{"id":"https://openalex.org/W2000484633","doi":"https://doi.org/10.1002/hep.24080","title":"Autoimmune acute liver failure: Proposed clinical and histological criteria","display_name":"Autoimmune acute liver failure: Proposed clinical and histological criteria","publication_year":2010,"publication_date":"2010-11-18","ids":{"openalex":"https://openalex.org/W2000484633","doi":"https://doi.org/10.1002/hep.24080","mag":"2000484633","pmid":"https://pubmed.ncbi.nlm.nih.gov/21274872","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3080034"},"language":"en","primary_location":{"id":"doi:10.1002/hep.24080","doi":"https://doi.org/10.1002/hep.24080","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.24080","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.24080","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.24080","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063422612","display_name":"R. Todd Stravitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R. Todd Stravitz","raw_affiliation_strings":["Section of Hepatology, Virginia Commonwealth University, Richmond, VA 23298-0341, USA. rstravit@vcu.edu","Section of Hepatology, Virginia Commonwealth University, Richmond, VA","These authors contributed equally to this work","fax: 804-828-4945"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hepatology, Virginia Commonwealth University, Richmond, VA 23298-0341, USA. rstravit@vcu.edu","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Section of Hepatology, Virginia Commonwealth University, Richmond, VA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]},{"raw_affiliation_string":"fax: 804-828-4945","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069869000","display_name":"Jay H. Lefkowitch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay H. Lefkowitch","raw_affiliation_strings":["Department of Pathology, Columbia University, New York, NY","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Columbia University, New York, NY","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063597784","display_name":"Robert J. Fontana","orcid":"https://orcid.org/0000-0001-9161-5892","observed_orcids":["https://orcid.org/0000-0001-9161-5892"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Fontana","raw_affiliation_strings":["Division of Gastroenterology, University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029678899","display_name":"Merrill Eric Gershwin","orcid":"https://orcid.org/0000-0001-5245-2680","observed_orcids":["https://orcid.org/0000-0001-5245-2680"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Eric Gershwin","raw_affiliation_strings":["Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016645912","display_name":"Patrick S.C. Leung","orcid":"https://orcid.org/0000-0001-5862-4316","observed_orcids":["https://orcid.org/0000-0001-5862-4316"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick S. C. Leung","raw_affiliation_strings":["Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085461623","display_name":"Richard K. Sterling","orcid":"https://orcid.org/0000-0002-8637-2475","observed_orcids":["https://orcid.org/0000-0002-8637-2475"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard K. Sterling","raw_affiliation_strings":["Section of Hepatology, Virginia Commonwealth University, Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hepatology, Virginia Commonwealth University, Richmond, VA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002183557","display_name":"Michael Peter Manns","orcid":"https://orcid.org/0000-0002-4485-8856","observed_orcids":["https://orcid.org/0000-0002-4485-8856"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael P. Manns","raw_affiliation_strings":["Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071510920","display_name":"Gary L. Norman","orcid":"https://orcid.org/0000-0001-8992-1866","observed_orcids":["https://orcid.org/0000-0001-8992-1866"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary L. Norman","raw_affiliation_strings":["INOVA Diagnostics, Inc., San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INOVA Diagnostics, Inc., San Diego, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070467866","display_name":"William M. Lee","orcid":"https://orcid.org/0000-0002-2783-5441","observed_orcids":["https://orcid.org/0000-0002-2783-5441"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William M. Lee","raw_affiliation_strings":["Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":null,"display_name":"and the Acute Liver Failure Study Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"and the Acute Liver Failure