{"id":"https://openalex.org/W2000489621","doi":"https://doi.org/10.1073/pnas.94.11.5574","title":"Both an N-terminal 65-kDa domain and a C-terminal 30-kDa domain of SecA cycle into the membrane at SecYEG during translocation","display_name":"Both an N-terminal 65-kDa domain and a C-terminal 30-kDa domain of SecA cycle into the membrane at SecYEG during translocation","publication_year":1997,"publication_date":"1997-05-27","ids":{"openalex":"https://openalex.org/W2000489621","doi":"https://doi.org/10.1073/pnas.94.11.5574","mag":"2000489621","pmid":"https://pubmed.ncbi.nlm.nih.gov/9159114","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/20820"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.94.11.5574","doi":"https://doi.org/10.1073/pnas.94.11.5574","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.94.11.5574","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC20820","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023221161","display_name":"Jerry Eichler","orcid":"https://orcid.org/0000-0001-9409-8026","observed_orcids":["https://orcid.org/0000-0001-9409-8026"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry Eichler","raw_affiliation_strings":["Department of Biochemistry, Dartmouth Medical School, 7200 Vail, Hanover, NH 03755-3844","Department of Biochemistry, Dartmouth Medical School, 7200 Vail, Hanover, NH 03755-3844, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Dartmouth Medical School, 7200 Vail, Hanover, NH 03755-3844","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"Department of Biochemistry, Dartmouth Medical School, 7200 Vail, Hanover, NH 03755-3844, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017690454","display_name":"William T. Wickner","orcid":"https://orcid.org/0000-0001-8431-0468","observed_orcids":["https://orcid.org/0000-0001-8431-0468"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Wickner","raw_affiliation_strings":["Department of Biochemistry, Dartmouth Medical School, 7200 Vail, Hanover, NH 03755-3844"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Dartmouth Medical School, 7200 Vail, Hanover, NH 03755-3844","institution_ids":["https://openalex.org/I107672454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I107672454"],"apc_list":null,"apc_paid":null,"fwci":4.6407,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.95560999,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"94","issue":"11","first_page":"5574","last_page":"5581"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/seca","display_name":"SecA","score":0.9950000047683716},{"id":"https://openalex.org/keywords/secyeg","display_name":"SecYEG","score":0.7350000143051147},{"id":"https://openalex.org/keywords/preprotein-translocation","display_name":"preprotein translocation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/n-terminal-domain","display_name":"N-terminal domain","score":0.6240000128746033},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.9990000128746033},{"id":"https://openalex.org/keywords/preprotein-translocase","display_name":"preprotein translocase","score":0.7639999985694885},{"id":"https://openalex.org/keywords/protease-resistance","display_name":"protease resistance","score":0.7379999756813049},{"id":"https://openalex.org/keywords/bacterial-inner-membrane","display_name":"bacterial inner membrane","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C113035283","wikidata":"https://www.wikidata.org/wiki/Q909555","display_name":"Translocase","level":4,"score":0.6683061122894287},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.6267117857933044},{"id":"https://openalex.org/C65871279","wikidata":"https://www.wikidata.org/wiki/Q42884945","display_name":"Inner membrane","level":3,"score":0.6237770915031433},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5805071592330933},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5220898985862732},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.5058926939964294},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4729328453540802},{"id":"https://openalex.org/C115335371","wikidata":"https://www.wikidata.org/wiki/Q142943","display_name":"Membrane transport protein","level":4,"score":0.4568934440612793},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.44873932003974915},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.4485984742641449},{"id":"https://openalex.org/C199229279","wikidata":"https://www.wikidata.org/wiki/Q610647","display_name":"Translocon","level":4,"score":0.44799157977104187},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.44190913438796997},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.4395405948162079},{"id":"https://openalex.org/C161200384","wikidata":"https://www.wikidata.org/wiki/Q1757382","display_name":"Integral membrane protein","level":4,"score":0.42430809140205383},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.4066981375217438},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4030839800834656},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3341299295425415},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.12155726552009583},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09082669019699097},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06716927886009216}],"mesh":[{"descriptor_ui":"D000069816","descriptor_name":"SEC Translocation