{"id":"https://openalex.org/W2000492133","doi":"https://doi.org/10.1213/01.ane.0000255046.06058.58","title":"The Immunomodulatory Effect of Sevoflurane in Endotoxin-Injured Alveolar Epithelial Cells","display_name":"The Immunomodulatory Effect of Sevoflurane in Endotoxin-Injured Alveolar Epithelial Cells","publication_year":2007,"publication_date":"2007-02-15","ids":{"openalex":"https://openalex.org/W2000492133","doi":"https://doi.org/10.1213/01.ane.0000255046.06058.58","mag":"2000492133","pmid":"https://pubmed.ncbi.nlm.nih.gov/17312223"},"language":"en","primary_location":{"id":"doi:10.1213/01.ane.0000255046.06058.58","doi":"https://doi.org/10.1213/01.ane.0000255046.06058.58","is_oa":false,"landing_page_url":"https://doi.org/10.1213/01.ane.0000255046.06058.58","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.zora.uzh.ch/id/eprint/13388/9/Suter_BeckSchimmer_AnesthAnalg_2007_V.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017468650","display_name":"Dominik Suter","orcid":"https://orcid.org/0000-0002-5415-7084","observed_orcids":["https://orcid.org/0000-0002-5415-7084"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Dominik Suter","raw_affiliation_strings":["Institute of Anesthesiology, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anesthesiology, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109143834","display_name":"Donat R. Spahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Donat R. Spahn","raw_affiliation_strings":["[University of Zurich, Z\u00fcrich, Switzerland]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[University of Zurich, Z\u00fcrich, Switzerland]","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113625731","display_name":"Stephan Blumenthal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124057","display_name":"Universit\u00e4tsklinik Balgrist","ror":"https://ror.org/02yzaka98","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210124057"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Stephan Blumenthal","raw_affiliation_strings":["Department of Anesthesiology, Orthopedic University Clinic Zurich Balgrist, Zurich, Switzerland","Orthopadische Universitatsklinik Balgrist, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Orthopedic University Clinic Zurich Balgrist, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210124057"]},{"raw_affiliation_string":"Orthopadische Universitatsklinik Balgrist, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210124057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025553863","display_name":"Livia Reyes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Livia Reyes","raw_affiliation_strings":["Universit\u00e4tsSpital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsSpital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010105960","display_name":"Christa Booy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Christa Booy","raw_affiliation_strings":["Universit\u00e4tsSpital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsSpital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055695940","display_name":"B Roth-Z' Graggen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Birgit Roth Z??graggen","raw_affiliation_strings":["Universit\u00e4tsSpital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsSpital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017647895","display_name":"Beatrice Beck\u2010Schimmer","orcid":"https://orcid.org/0000-0002-0648-6115","observed_orcids":["https://orcid.org/0000-0002-0648-6115"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Beatrice Beck-Schimmer","raw_affiliation_strings":["University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017468650","https://openalex.org/A5017647895","https://openalex.org/A5109143834"],"corresponding_institution_ids":["https://openalex.org/I202697423"],"apc_list":null,"apc_paid":null,"fwci":2.9718,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.90471488,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"104","issue":"3","first_page":"638","last_page":"645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.295199990272522,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.295199990272522,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.2583000063896179,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.2053000032901764,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sevoflurane","display_name":"sevoflurane","score":1.0},{"id":"https://openalex.org/keywords/alveolar-epithelial-cells","display_name":"alveolar epithelial cells","score":0.8370000123977661},{"id":"https://openalex.org/keywords/endotoxin-induced-lung-injury","display_name":"endotoxin-induced lung injury","score":0.8410000205039978},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9940000176429749},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.7570000290870667},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/volatile-anesthetics","display_name":"volatile