{"id":"https://openalex.org/W2000531537","doi":"https://doi.org/10.1074/jbc.m111.283879","title":"Dynamin Inhibition Blocks Botulinum Neurotoxin Type A Endocytosis in Neurons and Delays Botulism","display_name":"Dynamin Inhibition Blocks Botulinum Neurotoxin Type A Endocytosis in Neurons and Delays Botulism","publication_year":2011,"publication_date":"2011-08-05","ids":{"openalex":"https://openalex.org/W2000531537","doi":"https://doi.org/10.1074/jbc.m111.283879","mag":"2000531537","pmid":"https://pubmed.ncbi.nlm.nih.gov/21832053","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3195592"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m111.283879","doi":"https://doi.org/10.1074/jbc.m111.283879","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.283879","pdf_url":"http://www.jbc.org/article/S0021925820738044/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820738044/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003708021","display_name":"Callista B. Harper","orcid":"https://orcid.org/0000-0003-3489-9555","observed_orcids":["https://orcid.org/0000-0003-3489-9555"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Callista B. Harper","raw_affiliation_strings":["Queensland Brain Institute, the University of Queensland, Brisbane, Queensland 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queensland Brain Institute, the University of Queensland, Brisbane, Queensland 4072, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043736219","display_name":"Sally Martin","orcid":"https://orcid.org/0000-0001-9294-5404","observed_orcids":["https://orcid.org/0000-0001-9294-5404"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sally Martin","raw_affiliation_strings":["Queensland Brain Institute, the University of Queensland, Brisbane, Queensland 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queensland Brain Institute, the University of Queensland, Brisbane, Queensland 4072, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064960876","display_name":"Tam Hong Nguyen","orcid":"https://orcid.org/0000-0002-9049-5152","observed_orcids":["https://orcid.org/0000-0002-9049-5152","https://orcid.org/0000-0002-9833-4062"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tam H. Nguyen","raw_affiliation_strings":["Queensland Brain Institute, the University of Queensland, Brisbane, Queensland 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queensland Brain Institute, the University of Queensland, Brisbane, Queensland 4072, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029880001","display_name":"Shari Jane Daniels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Shari J. Daniels","raw_affiliation_strings":["Queensland Brain Institute, the University of Queensland, Brisbane, Queensland 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queensland Brain Institute, the University of Queensland, Brisbane, Queensland 4072, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111488659","display_name":"Nickolas A. Lavidis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nickolas A. Lavidis","raw_affiliation_strings":["School of Biomedical Sciences, the University of Queensland, Brisbane, Queensland 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences, the University of Queensland, Brisbane, Queensland 4072, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019497452","display_name":"Michel Robert Popoff","orcid":"https://orcid.org/0000-0001-9305-8989","observed_orcids":["https://orcid.org/0000-0001-9305-8989"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michel R. Popoff","raw_affiliation_strings":["Unit\u00e9 des Bact\u00e9ries ana\u00e9robies et Toxines, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 des Bact\u00e9ries ana\u00e9robies et Toxines, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris cedex, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024676710","display_name":"Gordana Hadzic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gordana Hadzic","raw_affiliation_strings":["Centre for Chemical Biology, Chemistry Building, the University of Newcastle, Callaghan, New South Wales 2308, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Chemical Biology, Chemistry Building, the University of Newcastle, Callaghan, New South Wales 2308, Australia","institution_ids":["https://openalex.org/I78757542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058396533","display_name":"Anna Mariana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I146584863","display_name":"Children's Medical Research Institute","ror":"https://ror.org/01bsaey45","country_code":"AU","type":"facility","lineage":["https://openalex.org/I146584863"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Anna Mariana","raw_affiliation_strings":["Children's Medical Research Institute, the University of Sydney, Sydney, New South Wales 2145, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Research