{"id":"https://openalex.org/W2000547781","doi":"https://doi.org/10.1002/eji.1830230826","title":"Antibody\u2010induced activation of the hyaluronan receptor function of CD44 requires multivalent binding by antibody","display_name":"Antibody\u2010induced activation of the hyaluronan receptor function of CD44 requires multivalent binding by antibody","publication_year":1993,"publication_date":"1993-08-01","ids":{"openalex":"https://openalex.org/W2000547781","doi":"https://doi.org/10.1002/eji.1830230826","mag":"2000547781","pmid":"https://pubmed.ncbi.nlm.nih.gov/7688309"},"language":"en","primary_location":{"id":"doi:10.1002/eji.1830230826","doi":"https://doi.org/10.1002/eji.1830230826","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830230826","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006863443","display_name":"Jayne Lesley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jayne Lesley","raw_affiliation_strings":["Department of Cancer Biology, Salk Institute, San Diego, CA 92186-5800"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Salk Institute, San Diego, CA 92186-5800","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111663565","display_name":"Paul W. Kincade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul W. Kincade","raw_affiliation_strings":["Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000824752","display_name":"Robert Hyman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Hyman","raw_affiliation_strings":["Department of Cancer Biology, The Salk Institute, San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, The Salk Institute, San Diego","institution_ids":["https://openalex.org/I1307098950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006863443"],"corresponding_institution_ids":["https://openalex.org/I1307098950"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":2.3232,"has_fulltext":false,"cited_by_count":122,"citation_normalized_percentile":{"value":0.88078831,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"23","issue":"8","first_page":"1902","last_page":"1909"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10869","display_name":"Polysaccharides and Plant Cell Walls","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hyaluronan-receptor","display_name":"hyaluronan receptor","score":0.9539999961853027},{"id":"https://openalex.org/keywords/hyaluronan-binding","display_name":"hyaluronan binding","score":0.8999999761581421},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.7289999723434448},{"id":"https://openalex.org/keywords/fab-fragment","display_name":"Fab fragment","score":0.7879999876022339},{"id":"https://openalex.org/keywords/antibody-aggregation","display_name":"antibody aggregation","score":0.49799999594688416},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.5849999785423279},{"id":"https://openalex.org/keywords/receptor-activation","display_name":"receptor activation","score":0.5680000185966492},{"id":"https://openalex.org/keywords/antibody-cross-linking","display_name":"antibody cross-linking","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6821168661117554},{"id":"https://openalex.org/C2776515853","wikidata":"https://www.wikidata.org/wiki/Q2191895","display_name":"Iodoacetamide","level":4,"score":0.6615334749221802},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6301814317703247},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5675204992294312},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5672889351844788},{"id":"https://openalex.org/C2909223937","wikidata":"https://www.wikidata.org/wiki/Q909628","display_name":"Immunoglobulin Fab Fragments","level":5,"score":0.49799108505249023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46893882751464844},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4574138820171356},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4312405586242676},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3789289593696594},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13109195232391357},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.08531591296195984},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.05908825993537903},{"id":"https://openalex.org/C85630698","wikidata":"https://www.wikidata.org/wiki/Q3826179","display_name":"Complementarity determining region","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016201","descriptor_name":"Receptors, Lymphocyte Homing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/eji.1830230826","doi":"https://doi.org/10.1002/eji.1830230826","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830230826","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:7688309","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7688309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.800000011920929}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1429221776","display_name":null,"funder_award_id":"AI19884","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1444238957","display_name":"CD44:  HYALURONIC ACID BINDING AND LYMPHOCYTE MIGRATION","funder_award_id":"5r01ai031613-09","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1489790205","display_name":"DEVELOPMENTAL DEFECTS AFFECTING HUMORAL IMMUNITY","funder_award_id":"5r01ai019884-09","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G493353704","display_name":null,"funder_award_id":"AI 31613","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6582943367","display_name":null,"funder_award_id":"CA 