anesthetics","score":0.8519999980926514},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.7730000019073486},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9620000123977661},{"id":"https://openalex.org/keywords/mip-1beta","display_name":"MIP-1\u03b2","score":0.9649999737739563},{"id":"https://openalex.org/keywords/mip-2","display_name":"CXCL2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cinc-1","display_name":"CINC-1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neutrophil-chemotaxis","display_name":"neutrophil chemotaxis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/neutrophil-adhesion","display_name":"neutrophil adhesion","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C2781453256","wikidata":"https://www.wikidata.org/wiki/Q419394","display_name":"Sevoflurane","level":2,"score":0.9627887606620789},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.7425457239151001},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7136082053184509},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.6161561608314514},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.5643965005874634},{"id":"https://openalex.org/C2778012055","wikidata":"https://www.wikidata.org/wiki/Q448687","display_name":"Alveolar macrophage","level":4,"score":0.5367108583450317},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5114372968673706},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49801182746887207},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47738999128341675},{"id":"https://openalex.org/C2778162923","wikidata":"https://www.wikidata.org/wiki/Q4990531","display_name":"Anesthetic","level":2,"score":0.47496816515922546},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4677678942680359},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.44032377004623413},{"id":"https://openalex.org/C2777011798","wikidata":"https://www.wikidata.org/wiki/Q1936963","display_name":"Minimum alveolar concentration","level":3,"score":0.4163254499435425},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.3713045120239258},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.32186704874038696},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2966007590293884},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21036556363105774},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14997553825378418},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13951826095581055},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0755089819431305},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.052638083696365356}],"mesh":[{"descriptor_ui":"D000077149","descriptor_name":"Sevoflurane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000777","descriptor_name":"Anesthetics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008738","descriptor_name":"Methyl Ethers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015846","descriptor_name":"Monokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018685","descriptor_name":"Anesthetics, Inhalation","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019402","descriptor_name":"Macrophage Inflammatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019743","descriptor_name":"Chemokines, CXC","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054360","descriptor_name":"Chemokine CXCL1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054407","descriptor_name":"Chemokine CCL4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054426","descriptor_name":"Chemokine CXCL2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1213/01.ane.0000255046.06058.58","doi":"https://doi.org/10.1213/01.ane.0000255046.06058.58","is_oa":false,"landing_page_url":"https://doi.org/10.1213/01.ane.0000255046.06058.58","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},{"id":"pmid:17312223","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17312223","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Journal Article"},{"id":"pmh:oai:www.zora.uzh.ch:13388","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/13388/9/Suter_BeckSchimmer_AnesthAnalg_2007_V.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/13388/9/Suter_BeckSchimmer_AnesthAnalg_2007_V.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Suter, D; Spahn, D R; Blumenthal, S; Reyes, L; Booy, Ch; Z'graggen, B R; Beck-Schimmer, B (2007). The immunomodulatory effect of sevoflurane in endotoxin-injured alveolar epithelial cells. Anesthesia and Analgesia, 104(3):638-645.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.333.3447","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.333.3447","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.anesthesia-analgesia.org/content/104/3/638.full.pdf","raw_type":"text"},{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/39255","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/39255","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Suter, D., Spahn, D. R., Blumenthal, S., Reyes, L., Booy, C., Z\u2019graggen, B. R., & Beck-Schimmer, B. (2007). The immunomodulatory effect of sevoflurane in endotoxin-injured alveolar epithelial cells. Anesthesia and Analgesia, 104, 638\u2013645. https://doi.org/10.1213/01.ane.0000255046.06058.58","raw_type":"Journal Article"},{"id":"doi:10.5167/uzh-13388","doi":"https://doi.org/10.5167/uzh-13388","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-13388","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:www.zora.uzh.ch:13388","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/13388/9/Suter_BeckSchimmer_AnesthAnalg_2007_V.