{"id":"https://openalex.org/W2000512310","doi":"https://doi.org/10.1159/000091034","title":"Trade-Off between L-Thyroxin and Melatonin in Immune Regulation of the Indian Palm Squirrel, Funambulus pennanti during the Reproductively Inactive Phase","display_name":"Trade-Off between L-Thyroxin and Melatonin in Immune Regulation of the Indian Palm Squirrel, Funambulus pennanti during the Reproductively Inactive Phase","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2000512310","doi":"https://doi.org/10.1159/000091034","mag":"2000512310","pmid":"https://pubmed.ncbi.nlm.nih.gov/16424677"},"language":"en","primary_location":{"id":"doi:10.1159/000091034","doi":"https://doi.org/10.1159/000091034","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000091034","pdf_url":null,"source":{"id":"https://openalex.org/S84102376","display_name":"Neuroendocrinology","issn_l":"0028-3835","issn":["0028-3835","1423-0194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064700242","display_name":"Seema Rai","orcid":"https://orcid.org/0000-0003-2368-4401","observed_orcids":["https://orcid.org/0000-0003-2368-4401"]},"institutions":[{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Seema Rai","raw_affiliation_strings":["Department of Zoology, Pineal Research Lab, Reproductive Biology Unit, Banaras Hindu University, Varanasi 221005, India","Department of Zoology, Pineal Research Lab, Reproductive Biology Unit, Banaras Hindu University, Varanasi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Pineal Research Lab, Reproductive Biology Unit, Banaras Hindu University, Varanasi 221005, India","institution_ids":["https://openalex.org/I91357014"]},{"raw_affiliation_string":"Department of Zoology, Pineal Research Lab, Reproductive Biology Unit, Banaras Hindu University, Varanasi, India","institution_ids":["https://openalex.org/I91357014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063431599","display_name":"Chandana Haldar","orcid":"https://orcid.org/0000-0001-6307-6705","observed_orcids":["https://orcid.org/0000-0001-6307-6705"]},"institutions":[{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chandana Haldar","raw_affiliation_strings":["Department of Zoology, Pineal Research Lab, Reproductive Biology Unit, Banaras Hindu University, Varanasi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Pineal Research Lab, Reproductive Biology Unit, Banaras Hindu University, Varanasi, India","institution_ids":["https://openalex.org/I91357014"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054168298","display_name":"Shiv Shankar Singh","orcid":"https://orcid.org/0000-0002-1053-1580","observed_orcids":["https://orcid.org/0000-0002-1053-1580"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiv Shankar Singh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3426,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.4833204,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"82","issue":"2","first_page":"103","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.09749999642372131,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/levothyroxine","display_name":"levothyroxine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.656000018119812},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-thyroid-axis","display_name":"hypothalamic-pituitary-thyroid axis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/funambulus-pennanti","display_name":"Funambulus pennanti","score":0.8659999966621399},{"id":"https://openalex.org/keywords/indian-palm-squirrel","display_name":"Indian palm squirrel","score":0.9179999828338623},{"id":"https://openalex.org/keywords/reproductive-seasonality","display_name":"seasonal reproduction","score":0.5230000019073486},{"id":"https://openalex.org/keywords/thymocyte-proliferation","display_name":"thymocyte proliferation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/splenocyte-proliferation","display_name":"splenocyte proliferation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/lymphocyte-count","display_name":"lymphocyte count","score":0.7409999966621399},{"id":"https://openalex.org/keywords/immunometabolism","display_name":"immunometabolism","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8598147630691528},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8508041501045227},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.8044503331184387},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.6509003639221191},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6506818532943726},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5816324353218079},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5555680394172668},{"id":"https://openalex.org/C2778288131","wikidata":"https://www.wikidata.org/wiki/Q327362","display_name":"Triiodothyronine","level":3,"score":0.5326138734817505},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.48591724038124084},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.47122064232826233},{"id":"https://openalex.org/C2778954852","wikidata":"https://www.wikidata.org/wiki/Q7799635","display_name":"Thymocyte","level":4,"score":0.4701576232910156},{"id":"https://openalex.org/C8264082","wikidata":"https://www.wikidata.org/wiki/Q7113259","display_name":"Ovariectomized