{"id":"https://openalex.org/W2000543898","doi":"https://doi.org/10.1073/pnas.1403424111","title":"Murine CD27 (\u2212) V\u03b36 (+) \u03b3\u03b4 T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages","display_name":"Murine CD27 (\u2212) V\u03b36 (+) \u03b3\u03b4 T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages","publication_year":2014,"publication_date":"2014-08-11","ids":{"openalex":"https://openalex.org/W2000543898","doi":"https://doi.org/10.1073/pnas.1403424111","mag":"2000543898","pmid":"https://pubmed.ncbi.nlm.nih.gov/25114209","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4151711"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1403424111","doi":"https://doi.org/10.1073/pnas.1403424111","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1403424111","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4151711","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054265552","display_name":"Margarida Rei","orcid":"https://orcid.org/0000-0001-5732-9972","observed_orcids":["https://orcid.org/0000-0001-5732-9972"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]},{"id":"https://openalex.org/I4405263123","display_name":"Instituto de Ci\u00eancias Biom\u00e9dicas Albel Salazar","ror":"https://ror.org/02trb6b02","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4405263123"]},{"id":"https://openalex.org/I4405263501","display_name":"Blizard Institute","ror":"https://ror.org/01y7pzx08","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405263501"]}],"countries":["GB","PT"],"is_corresponding":false,"raw_author_name":"Margarida Rei","raw_affiliation_strings":["Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, London E1 2AT, United Kingdom;","Graduate Program in Areas of Basic and Applied Biology, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal; and","Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, London E1 2AT, United Kingdom;","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]},{"raw_affiliation_string":"Graduate Program in Areas of Basic and Applied Biology, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal; and","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4405263123"]},{"raw_affiliation_string":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal;","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012057737","display_name":"Natacha Gon\u00e7alves\u2010Sousa","orcid":"https://orcid.org/0000-0001-5190-1122","observed_orcids":["https://orcid.org/0000-0001-5190-1122"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Natacha Gon\u00e7alves-Sousa","raw_affiliation_strings":["Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028, Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030570481","display_name":"Telma Lan\u00e7a","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Telma Lan\u00e7a","raw_affiliation_strings":["Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal;","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110405","display_name":"Richard G. Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard G. Thompson","raw_affiliation_strings":["Centre for Cancer and Inflammation, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cancer and Inflammation, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010775382","display_name":"Sofia Mensurado","orcid":"https://orcid.org/0000-0002-5157-0033","observed_orcids":["https://orcid.org/0000-0002-5157-0033"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Sofia Mensurado","raw_affiliation_strings":["Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal;","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061389369","display_name":"Frances R. Balkwill","orcid":"https://orcid.org/0000-0002-5587-9759","observed_orcids":["https://orcid.org/0000-0002-5587-9759"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Frances R. Balkwill","raw_affiliation_strings":["Centre for Cancer and Inflammation, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cancer and Inflammation, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007022644","display_name":"Hagen Kulbe","orcid":"https://orcid.org/0000-0002-4367-289X","observed_orcids":["https://orcid.org/0000-0002-4367-289X"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hagen Kulbe","raw_affiliation_strings":["Centre for Cancer and Inflammation, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cancer and Inflammation, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081521025","display_name":"Daniel J. Pennington","orcid":"https://orcid.org/0000-0001-7889-9923","observed_orcids":["https://orcid.org/0000-0001-7889-9923"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405263501","display_name":"Blizard Institute","ror":"https://ror.org/01y7pzx08","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405263501"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel J. Pennington","raw_affiliation_strings":["Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, London, E1 2AT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, London, E1 2AT, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030043762","display_name":"Bruno