Institute, the University of Sydney, Sydney, New South Wales 2145, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I146584863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021517640","display_name":"Ngoc Chau","orcid":"https://orcid.org/0000-0001-5507-0493","observed_orcids":["https://orcid.org/0000-0001-5507-0493"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I146584863","display_name":"Children's Medical Research Institute","ror":"https://ror.org/01bsaey45","country_code":"AU","type":"facility","lineage":["https://openalex.org/I146584863"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ngoc Chau","raw_affiliation_strings":["Children's Medical Research Institute, the University of Sydney, Sydney, New South Wales 2145, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Research Institute, the University of Sydney, Sydney, New South Wales 2145, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I146584863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026633618","display_name":"Adam McCluskey","orcid":"https://orcid.org/0000-0001-7125-863X","observed_orcids":["https://orcid.org/0000-0001-7125-863X"]},"institutions":[{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Adam McCluskey","raw_affiliation_strings":["Centre for Chemical Biology, Chemistry Building, the University of Newcastle, Callaghan, New South Wales 2308, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Chemical Biology, Chemistry Building, the University of Newcastle, Callaghan, New South Wales 2308, Australia","institution_ids":["https://openalex.org/I78757542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005523254","display_name":"Phillip James Robinson","orcid":"https://orcid.org/0000-0002-7878-0313","observed_orcids":["https://orcid.org/0000-0002-7878-0313"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I146584863","display_name":"Children's Medical Research Institute","ror":"https://ror.org/01bsaey45","country_code":"AU","type":"facility","lineage":["https://openalex.org/I146584863"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Phillip J. Robinson","raw_affiliation_strings":["Children's Medical Research Institute, the University of Sydney, Sydney, New South Wales 2145, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Research Institute, the University of Sydney, Sydney, New South Wales 2145, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I146584863"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019459840","display_name":"Fr\u00e9d\u00e9ric A. Meunier","orcid":"https://orcid.org/0000-0001-6400-1107","observed_orcids":["https://orcid.org/0000-0001-6400-1107","https://orcid.org/0000-0001-5157-8572","https://orcid.org/0000-0001-7953-2883"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Frederic A. Meunier","raw_affiliation_strings":["Queensland Brain Institute, the University of Queensland, Brisbane, Queensland 4072, Australia. Electronic address: f.meunier@uq.edu.au","Queensland Brain Institute  The University of Queensland  Brisbane  Queensland 4072  Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queensland Brain Institute, the University of Queensland, Brisbane, Queensland 4072, Australia. Electronic address: f.meunier@uq.edu.au","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"Queensland Brain Institute  The University of Queensland  Brisbane  Queensland 4072  Australia","institution_ids":["https://openalex.org/I165143802"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5019459840"],"corresponding_institution_ids":["https://openalex.org/I165143802"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":10.5753,"has_fulltext":true,"cited_by_count":163,"citation_normalized_percentile":{"value":0.9899109,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"286","issue":"41","first_page":"35966","last_page":"35976"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/botulinum-toxin-type-a","display_name":"botulinum toxin type A","score":0.9829999804496765},{"id":"https://openalex.org/keywords/botulism","display_name":"botulism","score":0.6439999938011169},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/synaptic-vesicles","display_name":"synaptic vesicles","score":0.7480000257492065},{"id":"https://openalex.org/keywords/clathrin-coated-vesicles","display_name":"clathrin-coated vesicles","score":0.925000011920929},{"id":"https://openalex.org/keywords/multivesicular-bodies","display_name":"multivesicular bodies","score":0.9589999914169312},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.8240000009536743},{"id":"https://openalex.org/keywords/motor-nerve-terminals","display_name":"motor nerve terminals","score":0.8960000276565552},{"id":"https://openalex.org/keywords/botulism-treatment","display_name":"botulism