rat","level":3,"score":0.4669899344444275},{"id":"https://openalex.org/C2778057883","wikidata":"https://www.wikidata.org/wiki/Q92793969","display_name":"Follicular cell","level":3,"score":0.41098183393478394},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.19158542156219482},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15839681029319763},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14218395948410034}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012098","descriptor_name":"Reproduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012589","descriptor_name":"Sciuridae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018655","descriptor_name":"Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000091034","doi":"https://doi.org/10.1159/000091034","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000091034","pdf_url":null,"source":{"id":"https://openalex.org/S84102376","display_name":"Neuroendocrinology","issn_l":"0028-3835","issn":["0028-3835","1423-0194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"journal-article"},{"id":"pmid:16424677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16424677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320767","display_name":"University Grants Commission","ror":"https://ror.org/04p800546"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W29119567","https://openalex.org/W170011754","https://openalex.org/W1528384739","https://openalex.org/W1967646697","https://openalex.org/W1973675862","https://openalex.org/W1989056972","https://openalex.org/W2022139066","https://openalex.org/W2070104950","https://openalex.org/W2073369034","https://openalex.org/W2075949667","https://openalex.org/W2084708183","https://openalex.org/W2090337684","https://openalex.org/W2096056801","https://openalex.org/W2151510773","https://openalex.org/W2322893553","https://openalex.org/W2328894348","https://openalex.org/W2416839131","https://openalex.org/W2417211262"],"related_works":["https://openalex.org/W2109343169","https://openalex.org/W3118502377","https://openalex.org/W2616592029","https://openalex.org/W2181502588","https://openalex.org/W2129095486","https://openalex.org/W1972302398","https://openalex.org/W4388158878","https://openalex.org/W1992471003","https://openalex.org/W2032767296","https://openalex.org/W2171407785"],"abstract_inverted_index":{"The":[0,39],"thyroid":[1],"gland":[2],"and":[3,12,33,65,71,119,158,167,174],"its":[4,81],"hormones":[5,34],"have":[6],"been":[7,43],"reported":[8],"to":[9,20,45],"influence":[10],"reproduction":[11],"metabolism":[13],"in":[14,134,144],"a":[15,26,74,94,107,162],"positive":[16],"manner.":[17],"However,":[18,114],"research":[19],"date":[21],"provides":[22],"strong":[23],"evidence":[24],"for":[25,179],"reciprocal":[27],"relationship":[28],"between":[29],"the":[30,36,47,131,170],"immune":[31,53,112,171],"system":[32,172],"of":[35,49,69,73,97,110,117,137,165],"hypothalamus-pituitary-thyroid":[37],"axis.":[38],"present":[40],"study":[41],"has":[42],"taken":[44],"elucidate":[46],"effect":[48,164],"L-thyroxin":[50,92,118,166],"(T(4))":[51],"on":[52,156,169],"parameters":[54],"such":[55],"as":[56],"total":[57],"leukocyte":[58],"count,":[59,62],"percent":[60,66],"lymphocyte":[61],"blastogenic":[63],"response":[64],"stimulation":[67],"ratio":[68],"thymocytes":[70],"splenocytes":[72],"seasonally":[75],"breeding":[76],"rodent,":[77],"Funambulus":[78],"pennanti,":[79],"during":[80,103],"reproductively":[82],"inactive":[83],"phase":[84],"when":[85],"peripheral":[86],"T(4)":[87,138],"is":[88,177],"low.":[89],"Treatment":[90],"with":[91,146],"at":[93],"near-physiological":[95],"dose":[96],"35":[98],"microg/100":[99,122],"g":[100,123],"body":[101,124],"weight":[102],"evening":[104],"hours":[105],"showed":[106],"significant":[108,154],"elevation":[109],"all":[111],"parameters.":[113],"combined":[115],"treatment":[116],"melatonin":[120,147,168],"(25":[121],"weight)":[125],"had":[126],"no":[127],"additive":[128],"effect.":[129],"On":[130],"other":[132],"hand,":[133],"vitro":[135],"supplementation":[136],"(10(-6)":[139],"M)":[140],"either":[141],"alone":[142],"or":[143],"combination":[145],"(0.5":[148],"microM)":[149],"did":[150],"not":[151],"induce":[152],"any":[153],"change":[155],"thymocyte":[157],"splenocyte":[159],"proliferation.":[160],"Therefore,":[161],"trade-off":[163],"(T-":[173],"B-cell":[175],"differentiation)":[176],"suggested":[178],"this":[180],"rodent.":[181]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}