{"id":"https://openalex.org/W2000504452","doi":"https://doi.org/10.1097/00007890-199904150-00437","title":"TACROLIMUS OR CYCLOSPORINE FOR IMMUNOSUPPRESSION AFTER HTx: WHICH TREATMENT REVEALS MORE SYSTEMIC SIDE EFFECTS DURING LONG TERM FOLLOW UP?","display_name":"TACROLIMUS OR CYCLOSPORINE FOR IMMUNOSUPPRESSION AFTER HTx: WHICH TREATMENT REVEALS MORE SYSTEMIC SIDE EFFECTS DURING LONG TERM FOLLOW UP?","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W2000504452","doi":"https://doi.org/10.1097/00007890-199904150-00437","mag":"2000504452"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-199904150-00437","doi":"https://doi.org/10.1097/00007890-199904150-00437","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199904150-00437","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104387165","display_name":"Bruno M. Meiser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. M. Meiser","raw_affiliation_strings":["Center***, 81366 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center***, 81366 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"D. Schmidt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Schmidt","raw_affiliation_strings":["Center***, 81366 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center***, 81366 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073839152","display_name":"Matthias Manuel Pfeiffer","orcid":"https://orcid.org/0000-0003-2607-5556","observed_orcids":["https://orcid.org/0000-0003-2607-5556"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Pfeiffer","raw_affiliation_strings":["Center***, 81366 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center***, 81366 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069956889","display_name":"Wolfgang von Scheidt","orcid":"https://orcid.org/0000-0003-4740-7783","observed_orcids":["https://orcid.org/0000-0003-4740-7783"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. v. Scheidt","raw_affiliation_strings":["Center***, 81366 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center***, 81366 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000912903","display_name":"V. Klauss","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. Klauss","raw_affiliation_strings":["Center***, 81366 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center***, 81366 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108408397","display_name":"Stephen M. Wildhirt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Wildhirt","raw_affiliation_strings":["Center***, 81366 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center***, 81366 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074684406","display_name":"P \u00dcberfuhr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. \u00dcberfuhr","raw_affiliation_strings":["Center***, 81366 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center***, 81366 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076167190","display_name":"Hermann C. Reichenspurner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Reichenspurner","raw_affiliation_strings":["Center***, 81366 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center***, 81366 Munich, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049461530","display_name":"Bruno Reichart","orcid":"https://orcid.org/0000-0003-2859-3664","observed_orcids":["https://orcid.org/0000-0003-2859-3664"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Reichart","raw_affiliation_strings":["Center***, 81366 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center***, 81366 Munich, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15986174,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"67","issue":"7","first_page":"S109","last_page":"S109"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":1.0},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9789999723434448},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7699999809265137},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/chronic-toxicity","display_name":"chronic toxicity","score":0.7149999737739563},{"id":"https://openalex.org/keywords/graft-rejection","display_name":"graft rejection","score":0.7400000095367432},{"id":"https://openalex.org/keywords/systemic-side-effects","display_name":"systemic side effects","score":0.7870000004768372},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.3409999907016754},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.5040000081062317},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.7789999842643738},{"id":"https://openalex.org/keywords/diuretic-therapy","display_name":"diuretic therapy","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8941348791122437},{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.825228214263916},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.8077921867370605},{"id":"https://openalex.org/C2776760755","wikidata":"https://www.wikidata.org/wiki/Q18939","display_name":"Azathioprine","level":3,"score":0.7822649478912354},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5486302971839905},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.513960063457489},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4993245601654053},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4746069312095642},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4642968773841858},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4588937759399414},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.43059203028678894},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.41642117500305176},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3082677125930786},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1810627579689026},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/00007890-199904150-00437","doi":"https://doi.org/10.1097/00007890-199904150-00437","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199904150-00437","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2106194537","https://openalex.org/W2035646807","https://openalex.org/W2102166696","https://openalex.org/W2170371096","https://openalex.org/W2093529832","https://openalex.org/W7217404600","https://openalex.org/W1965803678","https://openalex.org/W1970174615","https://openalex.org/W4255581794","https://openalex.org/W4206071440"],"abstract_inverted_index":{"409":[0],"In":[1],"a":[2,35],"controlled":[3],"randomized":[4],"clinical":[5],"trial":[6],"comparing":[7],"CsA":[8,69,112,151],"and":[9,16,57,67,81,88,108,147,195,206,217],"Tacrolimus":[10],"(Tac)":[11],"(in":[12],"combination":[13],"with":[14,34,201,212],"azathioprine":[15],"corticosteroids)":[17],"for":[18,29,105,110,168],"primary":[19,89],"immunosuppression":[20],"after":[21,84,138,181],"HTx,":[22,139],"Tac":[23,62,107,146,162,230,237],"proved":[24,183],"to":[25,124,164,184,203,221,239],"be":[26,165,240],"more":[27,39,166],"efficacious":[28,167],"prevention":[30,169],"of":[31,38,50,115,129,141,155,170,175,192,210,236,249],"rejection.":[32],"Now,":[33],"follow-up":[36,102],"period":[37],"than":[40,247],"2":[41,82,100,136,179],"years,":[42],"we":[43],"reinvestigated":[44],"the":[45,51,99,106,111,116,119,132,142,145,150,173,193,208,229,233],"long":[46],"term":[47],"side":[48],"effects":[49],"two":[52],"different":[53],"immunosuppressive":[54],"regimens.":[55],"Patients":[56],"methods:":[58],"Data":[59],"from":[60],"30":[61],"(mean":[63,72],"age:":[64,73],"53.1\u00b110.8":[65],"years)":[66,76],"22":[68],"patients":[70],"(pts)":[71],"52.8":[74],"\u00b17.0":[75],"were":[77,91],"compared":[78],"at":[79,241],"1":[80],"years":[83,137,180],"transplantation.":[85],"Demographic":[86],"data":[87],"diagnosis":[90],"comparable.":[92],"Results:":[93],"The":[94],"mean":[95],"rejection":[96],"incidence":[97,174],"during":[98],"year":[101],"was":[103,226],"1.3\u00b11.0":[104],"1.9\u00b10.7":[109],"group.":[113,231],"Evaluation":[114],"lab-data":[117,197],"revealed":[118,153,198],"following":[120,133],"results:":[121],"(Table)TableIn":[122],"order":[123],"achieve":[125,222],"these":[126,223],"values,":[127],"%":[128],"pts":[130,143,211],"needed":[131],"drug-treatments:":[134],"(Table)TableFurthermore,":[135],"31%":[140],"in":[144,149,159,187,228],"33%":[148],"group":[152],"signs":[154],"graft":[156,176],"vessel":[157,177],"disease":[158,178],"angiography.":[160],"Conclusions:":[161],"seems":[163,238],"rejection,":[171],"but":[172,244],"HTx":[182],"almost":[185],"identical":[186],"both":[188],"groups.":[189],"While":[190],"comparison":[191],"1-":[194],"2-year":[196],"similar":[199],"results":[200],"regard":[202],"creatinine,":[204],"glucose":[205],"lipids,":[207],"percentage":[209],"additional":[213],"diuretic,":[214],"lipid":[215],"lowering":[216],"antihypertonic":[218],"treatment":[219],"(necessary":[220],"values),":[224],"however,":[225],"lower":[227],"Therefore,":[232],"long-term":[234],"toxicity":[235],"least":[242],"equal,":[243],"not":[245],"worse":[246],"that":[248],"CsA.":[250]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
