{"id":"https://openalex.org/W2000542026","doi":"https://doi.org/10.1007/s00005-010-0095-9","title":"Iron and Immunity: Immunological Consequences of Iron Deficiency and Overload","display_name":"Iron and Immunity: Immunological Consequences of Iron Deficiency and Overload","publication_year":2010,"publication_date":"2010-09-27","ids":{"openalex":"https://openalex.org/W2000542026","doi":"https://doi.org/10.1007/s00005-010-0095-9","mag":"2000542026","pmid":"https://pubmed.ncbi.nlm.nih.gov/20878249","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3173740"},"language":"en","primary_location":{"id":"doi:10.1007/s00005-010-0095-9","doi":"https://doi.org/10.1007/s00005-010-0095-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00005-010-0095-9","pdf_url":null,"source":{"id":"https://openalex.org/S25199142","display_name":"Archivum Immunologiae et Therapiae Experimentalis","issn_l":"0004-069X","issn":["0004-069X","1661-4917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archivum Immunologiae et Therapiae Experimentalis","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3173740","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002816827","display_name":"Bobby J. Cherayil","orcid":"https://orcid.org/0000-0002-6602-3374","observed_orcids":["https://orcid.org/0000-0002-6602-3374"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bobby J. Cherayil","raw_affiliation_strings":["Department of Pediatrics, Mucosal Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School, Building 114, 16th Street, Charlestown, Boston, MA 02129, USA. cherayil@helix.mgh.harvard.edu","Mucosal Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Mucosal Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School, Building 114, 16th Street, Charlestown, Boston, MA 02129, USA. cherayil@helix.mgh.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Mucosal Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002816827"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":0.6026,"has_fulltext":false,"cited_by_count":172,"citation_normalized_percentile":{"value":0.46337818,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"58","issue":"6","first_page":"407","last_page":"415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iron-metabolism","display_name":"iron metabolism","score":0.8960000276565552},{"id":"https://openalex.org/keywords/iron-homeostasis","display_name":"iron homeostasis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/iron-deficiency","display_name":"iron deficiency","score":0.8109999895095825},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.9980000257492065},{"id":"https://openalex.org/keywords/immunity","display_name":"immunity","score":0.6520000100135803},{"id":"https://openalex.org/keywords/immune-activation","display_name":"immune activation","score":0.5189999938011169},{"id":"https://openalex.org/keywords/iron-deficiency-anemia","display_name":"iron deficiency anemia","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7314320802688599},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.6970146894454956},{"id":"https://openalex.org/C2911035656","wikidata":"https://www.wikidata.org/wiki/Q5925744","display_name":"Iron homeostasis","level":3,"score":0.5314164757728577},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5218523740768433},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49933910369873047},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4990415573120117},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4613421559333801},{"id":"https://openalex.org/C2777417653","wikidata":"https://www.wikidata.org/wiki/Q1313081","display_name":"Iron deficiency","level":3,"score":0.42133069038391113},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3344796895980835},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3280504047870636},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32599395513534546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2019646167755127},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.12897831201553345},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09233450889587402},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.05816599726676941}],"mesh":[{"descriptor_ui":"D000090463","descriptor_name":"Iron Deficiencies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019190","descriptor_name":"Iron Overload","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019190","descriptor_name":"Iron Overload","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00005-010-0095-9","doi":"https://doi.org/10.1007/s00005-010-0095-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00005-010-0095-9","pdf_url":null,"source":{"id":"https://openalex.org/S25199142","display_name":"Archivum Immunologiae et Therapiae Experimentalis","issn_l":"0004-069X","issn":["0004-069X","1661-4917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archivum Immunologiae et Therapiae Experimentalis","raw_type":"journal-article"},{"id":"pmid:20878249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20878249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archivum immunologiae et therapiae experimentalis","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3173740","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3173740","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Arch Immunol Ther Exp (Warsz)","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3173740","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3173740","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Arch Immunol Ther Exp (Warsz)","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3517301340","display_name":"Cross-talk between iron metabolism and intestinal inflammation","funder_award_id":"R56AI089700","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000907652","display_name":"Boston Area Nutrition Obesity Research Center (NORC)","funder_award_id":"P30DK040561","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W75033969","https://openalex.org/W105261860","https://openalex.org/W115335675","https://openalex.org/W164440110","https://openalex.org/W1508669696","https://openalex.org/W1536513081","https://openalex.org/W1569423741","https://openalex.org/W1606274933","https://openalex.org/W1619868467","https://openalex.org/W1874356889","https://openalex.org/W1915602451","https://openalex.org/W1923797593","https://openalex.org/W1930655854","https://openalex.org/W1951212149","https://openalex.org/W1967368224","https://openalex.org/W1970548725","https://openalex.org/W1973938903","https://openalex.org/W1976665224","https://openalex.org/W1977767277","https://openalex.org/W1980042430","https://openalex.org/W1983970155","https://openalex.org/W1988377666","https://openalex.org/W1992739131","https://openalex.org/W1992880469","https://openalex.org/W1993844758","https://openalex.org/W1997734311","https://openalex.org/W1999203566","https://openalex.org/W2002047195","https://openalex.org/W2002605005","https://openalex.org/W2002609383","https://openalex.org/W2009988274","https://openalex.org/W2011537701","https://openalex.org/W2012956876","https://openalex.org/W2017995298","https://openalex.org/W2019251546","https://openalex.org/W2021497905","https://openalex.org/W2029565279","https://openalex.org/W2031243558","https://openalex.org/W2031283301","https://openalex.org/W2036124167","https://openalex.org/W2039839821","https://openalex.org/W2043412323","https://openalex.org/W2043523270","https://openalex.org/W2046392948","https://openalex.org/W2046891044","https://openalex.org/W2049912996","https://openalex.org/W2050656944","https://openalex.org/W2050833520","https://openalex.org/W2052812527","https://openalex.org/W2056164705","https://openalex.org/W2062711706","https://openalex.org/W2063209492","https://openalex.org/W2066672803","https://openalex.org/W2067125890","https://openalex.org/W2069594569","https://openalex.org/W2072428422","https://openalex.org/W2073018837","https://openalex.org/W2074040887","https://openalex.org/W2075073615","https://openalex.org/W2082852603","https://openalex.org/W2086904281","https://openalex.org/W2088475546","https://openalex.org/W2088982636","https://openalex.org/W2089836445","https://openalex.org/W2095474715","https://openalex.org/W2099729056","https://openalex.org/W2106447915","https://openalex.org/W2107079905","https://openalex.org/W2107423980","https://openalex.org/W2107596308","https://openalex.org/W2109491705","https://openalex.org/W2111797468","https://openalex.org/W2113246637","https://openalex.org/W2114771952","https://openalex.org/W2116374020","https://openalex.org/W2122044177","https://openalex.org/W2122529586","https://openalex.org/W2127989675","https://openalex.org/W2132155262","https://openalex.org/W2134096693","https://openalex.org/W2140534638","https://openalex.org/W2146941284","https://openalex.org/W2149695811","https://openalex.org/W2150374661","https://openalex.org/W2157509649","https://openalex.org/W2159865605","https://openalex.org/W2161897724","https://openalex.org/W2163487646","https://openalex.org/W2167404536","https://openalex.org/W2242288937","https://openalex.org/W2469414933","https://openalex.org/W4213134081","https://openalex.org/W4214512061","https://openalex.org/W4235735146","https://openalex.org/W4245248161"],"related_works":["https://openalex.org/W1572389258","https://openalex.org/W2147907216","https://openalex.org/W1011783265","https://openalex.org/W2056164705","https://openalex.org/W3009942139","https://openalex.org/W7161130644","https://openalex.org/W7154460476","https://openalex.org/W2991203943","https://openalex.org/W2013761623","https://openalex.org/W4411330080"],"abstract_inverted_index":{"The":[0,41],"influence":[1],"of":[2,72,81],"iron":[3,39,55,73,90],"on":[4,33],"immune":[5,59,83],"function":[6],"has":[7],"been":[8,25],"long":[9],"appreciated.":[10],"However,":[11],"the":[12,34,52,58,82],"molecular":[13],"basis":[14],"for":[15,48],"this":[16],"interaction":[17],"is":[18,66],"less":[19],"well":[20],"understood.":[21],"Recently,":[22],"there":[23],"have":[24,30],"several":[26],"important":[27],"advances":[28],"that":[29,36],"shed":[31],"light":[32],"mechanisms":[35],"regulate":[37],"mammalian":[38],"metabolism.":[40],"new":[42],"insights":[43],"provide":[44],"a":[45],"conceptual":[46],"framework":[47],"understanding":[49],"and":[50,57,78],"manipulating":[51],"cross-talk":[53],"between":[54],"homeostasis":[56],"system.":[60],"This":[61],"article":[62],"will":[63],"review":[64],"what":[65],"currently":[67],"known":[68],"about":[69],"how":[70,79],"disturbances":[71],"metabolism":[74],"can":[75,85],"affect":[76],"immunity":[77],"activation":[80],"system":[84],"lead":[86],"to":[87],"alterations":[88],"in":[89],"balance.":[91]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
