Bari, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]},{"raw_affiliation_string":"Unit\u00e0 di Farmacologia, Dipartimento Farmacobiologico, Facolt\u00e0 di Farmacia, Universit\u00e0 di Bari, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004636149","display_name":"Alessandra Picollo","orcid":"https://orcid.org/0000-0003-2980-7951","observed_orcids":["https://orcid.org/0000-0003-2980-7951"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Picollo","raw_affiliation_strings":["Centro Nazionale delle Ricerche (CNR), Istituto di Biofisica, CNR, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nazionale delle Ricerche (CNR), Istituto di Biofisica, CNR, Genova, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082992801","display_name":"Elena Babini","orcid":"https://orcid.org/0000-0001-9906-4909","observed_orcids":["https://orcid.org/0000-0001-9906-4909"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E Babini","raw_affiliation_strings":["Centro Nazionale delle Ricerche (CNR), Istituto di Biofisica, CNR, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nazionale delle Ricerche (CNR), Istituto di Biofisica, CNR, Genova, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020262838","display_name":"Michael Pusch","orcid":"https://orcid.org/0000-0002-8644-8847","observed_orcids":["https://orcid.org/0000-0002-8644-8847"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Pusch","raw_affiliation_strings":["Centro Nazionale delle Ricerche (CNR), Istituto di Biofisica, CNR, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nazionale delle Ricerche (CNR), Istituto di Biofisica, CNR, Genova, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026407702","display_name":"Diana Conte Camerino","orcid":"https://orcid.org/0000-0003-0162-9698","observed_orcids":["https://orcid.org/0000-0003-0162-9698"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"D Conte Camerino","raw_affiliation_strings":["Unita\u0300 di Farmacologia, Dipartimento Farmacobiologico, Facolta\u0300 di Farmacia, Universita\u0300 di Bari, Bari, Italy","Unit\u00e0 di Farmacologia, Dipartimento Farmacobiologico, Facolt\u00e0 di Farmacia, Universit\u00e0 di Bari, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unita\u0300 di Farmacologia, Dipartimento Farmacobiologico, Facolta\u0300 di Farmacia, Universita\u0300 di Bari, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]},{"raw_affiliation_string":"Unit\u00e0 di Farmacologia, Dipartimento Farmacobiologico, Facolt\u00e0 di Farmacia, Universit\u00e0 di Bari, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026407702"],"corresponding_institution_ids":["https://openalex.org/I5561750"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":1.4728,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.79081448,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"150","issue":"2","first_page":"235","last_page":"247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/niflumic-acid","display_name":"niflumic acid","score":1.0},{"id":"https://openalex.org/keywords/voltage-gated-chloride-channels","display_name":"voltage-gated chloride channels","score":0.7009999752044678},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mitochondrial-calcium-efflux","display_name":"mitochondrial calcium efflux","score":0.972000002861023},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.921999990940094},{"id":"https://openalex.org/keywords/chelerythrine","display_name":"chelerythrine","score":0.8550000190734863},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7620000243186951},{"id":"https://openalex.org/keywords/muscle-excitability","display_name":"muscle excitability","score":0.7059999704360962},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C2779700409","wikidata":"https://www.wikidata.org/wiki/Q304285","display_name":"Niflumic acid","level":2,"score":0.9262392520904541},{"id":"https://openalex.org/C145822097","wikidata":"https://www.wikidata.org/wiki/Q106916978","display_name":"Chloride channel","level":2,"score":0.7699839472770691},{"id":"https://openalex.org/C2776108454","wikidata":"https://www.wikidata.org/wiki/Q5089853","display_name":"Chelerythrine","level":4,"score":0.7230788469314575},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6747735738754272},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6255285739898682},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5181925892829895},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5082914233207703},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.49531760811805725},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.4945025146007538},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.4913446009159088},{"id":"https://openalex.org/C100837961","wikidata":"https://www.wikidata.org/wiki/Q10290897","display_name":"Voltage clamp","level":3,"score":0.456596702337265},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4378894567489624},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.39852258563041687},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.35073816776275635},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3307972848415375},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32785195112228394},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1969834864139557},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.18054166436195374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1758829653263092},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1367138922214508},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009544","descriptor_name":"Niflumic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009544","descriptor_name":"Niflumic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009544","descriptor_name":"Niflumic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009544","descriptor_name":"Niflumic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/sj.bjp.0706954","doi":"https://doi.org/10.1038/sj.bjp.0706954","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0706954","pdf_url":null,"source