{"id":"https://openalex.org/W2000512353","doi":"https://doi.org/10.1111/j.1067-1927.2004.0abstractxp.x","title":"015 Impact of Hydration on MMP\u2010Activity","display_name":"015 Impact of Hydration on MMP\u2010Activity","publication_year":2004,"publication_date":"2004-04-01","ids":{"openalex":"https://openalex.org/W2000512353","doi":"https://doi.org/10.1111/j.1067-1927.2004.0abstractxp.x","mag":"2000512353"},"language":"en","primary_location":{"id":"doi:10.1111/j.1067-1927.2004.0abstractxp.x","doi":"https://doi.org/10.1111/j.1067-1927.2004.0abstractxp.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1067-1927.2004.0abstractxp.x","pdf_url":null,"source":{"id":"https://openalex.org/S121715350","display_name":"Wound Repair and Regeneration","issn_l":"1067-1927","issn":["1067-1927","1524-475X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wound Repair and Regeneration","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036729067","display_name":"Andrea A. Tandara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea A. Tandara","raw_affiliation_strings":["Wound Healing Research Laboratory, Division of Plastic and Reconstructive Surgery, Northwestern University, Chicago, IL 60611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wound Healing Research Laboratory, Division of Plastic and Reconstructive Surgery, Northwestern University, Chicago, IL 60611","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053373029","display_name":"Thomas A. Mustoe","orcid":"https://orcid.org/0000-0001-8502-1633","observed_orcids":["https://orcid.org/0000-0001-8502-1633"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A. Mustoe","raw_affiliation_strings":["Wound Healing Research Laboratory, Division of Plastic and Reconstructive Surgery, Northwestern University, Chicago, IL 60611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wound Healing Research Laboratory, Division of Plastic and Reconstructive Surgery, Northwestern University, Chicago, IL 60611","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000925171","display_name":"Jon E. Mogford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon E. Mogford","raw_affiliation_strings":["Wound Healing Research Laboratory, Division of Plastic and Reconstructive Surgery, Northwestern University, Chicago, IL 60611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wound Healing Research Laboratory, Division of Plastic and Reconstructive Surgery, Northwestern University, Chicago, IL 60611","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.15820674,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"12","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.5210000276565552,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.5210000276565552,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.3910999894142151,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":0.8769999742507935},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":1.0},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":1.0},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.9330000281333923},{"id":"https://openalex.org/keywords/timp-2","display_name":"TIMP-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.8159999847412109},{"id":"https://openalex.org/keywords/human-epidermal-keratinocytes","display_name":"human epidermal keratinocytes","score":0.843999981880188},{"id":"https://openalex.org/keywords/air-liquid-interface","display_name":"air-liquid interface","score":0.578000009059906},{"id":"https://openalex.org/keywords/collagen-secretion","display_name":"collagen secretion","score":0.5410000085830688},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.6899999976158142},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9660000205039978}],"concepts":[{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.7447014451026917},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.7079525589942932},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.639801561832428},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5967168211936951},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5786442160606384},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.5428727269172668},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4526594877243042},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.44671157002449036},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3941793441772461},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3483348488807678},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3110562264919281},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21322882175445557},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08491766452789307},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06482982635498047},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1111/j.1067-1927.2004.0abstractxp.x","doi":"https://doi.org/10.1111/j.1067-1927.2004.0abstractxp.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1067-1927.2004.0abstractxp.x","pdf_url":null,"source":{"id":"https://openalex.org/S121715350","display_name":"Wound Repair and Regeneration","issn_l":"1067-1927","issn":["1067-1927","1524-475X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wound Repair and Regeneration","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.5400000214576721}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2075416126","https://openalex.org/W2072640657","https://openalex.org/W2170798392","https://openalex.org/W2039466861","https://openalex.org/W2597133632","https://openalex.org/W2026974125","https://openalex.org/W2025473224","https://openalex.org/W1997983818","https://openalex.org/W2161068283","https://openalex.org/W3150156593"],"abstract_inverted_index":{"Hydration":[0],"of":[1,6,17,80,234],"keratinocytes":[2,35,63,85],"modifies":[3],"the":[4,14,50,106,143,148,232,242],"levels":[5],"cytokines":[7],"they":[8],"secrete,":[9],"which":[10],"in":[11,22,57,69,72,74,136,142,147,175],"turn":[12],"impacts":[13],"secretory":[15],"behaviour":[16],"dermal":[18,90],"fibroblasts.":[19],"In":[20],"an":[21],"vitro":[23],"coculture":[24,52,73,160,199],"model,":[25],"conditioned":[26],"media":[27],"(CM)":[28],"collagen":[29],"content":[30],"was":[31,111,156,172,195,201],"decreased":[32,174,185],"44%":[33],"when":[34],"were":[36,93,102,120],"hydrated.":[37,109],"We":[38,48],"hypothesized":[39],"that":[40,208,219],"this":[41],"is":[42],"partly":[43],"due":[44],"to":[45,54,76,139],"increased":[46,134,158,197],"MMP\u2010activity.":[47],"used":[49],"same":[51],"model":[53],"study":[55],"changes":[56],"MMP\u2010activity":[58],"and":[59,71,87,118,126,171,179,188,200,213,218,238],"TIMP":[60],"secreted":[61,129,152,167],"by":[62,67,130,154,159,168,198,203],"as":[64,66],"well":[65],"fibroblasts":[68,91],"monoculture":[70,177],"relation":[75],"air\u2010treatment":[77],"or":[78,108],"hydration":[79,182,221,235],"keratinocytes.":[81],"Stratified":[82],"human":[83,89],"epidermal":[84],"(HEK)":[86],"confluent":[88],"(HDF)":[92],"cocultured":[94],"for":[95,113],"72":[96],"h":[97],"under":[98],"serum\u2010free":[99],"conditions.":[100],"HEK":[101,212,220,237],"either":[103],"kept":[104],"at":[105],"air\u2010interface":[107],"CM":[110],"assayed":[112,121],"MMP\u20101,":[114,128],"\u22122,":[115],"\u22129,":[116],"TIMP\u20101":[117,193],"\u22122":[119],"using":[122],"zymograms,":[123],"western":[124],"blotting,":[125],"ELISA.":[127],"both":[131],"cell":[132],"types,":[133],"significantly":[135,157,173,196,222],"cocultures":[137],"compared":[138],"monocultures":[140],"(4\u2010fold":[141],"air\u2010treated":[144,169],"group,":[145],"26\u2010fold":[146],"hydrated":[149,176],"group).":[150],"MMP\u20102,":[151],"mainly":[153],"HDFs,":[155],"(hydration:":[161],"2.4\u2010fold,":[162],"air:":[163],"2.8\u2010fold).":[164],"MMP\u20109,":[165],"predominantly":[166],"HEKs":[170],"(76%)":[178],"coculture.":[180],"HEK\u2010monoculture":[181],"also":[183],"significant":[184],"MMP\u20101":[186],"(86%)":[187],"MMP\u20102":[189],"(81%)":[190],"activity.":[191,226],"HDF\u2010secreted":[192],"expression":[194],"unaffected":[202],"hydration.":[204],"Our":[205],"findings":[206,228],"demonstrate":[207],"paracrine":[209],"interactions":[210],"between":[211],"HDF":[214,239],"modify":[215],"MMP":[216,225],"activity":[217],"effects":[223],"on":[224,236],"The":[227],"provide":[229],"insight":[230],"into":[231],"role":[233],"ctivity":[240],"during":[241],"wound":[243],"healing":[244],"process.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}