Channels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081416","descriptor_name":"SecA Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010449","descriptor_name":"Peptide Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.94.11.5574","doi":"https://doi.org/10.1073/pnas.94.11.5574","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.94.11.5574","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:189702","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC20820","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:20820","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/20820","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:9159114","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9159114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"mag:3152350075","doi":null,"is_oa":false,"landing_page_url":"https://ci.nii.ac.jp/naid/80009716104","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:189702","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC20820","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W151834247","https://openalex.org/W1511406372","https://openalex.org/W1515069540","https://openalex.org/W1547447654","https://openalex.org/W1572793754","https://openalex.org/W1572886851","https://openalex.org/W1576501498","https://openalex.org/W1590719173","https://openalex.org/W1604426609","https://openalex.org/W1665555949","https://openalex.org/W1666626663","https://openalex.org/W1764246553","https://openalex.org/W1844558817","https://openalex.org/W1908462512","https://openalex.org/W1932645010","https://openalex.org/W1964517070","https://openalex.org/W1965731203","https://openalex.org/W1974902012","https://openalex.org/W1982019176","https://openalex.org/W1992470956","https://openalex.org/W2002723487","https://openalex.org/W2008223866","https://openalex.org/W2008415333","https://openalex.org/W2028858498","https://openalex.org/W2040338718","https://openalex.org/W2048052250","https://openalex.org/W2053211842","https://openalex.org/W2056613088","https://openalex.org/W2065123532","https://openalex.org/W2066537459","https://openalex.org/W2073075045","https://openalex.org/W2080304004","https://openalex.org/W2081704293","https://openalex.org/W2084407726","https://openalex.org/W2105931049","https://openalex.org/W2110816265","https://openalex.org/W2110965426","https://openalex.org/W2126106174","https://openalex.org/W2134791113","https://openalex.org/W2152737402","https://openalex.org/W2158291867","https://openalex.org/W2162097287","https://openalex.org/W2164358316","https://openalex.org/W2314225431"],"related_works":["https://openalex.org/W2134791113","https://openalex.org/W2066537459","https://openalex.org/W1964775821","https://openalex.org/W1964517070","https://openalex.org/W2110965426","https://openalex.org/W2144302243","https://openalex.org/W7015893319","https://openalex.org/W2129223580","https://openalex.org/W2010250752","https://openalex.org/W2126106174"],"abstract_inverted_index":{"SecA,":[0],"a":[1,56,76],"102-kDa":[2],"hydrophilic":[3],"protein,":[4],"couples":[5],"the":[6,12,17,41,50,70,113,141,146,165,183,188,196,199,217,220],"energy":[7],"of":[8,14,44,52,60,90,115,120,167,175,182,202,207,219,222],"ATP":[9,53],"binding":[10],"to":[11,216],"translocation":[13,48,205],"preprotein":[15,45,121,153,191,225],"across":[16],"bacterial":[18],"inner":[19,33],"membrane.":[20],"SecA":[21,61,104,125,176,203,223],"function":[22],"and":[23,31,54,98,108,131,209],"topology":[24],"were":[25],"studied":[26],"with":[27,32,110],"metabolically":[28],"labeled":[29],"[35S]SecA":[30,142,156],"membrane":[34,138,147,189,200],"vesicles":[35],"from":[36,64,160],"cells":[37],"that":[38,128,132,143,172],"overexpressed":[39],"SecYEGDFyajC,":[40],"integral":[42],"domain":[43,59,79],"translocase.":[46],"During":[47],"in":[49,224],"presence":[51,114],"preprotein,":[55],"65-kDa":[57],"N-terminal":[58],"is":[62,99],"protected":[63],"proteolytic":[65],"digestion":[66],"through":[67],"insertion":[68],"into":[69,145,187],"membrane,":[71],"as":[72,150,193,195],"previously":[73],"reported":[74],"for":[75],"30-kDa":[77],"C-terminal":[78],"[Economou,":[80],"A.":[81],"&":[82],"Wickner,":[83],"W.":[84],"(1994)":[85],"Cell":[86],"78,":[87],"835-843].":[88],"Insertion":[89],"both":[91],"domains":[92,127,174],"occurs":[93],"at":[94,148,204,210],"saturable":[95],"SecYEGDFyajC":[96,149,208],"sites":[97,206],"rapidly":[100],"followed":[101],"by":[102],"deinsertion.":[103],"also":[105],"associates":[106],"nonsaturably":[107],"unproductively":[109],"lipid.":[111],"In":[112],"ATP,":[116],"yet":[117],"without":[118],"involvement":[119],"or":[122],"SecYEG,":[123],"lipid-bound":[124],"forms":[126],"are":[129,214],"protease-resistant":[130,162],"remain":[133],"so":[134],"even":[135],"upon":[136,164],"subsequent":[137],"disruption.":[139],"Unlike":[140],"inserts":[144],"it":[151],"promotes":[152],"translocation,":[154,192],"lipid-associated":[155],"does":[157],"not":[158],"chase":[159],"its":[161],"state":[163],"addition":[166],"excess":[168],"SecA.":[169],"The":[170],"finding":[171],"two":[173],"(which":[177],"together":[178],"represent":[179],"most":[180],"regions":[181],"polypeptide":[184],"chain)":[185],"cycle":[186],"during":[190],"well":[194],"distinction":[197],"between":[198],"association":[201],"nonproductive":[211],"lipid":[212],"sites,":[213],"fundamental":[215],"study":[218],"role":[221],"movement.":[226]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