treatment","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C156407911","wikidata":"https://www.wikidata.org/wiki/Q420160","display_name":"Dynamin","level":4,"score":0.9562625885009766},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.8358352184295654},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.7648826837539673},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.6957812905311584},{"id":"https://openalex.org/C2779186577","wikidata":"https://www.wikidata.org/wiki/Q154865","display_name":"Botulism","level":2,"score":0.6834301948547363},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5613411664962769},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.5432634353637695},{"id":"https://openalex.org/C134499376","wikidata":"https://www.wikidata.org/wiki/Q14897641","display_name":"SNAP25","level":5,"score":0.49868011474609375},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.4387873113155365},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43012070655822754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4295775294303894},{"id":"https://openalex.org/C2780358027","wikidata":"https://www.wikidata.org/wiki/Q407752","display_name":"Neurotoxin","level":2,"score":0.42604103684425354},{"id":"https://openalex.org/C2777010668","wikidata":"https://www.wikidata.org/wiki/Q131268","display_name":"Clostridium botulinum","level":3,"score":0.42347386479377747},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.4189232587814331},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24974897503852844},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.19850078225135803},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1776549220085144},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.15485888719558716},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.15132209658622742},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.10705211758613586},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.07392510771751404},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001906","descriptor_name":"Botulism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001906","descriptor_name":"Botulism","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009284","descriptor_name":"Naphthols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013572","descriptor_name":"Synaptic Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019274","descriptor_name":"Botulinum Toxins, Type A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D022163","descriptor_name":"Clathrin-Coated Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034281","descriptor_name":"Dynamins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D034281","descriptor_name":"Dynamins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1074/jbc.m111.283879","doi":"https://doi.org/10.1074/jbc.m111.283879","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.283879","pdf_url":"http://www.jbc.org/article/S0021925820738044/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2461108","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3195592","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:21832053","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21832053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3195592","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3195592/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmh:oai:HAL:pasteur-01762247v1","doi":null,"is_oa":false,"landing_page_url":"https://pasteur.hal.science/pasteur-01762247","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biological Chemistry, 2011, 286 (41), pp.35966 - 35976. ⟨10.1074/jbc.M111.283879⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:uon:17423","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1959.13/1063910","pdf_url":null,"source":{"id":"https://openalex.org/S4377196471","display_name":"NOVA (University of Newcastle Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I78757542","host_organization_name":"University of Newcastle Australia","host_organization_lineage":["https://openalex.org/I78757542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m111.283879","doi":"https://doi.org/10.1074/jbc.m111.283879","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.283879","pdf_url":"http://www.jbc.org/article/S0021925820738044/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306648","display_name":"Children's Medical Research","ror":"https://ror.org/03fjgyw15"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000531537.pdf","grobid_xml":"https://content.openalex.org/works/W2000531537.