{"id":"https://openalex.org/W2000509433","doi":"https://doi.org/10.1172/jci113782","title":"Metabolic and functional consequences of inhibiting adenosine deaminase during renal ischemia in rats.","display_name":"Metabolic and functional consequences of inhibiting adenosine deaminase during renal ischemia in rats.","publication_year":1988,"publication_date":"1988-11-01","ids":{"openalex":"https://openalex.org/W2000509433","doi":"https://doi.org/10.1172/jci113782","mag":"2000509433","pmid":"https://pubmed.ncbi.nlm.nih.gov/3263396","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/442739"},"language":"en","primary_location":{"id":"doi:10.1172/jci113782","doi":"https://doi.org/10.1172/jci113782","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci113782","pdf_url":"http://www.jci.org/articles/view/113782/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/113782/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027165235","display_name":"Michael E. Stromski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M E Stromski","raw_affiliation_strings":["Department of Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06510","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039919140","display_name":"Aren van Waarde","orcid":"https://orcid.org/0000-0003-1183-1603","observed_orcids":["https://orcid.org/0000-0003-1183-1603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A van Waarde","raw_affiliation_strings":["Departments ofMolecular Biophysics and Biochemistry, Pathology,$ and Pediatrics ,","Pathology,$ and Pediatrics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments ofMolecular Biophysics and Biochemistry, Pathology,$ and Pediatrics ,","institution_ids":[]},{"raw_affiliation_string":"Pathology,$ and Pediatrics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084595279","display_name":"Malcolm J. Avison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M J Avison","raw_affiliation_strings":["Departments ofMolecular Biophysics and Biochemistry, Pathology,$ and Pediatrics ,","Pathology,$ and Pediatrics,","Renal Division, Brigham and Women's Hospital, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments ofMolecular Biophysics and Biochemistry, Pathology,$ and Pediatrics ,","institution_ids":[]},{"raw_affiliation_string":"Pathology,$ and Pediatrics,","institution_ids":[]},{"raw_affiliation_string":"Renal Division, Brigham and Women's Hospital, Boston, MA 02115","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069293478","display_name":"Gunilla Thulin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Thulin","raw_affiliation_strings":["Yale University School ofMedicine, New Haven, Connecticut 06510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School ofMedicine, New Haven, Connecticut 06510","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113434233","display_name":"Karen M. Gaudio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K M Gaudio","raw_affiliation_strings":["Yale University School ofMedicine, New Haven, Connecticut 06510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School ofMedicine, New Haven, Connecticut 06510","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082597667","display_name":"Michael J Kashgarian","orcid":"https://orcid.org/0000-0003-0362-7688","observed_orcids":["https://orcid.org/0000-0003-0362-7688"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Kashgarian","raw_affiliation_strings":["Renal Division , Brigham and Women's Hospital , Boston , MA 02115 ","Departments ofMolecular Biophysics and Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Division , Brigham and Women's Hospital , Boston , MA 02115 ","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Departments ofMolecular Biophysics and Biochemistry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008821583","display_name":"Robert G. Shulman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R G Shulman","raw_affiliation_strings":["Departments ofMolecular Biophysics and Biochemistry, Pathology,$ and Pediatrics ,","Pathology,$ and Pediatrics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments ofMolecular Biophysics and Biochemistry, Pathology,$ and Pediatrics ,","institution_ids":[]},{"raw_affiliation_string":"Pathology,$ and Pediatrics,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031476322","display_name":"Norman J. Siegel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N J Siegel","raw_affiliation_strings":["Renal Division , Brigham and Women's Hospital , Boston , MA 02115 ","Departments ofMolecular Biophysics and Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Division , Brigham and Women's Hospital , Boston , MA 02115 ","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Departments ofMolecular Biophysics and Biochemistry,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":3.2357,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.91575906,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"82","issue":"5","first_page":"1694","last_page":"1699"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenosine-deaminase-inhibition","display_name":"adenosine deaminase inhibition","score":0.9700000286102295},{"id":"https://openalex.org/keywords/2-deoxycoformycin","display_name":"2'-deoxycoformycin","score":0.9309999942779541},{"id":"https://openalex.org/keywords/renal-ischemia","display_name":"renal ischemia","score":0.968999981880188},{"id":"https://openalex.org/keywords/atp-recovery","display_name":"ATP recovery","score":0.7070000171661377},{"id":"https://openalex.org/keywords/adenine-nucleotide-pool","display_name":"adenine nucleotide pool","score":0.8970000147819519},{"id":"https://openalex.org/keywords/31p-nmr-spectroscopy","display_name":"31P NMR","score":0.7129999995231628},{"id":"https://openalex.org/keywords/renal-recovery","display_name":"renal function recovery","score":0.6420000195503235},{"id":"https://openalex.org/keywords/inulin-clearance","display_name":"inulin clearance","score":0.9129999876022339},{"id":"https://openalex.org/keywords/nucleotide-degradation","display_name":"nucleotide degradation","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C34628245","wikidata":"https://www.wikidata.org/wiki/Q356093","display_name":"Adenosine deaminase","level":3,"score":0.7977480888366699},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.7600971460342407},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.7098589539527893},{"id":"https://openalex.org/C2779564974","wikidata":"https://www.wikidata.org/wiki/Q80863","display_name":"Adenosine