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:17128287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17128287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2042903","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2042903","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},{"id":"pmh:oai:ricerca.uniba.it:11586/49830","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11586/49830","pdf_url":null,"source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ricerca.uniba.it:11586/49831","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11586/49831","pdf_url":null,"source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2042903","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2042903","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4300000071525574,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W116341769","https://openalex.org/W194428502","https://openalex.org/W1752385781","https://openalex.org/W1894088205","https://openalex.org/W1934405147","https://openalex.org/W1947692468","https://openalex.org/W1964347799","https://openalex.org/W1967557485","https://openalex.org/W1967838839","https://openalex.org/W1974237962","https://openalex.org/W1977831332","https://openalex.org/W1978409411","https://openalex.org/W1980858407","https://openalex.org/W1990769664","https://openalex.org/W1996024251","https://openalex.org/W1996666212","https://openalex.org/W2002697895","https://openalex.org/W2012429010","https://openalex.org/W2015686095","https://openalex.org/W2018632150","https://openalex.org/W2018983834","https://openalex.org/W2024487247","https://openalex.org/W2028088027","https://openalex.org/W2034848911","https://openalex.org/W2035075678","https://openalex.org/W2042389451","https://openalex.org/W2063934982","https://openalex.org/W2080083594","https://openalex.org/W2080156145","https://openalex.org/W2080962912","https://openalex.org/W2081841421","https://openalex.org/W2091553400","https://openalex.org/W2093013713","https://openalex.org/W2093908361","https://openalex.org/W2108425243","https://openalex.org/W2110798143","https://openalex.org/W2111814865","https://openalex.org/W2112543188","https://openalex.org/W2114096403","https://openalex.org/W2121135722","https://openalex.org/W2121695144","https://openalex.org/W2123832242","https://openalex.org/W2133433307","https://openalex.org/W2141124826","https://openalex.org/W2141260882","https://openalex.org/W2149083834","https://openalex.org/W2154588303","https://openalex.org/W2157376179","https://openalex.org/W2161424579","https://openalex.org/W2168984459","https://openalex.org/W2256971668","https://openalex.org/W2410622758","https://openalex.org/W2413213959","https://openalex.org/W2902722974"],"related_works":["https://openalex.org/W2248477734","https://openalex.org/W1896399110","https://openalex.org/W2091189172","https://openalex.org/W1979518023","https://openalex.org/W1970294642","https://openalex.org/W2011917699","https://openalex.org/W4291017566","https://openalex.org/W3028393563","https://openalex.org/W1844539864","https://openalex.org/W2014374660"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,189],"PURPOSE:":[2],"Given":[3],"the":[4,8,16,25,53,147,152,159,169,221,225],"crucial":[5],"role":[6],"of":[7,27,32,56,77,108,194,224,229],"skeletal":[9,197],"muscle":[10,23,64,97,198],"chloride":[11,18],"conductance":[12,66],"(gCl),":[13],"supported":[14],"by":[15,75,114,128,184,211,218],"voltage-gated":[17],"channel":[19,177,214],"CLC-1,":[20],"in":[21,95,126,173],"controlling":[22],"excitability,":[24],"availability":[26],"ligands":[28],"modulating":[29],"CLC-1":[30,71,113,206],"are":[31,155],"potential":[33],"medical":[34],"as":[35,37],"well":[36],"toxicological":[38],"importance.":[39],"Here,":[40],"we":[41],"focused":[42],"our":[43],"attention":[44],"on":[45,138,196,231],"niflumic":[46],"acid":[47],"(NFA),":[48],"a":[49,130],"molecule":[50],"belonging":[51],"to":[52,89,175,204],"fenamates":[54],"group":[55],"non-steroidal":[57],"anti-inflammatory":[58],"drugs":[59],"(NSAID).":[60],"EXPERIMENTAL":[61],"APPROACH:":[62],"Rat":[63],"Cl(-)":[65],"(gCl)":[67],"and":[68,81,111,207,216],"heterologously":[69],"expressed":[70],"currents":[72],"were":[73],"evaluated":[74],"means":[76],"current-clamp":[78],"(using":[79],"two-microelectrodes)":[80],"patch-clamp":[82],"techniques,":[83],"respectively.":[84],"Fura-2":[85],"fluorescence":[86],"was":[87,135],"used":[88,239],"determine":[90],"intracellular":[91,118],"calcium":[92,132,233],"concentration,":[93],"[Ca(2+)](i),":[94],"native":[96,103],"fibres.":[98],"KEY":[99],"RESULTS:":[100],"NFA":[101,122,170,179,195,230],"inhibited":[102,168],"gCl":[104,182,209],"with":[105,116,158,213,220],"an":[106,117],"IC(50)":[107],"42":[109],"muM":[110],"blocked":[112],"interacting":[115,212],"binding":[119],"site.":[120],"Additionally,":[121],"increased":[123],"basal":[124],"[Ca(2+)](i)":[125],"myofibres":[127],"promoting":[129,185],"mitochondrial":[131,232],"efflux":[133],"that":[134,146,150,200,236],"not":[136],"dependent":[137],"cyclooxygenase":[139],"or":[140],"CLC-1.":[141],"A":[142],"structure-activity":[143],"study":[144],"revealed":[145],"molecular":[148],"conditions":[149],"mediate":[151],"two":[153],"effects":[154,193],"different.":[156],"Pretreatment":[157],"Ca-dependent":[160],"protein":[161],"kinase":[162],"C":[163],"(PKC)":[164],"inhibitor":[165],"chelerythrine":[166],"partially":[167],"effect.":[171],"Therefore,":[172],"addition":[174],"direct":[176],"block,":[178],"also":[180],"inhibits":[181],"indirectly":[183,217],"PKC":[186],"activation.":[187],"CONCLUSIONS":[188],"IMPLICATIONS:":[190],"These":[191],"cellular":[192],"demonstrate":[199],"it":[201],"is":[202],"possible":[203],"modify":[205],"consequently":[208],"directly":[210],"proteins":[215],"interfering":[219],"calcium-dependent":[222],"regulation":[223],"channel.":[226],"The":[227],"effect":[228],"stores":[234],"suggests":[235],"NSAIDs,":[237],"widely":[238],"drugs,":[240],"could":[241],"have":[242],"potentially":[243],"dangerous":[244],"side-effects.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}