{"id":"https://openalex.org/W2000551092","doi":"https://doi.org/10.1002/1098-2795(200011)57:3<262::aid-mrd8>3.0.co;2-x","title":"In vitro development of porcine nuclear transfer embryos constructed using fetal fibroblasts","display_name":"In vitro development of porcine nuclear transfer embryos constructed using fetal fibroblasts","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2000551092","doi":"https://doi.org/10.1002/1098-2795(200011)57:3<262::aid-mrd8>3.0.co;2-x","mag":"2000551092","pmid":"https://pubmed.ncbi.nlm.nih.gov/11013434"},"language":"en","primary_location":{"id":"doi:10.1002/1098-2795(200011)57:3<262::aid-mrd8>3.0.co;2-x","doi":"https://doi.org/10.1002/1098-2795(200011)57:3<262::aid-mrd8>3.0.co;2-x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1098-2795(200011)57:3<262::aid-mrd8>3.0.co;2-x","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006250882","display_name":"Paul John Verma","orcid":"https://orcid.org/0000-0003-4266-8888","observed_orcids":["https://orcid.org/0000-0003-4266-8888"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Paul J. Verma","raw_affiliation_strings":["BresaGen Limited, Adelaide, South Australia, Australia. paul.verma@adelaide.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BresaGen Limited, Adelaide, South Australia, Australia. paul.verma@adelaide.edu.au","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112814365","display_name":"Z.T Du","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhong-Tao Du","raw_affiliation_strings":["BresaGen Limited, Adelaide, South Australia, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BresaGen Limited, Adelaide, South Australia, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lesley Crocker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lesley Crocker","raw_affiliation_strings":["BresaGen Limited, Adelaide, South Australia, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BresaGen Limited, Adelaide, South Australia, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057434229","display_name":"Renate Faast","orcid":"https://orcid.org/0000-0001-7037-4516","observed_orcids":["https://orcid.org/0000-0001-7037-4516"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Renate Faast","raw_affiliation_strings":["BresaGen Limited, Adelaide, South Australia, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BresaGen Limited, Adelaide, South Australia, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002425902","display_name":"Christopher G. Grupen","orcid":"https://orcid.org/0000-0001-8352-0404","observed_orcids":["https://orcid.org/0000-0001-8352-0404"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher G. Grupen","raw_affiliation_strings":["BresaGen Limited, Adelaide, South Australia, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BresaGen Limited, Adelaide, South Australia, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111906916","display_name":"S. M. McIlfatrick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen M. McIlfatrick","raw_affiliation_strings":["BresaGen Limited, Adelaide, South Australia, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BresaGen Limited, Adelaide, South Australia, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059077232","display_name":"Rodney J. Ashman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rodney J. Ashman","raw_affiliation_strings":["BresaGen Limited, Adelaide, South Australia, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BresaGen Limited, Adelaide, South Australia, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063848439","display_name":"Ian G. Lyons","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ian G. Lyons","raw_affiliation_strings":["BresaGen Limited, Adelaide, South Australia, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BresaGen Limited, Adelaide, South Australia, Australia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029200954","display_name":"Mark B. Nottle","orcid":"https://orcid.org/0000-0001-7625-5542","observed_orcids":["https://orcid.org/0000-0001-7625-5542"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark B. Nottle","raw_affiliation_strings":["BresaGen Limited, Adelaide, South Australia, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BresaGen Limited, Adelaide, South Australia, Australia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5006250882"],"corresponding_institution_ids":[],"apc_list":{"value":4260,"currency":"USD","value_usd":4260},"apc_paid":null,"fwci":1.5911,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.81668435,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"57","issue":"3","first_page":"262","last_page":"269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatic-cell-nuclear-transfer","display_name":"somatic cell nuclear transfer","score":0.8220000267028809},{"id":"https://openalex.org/keywords/fetal-fibroblasts","display_name":"fetal fibroblasts","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cell-cycle-synchronization","display_name":"cell cycle synchronization","score":0.6970000267028809},{"id":"https://openalex.org/keywords/serum-deprivation","display_name":"serum deprivation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/blastocyst-development","display_name":"blastocyst development","score":0.8539999723434448},{"id":"https://openalex.org/keywords/embryo-transfer","display_name":"embryo transfer","score":0.4020000100135803},{"id":"https://openalex.org/keywords/piglet-production","display_name":"piglet production","score":0.4230000078678131},{"id":"https://openalex.org/keywords/microsatellite-analysis","display_name":"microsatellite analysis","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8573901653289795},{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.8483392000198364},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.7345003485679626},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.722618579864502},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5745323300361633},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5432823896408081},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.513519823551178},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.47401338815689087},{"id":"https://openalex.org/C159399396","wikidata":"https://www.wikidata.org/wiki/Q1335221","display_name":"Inner