triphosphate","level":2,"score":0.6355196237564087},{"id":"https://openalex.org/C2910277799","wikidata":"https://www.wikidata.org/wiki/Q425470","display_name":"Deoxycoformycin","level":4,"score":0.5265949964523315},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5059062838554382},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5048085451126099},{"id":"https://openalex.org/C2994266630","wikidata":"https://www.wikidata.org/wiki/Q424021","display_name":"Adenine nucleotide","level":4,"score":0.5038956999778748},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47752276062965393},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.4374573528766632},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43540048599243164},{"id":"https://openalex.org/C2780721119","wikidata":"https://www.wikidata.org/wiki/Q7312492","display_name":"Renal ischemia","level":4,"score":0.43084716796875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37062686681747437},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33431923389434814},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33030813932418823},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.279148668050766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2724224925041199},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2704894542694092},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.21155548095703125},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003070","descriptor_name":"Coformycin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003070","descriptor_name":"Coformycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007444","descriptor_name":"Inulin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009700","descriptor_name":"Nucleoside Deaminases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015649","descriptor_name":"Pentostatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058892","descriptor_name":"Adenosine Deaminase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci113782","doi":"https://doi.org/10.1172/jci113782","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci113782","pdf_url":"http://www.jci.org/articles/view/113782/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:442739","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/442739","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:3263396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3263396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci113782","doi":"https://doi.org/10.1172/jci113782","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci113782","pdf_url":"http://www.jci.org/articles/view/113782/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.979200005531311,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2127675071","display_name":null,"funder_award_id":"AM 34576","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G779527957","display_name":"PATHOLOGY OF RECOVERY FROM ACUTE RENAL FAILURE","funder_award_id":"2r01am019930-09","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000509433.pdf","grobid_xml":"https://content.openalex.org/works/W2000509433.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1775749144","https://openalex.org/W1847685349","https://openalex.org/W1948704355","https://openalex.org/W1968126324","https://openalex.org/W1972280261","https://openalex.org/W1985881707","https://openalex.org/W1996197861","https://openalex.org/W2014422106","https://openalex.org/W2030066694","https://openalex.org/W2050590496","https://openalex.org/W2055340924","https://openalex.org/W2057520651","https://openalex.org/W2072034303","https://openalex.org/W2084900060","https://openalex.org/W2087564390","https://openalex.org/W2088392233","https://openalex.org/W2113603131","https://openalex.org/W2135143144","https://openalex.org/W2139723538","https://openalex.org/W2151473160","https://openalex.org/W2202469956","https://openalex.org/W2253446800","https://openalex.org/W2271117779","https://openalex.org/W2405242186","https://openalex.org/W2407030618","https://openalex.org/W2408550006","https://openalex.org/W4313310688"],"related_works":["https://openalex.org/W2415317342","https://openalex.org/W1996197861","https://openalex.org/W1970542751","https://openalex.org/W1976297336","https://openalex.org/W1966069708","https://openalex.org/W2419267205","https://openalex.org/W2396509040","https://openalex.org/W2253306738","https://openalex.org/W1977015569","https://openalex.org/W1477476730"],"abstract_inverted_index":{"The":[0,130],"concentrations":[1],"of":[2,29,35,43,50,65,69,77,82,112,138,170,181,198],"renal":[3,18],"ATP":[4,30,45,70,78,106,140],"have":[5],"been":[6],"measured":[7],"by":[8,85],"31P-nuclear":[9],"magnetic":[10],"resonance":[11],"(NMR)":[12],"before,":[13],"during,":[14],"and":[15],"after":[16,47,109,177,194],"bilateral":[17],"artery":[19],"occlusion.":[20],"Using":[21],"in":[22,97,149,154,162,172,187],"vivo":[23],"NMR,":[24],"the":[25,33,36,41,60,63,67,74,88,98,105,121,127,163,167,178],"initial":[26,107],"postischemic":[27,75,136],"recovery":[28,55,108,165],"increased":[31,104],"with":[32,53,87],"magnitude":[34],"residual":[37,99],"nucleotide":[38,101],"pool":[39],"at":[40,56,143],"end":[42],"ischemia.":[44],"levels":[46],"120":[48,144],"min":[49,111,145],"reflow":[51],"correlated":[52],"functional":[54,164],"24":[57,175],"h.":[58],"In":[59],"present":[61],"study":[62],"effect":[64],"blocking":[66],"degradation":[68],"during":[71,184],"ischemia":[72,113,185],"upon":[73],"restoration":[76,137],"was":[79,147,158],"investigated.":[80],"Inhibition":[81,180],"adenosine":[83,182],"deaminase":[84,183],"80%":[86],"tight-binding":[89],"inhibitor":[90],"2'-deoxycoformycin":[91],"led":[92],"to":[93,118,126,191],"a":[94,159,188,195],"20%":[95],"increase":[96],"adenine":[100],"pool.":[102],"This":[103],"45":[110],"from":[114,166],"52%":[115],"(in":[116,120],"controls)":[117],"62%":[119],"treated":[122,150],"animals),":[123],"as":[124],"compared":[125],"basal":[128],"levels.":[129],"inhibition":[131],"also":[132],"caused":[133],"an":[134],"accelerated":[135],"cellular":[139],"so":[141],"that":[142,192],"it":[146],"83%":[148],"rats":[151],"vs.":[152],"63%":[153],"untreated":[155],"animals.":[156],"There":[157],"corresponding":[160],"improvement":[161],"insult":[168],"(increase":[169],"33%":[171],"inulin":[173],"clearance":[174],"h":[176],"injury).":[179],"results":[186],"injury":[189],"similar":[190],"seen":[193],"shorter":[196],"period":[197],"insult.":[199]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}