Study Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5063422612"],"corresponding_institution_ids":["https://openalex.org/I184840846"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":9.4238,"has_fulltext":true,"cited_by_count":304,"citation_normalized_percentile":{"value":0.98142478,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"53","issue":"2","first_page":"517","last_page":"526"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoimmune-hepatitis","display_name":"autoimmune hepatitis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/histological-criteria","display_name":"histological criteria","score":0.6800000071525574},{"id":"https://openalex.org/keywords/lymphoid-follicles","display_name":"lymphoid follicles","score":0.8169999718666077},{"id":"https://openalex.org/keywords/plasma-cell-infiltration","display_name":"plasma cell infiltration","score":0.7149999737739563},{"id":"https://openalex.org/keywords/antinuclear-antibodies","display_name":"antinuclear antibodies","score":0.9129999876022339},{"id":"https://openalex.org/keywords/anti-smooth-muscle-antibodies","display_name":"anti-smooth muscle antibodies","score":0.9810000061988831},{"id":"https://openalex.org/keywords/serum-globulin","display_name":"serum globulin","score":0.8880000114440918},{"id":"https://openalex.org/keywords/liver-transplantation-avoidance","display_name":"liver transplantation avoidance","score":0.5609999895095825},{"id":"https://openalex.org/keywords/chronic-hepatitis","display_name":"chronic hepatitis","score":0.5720000267028809},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C2777203481","wikidata":"https://www.wikidata.org/wiki/Q786844","display_name":"Autoimmune hepatitis","level":3,"score":0.8865622282028198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7574162483215332},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.5970518589019775},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.5403864979743958},{"id":"https://openalex.org/C149443304","wikidata":"https://www.wikidata.org/wiki/Q185390","display_name":"Anti-nuclear antibody","level":4,"score":0.520204484462738},{"id":"https://openalex.org/C2780366471","wikidata":"https://www.wikidata.org/wiki/Q1072420","display_name":"Primary biliary cirrhosis","level":2,"score":0.5150480270385742},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4778582453727722},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4703122675418854},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.45877254009246826},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4544631838798523},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4252723455429077},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.378729909658432},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.3234953284263611},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2649911046028137},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D019693","descriptor_name":"Hepatitis, Autoimmune","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D019693","descriptor_name":"Hepatitis, Autoimmune","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019693","descriptor_name":"Hepatitis, Autoimmune","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/hep.24080","doi":"https://doi.org/10.1002/hep.24080","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.24080","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.24080","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:21274872","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21274872","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3080034","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3080034","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Hepatology","raw_type":"Text"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/79410","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2027.42/79410","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1002/hep.24080","doi":"https://doi.org/10.1002/hep.24080","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.24080","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.24080","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8799999952316284,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1161266311","display_name":null,"funder_award_id":"U01-58369","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G647138937","display_name":"Xenobiotics and Primary Biliary Cirrhosis","funder_award_id":"R01DK067003","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G750565536","display_name":null,"funder_award_id":"U\u201001 58369","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8996703355","display_name":"A Multi-Center Group to Study Acute Liver Failure","funder_award_id":"U01DK058369","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G922413851","display_name":null,"funder_award_id":"DK29588","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000484633.pdf","grobid_xml":"https://content.openalex.org/works/W2000484633.