{"id":"https://openalex.org/W2000488410","doi":"https://doi.org/10.1109/ultsym.2011.0276","title":"Micro-localized cell lysis by low power Focused Acoustic Transducer","display_name":"Micro-localized cell lysis by low power Focused Acoustic Transducer","publication_year":2011,"publication_date":"2011-10-01","ids":{"openalex":"https://openalex.org/W2000488410","doi":"https://doi.org/10.1109/ultsym.2011.0276","mag":"2000488410"},"language":"en","primary_location":{"id":"doi:10.1109/ultsym.2011.0276","doi":"https://doi.org/10.1109/ultsym.2011.0276","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ultsym.2011.0276","pdf_url":null,"source":{"id":"https://openalex.org/S4393917990","display_name":"IEEE International Ultrasonics Symposium","issn_l":"1948-5719","issn":["1948-5719"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Ultrasonics Symposium","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086677205","display_name":"Lingtao Wang","orcid":"https://orcid.org/0000-0003-0312-9160","observed_orcids":["https://orcid.org/0000-0003-0312-9160","https://orcid.org/0000-0003-3765-9282"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lingtao Wang","raw_affiliation_strings":["Department of EE-Electrophysics, University of Southern California, Los Angeles, CA, USA","Department of EE-Electrophysics, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of EE-Electrophysics, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of EE-Electrophysics, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067750617","display_name":"Yijia Li","orcid":"https://orcid.org/0000-0002-8791-8097","observed_orcids":["https://orcid.org/0000-0002-8791-8097"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi-Jia Li","raw_affiliation_strings":["Department of Medicine, University of Southern California, Los Angeles, CA, USA","Department of Medicine, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Medicine, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102087739","display_name":"Anderson Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anderson Lin","raw_affiliation_strings":["Department of EE-Electrophysics, University of Southern California, Los Angeles, CA, USA","Department of EE-Electrophysics, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of EE-Electrophysics, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of EE-Electrophysics, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111797338","display_name":"Youngki Choe","orcid":"https://orcid.org/0009-0003-8172-6611","observed_orcids":["https://orcid.org/0009-0003-8172-6611"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Youngki Choe","raw_affiliation_strings":["Department of EE-Electrophysics, University of Southern California, Los Angeles, CA, USA","Department of EE-Electrophysics, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of EE-Electrophysics, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of EE-Electrophysics, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011277587","display_name":"Mitchell Eric Gross","orcid":"https://orcid.org/0000-0002-1691-921X","observed_orcids":["https://orcid.org/0000-0002-1691-921X"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell Gross","raw_affiliation_strings":["Department of Medicine, University of Southern California, Los Angeles, CA, USA","Department of Medicine, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Medicine, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046110835","display_name":"Eun Sok Kim","orcid":"https://orcid.org/0000-0002-3158-5553","observed_orcids":["https://orcid.org/0000-0002-3158-5553"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eun Sok Kim","raw_affiliation_strings":["Department of EE-Electrophysics, University of Southern California, Los Angeles, CA, USA","Department of EE-Electrophysics, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of EE-Electrophysics, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of EE-Electrophysics, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":null,"apc_paid":null,"fwci":0.6766,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.64489556,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1123","last_page":"1126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.03240000084042549,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10822","display_name":"Acoustic Wave Phenomena Research","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mrna-release","display_name":"mRNA release","score":0.9380000233650208},{"id":"https://openalex.org/keywords/inertial-cavitation","display_name":"inertial