cell mass","level":5,"score":0.47350412607192993},{"id":"https://openalex.org/C160099875","wikidata":"https://www.wikidata.org/wiki/Q237118","display_name":"Embryo transfer","level":3,"score":0.4425355792045593},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.43472516536712646},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3742837905883789},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3610382080078125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34871554374694824},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23576056957244873},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.16000857949256897},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12187328934669495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001755","descriptor_name":"Blastocyst","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004624","descriptor_name":"Embryo Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005314","descriptor_name":"Embryonic and Fetal Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016895","descriptor_name":"Culture Media, Serum-Free","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053652","descriptor_name":"Nuclear Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/1098-2795(200011)57:3<262::aid-mrd8>3.0.co;2-x","doi":"https://doi.org/10.1002/1098-2795(200011)57:3<262::aid-mrd8>3.0.co;2-x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1098-2795(200011)57:3<262::aid-mrd8>3.0.co;2-x","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},{"id":"pmid:11013434","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11013434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular reproduction and development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324020","display_name":"South Australian Research and Development Institute","ror":"https://ror.org/042gmmd19"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1487014009","https://openalex.org/W1585827177","https://openalex.org/W1948355408","https://openalex.org/W1970894097","https://openalex.org/W1972832879","https://openalex.org/W1986392995","https://openalex.org/W1992525863","https://openalex.org/W1992555309","https://openalex.org/W2003701368","https://openalex.org/W2012021116","https://openalex.org/W2013258783","https://openalex.org/W2020385292","https://openalex.org/W2024926816","https://openalex.org/W2027543816","https://openalex.org/W2033992083","https://openalex.org/W2039058940","https://openalex.org/W2051360543","https://openalex.org/W2054161096","https://openalex.org/W2069080459","https://openalex.org/W2070304098","https://openalex.org/W2075679174","https://openalex.org/W2119301650","https://openalex.org/W2127442070","https://openalex.org/W2127467553","https://openalex.org/W2129602359","https://openalex.org/W2133955541","https://openalex.org/W2146108212","https://openalex.org/W2146124982","https://openalex.org/W2149224534"],"related_works":["https://openalex.org/W7096598571","https://openalex.org/W7006794519","https://openalex.org/W2050719958","https://openalex.org/W2349924613","https://openalex.org/W2172529399","https://openalex.org/W2068511732","https://openalex.org/W4253175868","https://openalex.org/W2153280033","https://openalex.org/W2371264574","https://openalex.org/W2020385292"],"abstract_inverted_index":{"The":[0,64,125],"in":[1,29,47,73],"vitro":[2,48],"development":[3,106],"of":[4,66,105,136,160,195,213,227,235],"porcine":[5],"nuclear":[6,170,241],"transfer":[7,171,242],"embryos":[8,68,172,243],"constructed":[9],"using":[10,31,97,128,174],"primary":[11],"cultures":[12],"from":[13,239],"day":[14],"25":[15],"fetal":[16],"fibroblasts":[17],"which":[18,196,216],"were":[19,39,57,148,177,190,208,217,237],"either":[20,61,98,218],"rapidly":[21],"dividing":[22],"(cycling)":[23],"or":[24,205,220],"had":[25,131,155,199],"their":[26],"cell-cycle":[27],"synchronized":[28],"G0/G1":[30],"serum":[32],"starvation":[33],"(serum-starved)":[34],"was":[35,71,94],"examined.":[36],"Oocyte-karyoplast":[37],"complexes":[38],"fused":[40],"and":[41,44,116,151,163,168],"activated":[42],"simultaneously":[43],"then":[45],"cultured":[46],"for":[49,60,141,184],"seven":[50],"days":[51],"to":[52,78,90,107,179,201,210],"assess":[53],"development.":[54],"Fusion":[55],"rates":[56,104],"not":[58,95],"different":[59,96],"cell":[62,134,139,157],"population.":[63,99],"proportion":[65],"reconstructed":[67,173],"that":[69,233],"cleaved":[70],"higher":[72],"the":[74,79,91,108,142,202,240],"cycling":[75,113,122,129],"group":[76,81],"compared":[77],"serum-starved":[80,146,175],"(79":[82],"vs.":[83,111,114,120,123],"56%":[84],"respectively;":[85],"P":[86],"<":[87],"0.05).":[88],"Development":[89],"4-cell":[92,203],"stage":[93,118,204],"Both":[100],"treatments":[101],"supported":[102],"similar":[103],"morula":[109],"(1.5":[110,119],"7%,":[112],"serum-starved)":[115],"blastocyst":[117,126],"3%,":[121],"serum-starved).":[124],"produced":[127,145],"cells":[130,147,176],"a":[132,211,225],"total":[133,212,226],"number":[135],"10.":[137],"Total":[138],"numbers":[140,159],"three":[143],"blastocysts":[144,154],"22,":[149],"24,":[150],"33.":[152],"These":[153,207],"inner":[156],"mass":[158],"0,":[161],"15,":[162],"4,":[164],"respectively.":[165],"Six":[166],"hundred":[167],"thirty-five":[169],"transferred":[178,209],"15":[180,214],"temporarily":[181],"mated":[182],"recipients":[183,215,223],"3-4":[185],"days.":[186],"Of":[187],"these,":[188],"486":[189],"recovered":[191],"(77%":[192],"recovery":[193],"rate)":[194],"106":[197],"(22%)":[198],"developed":[200],"later.":[206],"unmated":[219],"mated.":[221],"Seven":[222],"farrowed":[224],"51":[228],"piglets.":[229],"Microsatellite":[230],"analysis":[231],"revealed":[232],"none":[234],"these":[236],"derived":[238],"transferred.":[244]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