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W73738779","https://openalex.org/W1582812268","https://openalex.org/W1973130325","https://openalex.org/W1974366822","https://openalex.org/W1980776504","https://openalex.org/W1983690725","https://openalex.org/W1989769745","https://openalex.org/W1998891055","https://openalex.org/W1998983511","https://openalex.org/W2003442188","https://openalex.org/W2007984047","https://openalex.org/W2010404502","https://openalex.org/W2018625801","https://openalex.org/W2018784940","https://openalex.org/W2019661805","https://openalex.org/W2027587297","https://openalex.org/W2027890508","https://openalex.org/W2032153844","https://openalex.org/W2047028490","https://openalex.org/W2049470465","https://openalex.org/W2067445099","https://openalex.org/W2071276803","https://openalex.org/W2083171998","https://openalex.org/W2087358521","https://openalex.org/W2099612481","https://openalex.org/W2100395027","https://openalex.org/W2121191489","https://openalex.org/W2132675308","https://openalex.org/W2156015715","https://openalex.org/W2159616534","https://openalex.org/W2163721979","https://openalex.org/W2303084665","https://openalex.org/W2336081198","https://openalex.org/W2415856156","https://openalex.org/W4297752219"],"related_works":["https://openalex.org/W2052931635","https://openalex.org/W1963803235","https://openalex.org/W4235823470","https://openalex.org/W3092433364","https://openalex.org/W2800288569","https://openalex.org/W4396699376","https://openalex.org/W2027890508","https://openalex.org/W2796138640","https://openalex.org/W2008704581","https://openalex.org/W2784769141"],"abstract_inverted_index":{"UNLABELLED:":[0],"Identifying":[1],"autoimmune":[2,31,79,176,235,251],"hepatitis":[3,177,206],"as":[4],"the":[5,20,48,174,218,259],"etiology":[6],"of":[7,30,47,77,83,90,93,137,155,204,234,255],"acute":[8],"liver":[9,23],"failure":[10],"(ALF)":[11],"is":[12],"potentially":[13],"important,":[14],"because":[15],"administering":[16],"corticosteroids":[17],"might":[18],"avoid":[19],"need":[21],"for":[22,113,161],"transplantation.":[24],"However,":[25],"clinical":[26,64,243],"and":[27,41,66,103,133,163,201,224,242],"histological":[28,167,238,253],"criteria":[29],"ALF":[32,49,55,230],"(AI-ALF)":[33],"have":[34,173,232],"not":[35],"been":[36],"defined.":[37],"Liver":[38],"sections":[39,108],"(biopsies":[40],"explants)":[42],"from":[43],"a":[44,59,97,134],"72-patient":[45],"subset":[46],"Study":[50],"Group":[51],"Registry":[52],"with":[53,69,228],"indeterminate":[54,229],"were":[56,67,110,169],"reviewed":[57],"by":[58,237],"pathologist":[60],"blinded":[61],"to":[62,150,172,217,249],"all":[63],"data":[65],"diagnosed":[68],"probable":[70,112,156,164],"AI-ALF":[71,165,222,256],"based":[72],"on":[73],"four":[74],"features":[75,233,254],"suggestive":[76,154],"an":[78],"pathogenesis:":[80],"distinctive":[81],"patterns":[82],"massive":[84],"hepatic":[85],"necrosis":[86],"(present":[87],"in":[88,207,258],"42%":[89],"sections),":[91],"presence":[92],"lymphoid":[94],"follicles":[95],"(32%),":[96],"plasma":[98],"cell-enriched":[99],"inflammatory":[100],"infiltrate":[101],"(63%),":[102],"central":[104],"perivenulitis":[105],"(65%).":[106],"Forty-two":[107],"(58%)":[109],"considered":[111],"AI-ALF;":[114],"this":[115],"group":[116],"demonstrated":[117],"higher":[118,135,187,202],"serum":[119],"globulins":[120,188],"(3.7":[121],"\u00b1":[122,127,190,195],"0.2":[123,128,191,196],"g/dL":[124,192],"versus":[125,144,182,193,211],"3.0":[126,194],"g/dL;":[129,197],"P":[130,146,184,198,213],"=":[131,147,214],"0.037)":[132],"prevalence":[136],"antinuclear":[138],"and/or":[139],"anti-smooth":[140],"muscle":[141],"antibodies":[142],"(73%":[143],"48%;":[145,183],"0.034)":[148],"compared":[149,216],"those":[151],"without":[152,220],"histology":[153,223],"AI-ALF.":[157],"Thirty":[158],"patients":[159],"concordant":[160,221],"autoantibodies":[162],"upon":[166],"analysis":[168],"more":[170],"likely":[171],"classical":[175,250],"phenotype":[178],"(female":[179],"predominance":[180],"[72%":[181],"<":[185,199],"0.05],":[186],"[3.9":[189],"0.005],":[200],"incidence":[203],"chronic":[205],"long-term":[208],"follow-up":[209],"[67%":[210],"17%,":[212],"0.019])":[215],"population":[219],"autoantibodies.":[225],"CONCLUSION:":[226],"Patients":[227],"often":[231],"disease":[236],"analysis,":[239],"serological":[240],"testing,":[241],"recurrence":[244],"during":[245],"follow-up.":[246],"In":[247],"contrast":[248],"hepatitis,":[252],"predominate":[257],"centrilobular":[260],"zone.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":30},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":13}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}