Silva\u2010Santos","orcid":"https://orcid.org/0000-0003-4141-9302","observed_orcids":["https://orcid.org/0000-0003-4141-9302"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Bruno Silva-Santos","raw_affiliation_strings":["Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal;","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.3758,"has_fulltext":false,"cited_by_count":222,"citation_normalized_percentile":{"value":0.98381611,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"111","issue":"34","first_page":"E3562","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.07320000231266022,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.8759999871253967},{"id":"https://openalex.org/keywords/il-17a","display_name":"IL-17A","score":0.9340000152587891},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9760000109672546},{"id":"https://openalex.org/keywords/peritoneal-cancer","display_name":"peritoneal cancer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/il-17-receptor-a","display_name":"IL-17 receptor A","score":0.8140000104904175},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.7490000128746033},{"id":"https://openalex.org/keywords/tumor-inflammation","display_name":"tumor inflammation","score":0.6600000262260437},{"id":"https://openalex.org/keywords/id8-tumor-model","display_name":"ID8 tumor model","score":0.6890000104904175},{"id":"https://openalex.org/keywords/tumor-surveillance","display_name":"tumor surveillance","score":0.7089999914169312},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.5019999742507935},{"id":"https://openalex.org/keywords/angiogenic-factors","display_name":"angiogenic factors","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C2776885095","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immunosurveillance","level":3,"score":0.8733764886856079},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5973156690597534},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5379678606987},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.530469536781311},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5051432251930237},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.49504533410072327},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4943077564239502},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4853929281234741},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46438655257225037},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.41811513900756836},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4147990942001343},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23566105961799622},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.20764386653900146},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.19439095258712769},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08637237548828125},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016692","descriptor_name":"Receptors, Antigen, T-Cell, gamma-delta","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D016692","descriptor_name":"Receptors, Antigen, T-Cell, gamma-delta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016692","descriptor_name":"Receptors, Antigen, T-Cell, gamma-delta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018127","descriptor_name":"Tumor Necrosis Factor Receptor Superfamily, Member 7","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D018127","descriptor_name":"Tumor Necrosis Factor Receptor Superfamily, Member 7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018127","descriptor_name":"Tumor Necrosis Factor Receptor Superfamily, Member 7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053722","descriptor_name":"Receptors, Interleukin-17","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.1403424111","doi":"https://doi.org/10.1073/pnas.1403424111","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1403424111","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3123965","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4151711","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25114209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25114209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4151711","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4151711/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"mag:2741713961","doi":null,"is_oa":false,"landing_page_url":"https://www.pnas.org/content/111/34/E3562.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3123965","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4151711","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3056145406","display_name":null,"funder_award_id":"16354","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1484643071","https://openalex.org/W1560292036","https://openalex.org/W1614324271","https://openalex.org/W1677487429","https://openalex.org/W1821802349","https://openalex.org/W1852098389","https://openalex.org/W1920167267","https://openalex.org/W1935309503","https://openalex.org/W1976338357","https://openalex.org/W1978295910","https://openalex.org/W1982611882","https://openalex.org/W1983260461","https://openalex.org/W1989832114","https://openalex.org/W1997661057","https://openalex.org/W1997928688","https://openalex.org/W2000102677