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/13388/9/Suter_BeckSchimmer_AnesthAnalg_2007_V.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Suter, D; Spahn, D R; Blumenthal, S; Reyes, L; Booy, Ch; Z'graggen, B R; Beck-Schimmer, B (2007). The immunomodulatory effect of sevoflurane in endotoxin-injured alveolar epithelial cells. Anesthesia and Analgesia, 104(3):638-645.","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1502093553","https://openalex.org/W1502626182","https://openalex.org/W1849393445","https://openalex.org/W1892829132","https://openalex.org/W1937470673","https://openalex.org/W2016451772","https://openalex.org/W2021519589","https://openalex.org/W2042152235","https://openalex.org/W2049927822","https://openalex.org/W2053627700","https://openalex.org/W2062288037","https://openalex.org/W2065506122","https://openalex.org/W2069192159","https://openalex.org/W2070070465","https://openalex.org/W2074041808","https://openalex.org/W2078907724","https://openalex.org/W2105180121","https://openalex.org/W2111644555","https://openalex.org/W2115734416","https://openalex.org/W2122521963","https://openalex.org/W2158234041","https://openalex.org/W2160403606","https://openalex.org/W2162731097","https://openalex.org/W2170485407","https://openalex.org/W2336975188","https://openalex.org/W2471946346"],"related_works":["https://openalex.org/W2040704674","https://openalex.org/W2024383876","https://openalex.org/W1983945149","https://openalex.org/W7167328760","https://openalex.org/W2375380046","https://openalex.org/W2140135444","https://openalex.org/W2030688675","https://openalex.org/W2052958934","https://openalex.org/W2032850433","https://openalex.org/W2351464807"],"abstract_inverted_index":{"BACKGROUND:":[0],"Endotoxin-induced":[1],"lung":[2,17],"injury":[3],"is":[4,31],"a":[5,131],"useful":[6],"experimental":[7],"system":[8],"for":[9,69,76],"the":[10,35,47,52,117,121,138,192,230,239,248],"characterization":[11],"of":[12,37,49,80,120,125,134,195,216,242,254],"immunopathologic":[13],"mechanisms":[14],"in":[15,130,137,152,191,203],"acute":[16],"injury.":[18],"Although":[19],"alveolar":[20],"epithelial":[21],"cells":[22,146,154,206,256],"(AEC)":[23],"are":[24],"directly":[25],"exposed":[26],"to":[27,115,127,218,238],"volatile":[28],"anesthetics,":[29],"there":[30],"limited":[32],"information":[33],"about":[34],"effect":[36,48],"anesthetics":[38],"on":[39,56],"these":[40],"cells.":[41],"In":[42,104],"this":[43],"study":[44,225],"we":[45],"investigated":[46],"pretreatment":[50],"with":[51,64,143,158,236,251],"inhaled":[53],"anesthetic":[54],"sevoflurane":[55,68,128,159,228],"lipopolysaccharide":[57],"(LPS)-injured":[58],"AEC.":[59],"METHODS:":[60],"AEC":[61,126,219],"were":[62,108],"incubated":[63],"1.1":[65],"vol":[66],"%":[67],"0.5":[70],"h,":[71],"followed":[72],"by":[73,156,164,171,181],"LPS":[74,145,205],"stimulation":[75],"5":[77],"h.":[78],"Expression":[79],"monocyte":[81],"chemoattractant":[82],"protein-1":[83],"(MCP-1),":[84],"macrophage":[85,89],"inflammatory":[86,90,193,232,243],"protein-1beta":[87],"(MIP-1beta),":[88],"protein-2":[91],"(MIP-2),":[92],"cytokine-induced":[93],"neutrophil":[94],"chemoattractant-1":[95],"(CINC-1),":[96],"and":[97,112,169],"intercellular":[98],"adhesion":[99,215],"molecule-1":[100],"(ICAM-1)":[101],"was":[102,179,201],"analyzed.":[103],"addition,":[105],"functional":[106],"tests":[107],"performed":[109],"through":[110],"chemotaxis":[111],"adherence":[113],"assays":[114],"underline":[116],"biological":[118,249],"relevance":[119],"findings.":[122],"RESULTS:":[123],"Exposure":[124],"resulted":[129],"50%":[132],"downregulation":[133],"MCP-1":[135],"protein":[136,177],"sevoflurane-LPS":[139],"group":[140],"when":[141],"compared":[142],"non-sevoflurane-":[144],"(P":[147,160,166,173,183,207,220],"<":[148,161,167,174,184,208,221],"0.05).":[149,175,185],"MIP-1beta":[150],"concentration":[151],"LPS-stimulated":[153],"decreased":[155,214],"32%":[157],"0.05),":[162,168],"MIP-2":[163],"29%":[165],"CINC-1":[170],"20%":[172],"ICAM-1":[176],"expression":[178,240],"attenuated":[180],"36%":[182],"This":[186,224],"inhibition":[187],"caused":[188],"substantial":[189],"changes":[190],"response":[194],"neutrophils.":[196,259],"33%":[197],"less":[198,252],"chemotactic":[199],"activity":[200],"seen":[202],"sevoflurane-treated":[204],"0.001)":[209],"as":[210,212,258],"well":[211],"47%":[213],"neutrophils":[217],"0.001).":[222],"CONCLUSIONS:":[223],"shows":[226],"that":[227],"alters":[229],"LPS-induced":[231],"response,":[233],"not":[234],"only":[235],"respect":[237],"pattern":[241],"mediators,":[244],"but":[245],"also":[246],"regarding":[247],"consequences":[250],"accumulation":[253],"effector":[255],"such":[257]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