cavitation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.3630000054836273},{"id":"https://openalex.org/keywords/cancer-diagnosis-and-treatment","display_name":"cancer diagnosis and treatment","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.8121464252471924},{"id":"https://openalex.org/C73588182","wikidata":"https://www.wikidata.org/wiki/Q2663023","display_name":"Cytolysis","level":4,"score":0.6236575841903687},{"id":"https://openalex.org/C56318395","wikidata":"https://www.wikidata.org/wiki/Q215928","display_name":"Transducer","level":2,"score":0.5648925304412842},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.44171276688575745},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.36833447217941284},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3423337936401367},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2711576223373413},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2379608452320099},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.19169846177101135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18185386061668396},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.15515533089637756},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.15197226405143738},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11399844288825989},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/ultsym.2011.0276","doi":"https://doi.org/10.1109/ultsym.2011.0276","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ultsym.2011.0276","pdf_url":null,"source":{"id":"https://openalex.org/S4393917990","display_name":"IEEE International Ultrasonics Symposium","issn_l":"1948-5719","issn":["1948-5719"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Ultrasonics Symposium","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1668895875","https://openalex.org/W1883554510","https://openalex.org/W1981953976","https://openalex.org/W2014840564","https://openalex.org/W2015230575","https://openalex.org/W2055826997","https://openalex.org/W2090147784","https://openalex.org/W2126319786","https://openalex.org/W2171932900","https://openalex.org/W2539446173","https://openalex.org/W2597330657"],"related_works":["https://openalex.org/W2620370100","https://openalex.org/W1981714108","https://openalex.org/W1551032917","https://openalex.org/W2030400914","https://openalex.org/W1520397689","https://openalex.org/W4313341530","https://openalex.org/W1998825320","https://openalex.org/W2012343470","https://openalex.org/W1994503499","https://openalex.org/W1581925705"],"abstract_inverted_index":{"In":[0],"this":[1],"study,":[2],"we":[3],"designed":[4],"and":[5,28,37,71,136,180],"fabricated":[6],"Self":[7],"Focused":[8],"Acoustic":[9],"Transducer":[10],"(SFAT)":[11],"for":[12,80],"micron-sized":[13,167],"localized":[14,49],"cytolysis.":[15,119],"Monolayer":[16],"22RV1":[17,85],"prostate":[18],"cancer":[19,178],"cells":[20,128],"were":[21,44,69,162],"cultured":[22],"in":[23,107],"the":[24,32,48,62,67,81,99,108,118,124,133,140,145],"cell":[25,50,54,82,168],"culture":[26,109],"chamber":[27],"locally":[29],"lysed":[30,127],"by":[31,66,132,139],"SFAT.":[33],"Various":[34],"electric":[35,77,141],"powers":[36],"operating":[38],"frequencies":[39],"of":[40,84,104,126,151],"actuating":[41],"pulsed":[42],"signal":[43],"applied":[45,143],"to":[46,121,144,177],"characterize":[47],"lysis":[51,55,83,169],"effects.":[52],"The":[53,75,102],"area":[56,129],"was":[57,111],"around":[58],"2.28\u00d710\u22129m2and":[59],"1.64\u00d710\u22129m2,":[60],"when":[61],"acoustic":[63,95],"waves":[64],"produced":[65],"transducer":[68],"17.3":[70],"52":[72],"MHz,":[73],"respectively.":[74],"minimum":[76],"power":[78,142],"required":[79],"is":[86,130],"as":[87,89,156],"low":[88],"9":[90],"mW,":[91],"which":[92],"produces":[93],"an":[94],"intensity":[96],"0.15":[97],"W/cm2at":[98],"focal":[100],"spot.":[101],"amount":[103],"mRNA":[105],"released":[106],"media":[110],"increased":[112],"more":[113],"than":[114],"10":[115],"times":[116],"after":[117],"According":[120],"experiment":[122],"results,":[123],"size":[125],"determined":[131],"acoustic-wave":[134],"frequency,":[135],"very":[137],"little":[138],"device":[146],"above":[147],"a":[148],"threshold.":[149],"Signs":[150],"inertia":[152],"cavitation":[153,171],"phenomena":[154],"such":[155],"bubble":[157],"generation":[158],"or":[159],"temperature":[160],"raise":[161],"not":[163],"observed.":[164],"Therefore,":[165],"low-power":[166],"without":[170],"may":[172],"have":[173],"practical":[174],"applications":[175],"relating":[176],"diagnosis":[179],"therapeutics.":[181]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}