","https://openalex.org/W2002409863","https://openalex.org/W2006428939","https://openalex.org/W2012731604","https://openalex.org/W2021955841","https://openalex.org/W2023056761","https://openalex.org/W2024397767","https://openalex.org/W2029393400","https://openalex.org/W2030510126","https://openalex.org/W2030591271","https://openalex.org/W2043291701","https://openalex.org/W2044114076","https://openalex.org/W2044224359","https://openalex.org/W2052102821","https://openalex.org/W2052375870","https://openalex.org/W2057968053","https://openalex.org/W2058034626","https://openalex.org/W2060716894","https://openalex.org/W2063139530","https://openalex.org/W2064037601","https://openalex.org/W2068119757","https://openalex.org/W2068714945","https://openalex.org/W2088770181","https://openalex.org/W2095167461","https://openalex.org/W2100153750","https://openalex.org/W2109666345","https://openalex.org/W2110929110","https://openalex.org/W2113036897","https://openalex.org/W2114300975","https://openalex.org/W2120621109","https://openalex.org/W2121800716","https://openalex.org/W2124109795","https://openalex.org/W2126608150","https://openalex.org/W2127282925","https://openalex.org/W2128945160","https://openalex.org/W2131771270","https://openalex.org/W2134108915","https://openalex.org/W2136570726","https://openalex.org/W2136757803","https://openalex.org/W2139558439","https://openalex.org/W2139866287","https://openalex.org/W2144737008","https://openalex.org/W2151055438","https://openalex.org/W2152514732","https://openalex.org/W2156261200","https://openalex.org/W2159078804","https://openalex.org/W2162276243","https://openalex.org/W2162298266","https://openalex.org/W2162391015","https://openalex.org/W2164720040","https://openalex.org/W2168589719","https://openalex.org/W2170078909","https://openalex.org/W2995442355"],"related_works":["https://openalex.org/W2741713961","https://openalex.org/W2127282925","https://openalex.org/W3008238977","https://openalex.org/W2095167461","https://openalex.org/W2023056761","https://openalex.org/W2979394664","https://openalex.org/W3101968882","https://openalex.org/W2947901241","https://openalex.org/W2460443320","https://openalex.org/W2799980410"],"abstract_inverted_index":{"Cancer-associated":[0],"inflammation":[1],"mobilizes":[2],"a":[3,46,135],"variety":[4],"of":[5,33,53,86,94,144,156,168,206],"leukocyte":[6],"populations":[7],"that":[8,44,140,226],"can":[9,25],"inhibit":[10],"or":[11],"enhance":[12],"tumor":[13,60,74,82,115,129,228],"cell":[14,50,61,106,210,229],"growth":[15,116,230],"in":[16,45,67,71,127,175],"situ.":[17],"These":[18],"subsets":[19],"include":[20],"\u03b3\u03b4":[21,56,63,88,124,160,221],"T":[22,57,64,89,105,125,161,222],"cells,":[23],"which":[24,194],"infiltrate":[26],"tumors":[27],"and":[28,76,109,149,187,190,203,224,231],"typically":[29],"provide":[30],"large":[31,178],"amounts":[32],"antitumor":[34],"cytokines,":[35],"such":[36],"as":[37],"IFN-\u03b3.":[38,99],"By":[39],"contrast,":[40],"we":[41],"report":[42],"here":[43],"well-established":[47],"transplantable":[48],"(ID8":[49],"line)":[51],"model":[52],"peritoneal/ovarian":[54],"cancer,":[55],"cells":[58,65,90,126,162,223],"promote":[59],"growth.":[62],"accumulated":[66],"the":[68,128,145,165],"peritoneal":[69,171,179],"cavity":[70],"response":[72],"to":[73,134],"challenge":[75],"could":[77],"be":[78],"visualized":[79],"within":[80],"solid":[81],"foci.":[83],"Functional":[84],"characterization":[85],"tumor-associated":[87],"revealed":[91],"preferential":[92,154],"production":[93,122],"interleukin-17A":[95],"(IL-17),":[96],"rather":[97],"than":[98],"Consistent":[100],"with":[101,118,164,177],"this":[102,213],"finding,":[103],"both":[104],"receptor":[107,185],"(TCR)\u03b4-deficient":[108],"IL-17-deficient":[110],"mice":[111],"displayed":[112],"reduced":[113],"ID8":[114],"compared":[117],"wild-type":[119],"animals.":[120],"IL-17":[121,184],"by":[123,197],"environment":[130],"was":[131],"essentially":[132],"restricted":[133],"highly":[136],"proliferative":[137],"CD27((-))":[138,158],"subset":[139],"expressed":[141],"V\u03b36":[142],"instead":[143],"more":[146],"common":[147],"V\u03b31":[148],"V\u03b34":[150],"TCR":[151],"chains.":[152],"The":[153],"expansion":[155],"IL-17-secreting":[157],"V\u03b36((+))":[159],"associated":[163],"selective":[166],"mobilization":[167],"unconventional":[169],"small":[170],"macrophages":[172],"(SPMs)":[173],"that,":[174],"comparison":[176],"macrophages,":[180],"were":[181,195,201],"enriched":[182],"for":[183,188],"A,":[186],"protumor":[189],"proangiogenic":[191],"molecular":[192],"mediators,":[193],"up-regulated":[196],"IL-17.":[198],"Importantly,":[199],"SPMs":[200,225],"uniquely":[202],"directly":[204],"capable":[205],"promoting":[207],"ovarian":[208],"cancer":[209,234],"proliferation.":[211],"Collectively,":[212],"work":[214],"identifies":[215],"an":[216],"IL-17-dependent":[217],"lymphoid/myeloid":[218],"cross-talk":[219],"involving":[220],"promotes":[227],"thus":[232],"counteracts":[233],"immunosurveillance.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":32},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":25},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}