{"id":"https://openalex.org/W2000487735","doi":"https://doi.org/10.1213/00000539-197505000-00010","title":"Pyridostigmine as an Antagonist of d-Tubocurarine???Induced and Pancuronium-Induced Neuromuscular Blockade","display_name":"Pyridostigmine as an Antagonist of d-Tubocurarine???Induced and Pancuronium-Induced Neuromuscular Blockade","publication_year":1975,"publication_date":"1975-05-01","ids":{"openalex":"https://openalex.org/W2000487735","doi":"https://doi.org/10.1213/00000539-197505000-00010","mag":"2000487735","pmid":"https://pubmed.ncbi.nlm.nih.gov/1169015"},"language":"en","primary_location":{"id":"doi:10.1213/00000539-197505000-00010","doi":"https://doi.org/10.1213/00000539-197505000-00010","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-197505000-00010","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia & Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035671904","display_name":"Mark B. Ravin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"MARK B. RAVIN","raw_affiliation_strings":["Professor and Chairman Department of Anesthesiology, University of Kentucky Medical Center, Lexington, Kentucky 40506"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor and Chairman Department of Anesthesiology, University of Kentucky Medical Center, Lexington, Kentucky 40506","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035671904"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":null,"apc_paid":null,"fwci":1.7083,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.80143663,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"54","issue":"3","first_page":"317???321","last_page":"317???321"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyridostigmine","display_name":"pyridostigmine","score":1.0},{"id":"https://openalex.org/keywords/neuromuscular-blockade-reversal","display_name":"neuromuscular blockade reversal","score":0.878000020980835},{"id":"https://openalex.org/keywords/tubocurarine","display_name":"tubocurarine","score":0.9539999961853027},{"id":"https://openalex.org/keywords/pancuronium","display_name":"pancuronium","score":1.0},{"id":"https://openalex.org/keywords/atropine","display_name":"atropine","score":0.753000020980835},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cardiac-arrhythmia","display_name":"cardiac arrhythmias","score":0.7609999775886536},{"id":"https://openalex.org/keywords/bronchospasm","display_name":"bronchospasm","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C2779901103","wikidata":"https://www.wikidata.org/wiki/Q419472","display_name":"Pyridostigmine","level":3,"score":0.980807900428772},{"id":"https://openalex.org/C2775859210","wikidata":"https://www.wikidata.org/wiki/Q26272","display_name":"Atropine","level":2,"score":0.8225630521774292},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7579708099365234},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6487871408462524},{"id":"https://openalex.org/C2909465803","wikidata":"https://www.wikidata.org/wiki/Q3286619","display_name":"Neuromuscular Blockade","level":2,"score":0.5965589284896851},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5955469608306885},{"id":"https://openalex.org/C2777411258","wikidata":"https://www.wikidata.org/wiki/Q410546","display_name":"Neostigmine","level":2,"score":0.5107364654541016},{"id":"https://openalex.org/C2910532367","wikidata":"https://www.wikidata.org/wiki/Q419472","display_name":"Pyridostigmine Bromide","level":4,"score":0.483779639005661},{"id":"https://openalex.org/C2909581452","wikidata":"https://www.wikidata.org/wiki/Q27162963","display_name":"Glycopyrrolate","level":3,"score":0.47465330362319946},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.4183991551399231},{"id":"https://openalex.org/C2776860028","wikidata":"https://www.wikidata.org/wiki/Q1225289","display_name":"Muscle relaxant","level":2,"score":0.4116043746471405},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34500378370285034},{"id":"https://openalex.org/C2778105408","wikidata":"https://www.wikidata.org/wiki/Q8285","display_name":"Myasthenia gravis","level":2,"score":0.1846713125705719},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07810315489768982},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.056695520877838135}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001285","descriptor_name":"Atropine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009127","descriptor_name":"Muscle Rigidity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009407","descriptor_name":"Nerve Block","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D009469","descriptor_name":"Neuromuscular Junction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010197","descriptor_name":"Pancuronium","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D011729","descriptor_name":"Pyridostigmine Bromide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014403","descriptor_name":"Tubocurarine","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1213/00000539-197505000-00010","doi":"https://doi.org/10.1213/00000539-197505000-00010","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-197505000-00010","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia & Analgesia","raw_type":"journal-article"},{"id":"pmid:1169015","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1169015","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2026480468","https://openalex.org/W2409640024","https://openalex.org/W2089148342","https://openalex.org/W2397172166","https://openalex.org/W1966562013","https://openalex.org/W2034615264","https://openalex.org/W2068767408","https://openalex.org/W1996228932","https://openalex.org/W2078245138","https://openalex.org/W2064738745"],"abstract_inverted_index":{"In":[0,122],"an":[1,10,130],"evaluation":[2],"of":[3,7,12,53,60,109,119,133,142,151,164,205,213,216],"the":[4,107,116],"clinical":[5],"effectiveness":[6],"pyridostigmine":[8,54,110,134,206],"as":[9],"antagonist":[11],"d-tubocurarine-induced":[13],"and":[14,64,75,85,92,115,135,178],"pancuronium-induced":[15],"neuromuscular":[16,125],"blockade":[17,126],"in":[18,181,191],"patients":[19,147,192],"anesthetized":[20],"with":[21,45,193],"a":[22,154],"neurolept-nitrous":[23],"oxide":[24],"(N2O)":[25],"technic,":[26],"60":[27],"adults":[28],"received":[29],"either":[30,136,194],"d-tubocurarine":[31],"(dTc)":[32],"(N":[33,38],"equals":[34,39],"30)":[35],"or":[36,70,78,88,95,139,187,196],"pancuronium":[37,195],"30).":[40],"The":[41,50,201],"pancuronium-dTc":[42],"potency":[43],"ratio":[44],"neurolept-N2O":[46],"anesthesia":[47],"is":[48],"4.85:1.":[49],"mean":[51],"doses":[52],"necessary":[55,111],"for":[56,83,100,112],"50":[57],"percent":[58],"recovery":[59],"control":[61,175],"twitch":[62],"height":[63],"sustained":[65],"tetanus":[66],"were":[67],"5.72":[68],"plus":[69,77,87,94],"minus":[71,79,89,96],"0.45":[72],"(S.E.)":[73],"mg.":[74,91,138,141,150,215],"11.6":[76],"0.88":[80],"mg.,":[81,98],"respectively,":[82,99],"dTc,":[84],"4.05":[86],"0.24":[90],"8.27":[93],"0.41":[97],"pancuronium.":[101],"There":[102,170],"was":[103,127,171,189],"no":[104,172],"correlation":[105,173],"between":[106,174],"amount":[108],"relaxant":[113,120],"antagonism":[114],"total":[117],"dose":[118],"used.":[121],"24":[123],"patients,":[124],"reversed":[128],"by":[129,210],"intravenous":[131],"injection":[132],"0.6":[137,162],"1":[140,149,214],"atropine.":[143,217],"Within":[144],"2":[145],"minutes,":[146],"given":[148,161],"atropine":[152,165],"had":[153],"significantly":[155],"faster":[156],"heart":[157,176,182],"rate":[158,177],"than":[159,168],"those":[160],"mg":[163],"(p":[166],"smaller":[167],"0.0001).":[169],"maximum":[179],"changes":[180],"rate.":[183],"No":[184],"cardiac":[185,202],"arrhythmia":[186],"bronchospasm":[188],"observed":[190],"dTc":[197],"following":[198],"atropine-pyridostigmine":[199],"mixtures.":[200],"muscarinic":[203],"effects":[204],"could":[207],"be":[208],"modified":[209],"simultaneous":[211],"administration":[212]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}