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W637806715","https://openalex.org/W1486546665","https://openalex.org/W1557475289","https://openalex.org/W1649931880","https://openalex.org/W1840515050","https://openalex.org/W1963786196","https://openalex.org/W1970920351","https://openalex.org/W1976441735","https://openalex.org/W1978431105","https://openalex.org/W1979848038","https://openalex.org/W1980860909","https://openalex.org/W1982712294","https://openalex.org/W1990636181","https://openalex.org/W1994163441","https://openalex.org/W2007982098","https://openalex.org/W2008558256","https://openalex.org/W2011189824","https://openalex.org/W2013566508","https://openalex.org/W2014688619","https://openalex.org/W2015267452","https://openalex.org/W2018321735","https://openalex.org/W2018363788","https://openalex.org/W2025582056","https://openalex.org/W2025609921","https://openalex.org/W2026049773","https://openalex.org/W2028807809","https://openalex.org/W2031136388","https://openalex.org/W2032365189","https://openalex.org/W2033701533","https://openalex.org/W2036059965","https://openalex.org/W2036484541","https://openalex.org/W2037632846","https://openalex.org/W2038477730","https://openalex.org/W2041010702","https://openalex.org/W2042731166","https://openalex.org/W2048654645","https://openalex.org/W2050781047","https://openalex.org/W2052604870","https://openalex.org/W2052629150","https://openalex.org/W2056119251","https://openalex.org/W2057283557","https://openalex.org/W2061463538","https://openalex.org/W2063973309","https://openalex.org/W2066248618","https://openalex.org/W2068379293","https://openalex.org/W2069179176","https://openalex.org/W2069990903","https://openalex.org/W2078359618","https://openalex.org/W2087326433","https://openalex.org/W2087591804","https://openalex.org/W2090106870","https://openalex.org/W2095214002","https://openalex.org/W2098776203","https://openalex.org/W2105364466","https://openalex.org/W2112032807","https://openalex.org/W2120562958","https://openalex.org/W2122977798","https://openalex.org/W2128573075","https://openalex.org/W2134779664","https://openalex.org/W2136077343","https://openalex.org/W2137889830","https://openalex.org/W2141028120","https://openalex.org/W2144447780","https://openalex.org/W2147850752","https://openalex.org/W2151220738","https://openalex.org/W2151888693","https://openalex.org/W2152469298","https://openalex.org/W2153337344","https://openalex.org/W2157739177","https://openalex.org/W2160913295","https://openalex.org/W2162581172","https://openalex.org/W4296249670"],"related_works":["https://openalex.org/W2071648813","https://openalex.org/W2147024386","https://openalex.org/W3008357421","https://openalex.org/W3103529117","https://openalex.org/W2593473271","https://openalex.org/W7100738752","https://openalex.org/W943869171","https://openalex.org/W2069280414","https://openalex.org/W1577503046","https://openalex.org/W2091306821"],"abstract_inverted_index":{"The":[0],"botulinum":[1],"neurotoxins":[2],"(BoNTs)":[3],"are":[4,26],"di-chain":[5],"bacterial":[6],"proteins":[7],"responsible":[8],"for":[9,172],"the":[10,17,41,45,50,70,108,145,154,173],"paralytic":[11],"disease":[12],"botulism.":[13],"Following":[14],"binding":[15,63],"to":[16,68,116],"plasma":[18],"membrane":[19],"of":[20,47,151,156,175],"cholinergic":[21],"motor":[22,134],"nerve":[23,52,135],"terminals,":[24],"BoNTs":[25,48],"internalized":[27],"into":[28,88,133],"an":[29,85],"endocytic":[30,34],"compartment.":[31],"Although":[32],"several":[33],"pathways":[35],"have":[36],"been":[37],"characterized":[38],"in":[39,84,124,153,160],"neurons,":[40],"molecular":[42],"mechanism":[43],"underpinning":[44],"uptake":[46,185],"at":[49,144],"presynaptic":[51],"terminal":[53],"is":[54],"still":[55],"unclear.":[56],"Here,":[57],"a":[58,169],"recombinant":[59],"BoNT/A":[60],"heavy":[61],"chain":[62],"domain":[64],"(Hc)":[65],"was":[66,114,158],"used":[67],"unravel":[69],"internalization":[71,119,132],"pathway":[72],"by":[73,181],"fluorescence":[74],"and":[75,91,99,120,177],"electron":[76],"microscopy.":[77],"BoNT/A-Hc":[78,118,131],"initially":[79],"enters":[80],"cultured":[81],"hippocampal":[82,125],"neurons":[83],"activity-dependent":[86],"manner":[87],"synaptic":[89],"vesicles":[90,93],"clathrin-coated":[92],"before":[94],"also":[95,128],"entering":[96],"endosomal":[97],"structures":[98],"multivesicular":[100],"bodies.":[101],"We":[102],"found":[103],"that":[104],"inhibiting":[105],"dynamin":[106],"with":[107,130,163],"novel":[109],"potent":[110],"Dynasore":[111],"analog,":[112],"Dyngo-4a(TM),":[113],"sufficient":[115],"abolish":[117],"BoNT/A-induced":[121,142],"SNAP25":[122],"cleavage":[123],"neurons.":[126],"Dyngo-4a":[127,138],"interfered":[129],"terminals.":[136],"Furthermore,":[137],"afforded":[139],"protection":[140],"against":[141],"paralysis":[143],"rat":[146],"hemidiaphragm.":[147],"A":[148],"significant":[149],"delay":[150],">30%":[152],"onset":[155],"botulism":[157,176],"observed":[159],"mice":[161],"injected":[162],"Dyngo-4a.":[164],"Dynamin":[165],"inhibition":[166],"therefore":[167],"provides":[168],"therapeutic":[170],"avenue":[171],"treatment":[174],"other":[178],"diseases":[179],"caused":[180],"pathogens":[182],"sharing":[183],"dynamin-dependent":[184],"mechanisms.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}