13287","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1211643602","https://openalex.org/W1479909263","https://openalex.org/W1487425110","https://openalex.org/W1492070707","https://openalex.org/W1505531277","https://openalex.org/W1516024169","https://openalex.org/W1536864941","https://openalex.org/W1569428681","https://openalex.org/W1577893357","https://openalex.org/W1598762088","https://openalex.org/W1631062358","https://openalex.org/W1870544273","https://openalex.org/W1974861766","https://openalex.org/W1979116835","https://openalex.org/W1985585224","https://openalex.org/W1986223461","https://openalex.org/W1990942696","https://openalex.org/W1996787107","https://openalex.org/W2004062197","https://openalex.org/W2004203577","https://openalex.org/W2006696441","https://openalex.org/W2011541235","https://openalex.org/W2013355077","https://openalex.org/W2026233658","https://openalex.org/W2031742143","https://openalex.org/W2040544223","https://openalex.org/W2047075585","https://openalex.org/W2052986295","https://openalex.org/W2059226282","https://openalex.org/W2060623940","https://openalex.org/W2071167287","https://openalex.org/W2078292199","https://openalex.org/W2079569513","https://openalex.org/W2082665551","https://openalex.org/W2086530351","https://openalex.org/W2089562291","https://openalex.org/W2091436050","https://openalex.org/W2097863314","https://openalex.org/W2102791307","https://openalex.org/W2117269688","https://openalex.org/W2123257463","https://openalex.org/W2125572261","https://openalex.org/W2127401640","https://openalex.org/W2131480836","https://openalex.org/W2164620775","https://openalex.org/W2179076164"],"related_works":["https://openalex.org/W4252756124","https://openalex.org/W2006696441","https://openalex.org/W2004203577","https://openalex.org/W2157131142","https://openalex.org/W7096211362","https://openalex.org/W2388440598","https://openalex.org/W2050644354","https://openalex.org/W2067650446","https://openalex.org/W7095817119","https://openalex.org/W2147448836"],"abstract_inverted_index":{"CD44":[0,19,31,256,336,348,360],"can":[1],"function":[2,275],"as":[3],"a":[4,110,344],"receptor":[5,103,266,274,317],"for":[6,30,99,242,264],"hyaluronan":[7],"(HA).":[8],"However,":[9],"many":[10],"cell":[11,50,260,339],"lines":[12,51],"and":[13,52,87,90,125,144,303],"normal":[14,54],"hematopoietic":[15],"cells":[16],"that":[17,81,252,307,322],"express":[18],"do":[20],"not":[21,312,351],"constitutively":[22],"bind":[23,365],"HA.":[24],"A":[25],"monoclonal":[26],"antibody":[27,146,184,279,289],"(mAb)":[28],"specific":[29],"(IRAWB":[32,85],"14)":[33],"has":[34],"been":[35],"described":[36],"previously":[37],"which":[38,297,359],"induces":[39],"CD44-mediated":[40],"binding":[41,84,96,164,180,222,239,247,280,293,329],"of":[42,101,118,142,148,154,165,172,197,204,216,220,234,245,255,272,316,335,343],"HA":[43,83,102,167,221,246,265,273,292,328,366],"rapidly":[44],"(seconds":[45],"to":[46,92,112,120,137,177,212,230,300,364],"minutes)":[47],"in":[48,53,63,151,194,294,314,347,367],"some":[49],"murine":[55],"T":[56],"cells.":[57],"Of":[58],"16":[59],"CD44-specific":[60,249,324],"mAb":[61],"tested":[62],"the":[64,139,152,195,243,253,259,333,338],"present":[65],"study,":[66],"only":[67],"3":[68],"exhibited":[69],"this":[70],"activity.":[71],"Monovalent":[72,169],"Fab":[73,105,170,189,207,232],"fragments":[74,147,171],"were":[75,128,159,191,298,311],"prepared":[76],"from":[77,106],"two":[78],"IgG2a":[79],"antibodies":[80,108,174,325],"induce":[82,291],"14":[86,206],"IRAWB":[88,187,205,235],"26)":[89],"used":[91],"determine":[93],"whether":[94],"multivalent":[95,114,145,238],"was":[97,240],"required":[98,241],"induction":[100,196,271,315],"function.":[104,267,318],"both":[107,173],"had":[109,175],"tendency":[111],"form":[113],"aggregates.":[115],"After":[116],"addition":[117],"iodoacetamide":[119],"prevent":[121],"further":[122],"aggregation,":[123],"multimeric":[124],"monovalent":[126,143],"forms":[127,158],"separated":[129],"by":[130,227,248,330,358],"gel":[131],"filtration.":[132],"This":[133],"made":[134],"it":[135],"possible":[136,356],"compare":[138],"inducing":[140,163,202,327],"activity":[141,181,203],"identical":[149],"composition":[150],"absence":[153],"Fc":[155],"determinants.":[156],"Multimeric":[157],"very":[160,213],"active":[161],"at":[162,281],"fluorescein-conjugated":[166],"(Fl-HA).":[168],"20-":[176],"50-fold":[178],"lower":[179],"than":[182],"intact":[183],"or":[185],"multimer.":[186,218],"26":[188],"monomers":[190,233],"completely":[192],"inactive":[193],"HA-binding.":[198],"The":[199,341],"observed":[200],"weak":[201],"monomer":[208],"could":[209,223,290],"be":[210,225,362],"attributed":[211],"low":[214],"levels":[215],"contaminating":[217],"Induction":[219],"also":[224],"achieved":[226],"using":[228],"anti-immunoglobulin":[229],"cross-link":[231],"26.":[236],"Thus,":[237],"activation":[244],"antibody,":[250],"suggesting":[251,306],"distribution":[254,334],"molecules":[257],"on":[258,337],"surface":[261],"is":[262,350],"important":[263],"In":[268],"kinetic":[269],"studies,":[270],"occurred":[276],"simultaneously":[277],"with":[278],"0":[282],"degrees":[283],"C":[284],"(ice":[285],"water":[286],"bath).":[287],"Furthermore,":[288],"paraformaldehyde-fixed":[295],"cells,":[296],"permeable":[299],"propidium":[301],"iodide":[302],"trypan":[304],"blue,":[305],"intracellular":[308],"signaling":[309],"mechanisms":[310,357],"involved":[313],"We":[319,354],"conclude,":[320],"therefore,":[321],"these":[323],"are":[326],"directly":[331],"influencing":[332],"surface.":[340],"possibility":[342],"concurrent":[345],"change":[346],"conformation":[349],"ruled":[352],"out.":[353],"discuss":[355],"might":[361],"activated":[363],"vivo.":[368]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
